ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Courgette | Osteoprotegerin levels (ebi-a-GCST90000490) | rs12224049 | -7.7276858100176 | 2.95892802391008 | 0.0090106321767892 |
| Courgette | Osteoprotegerin levels (ebi-a-GCST90000490) | rs6877827 | -5.70297079403439 | 2.88223134939772 | 0.0478537164747782 |
| Courgette | Osteoprotegerin levels (ebi-a-GCST90000490) | All - Inverse variance weighted | -1.83324029236852 | 0.797716621005665 | 0.0215555471913697 |
| Courgette | Benign neoplasm of bone and articular cartilage (finn-b-CD2_BENIGN_BONE_CARTILAGE) | rs114874934 | 5.75802318838195 | 2.50336912904415 | 0.0214420155592428 |
| Courgette | Benign neoplasm of bone and articular cartilage (finn-b-CD2_BENIGN_BONE_CARTILAGE) | All - Inverse variance weighted | 1.41218472931661 | 0.644342551900703 | 0.0284035129369675 |
| Courgette | Benign neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_EXALLC) | rs114874934 | 5.84850640991367 | 2.51159487645613 | 0.0198801271379981 |
| Courgette | Benign neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_EXALLC) | All - Inverse variance weighted | 1.45652683663025 | 0.646056206053306 | 0.0241653998586151 |
| Courgette | Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) | All - Inverse variance weighted | -2.47395287242717 | 1.22551423756036 | 0.0435177921203015 |
| Courgette | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs114874934 | 5.81560342026577 | 2.95578523670274 | 0.0491218566527039 |
| Courgette | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | All - Inverse variance weighted | 1.5691570000673 | 0.774577907452587 | 0.0427830240545494 |
| Courgette | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs12224049 | 14.7449195216878 | 7.11833226065747 | 0.0383213511903892 |
| Courgette | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs6859913 | -12.6457608606441 | 5.92513558048651 | 0.0328217660382183 |
| Courgette | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs7969412 | 19.676178029478 | 9.99540163121082 | 0.0490078921214108 |
| Courgette | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | All - Inverse variance weighted | 0.848627360762758 | 0.404253660053542 | 0.0357953338382999 |
| Courgette | Pyogenic arthritis (finn-b-M13_PYOGARTH) | rs1287075 | -7.38399655221951 | 3.00531532825743 | 0.0140110889372632 |
| Courgette | Pyogenic arthritis (finn-b-M13_PYOGARTH) | rs77575696 | -5.15207246431208 | 2.50472294161068 | 0.0396917036186381 |
| Courgette | Pyogenic arthritis (finn-b-M13_PYOGARTH) | All - Inverse variance weighted | -1.84810108895854 | 0.672910830944819 | 0.0060248124623194 |
| Courgette | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | rs17577288 | 19.4194325333441 | 6.56552168939993 | 0.0030985342137975 |
| Courgette | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | rs77575696 | -13.0640943837656 | 6.03535637878617 | 0.0304188140356483 |
| Courgette | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | All - MR Egger | -9.62095318116413 | 3.88389921265804 | 0.0240456516614058 |
| Courgette | Spondylosis (finn-b-M13_SPONDYLOSIS) | rs6859913 | -1.68252384890746 | 0.779706173883947 | 0.0309360168022814 |
| Courgette | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs62432357 | -15.2886054405133 | 6.96937388123209 | 0.0282581197223961 |
| Courgette | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs6859913 | -11.5566975813325 | 5.87147159281029 | 0.0490358793044824 |
| Courgette | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | All - Inverse variance weighted | -4.67003069517463 | 1.91835360425144 | 0.014916701113193 |
| Courgette | Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) | rs77959176 | -3.34740882917466 | 1.53166986564299 | 0.0288548677059896 |
| Courgette | Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) | All - Inverse variance weighted | -1.05224094530399 | 0.339889417658671 | 0.0019626072645267 |
| Courgette | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | rs62432357 | 4.08869934365616 | 1.56505238034685 | 0.0089882692313032 |
| Courgette | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | rs77575696 | -4.75922381113238 | 1.56138572983523 | 0.0023031096407995 |
| Courgette | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | All - MR Egger | -3.09907916159007 | 1.14651772577592 | 0.0150791468694098 |
| Courgette | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | rs77575696 | -3.17531809480914 | 1.30866143702536 | 0.0152500308260036 |
| Courgette | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | All - MR Egger | -2.36817846568247 | 0.836436086545523 | 0.0115207567145904 |
| Courgette | Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) | rs114359626 | 21.5217094841965 | 10.5667859053574 | 0.0416769202188553 |
| Courgette | Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) | All - MR Egger | 11.3263637170124 | 4.900394302592 | 0.0336183091781996 |
| Courgette | Rheumatoid arthritis (ieu-a-833) | rs2279893 | 1.43345430414848 | 0.522145223429256 | 0.006045242102079 |
| Courgette | Rheumatoid arthritis (ieu-a-833) | rs79357024 | 2.91439448231174 | 1.32513967660881 | 0.0278558045507048 |
| Courgette | Rheumatoid arthritis (ieu-a-833) | All - Inverse variance weighted | 0.624864130466047 | 0.303033182957005 | 0.0392046862984237 |
| Courgette | Four-jointed box protein 1 (prot-a-1112) | rs77959176 | -3.63915547024952 | 1.57389635316699 | 0.0207669329896586 |
| Courgette | Four-jointed box protein 1 (prot-a-1112) | All - Inverse variance weighted | -0.978466523664815 | 0.344978703961423 | 0.0045638134143226 |
| Courgette | Four-jointed box protein 1 (prot-a-1112) | All - MR Egger | -1.74799756585495 | 0.747654123648063 | 0.0318702317312638 |
| Courgette | Heel bone mineral density (BMD) T-score automated (left) (ukb-a-361) | All - Inverse variance weighted | 0.135208400888673 | 0.0587523202254704 | 0.0213730585448554 |
| Courgette | Heel bone mineral density (BMD) T-score automated (left) (ukb-a-361) | All - MR Egger | 0.379810157937256 | 0.129523511067007 | 0.0093014980742716 |
| Courgette | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs142612411 | 0.714558851962448 | 0.258777488954292 | 0.005757410151994 |
| Courgette | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs72734891 | 0.60269804611606 | 0.267035248559498 | 0.0240081940800547 |
| Courgette | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs77575696 | -0.507252686759499 | 0.258309249458895 | 0.0495600351804124 |
| Courgette | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | All - Inverse variance weighted | 0.146168281240416 | 0.0604393023184233 | 0.0155876023176473 |
| Courgette | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | All - MR Egger | 0.301257577205713 | 0.130423050978551 | 0.0337170908322548 |
| Courgette | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs62432357 | -0.476204845793433 | 0.185030763060851 | 0.0100631351168434 |
| Courgette | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs7969412 | -0.401701880490815 | 0.19944238727946 | 0.0439964207426326 |
| Courgette | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | rs79357024 | 0.0539407908522166 | 0.0207791956247282 | 0.0094342502010549 |
| Courgette | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | All - Inverse variance weighted | 0.0155768679390717 | 0.0050553464193128 | 0.002061222957258 |
| Courgette | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | All - MR Egger | 0.029338659869784 | 0.0111255232384787 | 0.0172994019754068 |
| Courgette | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | rs77132876 | 0.0438023952616006 | 0.0183670313594057 | 0.0170866414087893 |
| Courgette | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | All - Inverse variance weighted | 0.0080936555434198 | 0.0041120519859933 | 0.0490362252679502 |
| Courgette | Heel bone mineral density (BMD) (left) (ukb-b-1096) | rs181239607 | 0.461843555127806 | 0.213292955980819 | 0.0303646044390682 |
| Courgette | Heel bone mineral density (BMD) (left) (ukb-b-1096) | All - Inverse variance weighted | 0.135676637149767 | 0.0484781667849976 | 0.0051306188359699 |
| Courgette | Heel bone mineral density (BMD) (left) (ukb-b-1096) | All - MR Egger | 0.313268905899258 | 0.106766194702425 | 0.0092661348900176 |
| Courgette | Diagnoses - main ICD10: M25.5 Pain in joint (ukb-b-13019) | rs11683704 | 0.0137739064395729 | 0.0060660998582979 | 0.0231690050803587 |
| Courgette | Diagnoses - main ICD10: M25.5 Pain in joint (ukb-b-13019) | All - Inverse variance weighted | 0.011429267280043 | 0.0046736749121029 | 0.014466902043889 |
| Courgette | Operative procedures - main OPCS: W20.5 Primary open reduction of fracture of ankle and extramedullary fixation NEC (ukb-b-13151) | All - Inverse variance weighted | -0.0095045964467269 | 0.0044357777322814 | 0.0321361900833591 |
| Courgette | Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) | rs181239607 | 0.503717178714228 | 0.213437014854922 | 0.0182735909696703 |
| Courgette | Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) | rs6877827 | 0.431796872338862 | 0.215712884795006 | 0.0453148159443234 |
| Courgette | Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) | All - Inverse variance weighted | 0.143535634106175 | 0.0484952770241405 | 0.003078529688202 |
| Courgette | Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) | All - MR Egger | 0.330360204327816 | 0.106809610767378 | 0.0066030777263105 |
| Courgette | Neck/shoulder pain for 3+ months (ukb-b-16118) | rs77575696 | 0.24846976691814 | 0.123721302656107 | 0.0446111860206027 |
| Courgette | Neck/shoulder pain for 3+ months (ukb-b-16118) | All - MR Egger | 0.168122474442024 | 0.061754997325539 | 0.0144808214535583 |
| Courgette | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs142612411 | 0.490289802143977 | 0.209290807058751 | 0.0191486367677888 |
| Courgette | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs72734891 | 0.678480616124958 | 0.222368855163312 | 0.0022796705316671 |
| Courgette | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | All - Inverse variance weighted | 0.148099613318968 | 0.0517562175151086 | 0.0042166214400796 |
| Courgette | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | All - MR Egger | 0.251689794903283 | 0.113832551275465 | 0.0410221463530554 |
| Courgette | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs116875006 | -0.353971883277115 | 0.165649221853238 | 0.0326080605115717 |
| Courgette | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs17577288 | 0.353893712114723 | 0.16119237532815 | 0.0281295948116679 |
| Courgette | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs7969412 | -0.369002638011569 | 0.163986059681986 | 0.0244357854753499 |
| Courgette | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | All - Inverse variance weighted | -0.090202522102983 | 0.0409539868222151 | 0.0276276555091518 |
| Courgette | Fractured heel (right) (ukb-b-3499) | rs142612411 | -0.0500325821535729 | 0.0253256425129075 | 0.0482034876812102 |
| Courgette | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs142612411 | 0.465298216216603 | 0.209253809008906 | 0.0261749030631675 |
| Courgette | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs72734891 | 0.69863931295802 | 0.222416510869167 | 0.0016829695384716 |
| Courgette | Heel bone mineral density (BMD) (right) (ukb-b-4657) | All - Inverse variance weighted | 0.148720123267384 | 0.0508262253813889 | 0.003432947484659 |
| Courgette | Heel bone mineral density (BMD) (ukb-b-8875) | rs116875006 | -0.348326248717891 | 0.165644694200599 | 0.0354787234876895 |
| Courgette | Heel bone mineral density (BMD) (ukb-b-8875) | rs17577288 | 0.372080660683963 | 0.16115357677327 | 0.0209514844173213 |
| Courgette | Heel bone mineral density (BMD) (ukb-b-8875) | rs7969412 | -0.385489484256637 | 0.163955565236332 | 0.0187138440428235 |
| Courgette | Heel bone mineral density (BMD) (ukb-b-8875) | All - Inverse variance weighted | -0.0911759767457777 | 0.0422000218641679 | 0.0307287990029873 |
| Courgette | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | rs77132876 | 0.0538906060779807 | 0.0217941701285546 | 0.0134093875603761 |
| Courgette | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | All - MR Egger | 0.0242367544361142 | 0.0107020222567407 | 0.0368919543868152 |
| Courgette | Other joint disorders (ukb-d-M13_OTHERJOINT) | All - Inverse variance weighted | 0.0247226907099585 | 0.0087586652675219 | 0.00476277864045 |
| Courgette | Other joint disorders (ukb-d-M13_OTHERJOINT) | All - MR Egger | 0.0414176100072146 | 0.019279360110915 | 0.0463950561682429 |
| Courgette | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | rs142612411 | 0.021428435030231 | 0.0099543133758691 | 0.0313439650622433 |
| Courgette | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | rs17577288 | 0.0228323952816926 | 0.0105342611394682 | 0.0302012020458142 |
| Courgette | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | All - Inverse variance weighted | 0.0059939461360031 | 0.0023539830727403 | 0.0108871705918991 |
| Courgette | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | rs6859913 | -1.32550049560271 | 0.648387239335072 | 0.0409235443273554 |
| Courgette | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | rs7969412 | -3.2687141508749 | 1.58958348459546 | 0.0397503583117411 |
| Courgette | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | All - Inverse variance weighted | -0.671488020125832 | 0.224727405592306 | 0.0028079920165418 |
| Courgette | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | rs7969412 | -3.13899174713812 | 1.59878022217382 | 0.0496035876374586 |
| Courgette | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | All - Inverse variance weighted | -0.639269775941158 | 0.226036997163315 | 0.0046815766156932 |
| Courgette | Pain in joint (ukb-e-745_CSA) | rs12224049 | -7.91938633733216 | 3.72904483969251 | 0.0336949274987297 |