ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Filtered coffee | Heel bone mineral density (ebi-a-GCST006979) | rs10468280 | 0.562898530534296 | 0.0550139748713528 | 1.42664069916588e-24 |
| Filtered coffee | Heel bone mineral density (ebi-a-GCST006979) | rs7610922 | -0.487304278319614 | 0.0599912332157983 | 4.55081171027756e-16 |
| Filtered coffee | Heel bone mineral density (ebi-a-GCST006979) | rs7788498 | -0.162417815618479 | 0.0594567736599658 | 0.0063009298982898 |
| Filtered coffee | Heel bone mineral density (ebi-a-GCST006979) | rs9791176 | 0.248396007674664 | 0.058332447955402 | 2.0600406358375e-05 |
| Filtered coffee | Osteoarthritis (hip) (ebi-a-GCST007091) | rs10468280 | 1.59049418511843 | 0.34538103654944 | 4.12382590278724e-06 |
| Filtered coffee | Osteoarthritis (hip) (ebi-a-GCST007091) | rs2470893 | 0.498288531431837 | 0.252195011826726 | 0.0481767024631146 |
| Filtered coffee | Osteoarthritis (hip) (ebi-a-GCST007091) | rs6968865 | 0.661927045584988 | 0.251364700855059 | 0.008455132138561 |
| Filtered coffee | Osteoarthritis (hip) (ebi-a-GCST007091) | All - Inverse variance weighted | 0.18950462663907 | 0.093390581028227 | 0.0424417834054268 |
| Filtered coffee | Shoulder impingement (ebi-a-GCST90014054) | All - Inverse variance weighted | 0.309953345055346 | 0.156869949790848 | 0.0481704290444066 |
| Filtered coffee | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) | rs10932789 | 1.03549506218288 | 0.410088912719881 | 0.0115681786526528 |
| Filtered coffee | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) | All - MR Egger | 1.97081942623947 | 0.795667512532817 | 0.0307404009873428 |
| Filtered coffee | Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) | rs78169764 | -5.79514945009856 | 1.98196430323519 | 0.0034562870290063 |
| Filtered coffee | Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) | All - Inverse variance weighted | -1.53907478781662 | 0.64882740620733 | 0.0176879450276568 |
| Filtered coffee | Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) | rs78169764 | -5.81477285904149 | 1.98285627636896 | 0.003362193499288 |
| Filtered coffee | Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) | All - Inverse variance weighted | -1.56983602478829 | 0.649499225942394 | 0.0156492557066179 |
| Filtered coffee | Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) | rs117372271 | 5.15074589444653 | 2.31525009402031 | 0.0261011228513545 |
| Filtered coffee | Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) | All - MR Egger | 3.51660429062304 | 1.48341660901432 | 0.0284909913519932 |
| Filtered coffee | Bicipital tendinitis (finn-b-M13_BICIPITALTEND) | rs4129316 | -4.13939713663406 | 1.85424098864996 | 0.0255889098410309 |
| Filtered coffee | Bicipital tendinitis (finn-b-M13_BICIPITALTEND) | All - Inverse variance weighted | -0.742253341116081 | 0.344908980356945 | 0.0313952500760148 |
| Filtered coffee | Cervical disc disorders (finn-b-M13_CERVICDISC) | All - Inverse variance weighted | -0.240701929535215 | 0.114412581581872 | 0.0353953320802544 |
| Filtered coffee | Infective bursitis (finn-b-M13_INFBURSA) | rs2830854 | 4.71955082140442 | 1.96556698942481 | 0.0163452342786186 |
| Filtered coffee | Infective bursitis (finn-b-M13_INFBURSA) | rs78169764 | -2.74281738634032 | 1.35936705586428 | 0.0436207917127066 |
| Filtered coffee | Infective bursitis (finn-b-M13_INFBURSA) | All - MR Egger | -3.79772316890162 | 1.34013813991772 | 0.0106108854714083 |
| Filtered coffee | Osteonecrosis (finn-b-M13_OSTEONECROSIS) | rs2830854 | -3.56703870086425 | 1.60694682840162 | 0.0264349617029968 |
| Filtered coffee | Osteonecrosis (finn-b-M13_OSTEONECROSIS) | All - MR Egger | 2.48418799822249 | 1.09232424222278 | 0.0347364256568842 |
| Filtered coffee | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs1215980 | -3.94914418609284 | 1.17777124843752 | 0.0007992177915188 |
| Filtered coffee | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | All - Inverse variance weighted | -0.566676310867925 | 0.284218570914516 | 0.0461734062330132 |
| Filtered coffee | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | rs76653299 | -1.37122243705898 | 0.461045250340423 | 0.0029379164157966 |
| Filtered coffee | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | All - MR Egger | -0.614485256948046 | 0.255498343346981 | 0.0265251116560173 |
| Filtered coffee | Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) | rs2830854 | -5.33550147965036 | 2.14077073221477 | 0.0126909007237142 |
| Filtered coffee | Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) | All - Inverse variance weighted | -1.19834585709136 | 0.493199918534727 | 0.0151098023373611 |
| Filtered coffee | Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) | rs74852036 | -3.07107224975933 | 1.41619393900819 | 0.0301176758815729 |
| Filtered coffee | Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) | rs7788498 | 3.413997711179 | 1.49382435061917 | 0.0222889314503051 |
| Filtered coffee | Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) | All - MR Egger | -1.99266572301734 | 0.830362497446777 | 0.026818778335573 |
| Filtered coffee | Knee and hip osteoarthritis (ieu-a-1170) | rs10468280 | 2.76624669493567 | 0.603371963766917 | 4.547568315537e-06 |
| Filtered coffee | Knee and hip osteoarthritis (ieu-a-1170) | rs3004179 | 0.989899270334596 | 0.495518779230154 | 0.0457488866260935 |
| Filtered coffee | Osteomodulin (prot-a-2147) | All - Inverse variance weighted | 0.364961016417569 | 0.157153434469154 | 0.0202155564981996 |
| Filtered coffee | Fractured bone site(s): Ankle (ukb-a-438) | All - Inverse variance weighted | -0.0037235623738147 | 0.0018410573078888 | 0.0431233800048246 |
| Filtered coffee | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs144522705 | 0.0040830519027728 | 0.0016832236276343 | 0.0152774853067691 |
| Filtered coffee | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs78169764 | 0.0041028266628609 | 0.0016252820865035 | 0.011590316222126 |
| Filtered coffee | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | All - MR Egger | 0.0025802512238788 | 0.0011346073748175 | 0.0347425504255566 |
| Filtered coffee | Non-cancer illness code self-reported: osteoporosis (ukb-a-87) | rs10468280 | -0.0242084243949302 | 0.0089493160584767 | 0.0068292340387345 |
| Filtered coffee | Non-cancer illness code self-reported: osteoporosis (ukb-a-87) | rs4129316 | -0.0211402537437387 | 0.0095481397523151 | 0.0268239354283968 |
| Filtered coffee | Non-cancer illness code self-reported: osteoporosis (ukb-a-87) | rs76653299 | 0.0190082880925236 | 0.0096033223849978 | 0.0477771769682386 |
| Filtered coffee | Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026) | rs10932789 | 0.010523732733646 | 0.004529226755446 | 0.0201514266315216 |
| Filtered coffee | Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026) | All - MR Egger | 0.0175289216441259 | 0.0077399712491049 | 0.0428438918477714 |
| Filtered coffee | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | rs10468280 | 0.0228435307809965 | 0.0065056726658482 | 0.0004458789981872 |
| Filtered coffee | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | rs2470893 | 0.0225082014224612 | 0.0047283310588326 | 1.9332017888121e-06 |
| Filtered coffee | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | rs2830854 | 0.0167115900013414 | 0.0061430812315728 | 0.0065204536782156 |
| Filtered coffee | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | All - Inverse variance weighted | 0.0059230297594718 | 0.0024561892666382 | 0.0158883051812904 |
| Filtered coffee | Operative procedures - secondary OPCS: Z66.5 Lumbar vertebra (ukb-b-17671) | All - Inverse variance weighted | 0.0026463723460739 | 0.0009480067185267 | 0.0052462375471564 |
| Filtered coffee | Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) | All - Inverse variance weighted | -0.0031390981858542 | 0.0011915506607128 | 0.0084270059187637 |
| Filtered coffee | Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) | rs10468280 | 0.0175875860187435 | 0.0068042676325726 | 0.0097439026652956 |
| Filtered coffee | Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) | rs2470893 | 0.0129426480069476 | 0.0049454221520776 | 0.0088681213813709 |
| Filtered coffee | Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) | All - Inverse variance weighted | 0.0042425641704216 | 0.0016427272466851 | 0.0098049116749898 |
| Filtered coffee | Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) | rs12535729 | 0.0101462633412102 | 0.0035060364426426 | 0.003804393864954 |
| Filtered coffee | Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) | All - Inverse variance weighted | 0.0024427761873002 | 0.0010522739477041 | 0.0202638592414792 |
| Filtered coffee | Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) | rs7610922 | -0.0091692827352366 | 0.0045378422107767 | 0.0433184775664217 |
| Filtered coffee | Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) | All - MR Egger | 0.0232194160194998 | 0.0073715004901502 | 0.0092439940258212 |
| Filtered coffee | Fractured bone site(s): Wrist (ukb-b-9571) | rs6968865 | -0.0145978583727487 | 0.0062234548402367 | 0.018995477286324 |
| Filtered coffee | Fractured bone site(s): Wrist (ukb-b-9571) | All - Inverse variance weighted | -0.0046833190464798 | 0.002032180416434 | 0.0211901981184223 |
| Filtered coffee | Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) | rs2470893 | 9.61188407978311 | 4.86492313136716 | 0.0481828146765408 |
| Filtered coffee | Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) | rs74852036 | 13.5871078614676 | 6.71896506456412 | 0.0431554374997922 |
| Filtered coffee | Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) | All - Inverse variance weighted | 2.31860211104974 | 0.747907531186127 | 0.0019344311332511 |
| Filtered coffee | Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) | All - MR Egger | 14.160166103846 | 5.606249242096 | 0.0253259150258647 |
| Filtered coffee | Knee pain for 3+ months (ukb-e-3773_AFR) | rs7788498 | -7.37936406679254 | 2.96937660081231 | 0.0129494675080407 |
| Filtered coffee | Knee pain for 3+ months (ukb-e-3773_AFR) | All - MR Egger | 13.8649649382074 | 6.12168229116121 | 0.0412562353689438 |
| Filtered coffee | Ankle spacing width (left) (ukb-e-4100_CSA) | rs10468280 | -1.17023221795575 | 0.539549031046563 | 0.0300896681232817 |
| Filtered coffee | Ankle spacing width (left) (ukb-e-4100_CSA) | All - Inverse variance weighted | -0.383084435651102 | 0.13119289975273 | 0.0035002138293927 |
| Filtered coffee | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | rs9791176 | -1.18494815851807 | 0.591536620272863 | 0.0451590904617476 |
| Filtered coffee | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | All - Inverse variance weighted | -0.278667289952827 | 0.140188811097867 | 0.0468338364360354 |
| Filtered coffee | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | rs6968865 | -1.85716619815079 | 0.812745866098024 | 0.0223098054560935 |
| Filtered coffee | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | rs78169764 | 5.27245319370981 | 2.03637466439511 | 0.0096216778426262 |
| Filtered coffee | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | All - Inverse variance weighted | -0.829133487238527 | 0.368905675287449 | 0.0246049790551709 |
| Filtered coffee | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | rs6968865 | -1.79704814052963 | 0.806671219160693 | 0.0258983212887301 |
| Filtered coffee | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | rs78169764 | 5.06729937294289 | 2.02299506738857 | 0.0122503303633545 |
| Filtered coffee | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | All - Inverse variance weighted | -0.86277820453973 | 0.353576996055265 | 0.0146814751478055 |
| Filtered coffee | Osteoarthrosis (ukb-e-740_AFR) | rs12535729 | 6.17083468658655 | 2.93142645955359 | 0.0352859043337594 |
| Filtered coffee | Osteoarthrosis (ukb-e-740_AFR) | All - Inverse variance weighted | 1.56787469479427 | 0.678468759998983 | 0.0208382783139355 |
| Filtered coffee | Osteoarthrosis (ukb-e-740_CSA) | rs10875059 | -3.15826043015507 | 1.5764578408674 | 0.0451354061307399 |
| Filtered coffee | Osteoarthrosis (ukb-e-740_CSA) | rs74852036 | -7.11478331437119 | 3.37738386016278 | 0.0351526141776272 |
| Filtered coffee | Osteoarthrosis (ukb-e-740_CSA) | All - Inverse variance weighted | -0.994703752987303 | 0.478950212086025 | 0.0378161758563396 |