ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Crumble | Total body bone mineral density (age 0-15) (ebi-a-GCST005345) | rs118130858 | 3.95721650052726 | 1.99514258104578 | 0.047319930664582 |
| Crumble | Total body bone mineral density (age 0-15) (ebi-a-GCST005345) | rs11869901 | 3.42715634466138 | 1.70743631508219 | 0.0447289842154695 |
| Crumble | Total body bone mineral density (age 0-15) (ebi-a-GCST005345) | rs147567393 | -5.77497254607523 | 2.53663739417521 | 0.0228086183368033 |
| Crumble | Total body bone mineral density (age 0-15) (ebi-a-GCST005345) | All - Inverse variance weighted | 1.01449266026773 | 0.372433491821911 | 0.0064504986482121 |
| Crumble | Osteoarthritis (self-reported) (ebi-a-GCST005811) | rs78006365 | 4.65161674439703 | 1.89683597238564 | 0.0141945038507723 |
| Crumble | Osteoarthritis (self-reported) (ebi-a-GCST005811) | All - Inverse variance weighted | 0.862780448095467 | 0.363389404005201 | 0.0175842262188487 |
| Crumble | Osteoprotegerin levels (ebi-a-GCST90010243) | rs116756799 | -18.9044609371614 | 5.83503940320274 | 0.0011960635700816 |
| Crumble | Osteoprotegerin levels (ebi-a-GCST90010243) | rs143152334 | -19.5566245794649 | 6.61611261582964 | 0.0031174939887001 |
| Crumble | Osteoprotegerin levels (ebi-a-GCST90010243) | rs150982043 | -30.4508012885862 | 12.2304978999307 | 0.0127835356635561 |
| Crumble | Osteoprotegerin levels (ebi-a-GCST90010243) | All - Inverse variance weighted | -2.97783286602361 | 1.49148056869027 | 0.0458728252147027 |
| Crumble | Spine arthritis or spondylitis (ebi-a-GCST90038657) | rs147567393 | -0.0491027039923094 | 0.0230091255793392 | 0.0328384051598371 |
| Crumble | Spine arthritis or spondylitis (ebi-a-GCST90038657) | rs192364903 | 0.0522630192706193 | 0.0205824640024595 | 0.011110587627701 |
| Crumble | Rheumatoid arthritis (ebi-a-GCST90038685) | rs72876166 | 0.0580466786965771 | 0.0260236991124872 | 0.0257121835368412 |
| Crumble | Rheumatoid arthritis (ebi-a-GCST90038685) | All - MR Egger | 0.0253932220211422 | 0.0106541935182238 | 0.026673273598439 |
| Crumble | Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) | rs114316275 | 59.8011942519978 | 30.3479986533657 | 0.0487793485965224 |
| Crumble | Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) | rs116756799 | 102.568155685356 | 46.3532597194992 | 0.0269149155605987 |
| Crumble | Other acquired deformities of ankle and foot (finn-b-M13_ANKLEFOOT) | All - MR Egger | -12.477947060908 | 5.37990738752214 | 0.0300508741464425 |
| Crumble | Chondromalacia (finn-b-M13_CHONDROMALACIA) | rs76702874 | 22.6178405411628 | 9.39246545483044 | 0.0160365152913143 |
| Crumble | Chondromalacia (finn-b-M13_CHONDROMALACIA) | All - Inverse variance weighted | 3.08555197672726 | 1.53818545470171 | 0.0448595806382246 |
| Crumble | Contracture of joint (finn-b-M13_CONTRACTUREJOINT) | All - MR Egger | -10.7249795229287 | 4.01525261603201 | 0.013954523134362 |
| Crumble | Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) | rs78978085 | -7.57758482071073 | 3.13555233960444 | 0.0156633536428976 |
| Crumble | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | rs11213675 | 20.7201787450991 | 9.9329949932336 | 0.0369790681892471 |
| Crumble | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | rs144949905 | -15.9002295163565 | 7.33407688029816 | 0.0301591965379607 |
| Crumble | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | rs78978085 | -8.9960489743413 | 4.25539246089174 | 0.034512270580193 |
| Crumble | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | All - MR Egger | -6.66302242667375 | 3.02454628004473 | 0.0383682906272337 |
| Crumble | Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) | rs144949905 | 6.91007075986198 | 2.74682225847782 | 0.0118809751067942 |
| Crumble | Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) | rs79103035 | 28.5514712302454 | 12.5016867355119 | 0.0223827277150681 |
| Crumble | Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) | All - Inverse variance weighted | 1.41784026875183 | 0.688370057444496 | 0.0394266094553012 |
| Crumble | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs114316275 | 27.5838545634956 | 13.422045821004 | 0.0398678490409834 |
| Crumble | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs144949905 | 11.488107857325 | 5.76095272331757 | 0.0461374853139775 |
| Crumble | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs72876166 | -19.4584274055336 | 9.33687243101451 | 0.0371564141617239 |
| Crumble | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | All - Inverse variance weighted | 2.8413687981269 | 1.44482129298122 | 0.0492306816079668 |
| Crumble | Bone morphogenetic protein 6 (prot-a-255) | rs11869901 | -8.79513957984783 | 3.27975177069745 | 0.00732605136859 |
| Crumble | Bone morphogenetic protein 6 (prot-a-255) | rs144949905 | -5.80704034510411 | 2.51945665766422 | 0.0211734043243815 |
| Crumble | Bone morphogenetic protein 6 (prot-a-255) | rs77190585 | -6.42962175115089 | 3.10108313657901 | 0.0381399875914009 |
| Crumble | Bone morphogenetic protein 6 (prot-a-255) | All - Inverse variance weighted | -2.1795296755386 | 0.64289374250354 | 0.0006984509417961 |
| Crumble | Bone morphogenetic protein 6 (prot-a-256) | rs143850547 | -7.83091559163428 | 3.20119744450484 | 0.0144352576567682 |
| Crumble | Bone morphogenetic protein 6 (prot-a-256) | rs79103035 | -5.78384914366753 | 2.95013348361816 | 0.049932927372746 |
| Crumble | Bone morphogenetic protein 6 (prot-a-256) | All - Inverse variance weighted | -1.35745096387016 | 0.642905948927756 | 0.0347353612430469 |
| Crumble | Bone proteoglycan II (prot-c-2666_53_2) | rs11213675 | 12.2148992484359 | 5.32240134424905 | 0.0217332517470495 |
| Crumble | Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) | rs72876166 | 0.0699523241617069 | 0.0330606301822333 | 0.0343550200518748 |
| Crumble | Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) | All - MR Egger | 0.0377376123827273 | 0.0118242005763402 | 0.0040597241093327 |
| Crumble | Fractured/broken bones in last 5 years (ukb-a-308) | rs116151876 | 0.206701352269798 | 0.0905359863132485 | 0.0224253619816089 |
| Crumble | Fractured/broken bones in last 5 years (ukb-a-308) | All - Inverse variance weighted | 0.0392923910238637 | 0.0184459942837508 | 0.0331607693279775 |
| Crumble | Diagnoses - secondary ICD10: M13.9 Arthritis, unspecified (ukb-b-11045) | rs11213675 | -0.0317294515742089 | 0.0147351221672965 | 0.0312934404380065 |
| Crumble | Diagnoses - secondary ICD10: M13.9 Arthritis, unspecified (ukb-b-11045) | All - Inverse variance weighted | -0.017312947229552 | 0.007771761926085 | 0.0259023027951916 |
| Crumble | Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) | rs11869901 | -0.0444457956530391 | 0.0218492886500935 | 0.0419315605759595 |
| Crumble | Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) | All - Inverse variance weighted | -0.0195357276568295 | 0.0097452417616085 | 0.0450012593925656 |
| Crumble | Non-cancer illness code, self-reported: bone disorder (ukb-b-14356) | rs11213675 | 0.0261075472457904 | 0.0124249076560938 | 0.0356210739623773 |
| Crumble | Ankle spacing width (ukb-b-4080) | rs11213675 | -1.05596034611729 | 0.283962850110618 | 0.0002002850564456 |
| Crumble | Ankle spacing width (ukb-b-4080) | rs114316275 | -0.65342328614207 | 0.298414603894608 | 0.0285496909741489 |
| Crumble | Ankle spacing width (ukb-b-4080) | rs116756799 | -0.733990775749757 | 0.289834713061569 | 0.0113269797233489 |
| Crumble | Ankle spacing width (ukb-b-4080) | All - Inverse variance weighted | -0.157948090364371 | 0.0657287107574681 | 0.0162598354903239 |
| Crumble | Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement (ukb-b-8136) | rs12452190 | 0.0527122035469059 | 0.0209136863389359 | 0.0117200066596943 |
| Crumble | Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement (ukb-b-8136) | rs76702874 | 0.0447153605384197 | 0.0212862412014518 | 0.0356699766043802 |
| Crumble | Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement (ukb-b-8136) | All - Inverse variance weighted | 0.0357784753390941 | 0.0092823663217358 | 0.0001159870980499 |
| Crumble | Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) | rs12452190 | -0.0734815072243987 | 0.0293167361725431 | 0.0121943552275934 |
| Crumble | Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) | All - Inverse variance weighted | -0.0260420421799496 | 0.0114287673987501 | 0.0226884968334669 |
| Crumble | Fractured/broken bones in last 5 years (ukb-e-2463_CSA) | rs192364903 | 8.76474709344432 | 4.35724695303101 | 0.0442691626604116 |
| Crumble | Fractured/broken bones in last 5 years (ukb-e-2463_CSA) | rs72876166 | 16.3310283873782 | 7.94597304884578 | 0.039854046605417 |
| Crumble | Ankle spacing width (ukb-e-3143_EAS) | rs147567393 | 4.27333934454412 | 1.78476824677307 | 0.0166503738517319 |
| Crumble | Ankle spacing width (ukb-e-3143_EAS) | All - MR Egger | 5.84299481110167 | 1.87593545575437 | 0.0207240776220051 |
| Crumble | Fractured bone site(s) (ukb-e-6151_p7_CSA) | rs192364903 | 13.3466553547727 | 6.62159645508104 | 0.0438392035507498 |
| Crumble | Fractured bone site(s) (ukb-e-6151_p7_CSA) | All - Inverse variance weighted | 7.92412785537759 | 3.45838775738929 | 0.0219473389864072 |