ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
Intake (exposure) | Outcome | SNP | b | se | P-value |
---|---|---|---|---|---|
Mango | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | rs1051412 | -2.70609019640041 | 1.05392022241915 | 0.0102392738958456 |
Mango | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | rs10976627 | -2.03865532058303 | 0.959193417024742 | 0.0335544991434689 |
Mango | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | rs17837122 | -2.60329457410871 | 1.30861482390283 | 0.0466624432847038 |
Mango | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | rs2622567 | -3.23772544154029 | 1.07543992087279 | 0.0026072727458102 |
Mango | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | All - Inverse variance weighted | -0.630783018812894 | 0.282893422172062 | 0.025763713220878 |
Mango | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | rs1051412 | -2.70662812458417 | 1.05414247169507 | 0.0102401909145546 |
Mango | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | rs10976627 | -2.02564102564103 | 0.947195776111439 | 0.0324708041707059 |
Mango | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | rs17837122 | -2.55056986384252 | 1.25563561366905 | 0.0422247940842957 |
Mango | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | rs2622567 | -3.23017646663129 | 1.07011079304099 | 0.0025399255263509 |
Mango | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | All - Inverse variance weighted | -0.635999656174002 | 0.282686090089988 | 0.0244588380257971 |
Mango | Joint disorder (ebi-a-GCST90038654) | rs10976627 | -0.215392479006937 | 0.0858612070660263 | 0.012120643869882 |
Mango | Joint disorder (ebi-a-GCST90038654) | All - MR Egger | 0.0889077574343823 | 0.0401505143416817 | 0.0374711183276712 |
Mango | Other joint disorder (ebi-a-GCST90038688) | rs2622567 | 0.0613788962551603 | 0.0294763801793318 | 0.03731436424309 |
Mango | Other joint disorder (ebi-a-GCST90038688) | rs838905 | 0.0562661791263412 | 0.0286975628574783 | 0.0499186349423135 |
Mango | Other joint disorder (ebi-a-GCST90038688) | All - Inverse variance weighted | 0.0142494946744077 | 0.0059517901509455 | 0.0166588100579645 |
Mango | Fracture of lower leg or ankle (ebi-a-GCST90038707) | rs11710157 | -0.0512686361969938 | 0.0195460100207748 | 0.0087166446322678 |
Mango | Fracture of lower leg or ankle (ebi-a-GCST90038707) | All - Inverse variance weighted | -0.0094766535361531 | 0.0044013861749614 | 0.0313103032201545 |
Mango | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | rs11623618 | -33.0789002258743 | 15.9825531583457 | 0.0384815609867752 |
Mango | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | rs838905 | -37.2588157019295 | 14.6262097653433 | 0.0108528763037325 |
Mango | Cervicalgia (finn-b-M13_CERVICALGIA) | rs2293122 | 10.5273807055449 | 4.43732602526772 | 0.0176700525432466 |
Mango | Cervicalgia (finn-b-M13_CERVICALGIA) | rs8009412 | 7.81745253384957 | 3.69552301600161 | 0.0343971799432385 |
Mango | Cervicalgia (finn-b-M13_CERVICALGIA) | All - Inverse variance weighted | 1.21282179574681 | 0.548951833693976 | 0.0271509311260657 |
Mango | Gluteal tendinitis (finn-b-M13_GLUTEALTEND) | rs71559841 | 4.49166450721258 | 2.04871285462112 | 0.0283482969374121 |
Mango | Gluteal tendinitis (finn-b-M13_GLUTEALTEND) | All - Inverse variance weighted | 3.89837236968696 | 1.55511604111773 | 0.0121827966924761 |
Mango | Shoulder lesions (finn-b-M13_SHOULDER) | rs2316231 | 4.31963153278017 | 1.76230366214651 | 0.0142409373309573 |
Mango | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | rs71559841 | -7.48610751202096 | 2.80618290465401 | 0.0076368095251536 |
Mango | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | All - Inverse variance weighted | -6.86439256623698 | 2.12851586380286 | 0.0012598736671377 |
Mango | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | rs76723741 | 39.3889083514843 | 16.3181169685061 | 0.0157864945642406 |
Mango | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | rs77258559 | 49.5293644603557 | 14.2183768281635 | 0.0004949487938753 |
Mango | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | All - Inverse variance weighted | 6.97695572035719 | 3.02731807960554 | 0.0211853110861009 |
Mango | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | rs2293122 | 5.76952548657834 | 2.00330746061748 | 0.0039767517097886 |
Mango | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | rs2316231 | 4.17387709455753 | 1.6828012412978 | 0.0131266375674905 |
Mango | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | rs2622567 | 3.68728807436363 | 1.66924527690786 | 0.0271777554792781 |
Mango | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | All - MR Egger | -0.849903027386704 | 0.385773296623848 | 0.0378731064671568 |
Mango | Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) | rs10976627 | -12.2616339483809 | 5.72921054848766 | 0.0323389239689649 |
Mango | Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) | rs11223956 | 14.247953751323 | 7.05217867646668 | 0.0433458529700195 |
Mango | Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) | rs71559841 | -3.21814030028593 | 1.34661342228069 | 0.0168574291530028 |
Mango | Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) | All - Inverse variance weighted | -1.92173038471461 | 0.918121634046449 | 0.0363392573807996 |
Mango | Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) | rs71559841 | -4.23474484111955 | 1.85380828034365 | 0.0223510362253612 |
Mango | Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) | All - Inverse variance weighted | -3.46275010193341 | 1.40704163693091 | 0.0138544703159066 |
Mango | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | rs8009412 | 11.925168501636 | 4.8041799208021 | 0.0130556185213769 |
Mango | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | All - MR Egger | -2.45794194313128 | 1.14406848622847 | 0.0424429887821505 |
Mango | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | rs71559841 | -7.07636494109674 | 2.27683979951407 | 0.0018837294813831 |
Mango | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | All - Inverse variance weighted | -4.81377670049539 | 1.728016382056 | 0.005340832551993 |
Mango | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | All - MR Egger | -7.66753991566128 | 2.87433687379662 | 0.0137521831162898 |
Mango | Crushing injury of wrist and hand (finn-b-ST19_CRUSHI_INJURY_WRIST_HAND) | rs17837122 | 220.437787963112 | 81.9153763598341 | 0.0071229045062182 |
Mango | Crushing injury of wrist and hand (finn-b-ST19_CRUSHI_INJURY_WRIST_HAND) | All - Inverse variance weighted | -4.41307873357707 | 2.15219433763917 | 0.0403154715485977 |
Mango | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | rs71559841 | -1.67883712843547 | 0.828344440679243 | 0.0426892173600923 |
Mango | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | All - MR Egger | -2.28325270161237 | 1.04568483108458 | 0.0394581758882171 |
Mango | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | rs117770183 | -8.65511582031146 | 3.51229839033022 | 0.0137307451110475 |
Mango | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | rs71559841 | -1.54594764597356 | 0.651158464063362 | 0.0175894194406136 |
Mango | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | rs72662496 | -26.0398470924787 | 11.3566745145693 | 0.0218531133027558 |
Mango | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | All - MR Egger | -2.1596450915305 | 1.0000365328048 | 0.0414733479639354 |
Mango | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | rs117322135 | 65.097462302317 | 22.8742633141668 | 0.004428855410959 |
Mango | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | rs117770183 | 11.3120599603329 | 5.47426720197587 | 0.0387901362898608 |
Mango | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | rs77258559 | 10.7013268870232 | 3.90460365366263 | 0.0061309429085841 |
Mango | Osteomyelitis (ieu-b-4975) | rs10976627 | 5.46814952116157 | 2.74257308956104 | 0.0461736247799897 |
Mango | Osteomyelitis (ieu-b-4975) | rs11623618 | -6.3602850689306 | 3.20010904276034 | 0.0468646515300724 |
Mango | Osteomyelitis (ieu-b-4975) | rs530565 | 8.49055329494994 | 3.31096037280294 | 0.0103360967173976 |
Mango | Osteomyelitis (ieu-b-4975) | rs71559841 | -1.37208833606864 | 0.583143412114648 | 0.0186267665308696 |
Mango | Osteocrin (prot-a-2157) | rs11710157 | -6.73270805328119 | 3.40645240131981 | 0.0481029961110037 |
Mango | Osteocrin (prot-a-2157) | rs2622567 | -9.11856375146682 | 3.66237396575307 | 0.0127816465501874 |
Mango | Osteocrin (prot-a-2157) | rs71559841 | 1.92025302157461 | 0.679951185263442 | 0.0047412962770675 |
Mango | Osteocrin (prot-a-2157) | rs72662496 | -9.80228348649401 | 3.75180375180375 | 0.0089833910780848 |
Mango | Neck/shoulder pain for 3+ months (ukb-a-341) | rs71559841 | -0.141523533619932 | 0.0652724345131705 | 0.030143657957394 |
Mango | Neck/shoulder pain for 3+ months (ukb-a-341) | rs76723741 | 0.891444412288852 | 0.354874364715499 | 0.01200490808935 |
Mango | Neck/shoulder pain for 3+ months (ukb-a-341) | All - Inverse variance weighted | -0.101485415732514 | 0.0475911620583793 | 0.0329704881912762 |
Mango | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs1051412 | 3.45195593518815 | 0.592468439187219 | 5.6637024752756e-09 |
Mango | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs10976627 | 1.07528856685483 | 0.536594489847502 | 0.0450794021124972 |
Mango | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs143611250 | 1.91838342206194 | 0.728776690136814 | 0.0084800533077433 |
Mango | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs2293122 | 1.35338443770665 | 0.643680716863542 | 0.0355032832010323 |
Mango | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | All - MR Egger | -0.411048964490849 | 0.173511909319942 | 0.0258728006235501 |
Mango | Pain type(s) experienced in last month: Knee pain (ukb-a-476) | rs71559841 | -0.0604647145201693 | 0.0274888538946585 | 0.0278346891823131 |
Mango | Pain type(s) experienced in last month: Knee pain (ukb-a-476) | rs72662496 | 0.300818713450292 | 0.149577985367459 | 0.0443131816604846 |
Mango | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs1051412 | 2.82594908934421 | 0.446521444931726 | 2.47060158968914e-10 |
Mango | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs10976627 | -0.83706574549948 | 0.401008790406381 | 0.0368519927897321 |
Mango | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs71559841 | -0.172606826532714 | 0.085760227506794 | 0.0441496159163484 |
Mango | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | All - MR Egger | -0.298820281944395 | 0.139077372386443 | 0.0415442336932689 |
Mango | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | rs71559841 | -0.0330511646655725 | 0.0092725629730035 | 0.0003646832748235 |
Mango | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | All - Inverse variance weighted | -0.023012924982229 | 0.0067527488526806 | 0.0006545663338665 |
Mango | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | All - MR Egger | -0.0304372580732581 | 0.0108132779397698 | 0.0093779771926126 |
Mango | Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) | rs1051412 | -0.0519085125719479 | 0.0187014979884317 | 0.0055094200579304 |
Mango | Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) | rs11623618 | -0.0516342394267466 | 0.0198780278837916 | 0.0093890513054238 |
Mango | Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) | All - Inverse variance weighted | -0.008115399739872 | 0.0031462149041829 | 0.0098967280993514 |
Mango | Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) | rs71559841 | -0.011219261001588 | 0.0044956733399335 | 0.0125755454142824 |
Mango | Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) | All - Inverse variance weighted | -0.0094215405695114 | 0.0040810588542001 | 0.0209656777312754 |
Mango | Operative procedures - secondary OPCS: Z81.5 Elbow joint (ukb-b-7443) | All - Inverse variance weighted | -0.0235498382739205 | 0.0090335443720798 | 0.0091357430933683 |
Mango | Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) | rs71559841 | -0.0105162091946233 | 0.0049931672657767 | 0.0351939342614799 |
Mango | Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) | All - Inverse variance weighted | -0.0101900394802446 | 0.0045419191566557 | 0.0248611317739029 |
Mango | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs11223956 | 0.133319682811511 | 0.065810761220463 | 0.0427849058263824 |
Mango | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs71559841 | -0.0326808459744454 | 0.0115302223905489 | 0.0045917013569306 |
Mango | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | All - Inverse variance weighted | -0.0190245962238761 | 0.0083972031663269 | 0.023476667952104 |
Mango | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | rs11223956 | -0.0856563153164173 | 0.0358939939476777 | 0.0170156672210561 |
Mango | Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) | rs1051412 | 0.0693250700014439 | 0.0301443629373144 | 0.0214613132567663 |
Mango | Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) | rs72662496 | 0.0651699956963115 | 0.0316063897116529 | 0.0392149053183743 |
Mango | Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) | All - Inverse variance weighted | 0.0094725666107416 | 0.0042196987156371 | 0.0247781297149427 |