ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Doughnut (ukb-b-6214)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Doughnut (👉 📊) Rheumatoid Arthritis (bbj-a-73) Weighted median 25 2.479497124 1.096933659 0.023797099
Doughnut (👉 📊) Total body bone mineral density (age 15-30) (ebi-a-GCST005344) Weighted median 28 -2.216659206 1.048441437 0.03449458
Doughnut (👉 📊) Total body bone mineral density (age 0-15) (ebi-a-GCST005345) MR Egger 32 1.585197466 0.732001262 0.038422607
Doughnut (👉 📊) Total body bone mineral density (age 0-15) (ebi-a-GCST005345) Inverse variance weighted 32 0.930613658 0.409754773 0.023138031
Doughnut (👉 📊) Osteoprotegerin levels (ebi-a-GCST90012002) Weighted median 33 0.922955782 0.451793981 0.041065438
Doughnut (👉 📊) Rheumatoid arthritis (ebi-a-GCST90013534) Inverse variance weighted 27 1.180807526 0.597674085 0.048192019
Doughnut (👉 📊) Bone mineral density (ebi-a-GCST90014022) Weighted median 28 0.220625715 0.100706429 0.028467656
Doughnut (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) MR Egger 13 0.777358227 0.325396829 0.035927759
Doughnut (👉 📊) Ulcerative colitis vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016625) MR Egger 13 0.677533481 0.307210827 0.049612814
Doughnut (👉 📊) Neck circumference (ebi-a-GCST90017133) MR Egger 25 -4.957080857 2.250591312 0.037916517
Doughnut (👉 📊) Heel bone mineral density T score (ebi-a-GCST90025982) MR Egger 9 0.62562844 0.214759857 0.022558944
Doughnut (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) MR Egger 31 -13.07174239 5.947970439 0.036108298
Doughnut (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) Weighted median 31 -14.84221759 5.070961897 0.003423548
Doughnut (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) Inverse variance weighted 31 -7.965626288 3.430114488 0.020218805
Doughnut (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) Weighted mode 31 -15.21020086 5.919553434 0.015397525
Doughnut (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) MR Egger 31 -13.12245994 5.951656604 0.03555036
Doughnut (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) Weighted median 31 -14.77059527 5.018393391 0.003247423
Doughnut (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) Inverse variance weighted 31 -7.988501462 3.431681898 0.01991913
Doughnut (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) Weighted mode 31 -15.27555583 5.750191344 0.012524682
Doughnut (👉 📊) Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) MR Egger 31 5.604419662 2.693553631 0.046403932
Doughnut (👉 📊) Bicipital tendinitis (finn-b-M13_BICIPITALTEND) MR Egger 31 6.323054274 2.540861233 0.018816219
Doughnut (👉 📊) Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) MR Egger 31 9.418138378 4.563575444 0.048090333
Doughnut (👉 📊) Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) Inverse variance weighted 31 6.469129729 2.619186908 0.013515083
Doughnut (👉 📊) Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) Inverse variance weighted 31 -7.045389852 3.230620443 0.029197003
Doughnut (👉 📊) Infective bursitis (finn-b-M13_INFBURSA) MR Egger 31 9.542011081 3.552414989 0.011837562
Doughnut (👉 📊) Infective bursitis (finn-b-M13_INFBURSA) Weighted median 31 7.233646453 2.931227976 0.013595117
Doughnut (👉 📊) Infective bursitis (finn-b-M13_INFBURSA) Inverse variance weighted 31 6.324302287 2.057229196 0.002110788
Doughnut (👉 📊) Patellar tendinitis (finn-b-M13_PATELLARTEND) MR Egger 31 10.80481963 5.134735247 0.044140428
Doughnut (👉 📊) Patellar tendinitis (finn-b-M13_PATELLARTEND) Inverse variance weighted 31 7.646640506 2.939675389 0.009290225
Doughnut (👉 📊) Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) MR Egger 31 8.752657366 3.801349368 0.028676614
Doughnut (👉 📊) Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) Inverse variance weighted 31 4.570256001 2.189792616 0.036881579
Doughnut (👉 📊) Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) Simple mode 31 -23.11420822 10.30360572 0.032414456
Doughnut (👉 📊) Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) MR Egger 31 1.524064146 0.688060999 0.0347711
Doughnut (👉 📊) Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) Inverse variance weighted 31 1.123849777 0.39516883 0.004455472
Doughnut (👉 📊) Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) Inverse variance weighted 31 0.9149944 0.393704805 0.020122168
Doughnut (👉 📊) Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) MR Egger 31 1.102010916 0.507332155 0.038160603
Doughnut (👉 📊) Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) Inverse variance weighted 31 0.692251589 0.292438672 0.017924774
Doughnut (👉 📊) Injury of muscle and tendon at wrist and hand level (finn-b-ST19_INJURY_MUSCLE_TENDON_WRIST_HAND_LEVEL) Simple mode 31 4.565023695 1.978723394 0.028134186
Doughnut (👉 📊) Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) MR Egger 31 -12.49403061 5.835711778 0.040812494
Doughnut (👉 📊) Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) MR Egger 31 -2.270069856 0.826817692 0.010264563
Doughnut (👉 📊) Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) Inverse variance weighted 31 -0.938352519 0.478629409 0.049937485
Doughnut (👉 📊) Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) Inverse variance weighted 31 -2.718719802 1.02367916 0.007911303
Doughnut (👉 📊) Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) Inverse variance weighted 31 3.739522026 1.572176132 0.017380205
Doughnut (👉 📊) Rheumatoid arthritis (ieu-a-832) Weighted median 9 2.958189584 1.487058764 0.046669317
Doughnut (👉 📊) Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) Weighted median 33 0.062477513 0.03000269 0.037306216
Doughnut (👉 📊) Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) Inverse variance weighted 33 -0.014159369 0.006297106 0.024541037
Doughnut (👉 📊) Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) MR Egger 33 -0.042449566 0.017776682 0.023222064
Doughnut (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis (ukb-b-14753) Inverse variance weighted 2 -0.027045396 0.012619731 0.032104756
Doughnut (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) Inverse variance weighted 5 0.055976356 0.021066664 0.007881471
Doughnut (👉 📊) Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) MR Egger 25 0.023965905 0.00886205 0.012653984
Doughnut (👉 📊) Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) MR Egger 33 0.031001332 0.012331143 0.017339614
Doughnut (👉 📊) Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) MR Egger 31 -0.019054239 0.009265304 0.048829324
Doughnut (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) Weighted median 33 0.023367119 0.011075644 0.034877731
Doughnut (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_AFR) MR Egger 11 4.335905766 1.754230584 0.035472062
Doughnut (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_AFR) Weighted median 11 2.715314019 1.309222515 0.038080267
Doughnut (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_AFR) Inverse variance weighted 11 2.506572619 0.939964536 0.007660748
Doughnut (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_AFR) Simple mode 11 4.332902535 1.731563638 0.031322831
Doughnut (👉 📊) Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) Inverse variance weighted 12 3.779631394 1.854377184 0.041527789
Doughnut (👉 📊) Ankle spacing width (left) (ukb-e-4100_AFR) Simple mode 12 3.567119709 1.610516665 0.048799449
Doughnut (👉 📊) Ankle spacing width (right) (ukb-e-4119_AFR) Simple mode 12 2.989027855 1.23833206 0.0343852
Doughnut (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_AFR) MR Egger 11 4.110595297 1.756398579 0.043994726
Doughnut (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_AFR) Weighted median 11 2.819147268 1.337148656 0.035002672
Doughnut (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_AFR) Inverse variance weighted 11 2.460300771 0.941270748 0.008953941
Doughnut (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_AFR) Simple mode 11 4.148860612 1.760832876 0.040213648
Doughnut (👉 📊) M75 Shoulder lesions (ukb-e-M75_CSA) MR Egger 20 11.88368753 5.653657245 0.049899683

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Doughnut Rheumatoid Arthritis (bbj-a-73) rs7572611 9.87234194186347 4.2956535682788 0.0215494696211859
Doughnut Rheumatoid Arthritis (bbj-a-73) rs79664534 -10.6904755150095 3.67588948825296 0.0036343554613306
Doughnut Total body bone mineral density (age 15-30) (ebi-a-GCST005344) rs117309828 -9.99234702751592 4.7613664034508 0.0358495175831096
Doughnut Total body bone mineral density (age 15-30) (ebi-a-GCST005344) rs118029434 8.98765650871354 4.50767245723526 0.046167630308472
Doughnut Total body bone mineral density (age 0-15) (ebi-a-GCST005345) rs114985318 6.28005186995788 3.15293604617803 0.0463918277373085
Doughnut Total body bone mineral density (age 0-15) (ebi-a-GCST005345) rs141512197 6.4762149032151 3.08534874247522 0.0358149610012785
Doughnut Total body bone mineral density (age 0-15) (ebi-a-GCST005345) All - Inverse variance weighted 0.93061365769528 0.409754773144883 0.0231380312774173
Doughnut Total body bone mineral density (age 0-15) (ebi-a-GCST005345) All - MR Egger 1.58519746576767 0.732001261700084 0.0384226066810863
Doughnut Osteoprotegerin levels (ebi-a-GCST90012002) rs10220097 4.76156413183095 1.87228060572321 0.0109845678607475
Doughnut Osteoprotegerin levels (ebi-a-GCST90012002) rs114985318 -5.62020174200434 2.86030685899863 0.0494264281366747
Doughnut Osteoprotegerin levels (ebi-a-GCST90012002) rs117118087 3.66294455560576 1.86643430366402 0.0497001109109519
Doughnut Osteoprotegerin levels (ebi-a-GCST90012002) rs1603810 -3.47470017346772 1.53688661518765 0.0237673352613926
Doughnut Rheumatoid arthritis (ebi-a-GCST90013534) rs75492419 2.5678260253595 1.03893650681212 0.0134513345818025
Doughnut Rheumatoid arthritis (ebi-a-GCST90013534) rs7572611 9.87056025228724 4.35177678992989 0.0233189775278944
Doughnut Rheumatoid arthritis (ebi-a-GCST90013534) rs79664534 -7.16535018217335 3.30708469946463 0.0302602800204716
Doughnut Rheumatoid arthritis (ebi-a-GCST90013534) All - Inverse variance weighted 1.18080752569136 0.597674084555233 0.0481920193601128
Doughnut Bone mineral density (ebi-a-GCST90014022) rs10922656 0.966977911833523 0.344621013238005 0.0050173635929432
Doughnut Bone mineral density (ebi-a-GCST90014022) rs116455686 1.1167323923556 0.365525240448957 0.0022495218469075
Doughnut Bone mineral density (ebi-a-GCST90014022) rs1603810 -1.0395126866649 0.366306901556398 0.0045422931785035
Doughnut Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) rs4467081 -3.25807745993422 1.52615207333761 0.0327747794725053
Doughnut Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) All - MR Egger 0.777358226946918 0.325396828607929 0.0359277592437954
Doughnut Ulcerative colitis vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016625) rs146089470 1.21403423576545 0.474577019435584 0.0105233857318094
Doughnut Ulcerative colitis vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016625) All - MR Egger 0.677533481316356 0.307210827396622 0.0496128137760589
Doughnut Neck circumference (ebi-a-GCST90017133) All - MR Egger -4.95708085738702 2.25059131240822 0.0379165172800437
Doughnut Heel bone mineral density T score (ebi-a-GCST90025982) rs116455686 0.850034795952963 0.325366071269249 0.0089869815103901
Doughnut Heel bone mineral density T score (ebi-a-GCST90025982) rs1603810 -0.820396757302884 0.322523006524418 0.0109690125804519
Doughnut Heel bone mineral density T score (ebi-a-GCST90025982) All - MR Egger 0.625628440002178 0.214759856674133 0.0225589443905665
Doughnut Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) All - Inverse variance weighted -7.96562628751068 3.4301144881187 0.0202188048052765
Doughnut Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) All - MR Egger -13.0717423919595 5.94797043872044 0.0361082982733062
Doughnut Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) All - Inverse variance weighted -7.98850146168836 3.43168189766126 0.0199191296051592
Doughnut Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) All - MR Egger -13.122459936486 5.95165660448796 0.0355503601251524
Doughnut Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs117118087 43.0032918092042 15.7598055035607 0.0063590508102785
Doughnut Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs117309828 25.8853097714544 12.7752461126378 0.0427434429452994
Doughnut Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) All - MR Egger 5.60441966158565 2.69355363146628 0.0464039315845063
Doughnut Bicipital tendinitis (finn-b-M13_BICIPITALTEND) rs34987892 34.3555592510564 16.5692818214116 0.038130521593281
Doughnut Bicipital tendinitis (finn-b-M13_BICIPITALTEND) All - MR Egger 6.32305427405942 2.54086123301931 0.0188162193677517
Doughnut Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) rs117003609 21.1794510763159 6.53651868714639 0.001194572177696
Doughnut Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) rs181595707 40.5794160748506 19.4228384624056 0.0366840628663846
Doughnut Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) All - Inverse variance weighted 6.46912972871918 2.61918690837765 0.0135150829110644
Doughnut Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) All - MR Egger 9.41813837837962 4.5635754441834 0.0480903331545785
Doughnut Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) rs10922656 -47.0591520974138 18.9757148088154 0.0131394434424976
Doughnut Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) rs116455686 44.8885637301262 21.255866240788 0.0347018900282904
Doughnut Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) rs80025943 -27.2462586394563 11.3346589794576 0.0162256264924917
Doughnut Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) All - Inverse variance weighted -7.04538985160441 3.2306204425556 0.029197003449526
Doughnut Infective bursitis (finn-b-M13_INFBURSA) rs117003609 12.8674864721813 5.07710728215458 0.0112635906748359
Doughnut Infective bursitis (finn-b-M13_INFBURSA) rs139743690 48.5673429905251 19.472599571014 0.0126263582618592
Doughnut Infective bursitis (finn-b-M13_INFBURSA) rs148780953 19.5735121241706 9.59124509354639 0.0412738298937133
Doughnut Infective bursitis (finn-b-M13_INFBURSA) rs76789854 37.6977476526841 14.2763149727509 0.0082764320894189
Doughnut Infective bursitis (finn-b-M13_INFBURSA) All - Inverse variance weighted 6.32430228651336 2.05722919579129 0.0021107878799709
Doughnut Infective bursitis (finn-b-M13_INFBURSA) All - MR Egger 9.54201108095531 3.5524149889258 0.0118375615060126
Doughnut Patellar tendinitis (finn-b-M13_PATELLARTEND) rs189325112 17.2143644877273 7.78307429928226 0.0269826120979767
Doughnut Patellar tendinitis (finn-b-M13_PATELLARTEND) rs2148761 55.951469163543 22.4444974207849 0.0126711178328333
Doughnut Patellar tendinitis (finn-b-M13_PATELLARTEND) rs76789854 41.532352060824 19.4213057793558 0.0324766447866089
Doughnut Patellar tendinitis (finn-b-M13_PATELLARTEND) All - Inverse variance weighted 7.64664050591071 2.93967538893143 0.009290224935713
Doughnut Patellar tendinitis (finn-b-M13_PATELLARTEND) All - MR Egger 10.8048196314421 5.13473524698071 0.0441404282815612
Doughnut Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) rs192831075 21.9805465189263 10.7113114895328 0.0401611767405816
Doughnut Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) All - Inverse variance weighted 4.57025600103914 2.18979261625968 0.0368815793647763
Doughnut Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) All - MR Egger 8.75265736594089 3.80134936811536 0.028676613825619
Doughnut Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) rs34987892 118.177076640487 45.3311966619549 0.0091347322730858
Doughnut Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) rs4467081 50.0200628980428 25.0529008892837 0.045871078796312
Doughnut Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) rs148780953 4.79188666839347 1.98001554125406 0.0155151391848583
Doughnut Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) rs2148761 7.52207676271728 3.30707623013599 0.0229335463134186
Doughnut Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) All - Inverse variance weighted 1.12384977712409 0.395168829597171 0.0044554718795597
Doughnut Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) All - MR Egger 1.52406414600933 0.68806099932088 0.0347711001139408
Doughnut Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) rs117118087 9.12777813636266 3.6145355967211 0.0115600342953316
Doughnut Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) rs12225516 2.79358224715914 1.32783810619553 0.035390873417258
Doughnut Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) rs1603810 5.34569257456573 2.25855511275402 0.0179395282354085
Doughnut Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) All - Inverse variance weighted 0.914994400177909 0.393704805036319 0.0201221681144499
Doughnut Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) rs2148761 5.45769022028577 2.14046958453587 0.0107796160861822
Doughnut Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) rs34987892 5.93379846250369 2.86485301565465 0.0383363633923402
Doughnut Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) rs80025943 2.9538575148366 1.00000384616864 0.0031384041887189
Doughnut Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) All - Inverse variance weighted 0.692251589197248 0.292438671530143 0.0179247735858658
Doughnut Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) All - MR Egger 1.10201091627066 0.507332154831929 0.0381606025393951
Doughnut Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) All - MR Egger -12.4940306081492 5.83571177819227 0.0408124938596462
Doughnut Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) rs117309828 -8.96615298987721 3.92649667791422 0.0224009654371217
Doughnut Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) rs118029434 -6.09144926653413 2.48088115582481 0.0140744681260827
Doughnut Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) All - Inverse variance weighted -0.938352518920759 0.478629409069826 0.0499374847295124
Doughnut Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) All - MR Egger -2.27006985635161 0.826817691948031 0.0102645625035355
Doughnut Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs117003609 -6.97588374040977 2.69271681766093 0.0095795182327169
Doughnut Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs148780953 11.1528422562713 5.11815338022276 0.0293260654789227
Doughnut Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs61751489 -22.1890182254154 9.85979761468054 0.0244201581456504
Doughnut Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs79664534 -8.73783653436977 3.97174387925899 0.0278068950269972
Doughnut Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) All - Inverse variance weighted -2.71871980202643 1.02367915971043 0.0079113031836025
Doughnut Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) rs117003609 10.0026207740019 4.14698945009995 0.0158644188091257
Doughnut Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) All - Inverse variance weighted 3.73952202592471 1.57217613163018 0.0173802052377237
Doughnut Rheumatoid arthritis (ieu-a-832) rs7572611 9.93933346992953 4.33961675857215 0.0219998045499329
Doughnut Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) rs10922656 0.222253253644641 0.112677422157677 0.0485555538712139
Doughnut Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) rs80025943 -0.281946084408017 0.113313897361144 0.0128396462330421
Doughnut Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) All - Inverse variance weighted -0.0141593686148664 0.0062971063108385 0.0245410372224006
Doughnut Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) All - MR Egger -0.0424495664558198 0.0177766823260411 0.0232220640585004
Doughnut Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis (ukb-b-14753) rs10922656 -0.0371008583291441 0.0175032738150651 0.0340353604328625
Doughnut Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis (ukb-b-14753) All - Inverse variance weighted -0.0270453956215876 0.0126197313993503 0.0321047561085349
Doughnut Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) rs4467081 0.120541149518319 0.0380737217190303 0.0015455433051998
Doughnut Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) rs76789854 0.081940392591765 0.0387154351103552 0.034304117479838
Doughnut Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) All - Inverse variance weighted 0.0559763558767058 0.0210666644402841 0.007881470844583
Doughnut Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) rs139743690 0.065903123666929 0.0211366326401865 0.0018210902102665
Doughnut Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) All - MR Egger 0.0239659052811258 0.0088620498837018 0.0126539841646853
Doughnut Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) rs118029434 0.0928242727640228 0.0389632907116474 0.0172024462083856
Doughnut Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) rs7187089 -0.120791872431243 0.0404375643105963 0.0028161880790707
Doughnut Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) rs7572611 0.089909846507443 0.0381624544555602 0.0184740855513337
Doughnut Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) All - MR Egger 0.0310013315379749 0.0123311425252146 0.0173396137673148
Doughnut Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) rs76789854 0.05939567738011 0.0299176387664712 0.0471104011072174
Doughnut Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) All - MR Egger -0.0190542388483215 0.0092653036940968 0.0488293244989717
Doughnut Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) rs34987892 0.123781303621507 0.0447495332330509 0.0056732613523969
Doughnut Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) rs80025943 0.0917122758164454 0.0446178639148612 0.0398301808886736
Doughnut Heel bone mineral density (BMD) (ukb-e-3148_AFR) All - Inverse variance weighted 2.50657261868516 0.939964536253992 0.0076607484777024
Doughnut Heel bone mineral density (BMD) (ukb-e-3148_AFR) All - MR Egger 4.33590576591839 1.75423058394579 0.0354720619821638
Doughnut Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) All - Inverse variance weighted 3.77963139413766 1.85437718401336 0.0415277890542079
Doughnut Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_AFR) All - Inverse variance weighted 2.46030077071891 0.941270748113205 0.0089539405443628
Doughnut Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_AFR) All - MR Egger 4.11059529747122 1.7563985786386 0.0439947262038704
Doughnut M75 Shoulder lesions (ukb-e-M75_CSA) All - MR Egger 11.8836875304626 5.65365724524543 0.0498996832963084