ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Oatcakes (ukb-b-6298)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Oatcakes (👉 📊) Neck circumference (ebi-a-GCST90017135) Weighted median 11 -2.423048006 1.041065102 0.019940253
Oatcakes (👉 📊) Neck circumference (ebi-a-GCST90017135) Inverse variance weighted 11 -2.099832254 0.758815791 0.005653156
Oatcakes (👉 📊) Juvenile rheumatoid arthritis (ebi-a-GCST90018653) Inverse variance weighted 6 -4.332724337 1.911718384 0.023426718
Oatcakes (👉 📊) Compression fracture (ebi-a-GCST90018828) MR Egger 15 1.17242862 0.504206276 0.036884242
Oatcakes (👉 📊) Bone disorder (ebi-a-GCST90038652) MR Egger 11 -0.025933546 0.009387895 0.022023902
Oatcakes (👉 📊) Spine arthritis or spondylitis (ebi-a-GCST90038657) Inverse variance weighted 11 -0.006680742 0.003148163 0.033828664
Oatcakes (👉 📊) Neck injury (ebi-a-GCST90038700) Inverse variance weighted 11 0.006420686 0.003254503 0.048511293
Oatcakes (👉 📊) Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) Weighted median 15 -2.031166767 1.012578994 0.044863276
Oatcakes (👉 📊) Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) MR Egger 15 -3.51343477 0.854391067 0.001224812
Oatcakes (👉 📊) Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) Weighted median 15 -2.290123295 0.725360953 0.001592817
Oatcakes (👉 📊) Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) Inverse variance weighted 15 -2.021121749 0.537412903 0.000169346
Oatcakes (👉 📊) Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) Simple mode 15 -2.401138129 1.055157191 0.039114923
Oatcakes (👉 📊) Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) Weighted mode 15 -2.248788122 0.897270529 0.025160729
Oatcakes (👉 📊) Contracture of joint (finn-b-M13_CONTRACTUREJOINT) MR Egger 15 -4.109510393 1.817030638 0.041503488
Oatcakes (👉 📊) Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) Weighted median 15 -2.046419534 0.916626739 0.02557831
Oatcakes (👉 📊) Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) Inverse variance weighted 15 2.322423153 0.881007037 0.008386487
Oatcakes (👉 📊) Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) MR Egger 15 -5.783698372 2.479011879 0.036354843
Oatcakes (👉 📊) Osteocrin (prot-a-2157) MR Egger 14 1.731454793 0.597119214 0.013334231
Oatcakes (👉 📊) Diagnoses - main ICD10: M51.2 Other specified intervertebral disk displacement (ukb-b-12872) Weighted median 3 -0.010328063 0.005201014 0.047057881
Oatcakes (👉 📊) Heel bone ultrasound T-score, manual entry (ukb-b-17612) Weighted median 11 0.32566946 0.161716386 0.044027287
Oatcakes (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) Inverse variance weighted 3 -0.014912501 0.007265607 0.040123185
Oatcakes (👉 📊) Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) Inverse variance weighted 3 -0.01054089 0.00501479 0.035556733
Oatcakes (👉 📊) Fractured bone site(s): Leg (ukb-b-3798) Weighted median 3 0.014311287 0.007012139 0.041257766
Oatcakes (👉 📊) Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) Inverse variance weighted 3 -0.013276 0.005033931 0.008356824
Oatcakes (👉 📊) Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) Inverse variance weighted 6 2.548786379 1.187933931 0.031907908
Oatcakes (👉 📊) Pain in joint (ukb-e-745_CSA) Inverse variance weighted 7 2.730504096 1.307131437 0.036714161

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Oatcakes Neck circumference (ebi-a-GCST90017135) rs136043 -4.6188454217525 2.05176377524535 0.0243755015781747
Oatcakes Neck circumference (ebi-a-GCST90017135) All - Inverse variance weighted -2.09983225419752 0.75881579101618 0.0056531555222002
Oatcakes Juvenile rheumatoid arthritis (ebi-a-GCST90018653) All - Inverse variance weighted -4.33272433666761 1.91171838403909 0.0234267182977112
Oatcakes Compression fracture (ebi-a-GCST90018828) All - MR Egger 1.17242862006895 0.504206275593186 0.0368842419579682
Oatcakes Bone disorder (ebi-a-GCST90038652) rs35664252 0.0429608235373446 0.0170152390371086 0.0115749670921993
Oatcakes Bone disorder (ebi-a-GCST90038652) rs77771805 -0.037312545583519 0.0172903907444226 0.0309283608003807
Oatcakes Bone disorder (ebi-a-GCST90038652) All - MR Egger -0.0259335464915137 0.0093878946748606 0.0220239023907069
Oatcakes Spine arthritis or spondylitis (ebi-a-GCST90038657) All - Inverse variance weighted -0.0066807423342966 0.0031481631034951 0.0338286637017068
Oatcakes Neck injury (ebi-a-GCST90038700) rs145714980 0.021872628913217 0.010460692923938 0.0365338914946408
Oatcakes Neck injury (ebi-a-GCST90038700) rs35664252 0.0248899777483086 0.0102628621518959 0.0152979658483127
Oatcakes Neck injury (ebi-a-GCST90038700) All - Inverse variance weighted 0.0064206858226806 0.003254503354789 0.0485112931804745
Oatcakes Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) rs112881275 -4.1421057224686 1.99290740755432 0.037670363968573
Oatcakes Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) rs141086082 -4.42267558876173 2.25627009885107 0.0499757875354688
Oatcakes Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) All - Inverse variance weighted -2.02112174853421 0.537412902665348 0.0001693464890849
Oatcakes Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) All - MR Egger -3.5134347700219 0.854391066795063 0.0012248124480372
Oatcakes Contracture of joint (finn-b-M13_CONTRACTUREJOINT) All - MR Egger -4.10951039328294 1.81703063830584 0.0415034876190577
Oatcakes Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) rs1887712 11.3773346969983 4.60336216226951 0.0134537324250145
Oatcakes Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) rs136043 6.06021422771726 2.8523129405635 0.0336144367396676
Oatcakes Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) rs143694703 5.04994223252841 2.33446136953974 0.0305246345436244
Oatcakes Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) All - Inverse variance weighted 2.32242315267297 0.88100703732721 0.0083864871521403
Oatcakes Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) rs17713739 20.2835272335369 8.04156188686545 0.0116578040645655
Oatcakes Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) All - MR Egger -5.78369837162858 2.47901187895525 0.0363548434894779
Oatcakes Osteocrin (prot-a-2157) All - MR Egger 1.73145479329685 0.59711921439699 0.0133342312051817
Oatcakes Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) All - Inverse variance weighted -0.0149125012012009 0.007265606622225 0.04012318483441
Oatcakes Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) rs17713739 -0.0193516456185923 0.0087775720562633 0.0274772931017227
Oatcakes Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) All - Inverse variance weighted -0.0105408904966769 0.0050147899276578 0.0355567334099747
Oatcakes Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) rs17713739 -0.0204460165252715 0.0088110647470086 0.0203142080887904
Oatcakes Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) All - Inverse variance weighted -0.0132760000745325 0.0050339312646484 0.0083568244848813
Oatcakes Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) rs17713739 10.2467737032636 4.29159642965706 0.0169570890650174
Oatcakes Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) All - Inverse variance weighted 2.54878637880008 1.18793393058676 0.0319079077304744
Oatcakes Pain in joint (ukb-e-745_CSA) rs136043 4.41157734807155 1.95288359330581 0.0238829608971837
Oatcakes Pain in joint (ukb-e-745_CSA) All - Inverse variance weighted 2.7305040958348 1.30713143748887 0.0367141610813363