ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Eggs in sandwiches (ukb-b-5382)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Eggs in sandwiches (👉 📊) Heel bone mineral density (ebi-a-GCST006288) Weighted median 15 0.319497622 0.142523125 0.024979165
Eggs in sandwiches (👉 📊) Heel bone mineral density (ebi-a-GCST006288) Inverse variance weighted 15 0.310218716 0.103529888 0.002731726
Eggs in sandwiches (👉 📊) Knee osteoarthritis (ebi-a-GCST007090) Weighted median 15 0.89033336 0.387013254 0.02141854
Eggs in sandwiches (👉 📊) Knee osteoarthritis (ebi-a-GCST007090) Inverse variance weighted 15 0.808189533 0.279815103 0.003873322
Eggs in sandwiches (👉 📊) Frozen shoulder (ebi-a-GCST90000513) Inverse variance weighted 8 1.101678528 0.529484438 0.037464789
Eggs in sandwiches (👉 📊) Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) MR Egger 15 23.74580165 10.05622892 0.034491339
Eggs in sandwiches (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) MR Egger 15 24.28084822 10.08885128 0.031684973
Eggs in sandwiches (👉 📊) Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) Inverse variance weighted 15 -5.053838744 2.101967719 0.01620183
Eggs in sandwiches (👉 📊) Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) MR Egger 15 6.666796266 2.762185027 0.031278387
Eggs in sandwiches (👉 📊) Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) MR Egger 15 20.73274615 8.086337382 0.023563425
Eggs in sandwiches (👉 📊) Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) Inverse variance weighted 15 5.961078154 2.800089966 0.033263521
Eggs in sandwiches (👉 📊) Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) MR Egger 15 -3.555653587 1.463028671 0.030311693
Eggs in sandwiches (👉 📊) Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) MR Egger 15 1.902954793 0.837668466 0.040738039
Eggs in sandwiches (👉 📊) Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) MR Egger 15 -7.469094332 3.384245818 0.045901763
Eggs in sandwiches (👉 📊) Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) Inverse variance weighted 15 -10.29446933 5.182946142 0.047008943
Eggs in sandwiches (👉 📊) Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) Weighted median 15 0.022937007 0.009083401 0.011564682
Eggs in sandwiches (👉 📊) Fractured bone site(s): Ankle (ukb-a-438) MR Egger 15 -0.057447429 0.018563748 0.008534977
Eggs in sandwiches (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) MR Egger 15 -0.046451485 0.018892692 0.028739073
Eggs in sandwiches (👉 📊) Operation code: bone surgery/joint surgery (ukb-b-12974) Wald ratio 1 0.048732284 0.021218783 0.0216383
Eggs in sandwiches (👉 📊) Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) Weighted median 15 0.040005024 0.017161504 0.019748576
Eggs in sandwiches (👉 📊) Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) Inverse variance weighted 15 0.041039486 0.012809088 0.001355631
Eggs in sandwiches (👉 📊) Shoulder lesions (ukb-d-M13_SHOULDER) MR Egger 15 0.051571077 0.021363509 0.031255855
Eggs in sandwiches (👉 📊) Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) MR Egger 15 0.051587045 0.021364934 0.031221524
Eggs in sandwiches (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) MR Egger 15 -0.042570819 0.018326435 0.037047639

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Eggs in sandwiches Heel bone mineral density (ebi-a-GCST006288) rs117640186 0.914910738937487 0.434823599129949 0.0353700449692789
Eggs in sandwiches Heel bone mineral density (ebi-a-GCST006288) rs141791743 1.02161158695732 0.40088960776385 0.0108230295824967
Eggs in sandwiches Heel bone mineral density (ebi-a-GCST006288) All - Inverse variance weighted 0.310218716456577 0.103529888394155 0.0027317260187184
Eggs in sandwiches Knee osteoarthritis (ebi-a-GCST007090) rs115683945 2.54322055023176 1.13592977429706 0.0251631466218557
Eggs in sandwiches Knee osteoarthritis (ebi-a-GCST007090) All - Inverse variance weighted 0.808189532684334 0.279815103073612 0.0038733215001431
Eggs in sandwiches Frozen shoulder (ebi-a-GCST90000513) All - Inverse variance weighted 1.10167852798803 0.529484437912784 0.0374647891295759
Eggs in sandwiches Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) rs920644 -62.3459918561367 19.4072106394506 0.0013157741425479
Eggs in sandwiches Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) All - MR Egger 23.7458016489481 10.0562289243627 0.0344913385179821
Eggs in sandwiches Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) rs114267116 35.1979408697416 17.1044748678968 0.0396073570840057
Eggs in sandwiches Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) rs920644 -62.3197777039898 19.4159486901662 0.0013286387893559
Eggs in sandwiches Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) All - MR Egger 24.2808482150834 10.0888512810125 0.0316849728759963
Eggs in sandwiches Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) All - Inverse variance weighted -5.05383874418987 2.10196771877822 0.0162018300683042
Eggs in sandwiches Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) All - MR Egger 6.66679626581407 2.76218502691429 0.0312783870866615
Eggs in sandwiches Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) rs920644 -34.9434648118698 15.4139214624002 0.0233898101550702
Eggs in sandwiches Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) All - MR Egger 20.7327461486668 8.08633738231922 0.0235634254226227
Eggs in sandwiches Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) rs114267116 20.9082869215432 10.2988211352477 0.0423399605176302
Eggs in sandwiches Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) rs9879100 28.143019837858 13.909457981283 0.0430421268648649
Eggs in sandwiches Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) All - Inverse variance weighted 5.9610781543682 2.80008996635569 0.033263521151999
Eggs in sandwiches Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) rs920644 5.80206567518918 2.77870012757554 0.0367932962736832
Eggs in sandwiches Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) rs9879100 -8.3051618043583 3.44360367497783 0.0158755231158103
Eggs in sandwiches Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) All - MR Egger -3.55565358711831 1.46302867089426 0.030311693442698
Eggs in sandwiches Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) All - MR Egger 1.90295479331935 0.837668466365019 0.0407380391451109
Eggs in sandwiches Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) All - MR Egger -7.46909433169171 3.38424581790542 0.045901763050484
Eggs in sandwiches Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) rs920644 -56.0458572901557 22.6839796578179 0.0134839770023049
Eggs in sandwiches Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) All - Inverse variance weighted -10.2944693329433 5.18294614218832 0.0470089428829944
Eggs in sandwiches Fractured bone site(s): Ankle (ukb-a-438) rs11913788 -0.0705904936136687 0.0296191569909129 0.0171595322079475
Eggs in sandwiches Fractured bone site(s): Ankle (ukb-a-438) All - MR Egger -0.0574474289514007 0.0185637483897322 0.0085349772320934
Eggs in sandwiches Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) rs72796468 -0.0818998688031512 0.036820379873082 0.0261277228274538
Eggs in sandwiches Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) rs920644 0.0656870729277713 0.033066007235106 0.0469729702004655
Eggs in sandwiches Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) All - MR Egger -0.0464514845585066 0.018892692100888 0.0287390732738648
Eggs in sandwiches Operation code: bone surgery/joint surgery (ukb-b-12974) rs920644 0.048732283602174 0.0212187833138184 0.021638300197575
Eggs in sandwiches Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) rs115683945 0.120829481164076 0.0511954083194235 0.0182669330913548
Eggs in sandwiches Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) rs9879100 0.111801882503342 0.0509360750120414 0.0281675442319058
Eggs in sandwiches Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) All - Inverse variance weighted 0.0410394856429913 0.0128090883515422 0.0013556310962703
Eggs in sandwiches Shoulder lesions (ukb-d-M13_SHOULDER) rs147079572 0.110424744203063 0.0355433472913162 0.0018914819105824
Eggs in sandwiches Shoulder lesions (ukb-d-M13_SHOULDER) All - MR Egger 0.0515710768918614 0.0213635091510959 0.0312558546762206
Eggs in sandwiches Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) rs147079572 0.11037006549515 0.0355457332712979 0.0019026882321541
Eggs in sandwiches Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) All - MR Egger 0.0515870447391989 0.0213649335255539 0.0312215237639677
Eggs in sandwiches Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) rs112216864 -0.0980729785166793 0.0330362396091979 0.0029911267145526
Eggs in sandwiches Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) All - MR Egger -0.0425708188336106 0.0183264354490762 0.037047639476318