ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Liver | Rheumatoid arthritis (ebi-a-GCST002318) | rs17001660 | 6.75113818577482 | 3.36075478181193 | 0.0445566442253928 |
| Liver | Rheumatoid arthritis (ebi-a-GCST002318) | rs28638120 | 6.7395934084397 | 2.99355647281594 | 0.0243623203509094 |
| Liver | Rheumatoid arthritis (ebi-a-GCST002318) | All - Inverse variance weighted | 1.72552271681244 | 0.806667315114399 | 0.0324295114543904 |
| Liver | Osteoarthritis (self-reported) (ebi-a-GCST005811) | rs34717472 | -5.43846325867351 | 2.22911267536884 | 0.0146976918294035 |
| Liver | Osteoarthritis (self-reported) (ebi-a-GCST005811) | All - Inverse variance weighted | -0.960504073285901 | 0.406147867350151 | 0.0180343426228211 |
| Liver | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | rs12548207 | -6.83738897868927 | 2.51211086162045 | 0.0064933239354715 |
| Liver | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | rs9903672 | 4.58996796516385 | 2.27843958451788 | 0.0439546977868027 |
| Liver | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | All - MR Egger | 2.40668099611291 | 0.946196107603873 | 0.0172632808193454 |
| Liver | Osteoarthritis (hip) (ebi-a-GCST007091) | rs12548207 | -3.99835189885145 | 1.82851458788938 | 0.0287668666870754 |
| Liver | Osteoarthritis (hip) (ebi-a-GCST007091) | All - MR Egger | 1.70615474125773 | 0.701687183978893 | 0.0222324788381475 |
| Liver | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | rs12548207 | -2.63306100656071 | 1.1946295307544 | 0.027518603622956 |
| Liver | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | rs34717472 | -2.37249539974277 | 1.19192352618656 | 0.0465385042512572 |
| Liver | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | All - MR Egger | 1.25628009055977 | 0.457636988998218 | 0.0108230524785353 |
| Liver | Osteoprotegerin levels (ebi-a-GCST90010243) | rs12548207 | -17.2648347388515 | 6.18827849008579 | 0.0052720203281657 |
| Liver | Osteoprotegerin levels (ebi-a-GCST90010243) | rs4372557 | -8.55127153846984 | 4.30629133713842 | 0.0470597095559379 |
| Liver | Osteoprotegerin levels (ebi-a-GCST90010243) | rs74798467 | -19.8089997268079 | 7.61760917925301 | 0.009310913928144 |
| Liver | Osteoprotegerin levels (ebi-a-GCST90010243) | All - Inverse variance weighted | -2.58782552650667 | 1.27609950123433 | 0.0425685874628363 |
| Liver | Rheumatoid arthritis (ebi-a-GCST90013534) | rs17001660 | 7.00807467644027 | 3.28570610468446 | 0.0329331269924597 |
| Liver | Rheumatoid arthritis (ebi-a-GCST90013534) | rs7316528 | 2.84051165704623 | 1.09484389350818 | 0.0094743924014802 |
| Liver | Rheumatoid arthritis (ebi-a-GCST90013534) | All - Inverse variance weighted | 0.973003227781578 | 0.369600159781038 | 0.0084738227512048 |
| Liver | Benign neoplasm: Skin of upper limb, including shoulder (finn-b-CD2_BENIGN_SKIN_UPPERLIMB) | All - MR Egger | -10.5622890801084 | 4.54541163084963 | 0.0282244996935534 |
| Liver | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | rs140002775 | -20.3534844149874 | 9.50606865227206 | 0.0322656284519369 |
| Liver | Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) | rs12548207 | -19.6016763821742 | 5.83905658399343 | 0.0007879489746685 |
| Liver | Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) | rs138468797 | 18.5352287282332 | 5.58689862672551 | 0.0009078662163059 |
| Liver | Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) | rs62569615 | 35.048033233805 | 16.801895365442 | 0.0369825076114355 |
| Liver | Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) | All - MR Egger | 6.84873069320629 | 2.18693926075354 | 0.0042654915903465 |
| Liver | Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) | rs17059810 | 9.09728734205396 | 4.3378240718878 | 0.0359758194617493 |
| Liver | Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) | All - MR Egger | 7.58136747636531 | 3.28582981416902 | 0.0292579556303379 |
| Liver | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | rs117958676 | -24.3213884976246 | 11.1908229283549 | 0.0297552384318807 |
| Liver | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | rs139870543 | 37.0995623073386 | 16.3091608903725 | 0.022919832390608 |
| Liver | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | rs140002775 | -14.0515543845927 | 7.07723552134148 | 0.0470935306457872 |
| Liver | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | rs34717472 | -33.1581773332471 | 13.5425215880054 | 0.0143472625329126 |
| Liver | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | rs73215188 | -16.4782540430209 | 8.04286387187942 | 0.0404812556481834 |
| Liver | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | All - Inverse variance weighted | -6.39478713821416 | 2.06919839074923 | 0.0019984272729178 |
| Liver | Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) | rs139771945 | -5.72401279485213 | 2.52342917001814 | 0.0233080700378973 |
| Liver | Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) | All - MR Egger | -4.41473119599331 | 1.89007035489122 | 0.0274895593134152 |
| Liver | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | rs139870543 | 11.83430692985 | 4.96236183728733 | 0.017087787007044 |
| Liver | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | rs58346866 | -4.56215778431634 | 2.20999711364899 | 0.0389866767176991 |
| Liver | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | rs73215188 | -5.29517977704506 | 2.01758517820694 | 0.0086772822390195 |
| Liver | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | All - Inverse variance weighted | -1.40800324726982 | 0.593728468967859 | 0.017717969865833 |
| Liver | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | rs139870543 | 12.5453446191052 | 5.00706779978541 | 0.0122268989830669 |
| Liver | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | rs73215188 | -4.58863243837337 | 2.03328623017742 | 0.0240232781909905 |
| Liver | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | All - Inverse variance weighted | -1.35509787008574 | 0.572566064565743 | 0.0179469860212398 |
| Liver | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | rs139870543 | 12.2302740262616 | 4.97726382478669 | 0.0140013637501269 |
| Liver | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | rs73215188 | -4.48265033757262 | 2.02151044119956 | 0.0265905998723586 |
| Liver | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | All - Inverse variance weighted | -1.31201069066681 | 0.575557678948958 | 0.0226345786631891 |
| Liver | Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) | All - Inverse variance weighted | -3.74495897483525 | 1.6976172054204 | 0.0273833637359601 |
| Liver | Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) | All - Inverse variance weighted | 0.969123940557393 | 0.493335590264278 | 0.049480080592058 |
| Liver | Osteomodulin (prot-a-2147) | rs117589991 | -8.88277455076599 | 4.19936139135161 | 0.0344071166731909 |
| Liver | Osteomodulin (prot-a-2147) | All - MR Egger | -3.92832523119259 | 1.51933200886866 | 0.0165352839609413 |
| Liver | Bone morphogenetic protein 10 (prot-a-254) | rs140002775 | 6.85081887354287 | 3.44770804602433 | 0.0469152300432172 |
| Liver | Bone morphogenetic protein 10 (prot-a-254) | rs76810103 | 9.13042846134834 | 3.32213838123901 | 0.0059894414904204 |
| Liver | Bone morphogenetic protein 10 (prot-a-254) | All - Inverse variance weighted | 1.67893915487243 | 0.779914887264044 | 0.0313406121784632 |
| Liver | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | All - MR Egger | 0.0481458661031152 | 0.0208506009242129 | 0.0298598620675386 |
| Liver | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | rs117589991 | -0.0904663032032338 | 0.0457598763544957 | 0.0480440321262333 |
| Liver | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | All - Inverse variance weighted | -0.0174221297294835 | 0.0086886466467707 | 0.0449459076571545 |
| Liver | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | rs4707531 | -0.0324331669026505 | 0.0152332265196115 | 0.0332454213179294 |
| Liver | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | All - Inverse variance weighted | -0.007063977549797 | 0.0029351278918 | 0.0160973083059107 |
| Liver | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | All - MR Egger | -0.0172171456267031 | 0.0061083372206761 | 0.0095082165363685 |
| Liver | Fractured bone site(s): Other bones (ukb-b-17738) | All - Inverse variance weighted | -0.0354249850546189 | 0.0177839007082142 | 0.0463744213969573 |
| Liver | Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) | rs12548207 | 0.0515998283634307 | 0.0234263193951761 | 0.0276198907592851 |
| Liver | Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) | All - Inverse variance weighted | 0.0382815347676431 | 0.0165961556514135 | 0.0210742982803954 |
| Liver | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | All - Inverse variance weighted | 0.0253724818868391 | 0.0124488685741433 | 0.0415363764538257 |
| Liver | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | rs17001660 | -0.0643824447371435 | 0.0214656110411179 | 0.0027057433711927 |
| Liver | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | rs28638120 | -0.054513420609297 | 0.022023058654715 | 0.0133128641139411 |
| Liver | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | All - Inverse variance weighted | -0.011147887764384 | 0.005217102681863 | 0.0326145311319847 |
| Liver | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | rs58346866 | -0.109037725038449 | 0.053448758653668 | 0.0413461193434638 |
| Liver | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | rs61861301 | -0.129221105602365 | 0.0553895661639399 | 0.0196507533795324 |
| Liver | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | All - Inverse variance weighted | -0.0216729841202808 | 0.0102803625655338 | 0.0350143345157131 |
| Liver | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | All - MR Egger | -0.0465667339928883 | 0.0213957181597779 | 0.0395904252926555 |
| Liver | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | rs58346866 | -0.10511616485803 | 0.052325666553223 | 0.0445494968685097 |
| Liver | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | All - Inverse variance weighted | -0.0235574167930214 | 0.010064333963729 | 0.0192484955600793 |
| Liver | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | All - MR Egger | -0.0485870011982663 | 0.0209461225316724 | 0.0291895934061253 |