ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Pancake (ukb-b-6500)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Pancake (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) MR Egger 43 -0.700571548 0.345732384 0.049268711
Pancake (👉 📊) Heel bone mineral density (ebi-a-GCST90029004) Weighted median 46 0.188533321 0.074528547 0.011416683
Pancake (👉 📊) Spine arthritis or spondylitis (ebi-a-GCST90038657) Weighted median 33 -0.019096676 0.008500723 0.024673495
Pancake (👉 📊) Other joint disorder (ebi-a-GCST90038688) Inverse variance weighted 33 -0.012848037 0.006305391 0.041587207
Pancake (👉 📊) Fractures (ebi-a-GCST90038703) Inverse variance weighted 33 -0.017413071 0.008449813 0.039325545
Pancake (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) MR Egger 45 -10.56103208 5.114830479 0.045006855
Pancake (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) Simple mode 45 -24.53014343 7.920310972 0.00339699
Pancake (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) MR Egger 45 -10.56668598 5.12965661 0.04549142
Pancake (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) Simple mode 45 -24.69518761 7.66078525 0.002386973
Pancake (👉 📊) Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) Simple mode 45 -20.58617134 9.288846586 0.031893691
Pancake (👉 📊) Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) Inverse variance weighted 45 -2.754285714 1.244486437 0.026884506
Pancake (👉 📊) Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) Inverse variance weighted 45 2.391120291 1.180960331 0.042895577
Pancake (👉 📊) Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) Inverse variance weighted 45 -0.540195873 0.25142672 0.0316723
Pancake (👉 📊) Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) Simple mode 45 -1.444803521 0.678883265 0.038958088
Pancake (👉 📊) Osteoporosis (finn-b-M13_OSTEOPOROSIS) Inverse variance weighted 45 -1.424920348 0.563409336 0.01143544
Pancake (👉 📊) Other shoulder lesions (finn-b-M13_SHOULDERNAS) Weighted mode 45 3.67015041 1.783652783 0.045577957
Pancake (👉 📊) Disorders of synovium and tendon (finn-b-M13_SYNOTEND) Inverse variance weighted 45 -0.646452386 0.321215795 0.044165422
Pancake (👉 📊) Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) Weighted median 45 -8.457675262 3.868693824 0.028802171
Pancake (👉 📊) Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) Inverse variance weighted 45 -5.166663578 2.615861606 0.048253534
Pancake (👉 📊) Transient synovitis (finn-b-M13_TRANSSYNOVITIS) Simple mode 45 -20.32300249 8.738051258 0.024700869
Pancake (👉 📊) Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) MR Egger 45 17.87392761 5.184931832 0.001278069
Pancake (👉 📊) Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) Weighted median 45 8.298295793 4.164849006 0.04632059
Pancake (👉 📊) Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) Inverse variance weighted 45 8.89551502 3.161123211 0.004892372
Pancake (👉 📊) Pain (limb, back, neck, head abdominally) (finn-b-PAIN) Inverse variance weighted 45 -0.472555951 0.174311324 0.0067083
Pancake (👉 📊) Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) MR Egger 45 2.130613788 0.935109689 0.027725677
Pancake (👉 📊) Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) Weighted median 45 5.826718478 2.47778249 0.018693571
Pancake (👉 📊) Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) Weighted mode 45 5.767205491 2.822090819 0.047009383
Pancake (👉 📊) Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) MR Egger 45 1.613190102 0.731742094 0.032882674
Pancake (👉 📊) Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) Weighted median 45 -7.189632611 2.860201894 0.011947875
Pancake (👉 📊) Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) Weighted mode 45 -7.405932945 3.163566741 0.023827142
Pancake (👉 📊) Rheumatoid arthritis (ieu-a-833) Inverse variance weighted 17 1.137839018 0.551264311 0.039012646
Pancake (👉 📊) Osteocalcin (prot-a-246) Inverse variance weighted 41 1.858594871 0.768619241 0.015601974
Pancake (👉 📊) Fractured/broken bones in last 5 years (ukb-a-308) MR Egger 46 -0.073820505 0.033007945 0.030440721
Pancake (👉 📊) Fractured/broken bones in last 5 years (ukb-a-308) Inverse variance weighted 46 -0.044040143 0.019693393 0.025332759
Pancake (👉 📊) Fracture resulting from simple fall (ukb-a-332) Weighted median 46 -0.327491993 0.139235338 0.018668997
Pancake (👉 📊) Fracture resulting from simple fall (ukb-a-332) Inverse variance weighted 46 -0.249129799 0.103613924 0.016198832
Pancake (👉 📊) Fractured bone site(s): Ankle (ukb-a-438) MR Egger 46 -0.031445688 0.013164134 0.021261207
Pancake (👉 📊) Fractured bone site(s): Ankle (ukb-a-438) Inverse variance weighted 46 -0.021477564 0.007854054 0.006245933
Pancake (👉 📊) Non-cancer illness code self-reported: bone disorder (ukb-a-84) Weighted median 46 -0.008969089 0.00449792 0.046146275
Pancake (👉 📊) Heel bone mineral density (BMD) (left) (ukb-b-1096) Weighted median 46 0.293523059 0.13746447 0.032739378
Pancake (👉 📊) Heel bone mineral density (BMD) (left) (ukb-b-1096) Inverse variance weighted 46 0.210646224 0.098953529 0.03327587
Pancake (👉 📊) Fracture resulting from simple fall (ukb-b-15251) Inverse variance weighted 25 -0.271849111 0.118351553 0.021620894
Pancake (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) Weighted median 46 0.322899767 0.139298383 0.020446935
Pancake (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) Inverse variance weighted 46 0.221289558 0.099399053 0.025995814
Pancake (👉 📊) Fractured heel (ukb-b-18389) Weighted median 46 -0.012186413 0.005766914 0.034587059
Pancake (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) Weighted median 46 0.335459447 0.137292939 0.014550224
Pancake (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) Inverse variance weighted 46 0.231500079 0.093982878 0.013769714
Pancake (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) Weighted median 46 0.272733606 0.099979458 0.006373962
Pancake (👉 📊) Non-cancer illness code, self-reported: joint pain (ukb-b-4122) Weighted median 4 -0.028986659 0.013493267 0.031695378
Pancake (👉 📊) Non-cancer illness code, self-reported: joint pain (ukb-b-4122) Inverse variance weighted 4 -0.026684971 0.011323601 0.018444098
Pancake (👉 📊) Heel bone mineral density (BMD) (right) (ukb-b-4657) Weighted median 46 0.299482676 0.133369944 0.024735828
Pancake (👉 📊) Heel bone mineral density (BMD) (right) (ukb-b-4657) Inverse variance weighted 46 0.212236543 0.093990781 0.023942104
Pancake (👉 📊) Operative procedures - main OPCS: W91.9 Unspecified other manipulation of joint (ukb-b-4663) Weighted median 3 0.028894609 0.014670244 0.04888348
Pancake (👉 📊) Operation code: shoulder surgery (ukb-b-5935) Inverse variance weighted 8 -0.048981675 0.016831099 0.003612106
Pancake (👉 📊) Non-cancer illness code, self-reported: joint disorder (ukb-b-8201) Weighted median 5 0.035055861 0.014895007 0.018596052
Pancake (👉 📊) Non-cancer illness code, self-reported: joint disorder (ukb-b-8201) Inverse variance weighted 5 0.03412918 0.012074775 0.004706182
Pancake (👉 📊) Fractured heel (left) (ukb-b-8221) Weighted median 46 0.029059492 0.014412714 0.04377488
Pancake (👉 📊) Fractured heel (left) (ukb-b-8221) Inverse variance weighted 46 0.024512826 0.011655748 0.035459853
Pancake (👉 📊) Heel bone mineral density (BMD) (ukb-b-8875) Weighted median 46 0.297736365 0.104031566 0.004210022
Pancake (👉 📊) Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) Inverse variance weighted 32 -0.011219686 0.004761299 0.018451345
Pancake (👉 📊) Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) MR Egger 42 -0.017590727 0.008144119 0.036827036
Pancake (👉 📊) Knee pain for 3+ months (ukb-e-3773_AFR) Weighted median 20 4.681128128 2.341852447 0.045619208
Pancake (👉 📊) Knee pain for 3+ months (ukb-e-3773_CSA) Inverse variance weighted 27 3.760294137 1.763827554 0.033015526
Pancake (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) MR Egger 15 2.86236398 1.292082189 0.045207173

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Pancake Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) rs140856674 -2.89334400517698 1.34941631259419 0.032021284285816
Pancake Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) rs76741543 4.19465965824158 1.40098482702021 0.0027527439622695
Pancake Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) rs934095 3.22711191427626 1.30089847030976 0.013113229220576
Pancake Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) All - MR Egger -0.700571547687995 0.345732384126219 0.0492687106083253
Pancake Heel bone mineral density (ebi-a-GCST90029004) rs115086731 0.766331364227151 0.35735581276449 0.0319969167299482
Pancake Heel bone mineral density (ebi-a-GCST90029004) rs144101066 -1.04199259231798 0.367323966446368 0.0045580594428043
Pancake Heel bone mineral density (ebi-a-GCST90029004) rs1445890 -0.844569829271885 0.352853507710349 0.0166865528656901
Pancake Heel bone mineral density (ebi-a-GCST90029004) rs145580229 0.780101975836733 0.336173754177628 0.0203121124249887
Pancake Heel bone mineral density (ebi-a-GCST90029004) rs151182658 0.724140468454598 0.358069464413073 0.0431405851218627
Pancake Heel bone mineral density (ebi-a-GCST90029004) rs74342372 0.765137160512794 0.375509550878271 0.0415902453412353
Pancake Spine arthritis or spondylitis (ebi-a-GCST90038657) rs13162631 0.0784452124336145 0.0368921821305842 0.0334752080863029
Pancake Spine arthritis or spondylitis (ebi-a-GCST90038657) rs76741543 0.0757015427002628 0.0361486229030903 0.0362443931151177
Pancake Other joint disorder (ebi-a-GCST90038688) rs12959805 -0.0767954328253106 0.0352356521301745 0.0292959578136653
Pancake Other joint disorder (ebi-a-GCST90038688) rs151182658 0.078655768512334 0.0388888637315613 0.0431166523145621
Pancake Other joint disorder (ebi-a-GCST90038688) rs1549469 -0.0878082037863336 0.0386405230251819 0.0230600516863256
Pancake Other joint disorder (ebi-a-GCST90038688) rs61689687 -0.0730279959441112 0.0345444858817262 0.0345129116421977
Pancake Other joint disorder (ebi-a-GCST90038688) All - Inverse variance weighted -0.0128480370705849 0.006305390724051 0.0415872070995346
Pancake Fractures (ebi-a-GCST90038703) All - Inverse variance weighted -0.0174130714170368 0.0084498128277999 0.039325545442663
Pancake Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) rs1450305 90.5597419570114 31.1764869449156 0.0036755251478543
Pancake Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) rs145580229 65.4937835143456 27.0618047351571 0.0155138588620027
Pancake Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) All - MR Egger -10.5610320771764 5.11483047914533 0.0450068549426615
Pancake Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) rs1450305 91.049133831994 31.2654672858215 0.0035897215115054
Pancake Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) rs145580229 66.3326028432023 27.2594323257254 0.0149585240148961
Pancake Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) All - MR Egger -10.5666859751231 5.12965661038183 0.0454914199882666
Pancake Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) rs12959805 44.1292356185973 18.7364820683064 0.0185098854969786
Pancake Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) rs142571999 32.8421188255947 15.1777230194392 0.0304768604791876
Pancake Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs140856674 62.9241419241675 29.3844673586336 0.0322411272052871
Pancake Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs145580229 33.8031014356547 12.1123754397214 0.0052579504716475
Pancake Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs561776 -11.2008584690635 4.45455604172559 0.0119210614279358
Pancake Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) All - Inverse variance weighted -2.75428571401803 1.24448643749613 0.0268845063018756
Pancake Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) rs140388606 23.7876420228048 9.60493089842198 0.0132637747791513
Pancake Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) rs145112375 25.9094073061951 10.5861197762252 0.0143855682144707
Pancake Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) rs147744499 12.44870319644 5.02530472592487 0.0132416323835741
Pancake Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) rs1549469 19.6153487247167 9.63627811136567 0.041793238988588
Pancake Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) All - Inverse variance weighted 2.39112029146128 1.18096033091558 0.0428955765209236
Pancake Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) rs12959805 -4.35088778230471 1.54251127542209 0.0047926136502613
Pancake Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) rs2195088 -6.90491559572013 2.26903741955676 0.0023415182417247
Pancake Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) rs4334476 -10.4349049235428 4.86394645957261 0.0319242594968021
Pancake Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) rs77299778 4.58085372125487 2.15267063404599 0.0333382154919935
Pancake Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) All - Inverse variance weighted -0.540195872837986 0.251426719918373 0.0316722999740354
Pancake Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) rs2195088 -7.68734229211901 2.21035541732684 0.0005054034669577
Pancake Osteoporosis (finn-b-M13_OSTEOPOROSIS) rs116924241 -30.4835992000378 14.496952899863 0.0354868355506115
Pancake Osteoporosis (finn-b-M13_OSTEOPOROSIS) rs56095783 -5.06035227490881 2.56767133806873 0.048747398369242
Pancake Osteoporosis (finn-b-M13_OSTEOPOROSIS) All - Inverse variance weighted -1.4249203477158 0.563409336417254 0.0114354402015809
Pancake Other shoulder lesions (finn-b-M13_SHOULDERNAS) rs113505885 5.15466989255642 2.43729478156714 0.0344372414807153
Pancake Disorders of synovium and tendon (finn-b-M13_SYNOTEND) rs117404891 -7.57223429532982 2.73124698759523 0.0055636780249861
Pancake Disorders of synovium and tendon (finn-b-M13_SYNOTEND) rs145112375 6.13253757508572 3.05498981670061 0.0447087947325158
Pancake Disorders of synovium and tendon (finn-b-M13_SYNOTEND) All - Inverse variance weighted -0.646452385706016 0.321215795377522 0.0441654216213102
Pancake Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) rs147744499 24.9585043226785 12.3214158426932 0.0428037573627659
Pancake Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) rs77299778 44.8240393799133 22.4524281830872 0.0458903438784507
Pancake Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) All - Inverse variance weighted -5.16666357814146 2.61586160622086 0.0482535340241936
Pancake Transient synovitis (finn-b-M13_TRANSSYNOVITIS) rs13162631 55.5197594501718 24.9433770696657 0.0260254564523885
Pancake Transient synovitis (finn-b-M13_TRANSSYNOVITIS) rs1549469 69.3964376241433 26.337890569207 0.008417403290533
Pancake Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) rs117543191 49.3343606866144 18.864774624374 0.0089186265601225
Pancake Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) rs13162631 69.8707435176507 26.6371836925961 0.0087145725263428
Pancake Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) rs140856674 210.050833170134 89.409330483724 0.0188079020110593
Pancake Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) rs142571999 38.1923306115218 14.5721602164565 0.0087695230114753
Pancake Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) All - Inverse variance weighted 8.89551502038513 3.16112321051433 0.0048923724801955
Pancake Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) All - MR Egger 17.8739276071386 5.1849318315141 0.0012780686869986
Pancake Pain (limb, back, neck, head abdominally) (finn-b-PAIN) rs12959805 -4.04070888452962 0.922153479871905 1.17693007920731e-05
Pancake Pain (limb, back, neck, head abdominally) (finn-b-PAIN) rs185371399 -4.39510917203572 1.50547964878745 0.003506970116356
Pancake Pain (limb, back, neck, head abdominally) (finn-b-PAIN) rs2195088 -3.11014611818555 1.34968605128807 0.0212031262615076
Pancake Pain (limb, back, neck, head abdominally) (finn-b-PAIN) rs934095 -2.63177988750032 1.16572068517906 0.0239679928376524
Pancake Pain (limb, back, neck, head abdominally) (finn-b-PAIN) All - Inverse variance weighted -0.472555951465104 0.174311323766875 0.0067083002367663
Pancake Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) rs13162631 10.162839737582 3.92455482661668 0.0096100840715536
Pancake Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) rs142571999 4.9250293923435 2.21288109387834 0.0260397371235446
Pancake Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) rs147744499 -7.98346282700121 2.09769558974777 0.0001413321528343
Pancake Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) rs62243378 -8.80721774218313 3.43935978774237 0.0104457222490472
Pancake Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) All - MR Egger 2.13061378772141 0.935109688622191 0.0277256768723645
Pancake Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) rs117699541 38.0298684150617 17.3758138687793 0.0286210605438627
Pancake Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) rs140388606 -30.7195435555929 14.7538464660638 0.037329871507731
Pancake Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) rs116924241 24.5090783112609 10.912870258098 0.0247112182104301
Pancake Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) All - MR Egger 1.61319010174533 0.731742094211379 0.0328826738039994
Pancake Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) rs145112375 78.5048596251515 21.5976178813581 0.0002781045443746
Pancake Rheumatoid arthritis (ieu-a-833) rs13162631 8.07921352702281 3.9766723289597 0.0421889178943223
Pancake Rheumatoid arthritis (ieu-a-833) rs56095783 7.83994648684968 3.96057304665003 0.0477599628329108
Pancake Rheumatoid arthritis (ieu-a-833) All - Inverse variance weighted 1.13783901770197 0.551264311414317 0.0390126464813006
Pancake Osteocalcin (prot-a-246) rs144101066 13.103306495371 4.90025916776479 0.0074951836654681
Pancake Osteocalcin (prot-a-246) rs72651826 9.84651876146168 4.72193650642586 0.0370446794226311
Pancake Osteocalcin (prot-a-246) All - Inverse variance weighted 1.85859487089108 0.768619241497958 0.0156019735327322
Pancake Fractured/broken bones in last 5 years (ukb-a-308) rs140856674 -0.336011937705951 0.132001907308226 0.0109118800405549
Pancake Fractured/broken bones in last 5 years (ukb-a-308) rs144101066 -0.279855688378567 0.142277036522771 0.0491858381865437
Pancake Fractured/broken bones in last 5 years (ukb-a-308) rs76741543 0.290693970865534 0.137289576270358 0.0342277535912154
Pancake Fractured/broken bones in last 5 years (ukb-a-308) All - Inverse variance weighted -0.0440401433182499 0.0196933925318116 0.0253327593495534
Pancake Fractured/broken bones in last 5 years (ukb-a-308) All - MR Egger -0.0738205048367442 0.0330079451467865 0.0304407209657622
Pancake Fracture resulting from simple fall (ukb-a-332) rs138627963 -2.03132100223009 0.735967466876558 0.0057789151720652
Pancake Fracture resulting from simple fall (ukb-a-332) rs1549469 -1.44951523427011 0.718691142051308 0.0437078280103483
Pancake Fracture resulting from simple fall (ukb-a-332) rs6959220 1.42873779660301 0.71620968007025 0.0460581886482735
Pancake Fracture resulting from simple fall (ukb-a-332) All - Inverse variance weighted -0.249129799188284 0.10361392442015 0.0161988324876303
Pancake Fractured bone site(s): Ankle (ukb-a-438) rs147744499 -0.105884239789008 0.0493799069274869 0.0320106319172195
Pancake Fractured bone site(s): Ankle (ukb-a-438) rs34814717 -0.118346693855558 0.0500073403553377 0.0179529810875162
Pancake Fractured bone site(s): Ankle (ukb-a-438) All - Inverse variance weighted -0.0214775638124687 0.0078540542594234 0.0062459333020389
Pancake Fractured bone site(s): Ankle (ukb-a-438) All - MR Egger -0.0314456877529643 0.0131641339322385 0.0212612066863255
Pancake Non-cancer illness code self-reported: bone disorder (ukb-a-84) rs114404019 0.0664199797770513 0.0231978623226615 0.0041939371711921
Pancake Heel bone mineral density (BMD) (left) (ukb-b-1096) rs114404019 -1.4391915783205 0.688749589027499 0.0366563002285028
Pancake Heel bone mineral density (BMD) (left) (ukb-b-1096) rs74342372 2.05861968897766 0.69286116658985 0.0029665165010313
Pancake Heel bone mineral density (BMD) (left) (ukb-b-1096) rs934095 1.18137392145384 0.591789050370333 0.0459039545196151
Pancake Heel bone mineral density (BMD) (left) (ukb-b-1096) All - Inverse variance weighted 0.210646224376582 0.0989535288880876 0.033275870086501
Pancake Fracture resulting from simple fall (ukb-b-15251) rs138627963 -1.4349888495343 0.616644365735275 0.0199603106051775
Pancake Fracture resulting from simple fall (ukb-b-15251) rs1549469 -1.33332762012497 0.611659896514752 0.0292684859028228
Pancake Fracture resulting from simple fall (ukb-b-15251) All - Inverse variance weighted -0.271849111193001 0.118351553227423 0.0216208938155956
Pancake Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) rs74342372 2.14708267185606 0.693292193714686 0.0019553101958427
Pancake Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) rs934095 1.16364376797577 0.591946855353916 0.0493227642523459
Pancake Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) All - Inverse variance weighted 0.221289557815532 0.0993990533639764 0.0259958139164416
Pancake Fractured heel (ukb-b-18389) rs147524950 0.0585835987612916 0.0281079973812001 0.0371390331970966
Pancake Fractured heel (ukb-b-18389) rs1549469 -0.0758302720058503 0.0283773155157408 0.007535248026425
Pancake Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) rs114404019 -1.40329274269089 0.686032518005248 0.0408036903496869
Pancake Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) rs74342372 1.37683293217938 0.691790000170704 0.0465637396213678
Pancake Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) All - Inverse variance weighted 0.231500078830634 0.0939828782178828 0.0137697140493004
Pancake Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) rs117543191 1.02091091990925 0.495411155344377 0.0393283647059089
Pancake Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) rs13162631 1.25977233676976 0.498081654170572 0.0114307024132409
Pancake Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) rs144101066 -1.40515100145255 0.506014107623711 0.0054879918670991
Pancake Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) rs79141368 -1.33503608266898 0.502433218725205 0.0078806392326074
Pancake Non-cancer illness code, self-reported: joint pain (ukb-b-4122) All - Inverse variance weighted -0.0266849709325615 0.0113236010215532 0.0184440977004697
Pancake Heel bone mineral density (BMD) (right) (ukb-b-4657) rs114404019 -1.43854642903668 0.686066636476989 0.0360110376124969
Pancake Heel bone mineral density (BMD) (right) (ukb-b-4657) All - Inverse variance weighted 0.212236543438774 0.0939907807113226 0.0239421039359177
Pancake Operation code: shoulder surgery (ukb-b-5935) rs1445890 -0.0940523882006684 0.0476815520632656 0.0485512964345605
Pancake Operation code: shoulder surgery (ukb-b-5935) rs1549469 -0.125007093900388 0.048392779266386 0.0097895205067757
Pancake Operation code: shoulder surgery (ukb-b-5935) All - Inverse variance weighted -0.0489816749805311 0.0168310994716401 0.0036121063470261
Pancake Non-cancer illness code, self-reported: joint disorder (ukb-b-8201) All - Inverse variance weighted 0.0341291801736676 0.0120747748440577 0.0047061824034092
Pancake Fractured heel (left) (ukb-b-8221) rs113505885 0.148728018163507 0.0577129355398101 0.0099653042040125
Pancake Fractured heel (left) (ukb-b-8221) rs117543191 0.209005179572792 0.0692526004879928 0.0025443882592025
Pancake Fractured heel (left) (ukb-b-8221) rs1445890 0.243057220346424 0.0671103595081783 0.0002926121860049
Pancake Fractured heel (left) (ukb-b-8221) All - Inverse variance weighted 0.024512826448071 0.0116557477379147 0.0354598530021351
Pancake Heel bone mineral density (BMD) (ukb-b-8875) rs117543191 1.06001455417148 0.495359787680322 0.0323638046253136
Pancake Heel bone mineral density (BMD) (ukb-b-8875) rs13162631 1.25988460637301 0.497964503280225 0.0114040062539359
Pancake Heel bone mineral density (BMD) (ukb-b-8875) rs144101066 -1.31765407675275 0.506074771079708 0.0092230250182972
Pancake Heel bone mineral density (BMD) (ukb-b-8875) rs79141368 -1.31520761703253 0.502387879245853 0.0088469431635688
Pancake Heel bone mineral density (BMD) (ukb-b-8875) rs80311620 -1.00885666277636 0.511369637373462 0.0485124153426929
Pancake Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) rs140856674 -0.0527396268828283 0.0264077041628705 0.0458110271097382
Pancake Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) rs1445890 -0.0568096284764444 0.027279094687528 0.0372937664496705
Pancake Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) rs79141368 0.0634408886537953 0.0282413949446481 0.0246797148049902
Pancake Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) All - Inverse variance weighted -0.0112196862904768 0.0047612987318368 0.0184513453977841
Pancake Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) rs117146107 0.0762101003191974 0.0333581281349749 0.0223360804409424
Pancake Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) rs185371399 -0.0639917990977027 0.0248161482501275 0.00991914097109
Pancake Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) All - MR Egger -0.017590726733378 0.0081441194983442 0.0368270358362065
Pancake Knee pain for 3+ months (ukb-e-3773_CSA) rs138627963 56.4607110061656 23.2139577594123 0.015007912519957
Pancake Knee pain for 3+ months (ukb-e-3773_CSA) All - Inverse variance weighted 3.76029413651914 1.7638275537973 0.0330155262692576
Pancake Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) rs56095783 3.73752159723555 1.75957477442887 0.0336613635144908
Pancake Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) All - MR Egger 2.86236397998253 1.2920821886104 0.0452071725247176