ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Baguette (ukb-b-5277)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Baguette (👉 📊) Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) Inverse variance weighted 14 0.519202926 0.249054002 0.037096523
Baguette (👉 📊) Compression fracture (ebi-a-GCST90018828) Inverse variance weighted 14 1.02675939 0.459721454 0.025520071
Baguette (👉 📊) Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) Weighted median 13 6.253366355 2.715120144 0.02126963
Baguette (👉 📊) Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) Inverse variance weighted 13 4.766438991 1.893653216 0.011833863
Baguette (👉 📊) Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) Weighted median 13 6.2732706 2.747361916 0.022408008
Baguette (👉 📊) Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) Inverse variance weighted 13 4.790068453 1.908503452 0.012078047
Baguette (👉 📊) Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) Weighted median 13 0.517616077 0.243974774 0.03387162
Baguette (👉 📊) Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) MR Egger 13 -11.09515486 3.790831455 0.013768027
Baguette (👉 📊) Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) Inverse variance weighted 13 -2.203085205 0.838791848 0.008626847
Baguette (👉 📊) Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) MR Egger 13 -5.081570678 1.598173064 0.008767217
Baguette (👉 📊) Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) Weighted median 13 -2.549873628 1.180116046 0.030718725
Baguette (👉 📊) Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) Weighted mode 13 -2.952306101 1.302901585 0.042749641
Baguette (👉 📊) Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) Inverse variance weighted 13 -1.644634645 0.830306356 0.047618596
Baguette (👉 📊) Osteomalacia (finn-b-M13_OSTEOMALACIA) Weighted median 13 5.88111256 2.839074951 0.03831312
Baguette (👉 📊) Osteomalacia (finn-b-M13_OSTEOMALACIA) Weighted mode 13 6.423377078 2.888875037 0.046148224
Baguette (👉 📊) Disorders of synovium and tendon (finn-b-M13_SYNOTEND) Weighted median 13 -0.744623169 0.307788947 0.015551886
Baguette (👉 📊) Disorders of synovium and tendon (finn-b-M13_SYNOTEND) Weighted mode 13 -0.750782553 0.337531227 0.046077925
Baguette (👉 📊) Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) Weighted median 13 -1.041513696 0.449666991 0.020547957
Baguette (👉 📊) Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) Inverse variance weighted 13 -0.805454841 0.326187483 0.013537757
Baguette (👉 📊) Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) Inverse variance weighted 13 2.918557756 1.138204465 0.010342078
Baguette (👉 📊) Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) Inverse variance weighted 13 0.748109308 0.356896859 0.036068898
Baguette (👉 📊) Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) Inverse variance weighted 13 0.603533978 0.285431183 0.034475651
Baguette (👉 📊) Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) MR Egger 13 4.941629756 2.064631531 0.035642083
Baguette (👉 📊) Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) Weighted median 13 1.646089899 0.782687883 0.035454906
Baguette (👉 📊) Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) MR Egger 13 5.448331567 2.397896403 0.044142178
Baguette (👉 📊) Shoulder region (finn-b-Z21_SHOUL_REGION) Inverse variance weighted 13 4.011307029 1.873454645 0.032263681
Baguette (👉 📊) Shoulder region (finn-b-Z21_SHOUL_REGION) Simple mode 13 11.54072899 4.685277608 0.029863572
Baguette (👉 📊) Bone sialoprotein 2 (prot-a-1396) Weighted median 13 1.192155483 0.55121629 0.030558675
Baguette (👉 📊) Bone sialoprotein 2 (prot-a-1396) Inverse variance weighted 13 0.98318093 0.403742857 0.014884954
Baguette (👉 📊) Heel bone mineral density (BMD) T-score automated (ukb-a-500) Inverse variance weighted 14 0.137473295 0.068776883 0.045626754
Baguette (👉 📊) Operation code: elbow surgery (ukb-b-10324) Inverse variance weighted 3 -0.013729737 0.006121809 0.02491243
Baguette (👉 📊) Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) Inverse variance weighted 3 0.012722691 0.005825992 0.028978337
Baguette (👉 📊) Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) Inverse variance weighted 3 0.018472917 0.006724589 0.00601303
Baguette (👉 📊) Neck/shoulder pain for 3+ months (ukb-b-16118) Inverse variance weighted 14 -0.061787961 0.031101232 0.046958702
Baguette (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) Inverse variance weighted 4 0.013100273 0.006323733 0.038302353
Baguette (👉 📊) Fractured heel (ukb-b-18389) MR Egger 14 -0.010872205 0.004981259 0.04966008
Baguette (👉 📊) Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) Weighted median 3 0.017558954 0.006621332 0.00800459
Baguette (👉 📊) Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) Inverse variance weighted 3 0.014279532 0.005245029 0.006479232
Baguette (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) Inverse variance weighted 14 0.093438141 0.039725965 0.018669399
Baguette (👉 📊) Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) Inverse variance weighted 3 -0.011123757 0.005179679 0.031747406
Baguette (👉 📊) Heel bone mineral density (BMD) (ukb-b-8875) Inverse variance weighted 14 0.088789528 0.039716035 0.025377391
Baguette (👉 📊) Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) MR Egger 13 0.01535566 0.006677347 0.042056714
Baguette (👉 📊) Rheumatoid arthritis (ukb-d-M13_RHEUMA) MR Egger 14 0.016800529 0.005358231 0.008604127
Baguette (👉 📊) Shoulder lesions (ukb-d-M13_SHOULDER) Weighted median 14 0.016407776 0.007280922 0.024225753
Baguette (👉 📊) Shoulder lesions (ukb-d-M13_SHOULDER) Inverse variance weighted 14 0.015094877 0.005128051 0.003244301
Baguette (👉 📊) Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) Weighted median 14 0.016380663 0.007126391 0.021528131
Baguette (👉 📊) Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) Inverse variance weighted 14 0.015010959 0.005128401 0.003422215
Baguette (👉 📊) Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) MR Egger 13 0.017803765 0.006031422 0.013166116

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Baguette Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) All - Inverse variance weighted 0.5192029262643 0.249054001994518 0.0370965230495543
Baguette Compression fracture (ebi-a-GCST90018828) rs73101535 4.69330926115761 1.69193735114266 0.0055384249357907
Baguette Compression fracture (ebi-a-GCST90018828) All - Inverse variance weighted 1.02675939042724 0.459721453821678 0.0255200708953894
Baguette Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) rs73101535 6.31129607246133 3.05619731024037 0.0389153035782346
Baguette Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) All - Inverse variance weighted 4.76643899075417 1.89365321637642 0.011833863478428
Baguette Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) rs189212671 18.8183765692201 9.42894832952669 0.0459547556896106
Baguette Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) rs73101535 6.28962091423267 3.05619731024037 0.0395911746446386
Baguette Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) All - Inverse variance weighted 4.79006845268192 1.90850345218573 0.0120780472655134
Baguette Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) rs11642278 -1.87517834576658 0.642044759691819 0.003493189056708
Baguette Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) rs73101535 0.554629048792056 0.274127001127108 0.0430467799220495
Baguette Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) rs73101535 -7.24205286698593 3.34689943236586 0.0304789709168638
Baguette Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) All - MR Egger -11.0951548625091 3.79083145543826 0.0137680268815522
Baguette Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs2362311 -7.92084773870759 3.54442476881131 0.0254347948861202
Baguette Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) All - Inverse variance weighted -2.20308520531693 0.83879184831685 0.0086268471265184
Baguette Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) rs10036869 6.6849438539828 2.95081791307427 0.0234848003599746
Baguette Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) rs73101535 -3.25892379014367 1.27883433549065 0.0108232290033655
Baguette Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) All - MR Egger -5.08157067758285 1.59817306427028 0.0087672169471498
Baguette Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) rs4747342 -10.1029812221148 4.8992215057197 0.0391924549976077
Baguette Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) All - Inverse variance weighted -1.64463464532297 0.830306355712386 0.0476185961130432
Baguette Osteomalacia (finn-b-M13_OSTEOMALACIA) rs73101535 6.09964452740505 3.09699760808254 0.0488917118205133
Baguette Disorders of synovium and tendon (finn-b-M13_SYNOTEND) rs73101535 -0.805805882382941 0.353177578196321 0.0225136493968653
Baguette Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) rs11642278 -2.55119372766432 1.1380158438982 0.0249748802891767
Baguette Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) rs73101535 -1.07738286489491 0.488328564798523 0.0273653582132177
Baguette Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) All - Inverse variance weighted -0.80545484098846 0.326187482542025 0.0135377565701616
Baguette Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) rs11642278 9.21283274224451 4.32446020681315 0.033138551968894
Baguette Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) All - Inverse variance weighted 2.918557755959 1.13820446515896 0.0103420777235241
Baguette Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) rs113040087 3.8166949526001 1.4333572734495 0.0077501297602012
Baguette Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) All - Inverse variance weighted 0.748109308189379 0.35689685928183 0.0360688975409462
Baguette Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) All - Inverse variance weighted 0.603533977902481 0.285431183069111 0.0344756513728267
Baguette Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) All - MR Egger 4.94162975604559 2.06463153121517 0.0356420831304269
Baguette Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs73101535 1.83728841220541 0.888681487374858 0.0386934795956273
Baguette Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) rs2362311 11.4933805548529 5.50917727745454 0.0369582928763001
Baguette Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) All - MR Egger 5.44833156663396 2.39789640260294 0.044142178032333
Baguette Shoulder region (finn-b-Z21_SHOUL_REGION) rs80058025 16.101908108891 7.80167254930361 0.0390267595258699
Baguette Shoulder region (finn-b-Z21_SHOUL_REGION) All - Inverse variance weighted 4.01130702868238 1.87345464513632 0.0322636814881689
Baguette Bone sialoprotein 2 (prot-a-1396) rs11642278 3.78093025151849 1.53207506148683 0.0135927560235416
Baguette Bone sialoprotein 2 (prot-a-1396) All - Inverse variance weighted 0.983180929728457 0.40374285711298 0.0148849540791694
Baguette Heel bone mineral density (BMD) T-score automated (ukb-a-500) rs112292259 0.388616856277457 0.18830401877431 0.0390391905151919
Baguette Heel bone mineral density (BMD) T-score automated (ukb-a-500) rs116997954 0.566434707097259 0.17265889034923 0.0010356537330667
Baguette Heel bone mineral density (BMD) T-score automated (ukb-a-500) rs80058025 0.509019111582061 0.186593686393194 0.0063728371683911
Baguette Heel bone mineral density (BMD) T-score automated (ukb-a-500) All - Inverse variance weighted 0.137473294655611 0.0687768828256929 0.0456267538758384
Baguette Operation code: elbow surgery (ukb-b-10324) rs966881 -0.0266569385976884 0.0094693828275087 0.0048767201930631
Baguette Operation code: elbow surgery (ukb-b-10324) All - Inverse variance weighted -0.0137297366446823 0.0061218094896542 0.0249124301468861
Baguette Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) All - Inverse variance weighted 0.0127226908874825 0.00582599185554 0.0289783372367616
Baguette Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) rs966881 0.0312361296282688 0.0107471891829472 0.0036555948757022
Baguette Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) All - Inverse variance weighted 0.0184729172459246 0.0067245891712303 0.0060130297381453
Baguette Neck/shoulder pain for 3+ months (ukb-b-16118) All - Inverse variance weighted -0.0617879612740183 0.0311012315833767 0.0469587020118234
Baguette Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) All - Inverse variance weighted 0.0131002733652908 0.0063237332501045 0.0383023530985665
Baguette Fractured heel (ukb-b-18389) rs2362311 0.0189361104084099 0.0086917671529358 0.0293594587813675
Baguette Fractured heel (ukb-b-18389) rs966881 0.0195056531278541 0.0087232434361779 0.0253481609380087
Baguette Fractured heel (ukb-b-18389) All - MR Egger -0.0108722050243869 0.0049812589425856 0.0496600802483916
Baguette Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) rs10036869 0.0194226590624983 0.008760602825274 0.026619951322581
Baguette Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) rs966881 0.0197185508676528 0.0093821451441888 0.0355786628045765
Baguette Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) All - Inverse variance weighted 0.0142795315590704 0.0052450294739566 0.0064792320819978
Baguette Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) rs116997954 0.320727328201277 0.142508449117537 0.0244118564828134
Baguette Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) All - Inverse variance weighted 0.0934381405980974 0.039725964623336 0.01866939897055
Baguette Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) All - Inverse variance weighted -0.0111237573528799 0.0051796789639024 0.0317474057665284
Baguette Heel bone mineral density (BMD) (ukb-b-8875) rs116997954 0.316892367630492 0.1424673770184 0.0261272374664214
Baguette Heel bone mineral density (BMD) (ukb-b-8875) All - Inverse variance weighted 0.0887895276464712 0.0397160350272683 0.0253773907528877
Baguette Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) rs2362311 0.0222045984765438 0.0088072912274784 0.0116968346078542
Baguette Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) rs4747342 0.0188974238432722 0.0091813244159814 0.0395665292331307
Baguette Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) rs73101535 0.026295409456489 0.007587274387103 0.000528803094995
Baguette Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) All - MR Egger 0.0153556603319079 0.0066773469527752 0.0420567137933349
Baguette Rheumatoid arthritis (ukb-d-M13_RHEUMA) rs2362311 0.0218858532197768 0.0091697444978497 0.0169982196189494
Baguette Rheumatoid arthritis (ukb-d-M13_RHEUMA) rs73101535 0.0231968818372374 0.0078995369166194 0.0033195349541172
Baguette Rheumatoid arthritis (ukb-d-M13_RHEUMA) All - MR Egger 0.0168005286058587 0.0053582306701572 0.0086041270179449
Baguette Shoulder lesions (ukb-d-M13_SHOULDER) rs189212671 0.0560689230366692 0.0195665327526151 0.0041628249678289
Baguette Shoulder lesions (ukb-d-M13_SHOULDER) All - Inverse variance weighted 0.0150948770487874 0.0051280510846102 0.0032443005917043
Baguette Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) rs189212671 0.0560334912319911 0.0195678955143335 0.0041893323138184
Baguette Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) All - Inverse variance weighted 0.0150109585429577 0.0051284013577934 0.0034222146532251
Baguette Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) rs2362311 0.0251637012676729 0.0081963066025803 0.0021396784691164
Baguette Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) rs4747342 0.0190650972600431 0.0085444256202378 0.0256618805751055
Baguette Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) rs73101535 0.0236271974785416 0.007060963295032 0.0008193556151749
Baguette Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) All - MR Egger 0.0178037647928549 0.0060314224126205 0.0131661164775556