ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Scone (ukb-b-5627)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Scone (👉 📊) Osteoprotegerin levels (ebi-a-GCST90000490) Inverse variance weighted 8 4.028985022 1.742565579 0.0207722
Scone (👉 📊) Ultradistal forearm bone mineral density (ebi-a-GCST90013422) Inverse variance weighted 6 -0.786513779 0.369143678 0.033118478
Scone (👉 📊) Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) Weighted median 10 0.796907681 0.39015364 0.041097166
Scone (👉 📊) Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) Weighted median 10 2.174321532 1.011382908 0.031567083
Scone (👉 📊) Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) Weighted median 10 3.746930434 1.908491482 0.049611988
Scone (👉 📊) Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) MR Egger 10 10.62913605 4.554362274 0.047874121
Scone (👉 📊) Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) Inverse variance weighted 10 3.815907823 1.755260097 0.029706317
Scone (👉 📊) Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) Inverse variance weighted 10 5.818724802 2.896273816 0.04453308
Scone (👉 📊) Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) Inverse variance weighted 10 -1.678624164 0.796503706 0.035075066
Scone (👉 📊) Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) Inverse variance weighted 10 -1.770056754 0.779792901 0.023213274
Scone (👉 📊) Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) Inverse variance weighted 10 -2.878107473 1.012534834 0.004476439
Scone (👉 📊) Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) Weighted median 9 0.022480539 0.010499944 0.032272806
Scone (👉 📊) Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) Inverse variance weighted 9 0.016091755 0.007588559 0.033961517
Scone (👉 📊) Fractured bone site(s): Other bones (ukb-b-17738) Weighted median 8 -0.042096221 0.021118003 0.046219769
Scone (👉 📊) Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) Weighted median 4 10.13510356 4.19258259 0.015632296
Scone (👉 📊) Pain in joint (ukb-e-745_CSA) Inverse variance weighted 2 -11.91076481 5.832220481 0.041128226
Scone (👉 📊) M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) Weighted median 3 9.750186019 4.878630239 0.045657075
Scone (👉 📊) M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) Inverse variance weighted 3 9.923281977 4.064066902 0.014617792

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Scone Osteoprotegerin levels (ebi-a-GCST90000490) rs79778360 8.13190818791827 3.94737719456169 0.0393910054615887
Scone Osteoprotegerin levels (ebi-a-GCST90000490) rs9522440 12.4976139247815 5.29649783073359 0.018294671319286
Scone Osteoprotegerin levels (ebi-a-GCST90000490) All - Inverse variance weighted 4.02898502153528 1.74256557909022 0.0207722001637918
Scone Ultradistal forearm bone mineral density (ebi-a-GCST90013422) rs115147089 -1.96434617989288 0.681280012928646 0.0039351133284638
Scone Ultradistal forearm bone mineral density (ebi-a-GCST90013422) All - Inverse variance weighted -0.786513778620494 0.369143677512886 0.0331184779903062
Scone Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) rs12901652 3.97324572652182 1.76272069629503 0.0241935528993841
Scone Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) rs12901652 -7.97905904096595 3.39517104090082 0.0187673643868806
Scone Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) rs9522440 9.49716852407403 4.68731220704299 0.0427500517186983
Scone Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) rs115147089 9.70802807363172 3.61694268300191 0.0072737847563319
Scone Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) All - Inverse variance weighted 3.81590782322045 1.75526009706629 0.0297063173017166
Scone Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) All - MR Egger 10.6291360538774 4.55436227439419 0.0478741212601957
Scone Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) rs1321812 34.2807484863083 16.0049873898382 0.0322032095742752
Scone Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) All - Inverse variance weighted 5.81872480232821 2.89627381560129 0.0445330801984631
Scone Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) rs12901652 -4.14015461462366 1.77900449025618 0.0199529674803577
Scone Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) rs79778360 -5.8432740115443 2.46488812430682 0.017759039813107
Scone Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) All - Inverse variance weighted -1.67862416427373 0.796503706356773 0.0350750658335676
Scone Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) rs149156735 -4.33363088323408 1.89046087626408 0.0218844515524514
Scone Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) All - Inverse variance weighted -1.77005675436057 0.779792901498599 0.0232132738879318
Scone Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) rs115147089 -5.09450224712184 2.2528935541464 0.0237397508992249
Scone Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) rs79778360 -10.0751468597681 3.57397664913018 0.0048169038313143
Scone Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) All - Inverse variance weighted -2.87810747253009 1.01253483391242 0.0044764392187334
Scone Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) All - Inverse variance weighted 0.0160917548388076 0.0075885593023491 0.0339615166191625
Scone Fractured bone site(s): Other bones (ukb-b-17738) rs112114606 -0.0798734013023063 0.0407304329779231 0.049876095269306
Scone Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) rs79778360 31.961308591102 9.18609794207402 0.0005027013571014
Scone Pain in joint (ukb-e-745_CSA) rs112114606 -15.420136456793 7.57516797675565 0.0417888858214002
Scone Pain in joint (ukb-e-745_CSA) All - Inverse variance weighted -11.9107648101836 5.8322204808298 0.0411282259492973
Scone M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) rs79778360 9.77064760545787 4.90532740337705 0.0463881623473341
Scone M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) All - Inverse variance weighted 9.92328197713121 4.06406690246127 0.0146177923445026