ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Tofu (ukb-b-5522)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Tofu (👉 📊) Total body bone mineral density (age 15-30) (ebi-a-GCST005344) Inverse variance weighted 35 2.517826393 1.061580893 0.017703076
Tofu (👉 📊) Osteoarthritis (Firth correction) (ebi-a-GCST90013881) Inverse variance weighted 44 -0.690456468 0.29593702 0.019641868
Tofu (👉 📊) Osteoarthritis (SPA correction) (ebi-a-GCST90013931) Inverse variance weighted 44 -0.694572093 0.295678019 0.018819731
Tofu (👉 📊) Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) Inverse variance weighted 15 1.061555963 0.460675955 0.02120333
Tofu (👉 📊) Bone disorder (ebi-a-GCST90038652) Inverse variance weighted 35 -0.029677564 0.012208677 0.015063105
Tofu (👉 📊) Osteoarthritis (ebi-a-GCST90038686) Inverse variance weighted 35 -0.044526362 0.021818346 0.041273072
Tofu (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) Simple mode 48 -21.87545068 10.6496219 0.045550645
Tofu (👉 📊) Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) Inverse variance weighted 48 4.881180751 2.385179201 0.040710849
Tofu (👉 📊) Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) MR Egger 48 -16.24986499 6.67037401 0.018776811
Tofu (👉 📊) Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) Inverse variance weighted 48 -4.116559339 1.540335447 0.00752865
Tofu (👉 📊) Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) Simple mode 48 -2.339232938 1.138981318 0.045582101
Tofu (👉 📊) Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) Inverse variance weighted 48 -2.521505083 1.123348933 0.02479176
Tofu (👉 📊) Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) Inverse variance weighted 48 -4.526355146 1.722286205 0.008586111
Tofu (👉 📊) Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) MR Egger 48 2.238471776 0.958266473 0.023907161
Tofu (👉 📊) Infective bursitis (finn-b-M13_INFBURSA) MR Egger 48 12.21915175 3.733546966 0.00202477
Tofu (👉 📊) Other juvenile arthritis (finn-b-M13_JUVEARTH) Inverse variance weighted 48 -3.493967039 1.692059352 0.038930579
Tofu (👉 📊) Pain (limb, back, neck, head abdominally) (finn-b-PAIN) Inverse variance weighted 48 0.459089289 0.213194192 0.031288392
Tofu (👉 📊) Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) Inverse variance weighted 48 5.934037979 2.641996909 0.02470127
Tofu (👉 📊) Fracture of femur (finn-b-ST19_FRACT_FEMUR) Inverse variance weighted 48 -1.884945876 0.708574905 0.007809593
Tofu (👉 📊) Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) Simple mode 48 -25.45639165 11.03860357 0.025561758
Tofu (👉 📊) Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) Inverse variance weighted 48 -2.761846377 1.337857026 0.038981624
Tofu (👉 📊) Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) MR Egger 48 11.6980838 3.811303387 0.00359244
Tofu (👉 📊) Ankle and foot (finn-b-Z21_ANKLE_FOOT) Simple mode 48 -21.90697336 10.07026279 0.034662714
Tofu (👉 📊) Femoral neck bone mineral density (ieu-a-980) Inverse variance weighted 46 -0.612921685 0.276941158 0.026884976
Tofu (👉 📊) Lumbar spine bone mineral density (ieu-a-982) Weighted median 47 -1.013850293 0.438127386 0.020664777
Tofu (👉 📊) Lumbar spine bone mineral density (ieu-a-982) Inverse variance weighted 47 -1.014648582 0.318339952 0.00143602
Tofu (👉 📊) Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) Inverse variance weighted 49 -0.051145107 0.023408304 0.028895231
Tofu (👉 📊) Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) Weighted median 49 -0.47158415 0.20007456 0.018421161
Tofu (👉 📊) Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) Inverse variance weighted 49 -0.354849114 0.143688998 0.013527798
Tofu (👉 📊) Fractured bone site(s): Wrist (ukb-a-439) MR Egger 49 0.043818752 0.021737955 0.049561022
Tofu (👉 📊) Fractured bone site(s): Wrist (ukb-a-439) Inverse variance weighted 49 0.029377178 0.012010324 0.014445346
Tofu (👉 📊) Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) MR Egger 49 -0.015087857 0.006710233 0.029273692
Tofu (👉 📊) Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) Weighted median 49 -0.012069514 0.004885639 0.013495965
Tofu (👉 📊) Non-cancer illness code self-reported: bone disorder (ukb-a-84) Inverse variance weighted 49 -0.010334498 0.004020299 0.010152862
Tofu (👉 📊) Operation code: bone surgery/joint surgery (ukb-b-12974) Weighted median 4 -0.058108181 0.027345751 0.03359131
Tofu (👉 📊) Non-cancer illness code, self-reported: bone disorder (ukb-b-14356) Wald ratio 1 -0.052200886 0.025287076 0.038986378
Tofu (👉 📊) Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) MR Egger 34 -0.112624421 0.045892189 0.019748683
Tofu (👉 📊) Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) Inverse variance weighted 34 -0.057303212 0.0236827 0.015536592
Tofu (👉 📊) Operative procedures - secondary OPCS: Z86.4 Metatarsophalangeal joint of great toe (ukb-b-17501) Wald ratio 1 -0.096167813 0.030169063 0.001434439
Tofu (👉 📊) Operative procedures - secondary OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-19546) Wald ratio 1 -0.056236714 0.028215074 0.046245648
Tofu (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) Inverse variance weighted 51 -0.249655978 0.115632521 0.030846568
Tofu (👉 📊) Heel bone mineral density (BMD) (right) (ukb-b-4657) Inverse variance weighted 51 -0.230274574 0.115652568 0.046471086
Tofu (👉 📊) Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) Inverse variance weighted 2 0.069181888 0.025200355 0.006046033
Tofu (👉 📊) Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) Wald ratio 1 0.062980618 0.028629503 0.027817521
Tofu (👉 📊) Knee pain for 3+ months (ukb-b-8906) MR Egger 51 -0.260123167 0.113208125 0.025885723
Tofu (👉 📊) Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) Inverse variance weighted 39 0.0136824 0.006439079 0.033594953
Tofu (👉 📊) Ankle spacing width (ukb-e-3143_AFR) Weighted median 18 1.752245571 0.87482692 0.045181307
Tofu (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_EAS) MR Egger 16 6.121939389 2.504638816 0.028356228
Tofu (👉 📊) Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) MR Egger 24 7.954660604 3.833318572 0.049872248
Tofu (👉 📊) Spondylosis and allied disorders (ukb-e-721_CSA) Inverse variance weighted 26 -11.76178168 4.950054696 0.017497135
Tofu (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) MR Egger 16 6.229942534 2.50509988 0.026118865
Tofu (👉 📊) M75 Shoulder lesions (ukb-e-M75_CSA) Inverse variance weighted 26 -6.136653094 2.999552083 0.040770492

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Tofu Total body bone mineral density (age 15-30) (ebi-a-GCST005344) rs11960530 8.14143195063285 3.86129648614042 0.0349902622338844
Tofu Total body bone mineral density (age 15-30) (ebi-a-GCST005344) rs79406768 15.9197928793592 6.52291011450713 0.0146630198319869
Tofu Total body bone mineral density (age 15-30) (ebi-a-GCST005344) All - Inverse variance weighted 2.51782639295444 1.06158089285385 0.017703076304257
Tofu Osteoarthritis (Firth correction) (ebi-a-GCST90013881) rs147917512 -4.01731911321165 2.02404568680493 0.0471670995675603
Tofu Osteoarthritis (Firth correction) (ebi-a-GCST90013881) rs7697383 -4.17047648542636 2.02371892805458 0.0393222886850404
Tofu Osteoarthritis (Firth correction) (ebi-a-GCST90013881) All - Inverse variance weighted -0.690456467995347 0.295937020020631 0.019641867933472
Tofu Osteoarthritis (SPA correction) (ebi-a-GCST90013931) rs147917512 -3.96244416114756 1.96827420374574 0.0440981596483225
Tofu Osteoarthritis (SPA correction) (ebi-a-GCST90013931) rs7697383 -4.14547041235843 1.99936909171081 0.0381360671479202
Tofu Osteoarthritis (SPA correction) (ebi-a-GCST90013931) All - Inverse variance weighted -0.694572092555969 0.295678018525202 0.018819730675943
Tofu Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) rs7697383 4.46754448882037 2.23707645388095 0.0458201907992241
Tofu Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) All - Inverse variance weighted 1.06155596323671 0.460675955175248 0.0212033299108277
Tofu Bone disorder (ebi-a-GCST90038652) rs12543850 -0.176353527776552 0.0683537042756917 0.009879625206546
Tofu Bone disorder (ebi-a-GCST90038652) rs148290110 -0.148764221831598 0.0733677490390002 0.042595835225314
Tofu Bone disorder (ebi-a-GCST90038652) rs182218128 -0.180629788984692 0.0782870790978853 0.0210395166771493
Tofu Bone disorder (ebi-a-GCST90038652) All - Inverse variance weighted -0.0296775642606262 0.0122086772898961 0.015063105194679
Tofu Osteoarthritis (ebi-a-GCST90038686) All - Inverse variance weighted -0.0445263617393189 0.0218183456620806 0.0412730718411875
Tofu Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) rs10980960 -41.4831457595539 20.0702802304315 0.0387441245834846
Tofu Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) rs146578953 27.4256639510603 12.1393488426811 0.0238686572207365
Tofu Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) rs56133404 30.2831371011058 11.816561943168 0.0103840644408175
Tofu Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) rs73784728 -51.0212699217006 24.5635624404309 0.0377912247354576
Tofu Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) All - Inverse variance weighted 4.88118075056276 2.38517920101249 0.0407108487784938
Tofu Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) All - MR Egger -16.2498649909286 6.67037400976222 0.0187768107710519
Tofu Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) rs114414462 -23.2589000277466 10.9599121759377 0.0338226743582843
Tofu Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) All - Inverse variance weighted -4.11655933896399 1.54033544683718 0.0075286501447962
Tofu Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) rs145218087 3.32534532432214 1.46297243688127 0.0230258102375299
Tofu Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) rs146906987 4.32928327205216 1.7840674321108 0.0152395134136319
Tofu Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) rs73784728 8.75891273661732 3.69780544596861 0.0178517575327946
Tofu Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) rs75173398 5.16359591047142 2.59410395120919 0.0465345266784597
Tofu Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) rs76522312 -2.7410939578649 1.12592612450196 0.0149113988034894
Tofu Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) rs117633973 -30.3888419273035 10.8481262327416 0.0050897383879662
Tofu Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) rs141063224 -26.408734104101 13.2233048319745 0.0458104441161461
Tofu Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) All - Inverse variance weighted -2.52150508302652 1.12334893325327 0.0247917598222223
Tofu Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs112346208 -31.2667674747573 13.3895907516707 0.0195353340150464
Tofu Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs117633973 -35.4395604395604 16.4694280078895 0.0314100229197313
Tofu Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs146578953 -17.5730125584542 8.82326990382636 0.04640764337158
Tofu Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs74348216 40.164469390419 16.7667406343819 0.016598410382748
Tofu Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) All - Inverse variance weighted -4.52635514637274 1.72228620486025 0.0085861105518457
Tofu Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs143090941 15.0537400776407 7.41642041833246 0.0423783824432623
Tofu Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs146906987 7.97393570108212 2.69019648905195 0.0030359738529432
Tofu Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs16879193 -14.3075901864522 5.93465959502356 0.0159152741539698
Tofu Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs73784728 12.6497520720982 5.50749816014574 0.021628831376889
Tofu Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) All - MR Egger 2.23847177582685 0.95826647266192 0.0239071613027841
Tofu Infective bursitis (finn-b-M13_INFBURSA) rs116461853 -62.6661668947602 26.4559488837943 0.017850797739466
Tofu Infective bursitis (finn-b-M13_INFBURSA) rs143090941 73.0959209687699 32.5156440118199 0.0245747128191302
Tofu Infective bursitis (finn-b-M13_INFBURSA) rs145218087 18.4172971808611 9.02465512444241 0.0412731236526735
Tofu Infective bursitis (finn-b-M13_INFBURSA) rs79406768 28.8961095376275 11.9754652395267 0.0158243139659754
Tofu Infective bursitis (finn-b-M13_INFBURSA) All - MR Egger 12.2191517501854 3.73354696574918 0.0020247701205796
Tofu Other juvenile arthritis (finn-b-M13_JUVEARTH) rs114414462 -27.1253302450147 12.0154898483587 0.0239749695728981
Tofu Other juvenile arthritis (finn-b-M13_JUVEARTH) rs116461853 49.276928843522 20.929401406916 0.0185508552673694
Tofu Other juvenile arthritis (finn-b-M13_JUVEARTH) All - Inverse variance weighted -3.49396703876392 1.6920593521207 0.038930579258725
Tofu Pain (limb, back, neck, head abdominally) (finn-b-PAIN) rs10980960 2.17827614787618 1.10283792392473 0.0482505291559966
Tofu Pain (limb, back, neck, head abdominally) (finn-b-PAIN) rs182218128 7.45096022535726 3.35407488672141 0.0263194775665614
Tofu Pain (limb, back, neck, head abdominally) (finn-b-PAIN) rs62388291 3.89617547614115 1.84355620090581 0.0345663696438829
Tofu Pain (limb, back, neck, head abdominally) (finn-b-PAIN) rs75173398 3.77547956466309 1.55055549265824 0.0148950563062521
Tofu Pain (limb, back, neck, head abdominally) (finn-b-PAIN) All - Inverse variance weighted 0.459089288753292 0.213194192439933 0.0312883919740002
Tofu Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) rs112346208 42.4288246101816 18.8689982602475 0.0245379728868299
Tofu Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) rs117160897 20.4576108288846 10.0309327475226 0.0414048876911297
Tofu Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) rs117243651 -39.1442198254837 14.192997669503 0.0058157047120491
Tofu Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) rs146906987 30.6392438453701 12.6616433556577 0.0155270245538197
Tofu Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) rs78144227 36.6343759639155 16.6922220682441 0.0281853131297755
Tofu Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) All - Inverse variance weighted 5.93403797897006 2.64199690902099 0.0247012703686122
Tofu Fracture of femur (finn-b-ST19_FRACT_FEMUR) rs111491287 24.2288631811244 12.2720614525784 0.0483464162347031
Tofu Fracture of femur (finn-b-ST19_FRACT_FEMUR) rs112346208 -12.4628066923565 5.3493325528836 0.0198173992190839
Tofu Fracture of femur (finn-b-ST19_FRACT_FEMUR) rs147917512 -10.084678129826 4.07843868868091 0.0134103761014337
Tofu Fracture of femur (finn-b-ST19_FRACT_FEMUR) rs72767206 -18.7687121040582 8.8560142903867 0.0340635861038682
Tofu Fracture of femur (finn-b-ST19_FRACT_FEMUR) rs9917110 -27.0300251442094 13.3327698776597 0.0426279028659312
Tofu Fracture of femur (finn-b-ST19_FRACT_FEMUR) All - Inverse variance weighted -1.88494587569134 0.708574905459184 0.0078095928286217
Tofu Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) rs16879193 202.586801790256 61.6205629711416 0.0010102759817268
Tofu Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) rs117633973 -35.3409411101719 12.9895745280361 0.0065140731447648
Tofu Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) rs145218087 -13.7052693933601 5.71277273665599 0.0164373402767873
Tofu Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) All - Inverse variance weighted -2.76184637665373 1.33785702607569 0.0389816241082138
Tofu Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) rs145218087 20.1495283484567 8.96182808727573 0.0245524434723283
Tofu Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) rs182218128 84.6461079589283 35.0835090365748 0.0158346914986419
Tofu Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) rs186806325 12.8789989110734 5.60381160484627 0.021547169662168
Tofu Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) rs6914092 -33.9185210033919 16.9816243616982 0.04578542646057
Tofu Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) rs79406768 -23.1759656652361 11.6626991711699 0.0469016638048038
Tofu Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) All - MR Egger 11.6980837962161 3.81130338664929 0.0035924403376141
Tofu Femoral neck bone mineral density (ieu-a-980) rs116461853 -4.50326449847018 2.14968749727595 0.036184674382991
Tofu Femoral neck bone mineral density (ieu-a-980) rs80130122 -4.62870404159269 2.17250470500925 0.033123418333407
Tofu Femoral neck bone mineral density (ieu-a-980) All - Inverse variance weighted -0.612921684570382 0.276941157866893 0.0268849764043542
Tofu Lumbar spine bone mineral density (ieu-a-982) rs116461853 -5.6107532318099 2.48119317637009 0.0237399105586413
Tofu Lumbar spine bone mineral density (ieu-a-982) rs186806325 -4.17847543041542 1.90062911739063 0.0279156550559456
Tofu Lumbar spine bone mineral density (ieu-a-982) rs80130122 -5.23533246681892 2.64489173353452 0.047769552154718
Tofu Lumbar spine bone mineral density (ieu-a-982) All - Inverse variance weighted -1.01464858175271 0.318339952043984 0.0014360203992646
Tofu Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) rs10980960 -0.413894387856453 0.181738099967805 0.022761024208835
Tofu Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) rs147917512 -0.437402962179866 0.164277644766436 0.0077543305799521
Tofu Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) rs7697383 -0.377531836115815 0.16587131543227 0.0228428625364054
Tofu Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) rs9917110 -0.353649608046147 0.174949817229066 0.0432347994249314
Tofu Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) All - Inverse variance weighted -0.0511451065292443 0.0234083041345302 0.0288952307955636
Tofu Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) rs6597123 -2.07622267872864 1.05577941382874 0.0492373343033846
Tofu Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) All - Inverse variance weighted -0.354849114262266 0.143688998361567 0.0135277984378381
Tofu Fractured bone site(s): Wrist (ukb-a-439) rs139598224 0.175669145283848 0.0874355261231065 0.0445235832739653
Tofu Fractured bone site(s): Wrist (ukb-a-439) rs146906987 0.147625740508802 0.0727569278600454 0.0424555830969867
Tofu Fractured bone site(s): Wrist (ukb-a-439) rs72767206 0.194194111085952 0.0817322900680135 0.0175025132877715
Tofu Fractured bone site(s): Wrist (ukb-a-439) rs9917110 0.180598284277474 0.0883649924989963 0.0409756438436046
Tofu Fractured bone site(s): Wrist (ukb-a-439) All - Inverse variance weighted 0.0293771782399387 0.0120103237270208 0.0144453455612647
Tofu Fractured bone site(s): Wrist (ukb-a-439) All - MR Egger 0.0438187522439083 0.0217379545746291 0.0495610215954304
Tofu Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) rs116461853 0.101508904366321 0.0254821781919298 6.79004072419394e-05
Tofu Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) rs7846725 0.0615123891349701 0.0250103285612982 0.01391386630319
Tofu Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) All - MR Egger -0.0150878566656411 0.0067102334514485 0.0292736923463993
Tofu Non-cancer illness code self-reported: bone disorder (ukb-a-84) rs182218128 -0.0600613675711813 0.0297150464827925 0.0432544845744639
Tofu Non-cancer illness code self-reported: bone disorder (ukb-a-84) rs6597123 -0.0590629425950263 0.0295938652342006 0.0459575132158688
Tofu Non-cancer illness code self-reported: bone disorder (ukb-a-84) rs79406768 -0.052322288057549 0.0252286493718615 0.0380864189120838
Tofu Non-cancer illness code self-reported: bone disorder (ukb-a-84) All - Inverse variance weighted -0.0103344975237541 0.0040202992752146 0.0101528621099289
Tofu Non-cancer illness code, self-reported: bone disorder (ukb-b-14356) rs6597123 -0.0522008855090401 0.0252870759062432 0.0389863781195996
Tofu Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) rs7697383 -0.282932434097139 0.140874452704328 0.0446006647633345
Tofu Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) rs7846725 0.300422391909807 0.14535790263404 0.0387551574344886
Tofu Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) All - Inverse variance weighted -0.0573032120065042 0.0236826995394783 0.0155365918155565
Tofu Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) All - MR Egger -0.112624421156661 0.0458921890231524 0.0197486825172592
Tofu Operative procedures - secondary OPCS: Z86.4 Metatarsophalangeal joint of great toe (ukb-b-17501) rs6597123 -0.0961678128947469 0.0301690633253799 0.0014344393460931
Tofu Operative procedures - secondary OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-19546) rs6597123 -0.0562367141745244 0.0282150740688758 0.0462456478037324
Tofu Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) rs112346208 2.21601385298278 0.835479570102271 0.0079925243403766
Tofu Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) rs146893802 -2.59282853859139 0.781596810688503 0.0009087638069585
Tofu Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) All - Inverse variance weighted -0.249655978337697 0.115632521303278 0.0308465676918474
Tofu Heel bone mineral density (BMD) (right) (ukb-b-4657) rs112346208 2.1369282799213 0.835536477895387 0.0105411691399299
Tofu Heel bone mineral density (BMD) (right) (ukb-b-4657) rs146893802 -2.48065941170133 0.781969435764824 0.0015122485353999
Tofu Heel bone mineral density (BMD) (right) (ukb-b-4657) rs79123483 -1.52332359244107 0.769062926164037 0.0476189953510139
Tofu Heel bone mineral density (BMD) (right) (ukb-b-4657) All - Inverse variance weighted -0.230274573758379 0.115652567641322 0.0464710859775659
Tofu Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) rs6597123 0.0702172942212241 0.0357697166115882 0.0496418196072389
Tofu Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) All - Inverse variance weighted 0.0691818881353348 0.0252003547570542 0.0060460325726271
Tofu Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) rs6597123 0.0629806183251885 0.028629502507241 0.0278175212263265
Tofu Knee pain for 3+ months (ukb-b-8906) All - MR Egger -0.26012316683603 0.113208124777014 0.0258857227962572
Tofu Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) rs117160897 0.0948310813539336 0.0422280462295161 0.0247239011806163
Tofu Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) rs72655784 0.110186581907917 0.0437626274549761 0.0118082399661922
Tofu Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) All - Inverse variance weighted 0.0136823998155157 0.0064390792122935 0.0335949528308195
Tofu Ankle spacing width (ukb-e-3143_AFR) rs73784728 -9.18720667897258 3.42635153884204 0.007332840306046
Tofu Heel bone mineral density (BMD) (ukb-e-3148_EAS) rs111491287 8.58121590293076 4.12144419710653 0.0373342906760263
Tofu Heel bone mineral density (BMD) (ukb-e-3148_EAS) rs7846725 -31.2220589293239 9.08502307225882 0.0005889526890324
Tofu Heel bone mineral density (BMD) (ukb-e-3148_EAS) All - MR Egger 6.1219393891153 2.50463881628033 0.0283562283232294
Tofu Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) rs7846725 -30.3998848956353 15.230773974081 0.0459392112340405
Tofu Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) All - MR Egger 7.95466060391899 3.83331857189216 0.0498722477586
Tofu Spondylosis and allied disorders (ukb-e-721_CSA) rs111491287 -25.751336970354 9.01950381195142 0.0043027010469337
Tofu Spondylosis and allied disorders (ukb-e-721_CSA) rs116461853 -51.2295260593276 18.0528072943453 0.0045431394808624
Tofu Spondylosis and allied disorders (ukb-e-721_CSA) rs139598224 -56.859044240876 28.7590100717552 0.0480318783422336
Tofu Spondylosis and allied disorders (ukb-e-721_CSA) rs141063224 -59.843384560028 17.7162931189577 0.0007304886337963
Tofu Spondylosis and allied disorders (ukb-e-721_CSA) rs148290110 -42.4336958411405 14.9993239197203 0.0046687780582716
Tofu Spondylosis and allied disorders (ukb-e-721_CSA) rs73784728 -43.6135944116689 17.2162100208718 0.011299851590256
Tofu Spondylosis and allied disorders (ukb-e-721_CSA) All - Inverse variance weighted -11.7617816810085 4.95005469620361 0.0174971349115184
Tofu Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) rs7846725 -29.4543847568934 9.21862635273321 0.0013978493595214
Tofu Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) rs9917110 8.76877892112325 4.44143934751833 0.0483464839810408
Tofu Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) All - MR Egger 6.22994253388476 2.50509987959874 0.0261188648467428
Tofu M75 Shoulder lesions (ukb-e-M75_CSA) rs116461853 -38.0669287563525 14.9408554816552 0.0108391765748874
Tofu M75 Shoulder lesions (ukb-e-M75_CSA) rs61874758 52.5811986925279 24.8922570655986 0.0346563042738159
Tofu M75 Shoulder lesions (ukb-e-M75_CSA) rs6597123 -44.8623888328889 21.8927436744797 0.040443551042295
Tofu M75 Shoulder lesions (ukb-e-M75_CSA) All - Inverse variance weighted -6.13665309434993 2.99955208312222 0.0407704922923752