ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Yorkshire pudding (ukb-b-5605)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Yorkshire pudding (👉 📊) Frozen shoulder (ebi-a-GCST90000513) Inverse variance weighted 12 -0.672899995 0.328485648 0.040511883
Yorkshire pudding (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) Inverse variance weighted 11 0.20960099 0.098168261 0.032751232
Yorkshire pudding (👉 📊) Bone disorder (ebi-a-GCST90038652) Weighted median 17 -0.023499667 0.009446363 0.012857412
Yorkshire pudding (👉 📊) Bone disorder (ebi-a-GCST90038652) Inverse variance weighted 17 -0.018626533 0.007765827 0.016461232
Yorkshire pudding (👉 📊) Osteoporosis (ebi-a-GCST90038656) Weighted median 17 -0.021091087 0.007960855 0.008064686
Yorkshire pudding (👉 📊) Osteoporosis (ebi-a-GCST90038656) Inverse variance weighted 17 -0.017266886 0.005488066 0.001653725
Yorkshire pudding (👉 📊) Osteoporosis (ebi-a-GCST90038656) Simple mode 17 -0.034130124 0.014519395 0.031894226
Yorkshire pudding (👉 📊) Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) Weighted median 15 -9.568173674 4.212435898 0.023122103
Yorkshire pudding (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) Weighted median 15 -9.560891009 4.190023452 0.022499805
Yorkshire pudding (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) Inverse variance weighted 15 -6.36671259 2.963975867 0.031711278
Yorkshire pudding (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) Inverse variance weighted 15 -6.361326519 2.96241246 0.031765693
Yorkshire pudding (👉 📊) Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) Weighted median 15 5.580793908 2.810021276 0.047029702
Yorkshire pudding (👉 📊) Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) Inverse variance weighted 15 0.877866606 0.288274199 0.00232488
Yorkshire pudding (👉 📊) Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) Inverse variance weighted 15 0.964656406 0.460748893 0.036289335
Yorkshire pudding (👉 📊) Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) MR Egger 15 12.36679681 5.305414806 0.036496492
Yorkshire pudding (👉 📊) Infective bursitis (finn-b-M13_INFBURSA) MR Egger 15 6.824541141 2.961762798 0.038357543
Yorkshire pudding (👉 📊) Patellar tendinitis (finn-b-M13_PATELLARTEND) MR Egger 15 12.82162238 4.277404988 0.010287773
Yorkshire pudding (👉 📊) Peroneal tendinitis (finn-b-M13_PERONEALTEND) Inverse variance weighted 15 5.824198089 2.783009037 0.036369683
Yorkshire pudding (👉 📊) Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) Inverse variance weighted 15 0.684594198 0.298775972 0.021944364
Yorkshire pudding (👉 📊) Psoriatic arthritis (ieu-b-5116) Weighted median 16 -1.528556901 0.736129466 0.037849731
Yorkshire pudding (👉 📊) Fracture resulting from simple fall (ukb-a-332) Inverse variance weighted 17 0.190487284 0.088260381 0.030909001
Yorkshire pudding (👉 📊) Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) MR Egger 17 -0.026714352 0.010351521 0.020884873
Yorkshire pudding (👉 📊) Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) Weighted median 17 -0.017289412 0.007430996 0.019983292
Yorkshire pudding (👉 📊) Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) Inverse variance weighted 17 -0.018934366 0.005350424 0.000401869
Yorkshire pudding (👉 📊) Non-cancer illness code self-reported: osteoporosis (ukb-a-87) Weighted median 17 -0.02076629 0.009180715 0.023700677
Yorkshire pudding (👉 📊) Non-cancer illness code self-reported: osteoporosis (ukb-a-87) Inverse variance weighted 17 -0.019187076 0.006560312 0.003447663
Yorkshire pudding (👉 📊) Non-cancer illness code self-reported: osteoporosis (ukb-a-87) Simple mode 17 -0.04199171 0.019665713 0.048547353
Yorkshire pudding (👉 📊) Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) Weighted median 17 0.008850195 0.004135458 0.032348621
Yorkshire pudding (👉 📊) Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) Weighted median 7 -0.030555241 0.012199854 0.012260454
Yorkshire pudding (👉 📊) Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) Inverse variance weighted 7 -0.025318855 0.009219335 0.006027569
Yorkshire pudding (👉 📊) Diagnoses - main ICD10: N32.0 Bladder-neck obstruction (ukb-b-123) Inverse variance weighted 2 -0.016904988 0.007612621 0.026374493
Yorkshire pudding (👉 📊) Diagnoses - main ICD10: M51.2 Other specified intervertebral disk displacement (ukb-b-12872) Inverse variance weighted 2 0.015802563 0.00775742 0.04164101
Yorkshire pudding (👉 📊) Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) Inverse variance weighted 7 -0.011597819 0.005734319 0.043121846
Yorkshire pudding (👉 📊) Operative procedures - main OPCS: T67.6 Primary simple repair of tendon (ukb-b-16193) Inverse variance weighted 2 -0.015289892 0.007674986 0.046352185
Yorkshire pudding (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) MR Egger 17 0.242842349 0.106738849 0.038006979
Yorkshire pudding (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) Inverse variance weighted 17 0.146856172 0.055614547 0.008275761
Yorkshire pudding (👉 📊) Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) Inverse variance weighted 2 0.014458037 0.006747612 0.032138041
Yorkshire pudding (👉 📊) Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) Inverse variance weighted 4 0.013307446 0.006609633 0.044078739
Yorkshire pudding (👉 📊) Fractured heel (left) (ukb-b-8221) Inverse variance weighted 17 -0.015787556 0.007742874 0.041452157
Yorkshire pudding (👉 📊) Heel bone mineral density (BMD) (ukb-b-8875) MR Egger 17 0.237473389 0.106712797 0.04181902
Yorkshire pudding (👉 📊) Heel bone mineral density (BMD) (ukb-b-8875) Inverse variance weighted 17 0.144449532 0.055602637 0.009379855
Yorkshire pudding (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) MR Egger 17 -0.032664291 0.014138883 0.035513601
Yorkshire pudding (👉 📊) Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) MR Egger 17 0.02954231 0.012030529 0.02674482
Yorkshire pudding (👉 📊) Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) Weighted median 17 -0.013454917 0.005333738 0.011648897
Yorkshire pudding (👉 📊) Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) Inverse variance weighted 17 -0.008699392 0.004062711 0.032251658
Yorkshire pudding (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_EAS) Inverse variance weighted 10 2.742919925 1.068249133 0.010238218
Yorkshire pudding (👉 📊) Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) Weighted median 12 -3.805462455 1.879681904 0.042916192
Yorkshire pudding (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) Weighted median 10 2.971781138 1.481946287 0.044928516
Yorkshire pudding (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) Inverse variance weighted 10 3.054892371 1.077834637 0.004592811
Yorkshire pudding (👉 📊) Internal derangement of knee (ukb-e-835_CSA) Inverse variance weighted 13 -4.333862134 1.562406915 0.005539943
Yorkshire pudding (👉 📊) M75 Shoulder lesions (ukb-e-M75_CSA) Inverse variance weighted 13 3.583462665 1.788787804 0.045146054

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Yorkshire pudding Frozen shoulder (ebi-a-GCST90000513) rs17863665 -2.42470218026523 1.06203641267701 0.0224263170385675
Yorkshire pudding Frozen shoulder (ebi-a-GCST90000513) All - Inverse variance weighted -0.672899995265179 0.328485648165124 0.0405118828570111
Yorkshire pudding Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) All - Inverse variance weighted 0.209600990252992 0.098168261076097 0.0327512321026385
Yorkshire pudding Bone disorder (ebi-a-GCST90038652) rs13058042 -0.0721883649002517 0.0260006165457853 0.0054962894366445
Yorkshire pudding Bone disorder (ebi-a-GCST90038652) rs3002162 -0.0563423924233066 0.0272764180564134 0.0388654908588625
Yorkshire pudding Bone disorder (ebi-a-GCST90038652) All - Inverse variance weighted -0.0186265333497271 0.0077658268495224 0.0164612324713441
Yorkshire pudding Osteoporosis (ebi-a-GCST90038656) rs13058042 -0.0464900929222576 0.0221756613469832 0.0360425799143015
Yorkshire pudding Osteoporosis (ebi-a-GCST90038656) All - Inverse variance weighted -0.0172668860597687 0.0054880657147047 0.001653724673452
Yorkshire pudding Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) All - Inverse variance weighted -6.36671259047295 2.96397586675569 0.0317112782610364
Yorkshire pudding Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) All - Inverse variance weighted -6.36132651917436 2.96241245956793 0.0317656932381923
Yorkshire pudding Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) rs58771985 2.74575590731819 1.35495526496903 0.0427181769670512
Yorkshire pudding Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) rs660959 2.30138010888405 1.09315555171992 0.0352684072267446
Yorkshire pudding Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) rs79273432 3.09407944098233 1.50340165740179 0.0395851002976411
Yorkshire pudding Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) All - Inverse variance weighted 0.877866606220708 0.288274199453997 0.002324880424071
Yorkshire pudding Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs11981557 6.63826607709422 3.31495101455902 0.0452284981496325
Yorkshire pudding Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs58771985 4.56670107822895 2.0216792842395 0.0238917682858998
Yorkshire pudding Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs79273432 5.14506840618309 2.27058696010214 0.0234535849222444
Yorkshire pudding Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) All - Inverse variance weighted 0.964656405547187 0.460748892571645 0.036289334580258
Yorkshire pudding Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) rs112606901 23.5591195423937 9.96186614534308 0.0180334622857228
Yorkshire pudding Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) rs77056729 22.8180230051955 10.1299997731243 0.0242894557323547
Yorkshire pudding Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) All - MR Egger 12.3667968108448 5.30541480619057 0.0364964922713842
Yorkshire pudding Infective bursitis (finn-b-M13_INFBURSA) All - MR Egger 6.82454114054883 2.96176279788686 0.0383575434005799
Yorkshire pudding Patellar tendinitis (finn-b-M13_PATELLARTEND) rs77056729 21.3263153118406 9.17995780112077 0.0201717021040132
Yorkshire pudding Patellar tendinitis (finn-b-M13_PATELLARTEND) rs79273432 41.9882627687084 15.4098669883683 0.0064347312586367
Yorkshire pudding Patellar tendinitis (finn-b-M13_PATELLARTEND) All - MR Egger 12.8216223803437 4.2774049876722 0.0102877730289938
Yorkshire pudding Peroneal tendinitis (finn-b-M13_PERONEALTEND) rs509497 26.6422731690584 11.4725668439007 0.0202189864649267
Yorkshire pudding Peroneal tendinitis (finn-b-M13_PERONEALTEND) All - Inverse variance weighted 5.82419808911556 2.78300903736478 0.0363696825270128
Yorkshire pudding Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) rs11981557 4.7842354423745 2.22483676166366 0.0315254899239897
Yorkshire pudding Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) rs58771985 3.64189034182152 1.347786189493 0.0068897303645975
Yorkshire pudding Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) rs79273432 3.18417092607008 1.52873988758272 0.037262807838901
Yorkshire pudding Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) All - Inverse variance weighted 0.684594198400189 0.298775972485218 0.0219443639032638
Yorkshire pudding Psoriatic arthritis (ieu-b-5116) rs184006295 31.1378693931009 7.8643193845464 7.51429696541131e-05
Yorkshire pudding Fracture resulting from simple fall (ukb-a-332) rs11981557 -0.73104288526199 0.347336608322785 0.0353165463498043
Yorkshire pudding Fracture resulting from simple fall (ukb-a-332) rs58771985 0.781615622849277 0.356945400321175 0.0285435045574249
Yorkshire pudding Fracture resulting from simple fall (ukb-a-332) All - Inverse variance weighted 0.190487283913769 0.0882603808202994 0.0309090011927054
Yorkshire pudding Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) rs182835721 -0.0586242949511625 0.0217976534402453 0.0071564005910074
Yorkshire pudding Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) All - Inverse variance weighted -0.0189343655717554 0.0053504243257027 0.0004018694605465
Yorkshire pudding Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) All - MR Egger -0.0267143518609425 0.0103515212399858 0.0208848727155668
Yorkshire pudding Non-cancer illness code self-reported: osteoporosis (ukb-a-87) rs660959 -0.0574394269563529 0.0279684567088826 0.0400026333260818
Yorkshire pudding Non-cancer illness code self-reported: osteoporosis (ukb-a-87) All - Inverse variance weighted -0.0191870756300739 0.0065603120041786 0.0034476629906334
Yorkshire pudding Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) rs184006295 -0.0509949793806526 0.01178347030401 1.50694534078828e-05
Yorkshire pudding Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) rs79273432 -0.0209828699487182 0.0096085243437046 0.0289786730235301
Yorkshire pudding Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) All - Inverse variance weighted -0.0253188551105219 0.0092193347861392 0.0060275687763216
Yorkshire pudding Diagnoses - main ICD10: N32.0 Bladder-neck obstruction (ukb-b-123) rs509497 -0.0212700817563318 0.0108159434375774 0.0492352386222777
Yorkshire pudding Diagnoses - main ICD10: N32.0 Bladder-neck obstruction (ukb-b-123) All - Inverse variance weighted -0.016904988128669 0.007612621307598 0.0263744928253064
Yorkshire pudding Diagnoses - main ICD10: M51.2 Other specified intervertebral disk displacement (ukb-b-12872) All - Inverse variance weighted 0.0158025634201372 0.0077574198396898 0.0416410104112811
Yorkshire pudding Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) All - Inverse variance weighted -0.0115978192657369 0.0057343185891298 0.0431218455068442
Yorkshire pudding Operative procedures - main OPCS: T67.6 Primary simple repair of tendon (ukb-b-16193) rs6931604 -0.0225315555062741 0.0108043651013657 0.0370318944038097
Yorkshire pudding Operative procedures - main OPCS: T67.6 Primary simple repair of tendon (ukb-b-16193) All - Inverse variance weighted -0.0152898920315956 0.0076749857640399 0.0463521850981175
Yorkshire pudding Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) rs184006295 0.593141043415673 0.22998330393331 0.0099069198975051
Yorkshire pudding Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) rs62555393 0.501140233206067 0.247182953255598 0.0426208961584575
Yorkshire pudding Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) All - Inverse variance weighted 0.146856171595306 0.0556145467086226 0.0082757610378264
Yorkshire pudding Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) All - MR Egger 0.242842348867921 0.106738849020293 0.0380069794054674
Yorkshire pudding Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) All - Inverse variance weighted 0.0144580367107501 0.0067476117561183 0.0321380408392719
Yorkshire pudding Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) All - Inverse variance weighted 0.0133074461989648 0.0066096326447015 0.044078739249035
Yorkshire pudding Fractured heel (left) (ukb-b-8221) All - Inverse variance weighted -0.0157875557678847 0.0077428744296256 0.041452156905299
Yorkshire pudding Heel bone mineral density (BMD) (ukb-b-8875) rs184006295 0.599435991528074 0.229942006241851 0.0091365835514306
Yorkshire pudding Heel bone mineral density (BMD) (ukb-b-8875) rs62555393 0.52583066762976 0.247150190898772 0.0333723031865476
Yorkshire pudding Heel bone mineral density (BMD) (ukb-b-8875) All - Inverse variance weighted 0.144449531644185 0.0556026368134296 0.009379854883542
Yorkshire pudding Heel bone mineral density (BMD) (ukb-b-8875) All - MR Egger 0.237473388850748 0.106712797464184 0.0418190203426737
Yorkshire pudding Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) All - MR Egger -0.0326642908217059 0.0141388827487616 0.0355136011221621
Yorkshire pudding Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) rs17863665 0.0557973701955496 0.025006995954147 0.0256632222656017
Yorkshire pudding Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) All - MR Egger 0.0295423099634281 0.0120305293159209 0.0267448199685812
Yorkshire pudding Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) rs2854497 -0.0319878410594047 0.0142181509741352 0.0244623363808626
Yorkshire pudding Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) All - Inverse variance weighted -0.0086993915969605 0.0040627107777819 0.0322516581450404
Yorkshire pudding Heel bone mineral density (BMD) (ukb-e-3148_EAS) rs58771985 6.62996100022941 3.01316242257398 0.0277832708365531
Yorkshire pudding Heel bone mineral density (BMD) (ukb-e-3148_EAS) All - Inverse variance weighted 2.74291992451891 1.06824913336959 0.0102382175314148
Yorkshire pudding Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) rs58771985 6.79771736636843 3.06047832071576 0.0263422206070827
Yorkshire pudding Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) All - Inverse variance weighted 3.0548923707848 1.07783463749041 0.0045928107896403
Yorkshire pudding Internal derangement of knee (ukb-e-835_CSA) rs2854497 -6.77261211709052 2.8734558444373 0.0184253759745537
Yorkshire pudding Internal derangement of knee (ukb-e-835_CSA) rs58771985 -13.4850309704061 6.16325418674008 0.0286716019942189
Yorkshire pudding Internal derangement of knee (ukb-e-835_CSA) rs6962977 -14.1666359763808 7.09559410255466 0.0458751989127633
Yorkshire pudding Internal derangement of knee (ukb-e-835_CSA) All - Inverse variance weighted -4.3338621344705 1.56240691549475 0.0055399425566992
Yorkshire pudding M75 Shoulder lesions (ukb-e-M75_CSA) rs2854497 7.6301649341235 3.34613746254045 0.0225904743162303
Yorkshire pudding M75 Shoulder lesions (ukb-e-M75_CSA) All - Inverse variance weighted 3.58346266525509 1.78878780410285 0.0451460535708388