ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
Intake (exposure) | Outcome | SNP | b | se | P-value |
---|---|---|---|---|---|
Bread roll | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | rs115967948 | 1.98146708853778 | 0.589150023316569 | 0.0007702665241437 |
Bread roll | Menstruation quality of life impact (stiff neck) (ebi-a-GCST006652) | rs1530299 | 3.55115148413511 | 1.80261368621143 | 0.0488382101965608 |
Bread roll | Menstruation quality of life impact (stiff neck) (ebi-a-GCST006652) | All - Inverse variance weighted | 1.92806324279884 | 0.92505894968583 | 0.037136535844996 |
Bread roll | Heel bone mineral density (ebi-a-GCST006979) | All - MR Egger | 0.0843213279175797 | 0.0378735823122129 | 0.0429203257235639 |
Bread roll | Neck circumference (ebi-a-GCST90017134) | rs80081868 | -8.94385343710142 | 3.28645078890395 | 0.0064999690990196 |
Bread roll | Neck circumference (ebi-a-GCST90017134) | All - MR Egger | -3.2560119909296 | 1.21870513320191 | 0.0192021319712579 |
Bread roll | Neck circumference (BMI adjusted) (ebi-a-GCST90017137) | rs80081868 | -8.94385343710142 | 3.28645078890395 | 0.0064999690990196 |
Bread roll | Neck circumference (BMI adjusted) (ebi-a-GCST90017137) | All - MR Egger | -3.2560119909296 | 1.21870513320191 | 0.0192021319712579 |
Bread roll | Rheumatoid arthritis (ebi-a-GCST90018910) | rs35522968 | 1.76925837006526 | 0.850352538951397 | 0.0374689311947231 |
Bread roll | Rheumatoid arthritis (ebi-a-GCST90018910) | All - Inverse variance weighted | 0.320447192563745 | 0.130836903133765 | 0.014316951987693 |
Bread roll | Neck injury (ebi-a-GCST90038700) | rs80081868 | -0.0209914040015437 | 0.0081850450048197 | 0.0103293442486114 |
Bread roll | Neck injury (ebi-a-GCST90038700) | All - Inverse variance weighted | -0.0042349456003555 | 0.0020041203331892 | 0.034590547718037 |
Bread roll | Fracture of pelvis or lower limb (ebi-a-GCST90038706) | rs153408 | 0.0216745554379419 | 0.0069002970237442 | 0.001683118483138 |
Bread roll | Fracture of pelvis or lower limb (ebi-a-GCST90038706) | rs35522968 | 0.017779077535232 | 0.0086473706166004 | 0.0397815849349649 |
Bread roll | Fracture of pelvis or lower limb (ebi-a-GCST90038706) | All - Inverse variance weighted | 0.0049787430353506 | 0.0024325319863134 | 0.0406843256183402 |
Bread roll | Fracture of lower leg or ankle (ebi-a-GCST90038707) | rs153408 | 0.0171901695407284 | 0.0055259869224587 | 0.0018658933258085 |
Bread roll | Fracture of lower leg or ankle (ebi-a-GCST90038707) | rs1605619 | 0.0141528697261593 | 0.0068768522369214 | 0.0395858367182686 |
Bread roll | Fracture of lower leg or ankle (ebi-a-GCST90038707) | All - Inverse variance weighted | 0.0052934374418513 | 0.0016975091565482 | 0.0018186314042749 |
Bread roll | Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) | rs153408 | -4.21993209874358 | 1.83028934148526 | 0.0211324740414501 |
Bread roll | Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) | All - Inverse variance weighted | -1.05767555002472 | 0.505533719796531 | 0.0364209996919889 |
Bread roll | Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) | rs2103867 | -15.3141407378696 | 6.95349847892221 | 0.0276395456587421 |
Bread roll | Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) | All - MR Egger | -5.96344273067293 | 2.78294691181231 | 0.0478456445019418 |
Bread roll | Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) | All - Inverse variance weighted | 1.18794395747621 | 0.564424898041078 | 0.0353176041704351 |
Bread roll | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs7172972 | 3.92464915328489 | 1.69116425215644 | 0.0203041817154633 |
Bread roll | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs77266288 | 6.20114127387274 | 2.84493848335917 | 0.0292789540864287 |
Bread roll | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs9849625 | 6.27984440148145 | 2.31534322517528 | 0.0066823403429822 |
Bread roll | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | All - Inverse variance weighted | 1.23082922963205 | 0.598600538828692 | 0.0397653667167365 |
Bread roll | Other juvenile arthritis (finn-b-M13_JUVEARTH) | rs115967948 | -2.73881932918482 | 1.34383665364616 | 0.0415439626574589 |
Bread roll | Other juvenile arthritis (finn-b-M13_JUVEARTH) | rs153408 | -5.40590294864215 | 2.01084012758922 | 0.0071799576557068 |
Bread roll | Other juvenile arthritis (finn-b-M13_JUVEARTH) | All - Inverse variance weighted | -1.4476419258024 | 0.616201445028106 | 0.0188087562056629 |
Bread roll | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | rs115967948 | 2.6666131806307 | 1.18237568257375 | 0.0241144354734533 |
Bread roll | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | rs7172972 | 4.942066861036 | 1.65566415396468 | 0.0028362907959155 |
Bread roll | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | All - MR Egger | 2.5004495472555 | 1.13255663549223 | 0.0422034680903982 |
Bread roll | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | rs116935289 | 3.41128253162114 | 1.40616854959892 | 0.0152687345373311 |
Bread roll | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | rs35522968 | 2.78151336497481 | 1.2675066146634 | 0.0282011780562377 |
Bread roll | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | rs7172972 | 1.3316313428101 | 0.660906083357252 | 0.0439196196293285 |
Bread roll | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | rs9849625 | 2.54361650089679 | 0.913093102886026 | 0.0053409925250672 |
Bread roll | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | All - Inverse variance weighted | 0.668430449593356 | 0.223268601388671 | 0.0027549045234937 |
Bread roll | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | rs116935289 | 3.19359116620206 | 1.36851382693183 | 0.0196156311050967 |
Bread roll | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | rs35522968 | 2.89819981971943 | 1.22812493618709 | 0.0182819570312983 |
Bread roll | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | rs9849625 | 2.18490135333442 | 0.889799911485873 | 0.0140689777449402 |
Bread roll | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | All - Inverse variance weighted | 0.632399061168877 | 0.202473043686778 | 0.0017879033649671 |
Bread roll | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | All - Inverse variance weighted | 0.708163929029377 | 0.349912584602317 | 0.0429875454528784 |
Bread roll | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | rs115967948 | 1.35286242221543 | 0.536531798284101 | 0.0116857227556234 |
Bread roll | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | rs116935289 | 4.73390466530247 | 1.63209688560142 | 0.0037256226717417 |
Bread roll | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | rs35522968 | 3.3474426704862 | 1.44107771609602 | 0.0201858957025961 |
Bread roll | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | rs9849625 | 3.07470126482029 | 1.04819361300692 | 0.0033534364549463 |
Bread roll | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | All - Inverse variance weighted | 0.861893810742219 | 0.274486270389876 | 0.0016893329245511 |
Bread roll | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | rs115967948 | 1.38796263331812 | 0.536531798284101 | 0.009683922812626 |
Bread roll | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | rs116935289 | 4.5597515729672 | 1.62503662510134 | 0.005017038725226 |
Bread roll | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | rs35522968 | 3.01196911309543 | 1.44399487746464 | 0.0369914346605371 |
Bread roll | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | rs9849625 | 3.1212876476206 | 1.04353497472689 | 0.0027800045805788 |
Bread roll | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | All - Inverse variance weighted | 0.826962127107366 | 0.261272075264439 | 0.0015500950829404 |
Bread roll | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs9849625 | 4.9241806619925 | 1.87743122685239 | 0.008720308330466 |
Bread roll | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | All - Inverse variance weighted | 1.07379018826097 | 0.396498580148611 | 0.0067652977684395 |
Bread roll | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | rs115967948 | 1.32578511650763 | 0.533523208761013 | 0.0129565116513041 |
Bread roll | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | rs116935289 | 4.53268724105024 | 1.61444623435123 | 0.0049915252947562 |
Bread roll | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | rs35522968 | 3.17824731110651 | 1.4367019740431 | 0.0269540408676773 |
Bread roll | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | rs9849625 | 2.93028347813934 | 1.03887633644686 | 0.0047929777260234 |
Bread roll | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | All - Inverse variance weighted | 0.818212306494242 | 0.264361399807405 | 0.0019677832616271 |
Bread roll | Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) | All - Inverse variance weighted | 0.52519234049464 | 0.264959178782667 | 0.0474609750615246 |
Bread roll | Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) | rs9849625 | -2.66939973445762 | 1.02490042160676 | 0.0091996217280855 |
Bread roll | Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) | All - Inverse variance weighted | -0.46137025509377 | 0.216149344162011 | 0.0328020703799703 |
Bread roll | Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) | rs72659610 | -10.1853946632056 | 4.16631937415906 | 0.0144973284587218 |
Bread roll | Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) | All - Inverse variance weighted | -3.95750960943782 | 1.52515004641854 | 0.009463690012651 |
Bread roll | Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) | rs7172972 | -6.53126274604589 | 2.95934861096424 | 0.0273145229607292 |
Bread roll | Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) | rs72659610 | -4.94623911982187 | 2.32189847945418 | 0.0331504501571901 |
Bread roll | Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) | rs77266288 | 9.88719200448593 | 4.90854965860738 | 0.0439801745210047 |
Bread roll | Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) | All - MR Egger | -4.25210862726493 | 1.59068171484307 | 0.0166631327707478 |
Bread roll | Rheumatoid arthritis (ieu-a-831) | All - Inverse variance weighted | 1.2230209663092 | 0.500085450072511 | 0.0144601724587945 |
Bread roll | Rheumatoid arthritis (ieu-a-833) | rs9849625 | 1.90174931867415 | 0.743010877920384 | 0.0104817588927164 |
Bread roll | Rheumatoid arthritis (ieu-a-833) | All - Inverse variance weighted | 0.710873418321502 | 0.271841213370096 | 0.0089219147647607 |
Bread roll | Bone sialoprotein 2 (prot-a-1396) | rs74799373 | -2.94561637390213 | 1.10374843161857 | 0.0076136611689998 |
Bread roll | Bone sialoprotein 2 (prot-a-1396) | All - MR Egger | -1.20911457262832 | 0.503849621633365 | 0.02893351632243 |
Bread roll | Alkaline phosphatase, bone (prot-c-2795_23_3) | rs9849625 | 6.02361929607976 | 2.0488504810044 | 0.0032821282488283 |
Bread roll | Alkaline phosphatase, bone (prot-c-2795_23_3) | All - Inverse variance weighted | 4.40888042389883 | 1.61022329568379 | 0.0061803683131307 |
Bread roll | Heel bone mineral density (BMD) T-score automated (left) (ukb-a-361) | All - MR Egger | 0.204777811462854 | 0.0881093060936557 | 0.0336098016036666 |
Bread roll | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs116935289 | 0.368018431986746 | 0.180890934272505 | 0.0419035326776787 |
Bread roll | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | All - MR Egger | 0.214144757788013 | 0.0843019273181036 | 0.0218308340822316 |
Bread roll | Fractured bone site(s): Arm (ukb-a-440) | rs77633916 | 0.02356044507805 | 0.0114230124360043 | 0.0391561452014527 |
Bread roll | Fractured bone site(s): Arm (ukb-a-440) | All - MR Egger | 0.0111196570827243 | 0.0049705988868405 | 0.0398655304678755 |
Bread roll | Diagnoses - secondary ICD10: G55.1 Nerve root and plexus compressions in intervertebral disk disorders (ukb-b-1220) | rs3091470 | 0.0139612832171938 | 0.0066671660464909 | 0.0362568068843756 |
Bread roll | Diagnoses - secondary ICD10: G55.1 Nerve root and plexus compressions in intervertebral disk disorders (ukb-b-1220) | All - Inverse variance weighted | 0.0058122874424531 | 0.0024254279400522 | 0.0165571610612752 |
Bread roll | Diagnoses - main ICD10: M51.2 Other specified intervertebral disk displacement (ukb-b-12872) | All - Inverse variance weighted | 0.0051591039783353 | 0.0022468785404002 | 0.0216689899093356 |
Bread roll | Non-cancer illness code, self-reported: fracture lower leg / ankle (ukb-b-13979) | All - Inverse variance weighted | 0.004564241739726 | 0.0021932614540178 | 0.0374312079342467 |
Bread roll | Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) | rs153408 | 0.0268741348608166 | 0.0085180674693506 | 0.0016052187340204 |
Bread roll | Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) | rs6022239 | 0.0207159689101632 | 0.0099801240295275 | 0.0379196152998395 |
Bread roll | Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) | All - Inverse variance weighted | 0.0095985536807899 | 0.0047380281419544 | 0.0427797392842974 |
Bread roll | Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) | All - Inverse variance weighted | -0.0070543252376161 | 0.0028998406262932 | 0.0149883829103914 |
Bread roll | Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) | All - Inverse variance weighted | 0.0054811359535474 | 0.002249413652041 | 0.0148221579553864 |
Bread roll | Non-cancer illness code, self-reported: other joint disorder (ukb-b-5316) | All - Inverse variance weighted | 0.0062947476338396 | 0.0027141135248288 | 0.0203806893358338 |
Bread roll | Operative procedures - main OPCS: W90.1 Aspiration of joint (ukb-b-9333) | All - Inverse variance weighted | 0.0049618633140888 | 0.0022625563331663 | 0.0283049184359208 |
Bread roll | Knee pain for 3+ months (ukb-e-3773_CSA) | rs7172972 | -2.04843119778842 | 0.971343112225629 | 0.0349562622346938 |
Bread roll | Knee pain for 3+ months (ukb-e-3773_CSA) | All - Inverse variance weighted | -1.33245077285389 | 0.62065601520716 | 0.0318058146630895 |