ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Garlic bread (ukb-b-602)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Garlic bread (👉 📊) Compression fracture (ebi-a-GCST90018828) Inverse variance weighted 20 1.194591011 0.587703731 0.042088752
Garlic bread (👉 📊) Heel bone mineral density T score (ebi-a-GCST90025982) Inverse variance weighted 8 0.185114689 0.062922199 0.003261405
Garlic bread (👉 📊) Cervical spondylosis (ebi-a-GCST90038693) Weighted median 21 -0.011853345 0.005673877 0.036697956
Garlic bread (👉 📊) Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) Weighted median 23 2.897541319 1.373866654 0.034941029
Garlic bread (👉 📊) Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) Inverse variance weighted 23 1.975648048 1.001481974 0.048526957
Garlic bread (👉 📊) Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) MR Egger 23 -8.677986015 3.34977045 0.017062691
Garlic bread (👉 📊) Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) Inverse variance weighted 23 -4.510058225 1.979115423 0.022677454
Garlic bread (👉 📊) Pain in joint (finn-b-JOINTPAIN) Weighted median 23 -0.70354699 0.348818439 0.043701438
Garlic bread (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) MR Egger 23 6.435448504 2.928193804 0.039321369
Garlic bread (👉 📊) Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) Inverse variance weighted 23 1.85166679 0.890542186 0.037593661
Garlic bread (👉 📊) Osteomyelitis (finn-b-M13_OSTEOMYELITIS) Inverse variance weighted 23 -2.004203898 0.871380824 0.0214464
Garlic bread (👉 📊) Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) Inverse variance weighted 23 0.429905238 0.19814374 0.030032348
Garlic bread (👉 📊) Pain (limb, back, neck, head abdominally) (finn-b-PAIN) Weighted mode 23 -0.498630836 0.232345317 0.043154316
Garlic bread (👉 📊) Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) MR Egger 23 1.929122743 0.783015197 0.022468289
Garlic bread (👉 📊) Fracture of neck (finn-b-ST19_FRACT_NECK) Inverse variance weighted 23 -1.863672143 0.95021555 0.049842272
Garlic bread (👉 📊) Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) Weighted mode 23 -1.572297444 0.756647361 0.049585993
Garlic bread (👉 📊) Injuries to the neck (finn-b-ST19_INJURI_NECK) Inverse variance weighted 23 -0.866526701 0.431400225 0.044575583
Garlic bread (👉 📊) Injuries to the neck (finn-b-ST19_INJURI_NECK) Simple mode 23 -2.053874285 0.942029216 0.040217926
Garlic bread (👉 📊) Knee and hip osteoarthritis (ieu-a-1170) Inverse variance weighted 3 -2.544726075 1.170498182 0.029701092
Garlic bread (👉 📊) Psoriatic arthritis (ieu-b-5116) MR Egger 19 -2.635787575 0.937062512 0.01197771
Garlic bread (👉 📊) Psoriatic arthritis (ieu-b-5116) Inverse variance weighted 19 -1.403145214 0.532851854 0.008456596
Garlic bread (👉 📊) Fractured/broken bones in last 5 years (ukb-a-308) Inverse variance weighted 20 -0.036550976 0.016584843 0.027532905
Garlic bread (👉 📊) Fractured bone site(s): Other bones (ukb-a-441) Inverse variance weighted 20 -0.033436432 0.0144731 0.020874504
Garlic bread (👉 📊) Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) Weighted median 20 -0.006296244 0.002892815 0.029517094
Garlic bread (👉 📊) Diagnoses - secondary ICD10: G55.1 Nerve root and plexus compressions in intervertebral disk disorders (ukb-b-1220) Weighted median 4 0.020181484 0.008321901 0.015303952
Garlic bread (👉 📊) Diagnoses - secondary ICD10: G55.1 Nerve root and plexus compressions in intervertebral disk disorders (ukb-b-1220) Inverse variance weighted 4 0.017561289 0.006916815 0.011119297
Garlic bread (👉 📊) Operative procedures - secondary OPCS: Z84.1 Sacroiliac joint (ukb-b-16715) Inverse variance weighted 2 -0.013986468 0.006512945 0.031754482
Garlic bread (👉 📊) Diagnoses - main ICD10: M51.1 Lumbar and other intervertebral disk disorders with radiculopathy (ukb-b-18279) Inverse variance weighted 4 0.013496531 0.006789891 0.046840557
Garlic bread (👉 📊) Ankle spacing width (ukb-b-4080) MR Egger 23 0.16845253 0.080502609 0.048718879
Garlic bread (👉 📊) Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) Inverse variance weighted 4 -0.014361724 0.007078429 0.042464166
Garlic bread (👉 📊) Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) Inverse variance weighted 2 -0.015033497 0.006928775 0.030028123
Garlic bread (👉 📊) Knee pain for 3+ months (ukb-b-8906) MR Egger 23 -0.194845512 0.070136312 0.011269062
Garlic bread (👉 📊) Internal derangement of knee (ukb-e-835_CSA) Inverse variance weighted 13 -3.336756987 1.637718281 0.041605709
Garlic bread (👉 📊) M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) Inverse variance weighted 13 -3.993887604 1.459575714 0.006212781

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Garlic bread Compression fracture (ebi-a-GCST90018828) rs144832700 7.72545875525791 3.22942142152933 0.0167471929528638
Garlic bread Compression fracture (ebi-a-GCST90018828) rs191400124 8.97405628804603 3.22501344769758 0.0053918346264458
Garlic bread Compression fracture (ebi-a-GCST90018828) All - Inverse variance weighted 1.19459101112094 0.587703730700419 0.0420887523638519
Garlic bread Heel bone mineral density T score (ebi-a-GCST90025982) rs76824822 0.533148306759784 0.184931040541134 0.0039396074912778
Garlic bread Heel bone mineral density T score (ebi-a-GCST90025982) All - Inverse variance weighted 0.18511468872634 0.0629221993525555 0.0032614045965547
Garlic bread Cervical spondylosis (ebi-a-GCST90038693) rs144832700 -0.0332444007267321 0.0166167431352337 0.0454293841693246
Garlic bread Cervical spondylosis (ebi-a-GCST90038693) rs183874897 -0.0308134771889419 0.014940238351019 0.0391650239569902
Garlic bread Cervical spondylosis (ebi-a-GCST90038693) rs79896327 -0.0303580345816059 0.0142071878911255 0.0326136006622265
Garlic bread Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) All - Inverse variance weighted 1.97564804815466 1.00148197413784 0.0485269566187991
Garlic bread Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) rs138905810 -12.6514003791454 5.49284938091423 0.0212648318296757
Garlic bread Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) All - Inverse variance weighted -4.51005822451582 1.97911542264131 0.0226774544958626
Garlic bread Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) All - MR Egger -8.67798601539437 3.3497704501565 0.0170626912875232
Garlic bread Pain in joint (finn-b-JOINTPAIN) rs191400124 3.10818277185646 1.24862784805197 0.0128002560911698
Garlic bread Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) rs146515099 20.5491222040639 8.70781985368899 0.0182824755950042
Garlic bread Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) All - MR Egger 6.4354485037502 2.92819380425609 0.0393213693377247
Garlic bread Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) rs116618931 8.24670298097061 3.20797458315327 0.0101496609684585
Garlic bread Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) rs7281491 10.0545134870078 4.73569352287888 0.0337425971241177
Garlic bread Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) All - Inverse variance weighted 1.85166678972932 0.890542185898197 0.0375936612613764
Garlic bread Osteomyelitis (finn-b-M13_OSTEOMYELITIS) rs144832700 -14.0181144041628 5.751424381458 0.0147962036071451
Garlic bread Osteomyelitis (finn-b-M13_OSTEOMYELITIS) rs17154963 -13.848539252489 4.80251346499102 0.0039315482662105
Garlic bread Osteomyelitis (finn-b-M13_OSTEOMYELITIS) All - Inverse variance weighted -2.00420389813121 0.871380824450123 0.0214463995271598
Garlic bread Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) All - Inverse variance weighted 0.429905238022141 0.198143739839612 0.0300323478441559
Garlic bread Pain (limb, back, neck, head abdominally) (finn-b-PAIN) rs191400124 1.52853467558799 0.625530910232663 0.0145423544634039
Garlic bread Pain (limb, back, neck, head abdominally) (finn-b-PAIN) rs703482 1.35416257801154 0.641101123889521 0.0346654493546654
Garlic bread Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) rs72763074 -5.95012198427758 2.4329086473299 0.0144578276182169
Garlic bread Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) All - MR Egger 1.92912274250439 0.783015196989195 0.022468288802403
Garlic bread Fracture of neck (finn-b-ST19_FRACT_NECK) All - Inverse variance weighted -1.86367214250589 0.95021554959304 0.0498422723825299
Garlic bread Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) rs144854507 -16.1624986349241 6.18971773321163 0.0090229045680903
Garlic bread Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) rs4663432 -6.08017201845311 2.85482602265031 0.033189183105633
Garlic bread Injuries to the neck (finn-b-ST19_INJURI_NECK) All - Inverse variance weighted -0.866526701317781 0.431400224756416 0.044575583389876
Garlic bread Knee and hip osteoarthritis (ieu-a-1170) All - Inverse variance weighted -2.54472607490947 1.17049818173508 0.0297010915059839
Garlic bread Psoriatic arthritis (ieu-b-5116) rs146515099 -5.24066618504205 1.56877529405989 0.0008359460644452
Garlic bread Psoriatic arthritis (ieu-b-5116) rs7332774 5.06844292533088 2.26966106033457 0.0255405260953255
Garlic bread Psoriatic arthritis (ieu-b-5116) All - Inverse variance weighted -1.4031452136058 0.532851853810743 0.008456596330918
Garlic bread Psoriatic arthritis (ieu-b-5116) All - MR Egger -2.63578757524174 0.937062511725896 0.0119777103710193
Garlic bread Fractured/broken bones in last 5 years (ukb-a-308) rs144854507 -0.191658716602002 0.0709382037867721 0.0068971438413317
Garlic bread Fractured/broken bones in last 5 years (ukb-a-308) rs7281491 -0.153445305390385 0.0655404080118039 0.0192202156519164
Garlic bread Fractured/broken bones in last 5 years (ukb-a-308) All - Inverse variance weighted -0.0365509756805759 0.0165848431707138 0.0275329052715087
Garlic bread Fractured bone site(s): Other bones (ukb-a-441) rs116618931 -0.115453366829875 0.051308834633778 0.0244384447905994
Garlic bread Fractured bone site(s): Other bones (ukb-a-441) rs144832700 0.106163523707502 0.052278673466867 0.042283064774221
Garlic bread Fractured bone site(s): Other bones (ukb-a-441) rs144854507 -0.142130260178315 0.0534141320898951 0.007792951591665
Garlic bread Fractured bone site(s): Other bones (ukb-a-441) rs55947176 -0.165759199432669 0.0541818020644551 0.0022184376047785
Garlic bread Fractured bone site(s): Other bones (ukb-a-441) All - Inverse variance weighted -0.0334364315687261 0.0144731004843425 0.0208745039975046
Garlic bread Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) rs4663432 0.0319160438185424 0.0098989877515815 0.0012633728406132
Garlic bread Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) rs79303515 -0.0208214142250247 0.0088119438594782 0.0181343824414772
Garlic bread Diagnoses - secondary ICD10: G55.1 Nerve root and plexus compressions in intervertebral disk disorders (ukb-b-1220) All - Inverse variance weighted 0.0175612886112445 0.0069168146843252 0.0111192973220802
Garlic bread Operative procedures - secondary OPCS: Z84.1 Sacroiliac joint (ukb-b-16715) All - Inverse variance weighted -0.0139864684207295 0.0065129448448052 0.0317544817766592
Garlic bread Diagnoses - main ICD10: M51.1 Lumbar and other intervertebral disk disorders with radiculopathy (ukb-b-18279) All - Inverse variance weighted 0.0134965310058549 0.0067898907212076 0.046840556509716
Garlic bread Ankle spacing width (ukb-b-4080) rs17154963 0.456683531907948 0.230523094499755 0.0475828670764674
Garlic bread Ankle spacing width (ukb-b-4080) rs75005472 0.437478889277675 0.215912883254419 0.0427460940134345
Garlic bread Ankle spacing width (ukb-b-4080) All - MR Egger 0.168452530374552 0.0805026086854103 0.0487188793803928
Garlic bread Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) rs55947176 -0.0334918446142936 0.0141921440390828 0.0182805427656838
Garlic bread Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) All - Inverse variance weighted -0.0143617242479387 0.0070784290569322 0.0424641659706709
Garlic bread Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) rs7281491 -0.0198541300371964 0.0093803839799263 0.0342973481246442
Garlic bread Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) All - Inverse variance weighted -0.0150334972916072 0.0069287754680172 0.0300281232548439
Garlic bread Knee pain for 3+ months (ukb-b-8906) rs117672019 -0.428991764348307 0.175843247974044 0.0147024733806622
Garlic bread Knee pain for 3+ months (ukb-b-8906) rs4663432 0.372503166123541 0.188528762372178 0.0481726032508023
Garlic bread Knee pain for 3+ months (ukb-b-8906) All - MR Egger -0.194845512266866 0.0701363115655486 0.0112690621992988
Garlic bread Internal derangement of knee (ukb-e-835_CSA) rs79896327 -10.3400574164306 4.97665730975761 0.0377359523145641
Garlic bread Internal derangement of knee (ukb-e-835_CSA) All - Inverse variance weighted -3.33675698657207 1.63771828103593 0.041605708909311
Garlic bread M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) rs79896327 -13.3596261769625 4.31791957874785 0.0019748010701271
Garlic bread M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) All - Inverse variance weighted -3.99388760379388 1.4595757138402 0.0062127808534155