ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Breaded fish | Total body bone mineral density (age 0-15) (ebi-a-GCST005345) | All - Inverse variance weighted | 0.627183224102217 | 0.310418553094173 | 0.0433373796969571 |
| Breaded fish | Osteoarthritis of the hip or knee (hospital diagnosed) (ebi-a-GCST005812) | All - MR Egger | -2.05057303993867 | 0.895275490355083 | 0.0342847980007141 |
| Breaded fish | Osteoarthritis of the knee (hospital diagnosed) (ebi-a-GCST005813) | rs4880869 | 5.00083894293191 | 2.42214809340231 | 0.0389580488545357 |
| Breaded fish | Osteoarthritis of the knee (hospital diagnosed) (ebi-a-GCST005813) | All - MR Egger | -2.62531247274946 | 1.08909277515687 | 0.0268389528573943 |
| Breaded fish | Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) | rs117267390 | -8.03250869516437 | 3.77728758955619 | 0.0334593011881055 |
| Breaded fish | Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) | rs13332415 | -5.65816483876564 | 2.74139376650411 | 0.0390202030280371 |
| Breaded fish | Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) | rs4880869 | -8.89935681041887 | 4.14302978247408 | 0.0317112851376809 |
| Breaded fish | Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) | All - Inverse variance weighted | -2.20434914319285 | 0.85401093012855 | 0.0098465495672346 |
| Breaded fish | Achilles tendon injury (ebi-a-GCST90018787) | rs73252530 | -3.84325418194804 | 1.80825676112305 | 0.0335539298099937 |
| Breaded fish | Achilles tendon injury (ebi-a-GCST90018787) | All - MR Egger | -1.87963831349414 | 0.726368301347323 | 0.0185723800027821 |
| Breaded fish | Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) | rs10811184 | 22.0755072451897 | 9.64523554033797 | 0.0220940363789776 |
| Breaded fish | Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) | All - MR Egger | -12.6025609953862 | 4.94503144656326 | 0.0201616332145218 |
| Breaded fish | Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) | rs10811184 | 22.3110066267478 | 9.63499643679197 | 0.0205789341081058 |
| Breaded fish | Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) | All - MR Egger | -12.6247568431366 | 4.93558694894302 | 0.0197701966226238 |
| Breaded fish | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | rs10134161 | 34.3686318926421 | 16.1097159621035 | 0.0328910933950029 |
| Breaded fish | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | rs116543936 | 86.3754920829748 | 32.5109777958179 | 0.007888387934194 |
| Breaded fish | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | All - Inverse variance weighted | 6.389049384796 | 3.05227115393886 | 0.0363302697265848 |
| Breaded fish | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs150700219 | 7.85099599204406 | 3.21585991144516 | 0.0146330151122568 |
| Breaded fish | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs4880869 | 4.88384635359447 | 1.80772226993988 | 0.0068994802671577 |
| Breaded fish | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs9467377 | -3.65974091357977 | 1.61041509336535 | 0.0230536078291917 |
| Breaded fish | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | rs117267390 | -5.37537465339552 | 1.64086166273982 | 0.0010530859103889 |
| Breaded fish | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | rs150700219 | 4.62014372669938 | 2.10642572288133 | 0.0282816636608508 |
| Breaded fish | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | rs182530882 | -4.36309804697609 | 1.48988476702236 | 0.0034062352189297 |
| Breaded fish | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | All - Inverse variance weighted | -0.881276238456146 | 0.426854364608303 | 0.0389624789479739 |
| Breaded fish | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | rs12613033 | -2.15556323498719 | 0.906705170272388 | 0.0174371321495969 |
| Breaded fish | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | All - Inverse variance weighted | -1.00966234541283 | 0.314988890287284 | 0.0013487943172107 |
| Breaded fish | Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) | rs150700219 | 30.092153001969 | 10.6920470560014 | 0.0048861898771279 |
| Breaded fish | Spondylosis (finn-b-M13_SPONDYLOSIS) | rs12613033 | -2.87750584226067 | 1.28307335415904 | 0.0249183176873749 |
| Breaded fish | Spondylosis (finn-b-M13_SPONDYLOSIS) | All - Inverse variance weighted | -1.07533398393 | 0.448164878657915 | 0.0164212466540635 |
| Breaded fish | Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) | rs113224254 | 114.396874570294 | 52.935752359845 | 0.0306913796301634 |
| Breaded fish | Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) | rs73240476 | 81.0615192470429 | 28.6930187123651 | 0.0047261378673352 |
| Breaded fish | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | rs10811184 | 0.0795065366437038 | 0.0377734864557138 | 0.0353066409315318 |
| Breaded fish | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | rs72815688 | 0.0809901015587792 | 0.0395994284905199 | 0.0408317839619597 |
| Breaded fish | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | All - Inverse variance weighted | 0.0167710920827465 | 0.0085014939571351 | 0.0485271378412823 |
| Breaded fish | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | All - MR Egger | -0.0130427647911052 | 0.00546721194755 | 0.0282468417655498 |
| Breaded fish | Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) | rs4880869 | 0.0528149531590196 | 0.0179941273994767 | 0.003334169293739 |
| Breaded fish | Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) | All - Inverse variance weighted | 0.0092596452409058 | 0.0043297793752848 | 0.0324684693644621 |
| Breaded fish | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | rs13332415 | 0.0520999980725121 | 0.0257211214124631 | 0.0428086045335677 |
| Breaded fish | Non-cancer illness code, self-reported: fracture lower leg / ankle (ukb-b-13979) | rs4880869 | 0.0324536084533488 | 0.0134506521782554 | 0.0158309075847153 |
| Breaded fish | Non-cancer illness code, self-reported: fracture lower leg / ankle (ukb-b-13979) | All - Inverse variance weighted | 0.0221365718621132 | 0.0106803853973547 | 0.0382059884701912 |
| Breaded fish | Non-cancer illness code, self-reported: ankylosing spondylitis (ukb-b-18194) | All - Inverse variance weighted | -0.016379485562458 | 0.0080414905470873 | 0.0416628877967422 |
| Breaded fish | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | rs116624476 | 0.0349134407925701 | 0.0152209531531783 | 0.0218034300164717 |
| Breaded fish | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | rs150700219 | 0.0539914643531799 | 0.0157817513068335 | 0.0006236091243846 |
| Breaded fish | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | All - MR Egger | 0.0184631560783441 | 0.0077960920690301 | 0.030801529558817 |
| Breaded fish | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | rs150700219 | 0.0410355718583522 | 0.0191361405683102 | 0.0320007162958278 |
| Breaded fish | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | rs4880869 | 0.044171543854743 | 0.0172577552284122 | 0.0104817275405652 |
| Breaded fish | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | All - Inverse variance weighted | 0.0100274946976662 | 0.0040252259306413 | 0.0127325620936168 |
| Breaded fish | Heel bone mineral density (BMD) (ukb-e-3148_AFR) | rs116624476 | 4.85570358772187 | 2.47538363320332 | 0.0498094934240115 |
| Breaded fish | Heel bone mineral density (BMD) (ukb-e-3148_AFR) | rs4880869 | 8.81888820086691 | 3.64041307951981 | 0.0154142712526865 |
| Breaded fish | Heel bone mineral density (BMD) (ukb-e-3148_AFR) | All - MR Egger | -2.64732170858197 | 1.0611762606707 | 0.0297853537924434 |
| Breaded fish | Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) | All - MR Egger | 5.25306796132141 | 2.38548163141695 | 0.0479558030387947 |
| Breaded fish | Ankle spacing width (left) (ukb-e-4100_AFR) | rs113224254 | 1.21187242681852 | 0.546181782886169 | 0.0264997998102206 |
| Breaded fish | Ankle spacing width (left) (ukb-e-4100_AFR) | rs13332415 | 1.91327268171392 | 0.790992849019872 | 0.0155707614073811 |
| Breaded fish | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_AFR) | rs4880869 | 9.142480474602 | 3.64640552903342 | 0.0121671767355854 |
| Breaded fish | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_AFR) | All - MR Egger | -2.7165402405952 | 1.06291974348259 | 0.0267208505805685 |
| Breaded fish | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | All - Inverse variance weighted | 2.14095941400019 | 1.09220311753067 | 0.0499699728282253 |