ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Cheese spread | Heel bone mineral density (ebi-a-GCST006288) | All - Inverse variance weighted | -0.254138279770292 | 0.106089972600521 | 0.0165978207561203 |
| Cheese spread | Osteoprotegerin levels (ebi-a-GCST90000490) | rs35321803 | 21.7125236909805 | 10.6159357863029 | 0.0408276089459856 |
| Cheese spread | Osteoprotegerin levels (ebi-a-GCST90000490) | All - Inverse variance weighted | 3.89558192062726 | 1.81378328482074 | 0.0317323558454119 |
| Cheese spread | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | rs183506663 | -11.8167001003009 | 5.3598294884654 | 0.027476672525538 |
| Cheese spread | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | rs35321803 | -12.6074634757862 | 6.10172713931782 | 0.0388084409048101 |
| Cheese spread | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | All - MR Egger | -6.73222215603046 | 3.04223456555261 | 0.0440203482140019 |
| Cheese spread | Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) | rs188704935 | 30.3012880987412 | 13.0717587813629 | 0.0204453664627019 |
| Cheese spread | Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) | All - MR Egger | 7.1944704175709 | 3.29144741583395 | 0.0397594152704554 |
| Cheese spread | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | All - Inverse variance weighted | -8.18392850198075 | 3.90499293341974 | 0.0361034747117453 |
| Cheese spread | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | rs117478230 | 93.1478435491436 | 41.6383169400351 | 0.0252817435684886 |
| Cheese spread | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | rs77950337 | 68.3961392936111 | 27.1558161256788 | 0.0117803931628407 |
| Cheese spread | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | All - Inverse variance weighted | 5.97054685400663 | 2.76658684648153 | 0.0309207382573026 |
| Cheese spread | Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) | rs117333759 | -20.2909338604739 | 9.86281938295056 | 0.0396558613182908 |
| Cheese spread | Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) | All - Inverse variance weighted | -7.63780730903402 | 3.87219187563575 | 0.0485552413912909 |
| Cheese spread | Loose body in joint (finn-b-M13_LOOSEJOINT) | rs113691042 | 36.4096364520109 | 16.8974413300597 | 0.0311819832002555 |
| Cheese spread | Loose body in joint (finn-b-M13_LOOSEJOINT) | rs117333759 | 20.1575101735561 | 6.57638330518562 | 0.0021757093177191 |
| Cheese spread | Loose body in joint (finn-b-M13_LOOSEJOINT) | All - MR Egger | 12.9020390576578 | 5.8164196447879 | 0.0371720565705577 |
| Cheese spread | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | rs118179687 | 89.4977501243193 | 42.0259796965397 | 0.0332061772927957 |
| Cheese spread | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | rs36100673 | 39.9799813292914 | 20.2050909946096 | 0.0478488575130333 |
| Cheese spread | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | All - Inverse variance weighted | 9.2303802799309 | 4.46949609995619 | 0.0389045686289964 |
| Cheese spread | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | rs117333759 | -6.94856516869319 | 2.86509811907713 | 0.0152980546371056 |
| Cheese spread | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | rs12499561 | 12.1848431545001 | 5.11213720316623 | 0.0171482999910066 |
| Cheese spread | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | rs36100673 | 10.4682160582434 | 5.10504783114337 | 0.0403096398785209 |
| Cheese spread | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | rs718715 | -10.4723180039027 | 4.64732854586736 | 0.0242335619130699 |
| Cheese spread | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | All - Inverse variance weighted | -3.07391979046755 | 1.37471524195137 | 0.0253490786418489 |
| Cheese spread | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | All - MR Egger | -7.48660466385964 | 2.68789508667188 | 0.0107893855713485 |
| Cheese spread | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs139087594 | 4.25203392221717 | 2.08878717100622 | 0.0417857865676267 |
| Cheese spread | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs75089783 | 2.84659133731817 | 1.28705351707665 | 0.0269865907560836 |
| Cheese spread | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs78039274 | 2.00615220008025 | 0.932775040037311 | 0.0314970989108344 |
| Cheese spread | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | All - Inverse variance weighted | 0.746651927859586 | 0.32369393106311 | 0.0210737672012983 |
| Cheese spread | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | rs117333759 | 2.1874462355209 | 1.03930029809661 | 0.0353148410473903 |
| Cheese spread | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | All - Inverse variance weighted | 0.945016617840322 | 0.407812927095945 | 0.0204885003231726 |
| Cheese spread | Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) | rs150138628 | 26.5608358571284 | 9.76991318938281 | 0.0065551739114742 |
| Cheese spread | Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) | All - Inverse variance weighted | 2.60967455518443 | 1.055256191717 | 0.0133974908497333 |
| Cheese spread | Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) | rs718715 | 26.3137567256468 | 9.75052583192879 | 0.0069610624728899 |
| Cheese spread | Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) | All - Inverse variance weighted | 5.64616405169306 | 2.36691924520474 | 0.0170583088606255 |
| Cheese spread | Ankle and foot (finn-b-Z21_ANKLE_FOOT) | rs10090300 | 47.4771241830065 | 22.559186637618 | 0.0353297720073481 |
| Cheese spread | Ankle and foot (finn-b-Z21_ANKLE_FOOT) | rs73250437 | 92.8445070694567 | 44.2911009564946 | 0.0360614475558094 |
| Cheese spread | Femoral neck bone mineral density (ieu-a-980) | rs73250437 | -4.08053166879562 | 1.43417130867254 | 0.004438087759426 |
| Cheese spread | Femoral neck bone mineral density (ieu-a-980) | All - Inverse variance weighted | -0.633140858060799 | 0.257389681577407 | 0.0138993816664881 |
| Cheese spread | Fracture resulting from simple fall (ukb-a-332) | rs113691042 | -1.18321223375749 | 0.562934805638297 | 0.0355652171171417 |
| Cheese spread | Fracture resulting from simple fall (ukb-a-332) | rs150138628 | -1.27912975182516 | 0.594352252375541 | 0.0313862639238998 |
| Cheese spread | Fracture resulting from simple fall (ukb-a-332) | All - MR Egger | -0.56373387499481 | 0.236825154215817 | 0.026384310334541 |
| Cheese spread | Diagnoses - secondary ICD10: M13.9 Arthritis, unspecified (ukb-b-11045) | rs36100673 | -0.0361731356895902 | 0.0183517865516406 | 0.0487128798295375 |
| Cheese spread | Diagnoses - secondary ICD10: M13.9 Arthritis, unspecified (ukb-b-11045) | All - Inverse variance weighted | -0.0259405881414333 | 0.0124016051337883 | 0.0364642729509649 |
| Cheese spread | Diagnoses - secondary ICD10: M06.99 Rheumatoid arthritis, unspecified (Site unspecified) (ukb-b-11874) | rs718715 | 0.0348216603499299 | 0.0170835544085673 | 0.0415184691212814 |
| Cheese spread | Diagnoses - secondary ICD10: M06.99 Rheumatoid arthritis, unspecified (Site unspecified) (ukb-b-11874) | All - Inverse variance weighted | 0.0269375788187368 | 0.0125924970340645 | 0.0324213439484314 |
| Cheese spread | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | All - Inverse variance weighted | -0.0336616305473798 | 0.0148493937138827 | 0.0233982283611242 |
| Cheese spread | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs139087594 | 0.306184455974793 | 0.12392660636747 | 0.0134851965023757 |
| Cheese spread | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs73250437 | 0.299765156204046 | 0.138639047280421 | 0.030602870158783 |
| Cheese spread | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | All - MR Egger | 0.136682202631638 | 0.0562635054693805 | 0.023746834302196 |
| Cheese spread | Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) | rs12499561 | -0.0588667179712694 | 0.0255751612430372 | 0.0213512812558099 |
| Cheese spread | Fractured heel (left) (ukb-b-8221) | rs117844021 | -0.117771618330322 | 0.0573679971556897 | 0.0400808279805928 |
| Cheese spread | Fractured heel (left) (ukb-b-8221) | All - MR Egger | -0.056596148692594 | 0.0222516449142787 | 0.0185174133139189 |
| Cheese spread | Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) | rs10090300 | 12.0319535221496 | 4.97138707334786 | 0.0155102350270299 |
| Cheese spread | Spondylosis and allied disorders (ukb-e-721_CSA) | rs75089783 | -67.4253711873938 | 22.8365036205627 | 0.0031518550372775 |
| Cheese spread | Spondylosis and allied disorders (ukb-e-721_CSA) | rs77950337 | -30.6017446002354 | 14.8760679475881 | 0.0396754102844166 |
| Cheese spread | Spondylosis and allied disorders (ukb-e-721_CSA) | All - MR Egger | -34.3351732703603 | 13.6246228199792 | 0.0303830418981256 |