ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Banana (ukb-b-5362)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Banana (👉 📊) Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) Simple mode 15 2.229369286 0.879163903 0.023763288
Banana (👉 📊) Osteoprotegerin levels (ebi-a-GCST90012002) Inverse variance weighted 16 0.190565493 0.090656961 0.035548869
Banana (👉 📊) Shoulder impingement (ebi-a-GCST90014054) Inverse variance weighted 11 -0.51813546 0.240122197 0.030943455
Banana (👉 📊) Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) MR Egger 16 1.316700449 0.575989922 0.038355847
Banana (👉 📊) Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) MR Egger 16 -6.884213232 3.039414347 0.039909529
Banana (👉 📊) Calcific tendinitis (finn-b-M13_CALCTENDINITIS) MR Egger 16 6.408068123 2.70779881 0.032909638
Banana (👉 📊) Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) MR Egger 16 5.629925695 2.459699517 0.038146598
Banana (👉 📊) Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) MR Egger 16 0.774905929 0.240868647 0.006205468
Banana (👉 📊) Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) Weighted median 16 1.760261858 0.815564589 0.030901771
Banana (👉 📊) Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) Inverse variance weighted 16 1.340333606 0.569317647 0.018558586
Banana (👉 📊) Pyogenic arthritis (finn-b-M13_PYOGARTH) Weighted median 16 1.1343998 0.530636439 0.03253218
Banana (👉 📊) Pyogenic arthritis (finn-b-M13_PYOGARTH) Inverse variance weighted 16 0.897952404 0.391179934 0.021704652
Banana (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) MR Egger 16 0.69097402 0.289315706 0.031567802
Banana (👉 📊) Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) MR Egger 16 -4.089480299 1.740768013 0.034012722
Banana (👉 📊) Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) Inverse variance weighted 16 -1.990375096 0.738367958 0.007025329
Banana (👉 📊) Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) MR Egger 16 0.510139598 0.201570874 0.02399285
Banana (👉 📊) Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) Inverse variance weighted 16 0.886582848 0.399713488 0.026551706
Banana (👉 📊) Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) Weighted median 16 1.477718998 0.733897005 0.044059566
Banana (👉 📊) Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) MR Egger 16 2.216265943 0.851303135 0.020839758
Banana (👉 📊) Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) Inverse variance weighted 15 0.003288318 0.001572156 0.036474513
Banana (👉 📊) Heel bone mineral density (BMD), manual entry (ukb-b-11364) Inverse variance weighted 16 0.12575462 0.058167477 0.030622768
Banana (👉 📊) Operative procedures - secondary OPCS: Z84.1 Sacroiliac joint (ukb-b-16715) Inverse variance weighted 2 0.005743182 0.002152465 0.007626142
Banana (👉 📊) Operation code: ankle surgery (ukb-b-4274) Weighted median 4 -0.00490435 0.002212846 0.026670359
Banana (👉 📊) Operation code: ankle surgery (ukb-b-4274) Inverse variance weighted 4 -0.004145468 0.001917982 0.030666817
Banana (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) Inverse variance weighted 7 -0.003706598 0.001741027 0.033256601
Banana (👉 📊) M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) MR Egger 13 -2.806796805 1.18592284 0.037365005

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Banana Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) rs111386164 -5.91243489137009 1.88356847851091 0.0016955203666996
Banana Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) rs11725846 3.5215667756086 1.64084949857713 0.031858212383431
Banana Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) rs12144594 3.00370268190332 1.4485327215438 0.0381148562493568
Banana Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) rs6566594 2.81549412107667 1.4306571622916 0.0490711883671916
Banana Osteoprotegerin levels (ebi-a-GCST90012002) rs4841580 0.731067215347842 0.274150205755441 0.0076607611351794
Banana Osteoprotegerin levels (ebi-a-GCST90012002) All - Inverse variance weighted 0.190565493297947 0.0906569613425872 0.0355488693477044
Banana Shoulder impingement (ebi-a-GCST90014054) rs693739 -2.03615804587416 0.757179710966904 0.0071637559463846
Banana Shoulder impingement (ebi-a-GCST90014054) All - Inverse variance weighted -0.51813546020756 0.24012219662303 0.0309434547558901
Banana Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) All - MR Egger 1.31670044916578 0.575989922396045 0.0383558467045763
Banana Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) rs4841580 11.1402078401247 5.03751003075623 0.0270046043932439
Banana Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) All - MR Egger -6.88421323197422 3.03941434694657 0.0399095290093779
Banana Calcific tendinitis (finn-b-M13_CALCTENDINITIS) All - MR Egger 6.40806812283532 2.70779881023604 0.0329096384699347
Banana Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) rs1010086 -11.8235249964918 3.72034736295905 0.0014825886210409
Banana Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) rs76722032 5.62334492964328 2.72748177104582 0.0392329619401866
Banana Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) All - MR Egger 5.62992569509346 2.45969951706118 0.0381465980200434
Banana Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) rs6566594 -0.860668822965976 0.388689145855602 0.0268091307155959
Banana Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) rs76722032 0.674267318433682 0.290031376796006 0.020082219196433
Banana Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) All - MR Egger 0.774905929127661 0.240868647292463 0.0062054682167894
Banana Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) All - Inverse variance weighted 1.34033360594993 0.569317646635895 0.0185585856653284
Banana Pyogenic arthritis (finn-b-M13_PYOGARTH) rs79265768 3.62161985416735 1.82846679527842 0.0476264197252059
Banana Pyogenic arthritis (finn-b-M13_PYOGARTH) All - Inverse variance weighted 0.897952404048512 0.391179934138529 0.0217046524665981
Banana Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) All - MR Egger 0.690974019568881 0.289315706373931 0.0315678016910684
Banana Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) rs73164291 -6.82877257097615 2.78075150292136 0.0140599075087626
Banana Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) All - Inverse variance weighted -1.99037509562746 0.738367958374047 0.0070253293509452
Banana Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) All - MR Egger -4.08948029859595 1.740768013457 0.0340127218780244
Banana Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) rs111386164 0.546920108530887 0.266604509729541 0.0402252290221024
Banana Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) All - MR Egger 0.510139597794723 0.201570873693298 0.0239928497865811
Banana Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) rs76722032 2.76234487771951 1.14306483796073 0.0156656805784192
Banana Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) All - Inverse variance weighted 0.886582847621004 0.39971348797148 0.0265517056077923
Banana Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) rs76722032 3.108008871548 1.02512368985187 0.0024306968480163
Banana Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) All - MR Egger 2.21626594255223 0.851303134518979 0.0208397577711989
Banana Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) rs75999182 0.0129055531816802 0.0060279458231662 0.0322777683963878
Banana Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) All - Inverse variance weighted 0.0032883176068174 0.0015721558288534 0.0364745132653093
Banana Heel bone mineral density (BMD), manual entry (ukb-b-11364) rs4841580 0.729710742975615 0.195318314090464 0.0001869648783704
Banana Heel bone mineral density (BMD), manual entry (ukb-b-11364) All - Inverse variance weighted 0.125754620291952 0.0581674769145054 0.0306227678175463
Banana Operative procedures - secondary OPCS: Z84.1 Sacroiliac joint (ukb-b-16715) rs4841580 0.0073933455749015 0.0027940760709706 0.008143083468156
Banana Operative procedures - secondary OPCS: Z84.1 Sacroiliac joint (ukb-b-16715) All - Inverse variance weighted 0.0057431818109621 0.0021524646487319 0.0076261417538278
Banana Operation code: ankle surgery (ukb-b-4274) rs4841580 -0.0071377861799739 0.0030825049332758 0.0205812224156934
Banana Operation code: ankle surgery (ukb-b-4274) All - Inverse variance weighted -0.0041454682615713 0.0019179823168523 0.0306668170123558
Banana Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) rs6566594 -0.010308764940239 0.0047337479350889 0.0294270874790957
Banana Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) All - Inverse variance weighted -0.0037065981222102 0.0017410274168038 0.0332566007860042
Banana M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) rs76722032 -2.49605008419069 0.965040463456788 0.0096964063728341
Banana M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) All - MR Egger -2.80679680455489 1.18592283973189 0.0373650053409722