ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Lamb | Total body bone mineral density (age over 60) (ebi-a-GCST005349) | rs140791170 | 1.87784686399574 | 0.946948418596141 | 0.0473617501490476 |
| Lamb | Total body bone mineral density (age over 60) (ebi-a-GCST005349) | rs74380169 | -3.07510604434778 | 1.2746926694369 | 0.0158466070506829 |
| Lamb | Knee osteoarthritis (ebi-a-GCST007090) | rs147244930 | -1.94946040532808 | 0.741859505781847 | 0.0085938346559373 |
| Lamb | Knee osteoarthritis (ebi-a-GCST007090) | All - Inverse variance weighted | -0.436899217441335 | 0.191048639754869 | 0.0222046912617339 |
| Lamb | Neck circumference (ebi-a-GCST90017134) | All - Inverse variance weighted | -3.45020399504126 | 1.7218779567791 | 0.0450974050488127 |
| Lamb | Neck circumference (BMI adjusted) (ebi-a-GCST90017137) | All - Inverse variance weighted | -3.45020399504126 | 1.7218779567791 | 0.0450974050488127 |
| Lamb | Compression fracture (ebi-a-GCST90018608) | rs12338051 | -4.13913610885285 | 1.75673912113303 | 0.0184655946280517 |
| Lamb | Compression fracture (ebi-a-GCST90018608) | All - Inverse variance weighted | -2.63049353633286 | 1.11728133376818 | 0.018554137643406 |
| Lamb | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | rs142252464 | 9.94084966900786 | 3.58706090885435 | 0.005583163216836 |
| Lamb | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | rs147244930 | 36.9831933891336 | 13.7593314614965 | 0.0071910964831109 |
| Lamb | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | All - Inverse variance weighted | 6.56984984675629 | 2.80885913742213 | 0.0193367541765883 |
| Lamb | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | rs142252464 | 9.94084966900786 | 3.58822781220791 | 0.0055986371050254 |
| Lamb | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | rs147244930 | 36.9100054558278 | 13.749351288773 | 0.0072640407548174 |
| Lamb | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | All - Inverse variance weighted | 6.56533449504129 | 2.80544873872626 | 0.0192729860118247 |
| Lamb | Benign neoplasm of bone and articular cartilage (finn-b-CD2_BENIGN_BONE_CARTILAGE) | rs11687610 | -7.09491984205606 | 3.17422667466618 | 0.0254065291596816 |
| Lamb | Benign neoplasm of bone and articular cartilage (finn-b-CD2_BENIGN_BONE_CARTILAGE) | rs142252464 | 2.29879960652019 | 1.1108919925925 | 0.0385153430781951 |
| Lamb | Benign neoplasm of bone and articular cartilage (finn-b-CD2_BENIGN_BONE_CARTILAGE) | All - MR Egger | 3.41358652689727 | 1.35984961131433 | 0.028972666064513 |
| Lamb | Benign neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_EXALLC) | rs11687610 | -6.94144075009418 | 3.18817931938999 | 0.0294624498763925 |
| Lamb | Benign neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_EXALLC) | rs142252464 | 2.2567910857919 | 1.11205889594606 | 0.0424195087515528 |
| Lamb | Benign neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_EXALLC) | All - MR Egger | 3.32743153415053 | 1.36500451377914 | 0.0329585361277479 |
| Lamb | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | rs11687610 | -11.9155585941315 | 5.17643119253254 | 0.0213415572302346 |
| Lamb | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | rs142252464 | 4.73646071211444 | 1.81453471479132 | 0.0090465657806251 |
| Lamb | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | rs78938647 | 14.1920763327111 | 6.21447832399917 | 0.0223884849598998 |
| Lamb | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | All - MR Egger | 6.28049171170768 | 2.13073755940482 | 0.013266992352174 |
| Lamb | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | rs11687610 | -11.8248664034268 | 5.18340751489445 | 0.0225311703015071 |
| Lamb | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | rs142252464 | 4.7247916785788 | 1.81686852149844 | 0.0093084272742429 |
| Lamb | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | rs78938647 | 14.4451358639286 | 6.25181497614603 | 0.0208576815423433 |
| Lamb | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | All - MR Egger | 6.2376045950532 | 2.14673941300114 | 0.0143006813097392 |
| Lamb | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | rs142252464 | -7.88943357344315 | 2.72355242721732 | 0.0037705755615842 |
| Lamb | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | All - Inverse variance weighted | -4.53132330376516 | 1.99484768504462 | 0.0231159150125546 |
| Lamb | Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) | All - MR Egger | -8.86194619678682 | 2.94653406269513 | 0.011917229155374 |
| Lamb | Infective bursitis (finn-b-M13_INFBURSA) | rs142252464 | 3.99664398595515 | 1.8950510461872 | 0.0349454320528713 |
| Lamb | Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) | rs142252464 | 4.59409850297969 | 1.67800702242438 | 0.0061845976337271 |
| Lamb | Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) | All - MR Egger | 5.12844151290992 | 1.82598905932163 | 0.0170115822922367 |
| Lamb | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | rs150703524 | -1.79023579680329 | 0.804452181252308 | 0.0260537378323015 |
| Lamb | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | All - Inverse variance weighted | -0.429929615047013 | 0.218458549117411 | 0.0490663573932246 |
| Lamb | Osteoporosis with pathological fracture (FG) (finn-b-OSTEOPOROSIS_FRACTURE_FG) | All - MR Egger | 3.79780360649919 | 1.52491326538963 | 0.0300084904845463 |
| Lamb | Postmenopausal osteoporosis with pathological fracture (finn-b-OSTPOPATFRCTURE_POSTEMENO) | All - MR Egger | 4.12939225163878 | 1.69367513990739 | 0.0329319851842541 |
| Lamb | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | rs142252464 | 1.95573002057251 | 0.885679645354733 | 0.0272325193923116 |
| Lamb | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | All - Inverse variance weighted | 1.47833940009561 | 0.629375297362468 | 0.0188289818637548 |
| Lamb | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | rs142252464 | 1.49246938920778 | 0.716478659088018 | 0.0372455826449668 |
| Lamb | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | rs147244930 | 5.78850017964311 | 2.78446818986281 | 0.037630859468905 |
| Lamb | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | All - Inverse variance weighted | 1.35873080299604 | 0.506832294866679 | 0.0073439994946597 |
| Lamb | Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) | rs10001236 | 20.513429997623 | 9.0642579827272 | 0.0236287929051627 |
| Lamb | Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) | rs116822304 | 17.2287430941796 | 8.36697111181384 | 0.0394810784823584 |
| Lamb | Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) | All - Inverse variance weighted | 5.43625134813228 | 2.05812236399293 | 0.008257282955795 |
| Lamb | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs142252464 | -4.63727392706154 | 1.75385574040601 | 0.0081921705381427 |
| Lamb | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | All - MR Egger | -5.1096608607799 | 1.89513465285797 | 0.0207975038183423 |
| Lamb | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | All - Inverse variance weighted | -1.10593777781858 | 0.53221564970064 | 0.0377104567401998 |
| Lamb | Shoulder region (finn-b-Z21_SHOUL_REGION) | rs142252464 | -6.93724043693529 | 3.42369443935545 | 0.0427397831162936 |
| Lamb | Shoulder region (finn-b-Z21_SHOUL_REGION) | All - Inverse variance weighted | -6.80910108532584 | 2.39309601671059 | 0.0044368158360321 |
| Lamb | Bone morphogenetic protein 7 (prot-a-257) | rs10001236 | 4.97583392758102 | 2.09967514460027 | 0.0177971648657064 |
| Lamb | Bone morphogenetic protein 7 (prot-a-257) | rs142252464 | -2.8075694686739 | 1.26959084867714 | 0.0270083533441735 |
| Lamb | Bone morphogenetic protein 7 (prot-a-257) | All - MR Egger | -2.35010510106915 | 0.972672276026313 | 0.032546442841638 |
| Lamb | Fractured bone site(s): Ankle (ukb-a-438) | All - Inverse variance weighted | -0.0188579049385906 | 0.0061225624425791 | 0.0020695376091635 |
| Lamb | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | All - Inverse variance weighted | -0.0185286595682661 | 0.0071861504671868 | 0.0099263454035519 |
| Lamb | Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) | All - Inverse variance weighted | -0.0164498181937566 | 0.0066755952843003 | 0.0137330008032134 |
| Lamb | Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) | All - Inverse variance weighted | -0.0170095654175231 | 0.0066422793368309 | 0.0104430709721909 |
| Lamb | Operative procedures - secondary OPCS: Z85.6 Ankle joint (ukb-b-15453) | All - Inverse variance weighted | 0.0119343091687887 | 0.0057705566477665 | 0.0386270208757267 |
| Lamb | Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) | rs10001236 | 0.0210694081293083 | 0.010333729498455 | 0.0414603271723145 |
| Lamb | Diagnoses - secondary ICD10: M47.82 Other spondylosis (Cervical region) (ukb-b-2625) | All - Inverse variance weighted | 0.0116803773307738 | 0.0056974463300914 | 0.0403539437619892 |
| Lamb | Ankle spacing width (ukb-b-4080) | rs78938647 | -0.58694046878241 | 0.189724331051649 | 0.0019771130941663 |
| Lamb | Ankle spacing width (ukb-b-4080) | All - Inverse variance weighted | -0.12624086163629 | 0.0526772246402805 | 0.0165525854137235 |
| Lamb | Ankle spacing width (ukb-b-4080) | All - MR Egger | -0.216010602193203 | 0.097435086690187 | 0.0450694595603906 |
| Lamb | Fractured heel (left) (ukb-b-8221) | All - Inverse variance weighted | -0.0193141164235648 | 0.0073247886857396 | 0.0083688332883669 |
| Lamb | Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) | All - Inverse variance weighted | -0.0121490571623844 | 0.0054546028243417 | 0.0259269820784366 |
| Lamb | Knee pain for 3+ months (ukb-b-8906) | rs116822304 | -0.32432076489518 | 0.153730166111721 | 0.0348863162907215 |
| Lamb | Knee pain for 3+ months (ukb-b-8906) | rs74380169 | 0.30464650683797 | 0.154151033077195 | 0.0481224102704167 |
| Lamb | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs146003962 | -0.0663862559910048 | 0.0317285870347981 | 0.0364101850114586 |
| Lamb | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs147244930 | -0.0859838454270849 | 0.033213349479035 | 0.0096301530344898 |
| Lamb | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | All - Inverse variance weighted | -0.0300423968928703 | 0.0092588879198301 | 0.001175707072341 |
| Lamb | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | All - MR Egger | -0.0550887956667367 | 0.0170340076100212 | 0.0071653045536123 |
| Lamb | Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) | rs1156065 | -0.0301738835061385 | 0.0117660902900215 | 0.0103331033351325 |
| Lamb | Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) | All - Inverse variance weighted | -0.0074123916446282 | 0.0030816187421073 | 0.016156696296146 |
| Lamb | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | rs78938647 | -0.0449008504459656 | 0.0220161792159303 | 0.0414053460641913 |
| Lamb | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | All - MR Egger | -0.0337255288804838 | 0.0107511118789195 | 0.0085806353655914 |