ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Yogurt | Heel bone mineral density (ebi-a-GCST006288) | rs113580100 | 0.319822635496005 | 0.131357499932745 | 0.0149020933903833 |
| Yogurt | Heel bone mineral density (ebi-a-GCST006288) | rs149870452 | 0.318185425808134 | 0.139891379525381 | 0.0229348751161327 |
| Yogurt | Heel bone mineral density (ebi-a-GCST006288) | rs3741434 | 0.319893888746519 | 0.135513476523448 | 0.018245116738617 |
| Yogurt | Heel bone mineral density (ebi-a-GCST006288) | All - Inverse variance weighted | 0.110950504992979 | 0.0496498191424038 | 0.025439625408553 |
| Yogurt | Menstruation quality of life impact (joint pain) (ebi-a-GCST006647) | All - Inverse variance weighted | 4.52920252995293 | 1.95283351754223 | 0.0203788932857641 |
| Yogurt | Heel bone mineral density (ebi-a-GCST006979) | rs113580100 | 0.151105600559565 | 0.0747010297205813 | 0.0430932778886599 |
| Yogurt | Heel bone mineral density (ebi-a-GCST006979) | rs149870452 | 0.171752904396872 | 0.0724840156385447 | 0.0178108065681953 |
| Yogurt | Heel bone mineral density (ebi-a-GCST006979) | All - Inverse variance weighted | 0.0572154314200244 | 0.0241830955491694 | 0.0179850048893968 |
| Yogurt | Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) | rs113580100 | 6.49599078362892 | 3.28255678338521 | 0.047822492285271 |
| Yogurt | Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) | rs150992808 | 3.82751879969346 | 1.80210628412683 | 0.0336773339536488 |
| Yogurt | Osteoprotegerin levels (ebi-a-GCST90010243) | All - Inverse variance weighted | 1.23432329986719 | 0.586834646228692 | 0.0354344940704215 |
| Yogurt | Osteopontin levels (ebi-a-GCST90010244) | All - Inverse variance weighted | 1.52928470184028 | 0.575701579647466 | 0.0078983522617013 |
| Yogurt | Ultradistal forearm bone mineral density (ebi-a-GCST90013422) | All - Inverse variance weighted | -0.340013691654827 | 0.15358602187243 | 0.0268403192151409 |
| Yogurt | Achilles tendon injury (ebi-a-GCST90018567) | All - Inverse variance weighted | -3.14604561009644 | 1.4002143706967 | 0.0246508044162052 |
| Yogurt | Rheumatoid arthritis (ebi-a-GCST90018690) | rs11521361 | -1.80327035862525 | 0.743118900983189 | 0.0152400300919097 |
| Yogurt | Rheumatoid arthritis (ebi-a-GCST90018690) | All - Inverse variance weighted | -0.776221555653626 | 0.353834167867142 | 0.028253824231859 |
| Yogurt | Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) | rs149870452 | -9.91066486491501 | 4.35595108883316 | 0.0228938667734709 |
| Yogurt | Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) | All - MR Egger | -10.3705214514181 | 3.88317268253741 | 0.0319704287936353 |
| Yogurt | Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) | rs149870452 | -9.84057383934931 | 4.34667433544946 | 0.0235783155757198 |
| Yogurt | Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) | All - MR Egger | -10.3583950778708 | 3.87965828097048 | 0.0320031874486725 |
| Yogurt | Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) | All - Inverse variance weighted | -1.39307865960749 | 0.623146324244689 | 0.0253808531433001 |
| Yogurt | Chondromalacia (finn-b-M13_CHONDROMALACIA) | rs149870452 | 7.84194886035085 | 3.18914166323942 | 0.0139342931565605 |
| Yogurt | Chondromalacia (finn-b-M13_CHONDROMALACIA) | rs392542 | 5.71870677668578 | 2.66410717739669 | 0.0318271046836942 |
| Yogurt | Chondromalacia (finn-b-M13_CHONDROMALACIA) | All - Inverse variance weighted | 2.26149557759866 | 1.08587966493505 | 0.0372841215075543 |
| Yogurt | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | rs2819017 | 1.07168287776821 | 0.493885174094524 | 0.0300142016463486 |
| Yogurt | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | All - Inverse variance weighted | 0.380470137922109 | 0.180762561120193 | 0.0353081916007585 |
| Yogurt | Peroneal tendinitis (finn-b-M13_PERONEALTEND) | rs150992808 | 16.6053980266309 | 7.59471692690871 | 0.0287833803017912 |
| Yogurt | Peroneal tendinitis (finn-b-M13_PERONEALTEND) | All - MR Egger | 13.7064725629573 | 5.21304412670251 | 0.0339488745639147 |
| Yogurt | Other shoulder lesions (finn-b-M13_SHOULDERNAS) | All - Inverse variance weighted | -1.28012877848041 | 0.613433222131109 | 0.0369038097787671 |
| Yogurt | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | rs149870452 | -11.1784878273534 | 4.37347384522459 | 0.0105890864421005 |
| Yogurt | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | rs150992808 | -13.2510896637609 | 5.68032139093783 | 0.0196583126110329 |
| Yogurt | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | All - Inverse variance weighted | -3.13235354269523 | 1.43099973777558 | 0.0286021676316195 |
| Yogurt | Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) | rs149870452 | -6.7606917159623 | 3.06029786624365 | 0.0271634212698923 |
| Yogurt | Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) | All - Inverse variance weighted | -2.25486718716954 | 0.90390164992914 | 0.0126101496535852 |
| Yogurt | Hip osteoarthritis (ieu-a-1169) | All - Inverse variance weighted | -1.56749875023687 | 0.793699049592792 | 0.0482762802251514 |
| Yogurt | Osteomyelitis (ieu-b-4975) | rs2819017 | 1.69686718564568 | 0.852493760504051 | 0.0465386781652928 |
| Yogurt | Osteomyelitis (ieu-b-4975) | All - Inverse variance weighted | 0.534300808049632 | 0.262559097557153 | 0.0418535385877274 |
| Yogurt | Psoriatic arthritis (ieu-b-5116) | rs2819017 | -3.1095106461025 | 0.929487102644204 | 0.0008216254950075 |
| Yogurt | Psoriatic arthritis (ieu-b-5116) | All - Inverse variance weighted | -0.933957534082578 | 0.333079062711647 | 0.0050471099283087 |
| Yogurt | Bone sialoprotein 2 (prot-a-1396) | rs2819017 | 2.45264336455679 | 1.0189378591756 | 0.0160815793524475 |
| Yogurt | Bone sialoprotein 2 (prot-a-1396) | All - Inverse variance weighted | 0.72026311835847 | 0.363088664723589 | 0.0472880235290995 |
| Yogurt | Bone morphogenetic protein 6 (prot-a-256) | rs11521361 | -2.03861741334345 | 0.933601067672303 | 0.0289911713036544 |
| Yogurt | Bone morphogenetic protein 6 (prot-a-256) | All - Inverse variance weighted | -0.646306075512443 | 0.308338277982136 | 0.0360738356008738 |
| Yogurt | Fractured bone site(s): Other bones (ukb-a-441) | rs11678849 | -0.0518140511824806 | 0.0219151746563354 | 0.0180641696586513 |
| Yogurt | Fractured bone site(s): Other bones (ukb-a-441) | All - MR Egger | 0.0408911585816018 | 0.016995675036513 | 0.0427760621085712 |
| Yogurt | Heel bone mineral density (BMD) (left) (ukb-b-1096) | rs113580100 | 0.348307298878496 | 0.139559342257473 | 0.0125685894519073 |
| Yogurt | Heel bone mineral density (BMD) (left) (ukb-b-1096) | rs3741434 | 0.31938980397016 | 0.139428159471021 | 0.021980057059875 |
| Yogurt | Heel bone mineral density (BMD) (left) (ukb-b-1096) | All - Inverse variance weighted | 0.083311736510719 | 0.0423777374608541 | 0.0493065032580155 |
| Yogurt | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | rs3741434 | -0.0225802381870971 | 0.0105916096637839 | 0.0330151804477396 |
| Yogurt | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | rs392542 | -0.0265852350070982 | 0.0101203592530281 | 0.008616506900119 |
| Yogurt | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | rs7157038 | 0.0253796482450621 | 0.0107650516429043 | 0.0183936731192039 |
| Yogurt | Fractured/broken bones in last 5 years (ukb-b-13346) | rs11678849 | -0.0535449154958551 | 0.0249791942602865 | 0.0320665089159794 |
| Yogurt | Fractured/broken bones in last 5 years (ukb-b-13346) | All - Inverse variance weighted | -0.0176984251831235 | 0.0077840769336666 | 0.0229858121782835 |
| Yogurt | Fractured bone site(s): Ankle (ukb-b-15582) | rs2819017 | -0.0233952447968238 | 0.0099319589260155 | 0.0184952128078718 |
| Yogurt | Fractured bone site(s): Ankle (ukb-b-15582) | rs3741434 | -0.0202611947654035 | 0.0099165021585529 | 0.0410346638904167 |
| Yogurt | Fractured bone site(s): Ankle (ukb-b-15582) | All - Inverse variance weighted | -0.0086893080536839 | 0.0042510171985135 | 0.0409482280057056 |
| Yogurt | Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) | rs11678849 | -0.0114925637074276 | 0.0041868438432694 | 0.006052510824442 |
| Yogurt | Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) | rs392542 | -0.0082810669566772 | 0.0039830956925401 | 0.0376124814660867 |
| Yogurt | Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) | All - Inverse variance weighted | -0.0071636430567635 | 0.0028993867752484 | 0.0134832226577411 |
| Yogurt | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | All - Inverse variance weighted | 0.0865061836686092 | 0.0410814064177222 | 0.0352281641146627 |
| Yogurt | Heel bone mineral density (BMD) (right) (ukb-b-4657) | All - Inverse variance weighted | 0.08556094636213 | 0.041086689206298 | 0.0373014511222324 |
| Yogurt | Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement (ukb-b-8136) | rs11521361 | -0.0121231924871132 | 0.0059431513474465 | 0.0413643424987065 |
| Yogurt | Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement (ukb-b-8136) | All - Inverse variance weighted | -0.0057370018402323 | 0.0027721465586529 | 0.0384976852967557 |
| Yogurt | Fractured bone site(s): Wrist (ukb-b-9571) | All - Inverse variance weighted | -0.0102608234272351 | 0.0043786365200783 | 0.0191097426332267 |
| Yogurt | Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) | All - MR Egger | 8.83548483947764 | 3.59978237217773 | 0.049490865764165 |
| Yogurt | Osteoarthrosis (ukb-e-740_CSA) | All - Inverse variance weighted | -1.96938467493688 | 0.996826148844262 | 0.0481938523391071 |