ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Soft cheese | Rheumatoid Arthritis (bbj-a-73) | rs62224239 | 4.91039581912843 | 2.21064372337197 | 0.0263339277508219 |
| Soft cheese | Rheumatoid Arthritis (bbj-a-73) | All - Inverse variance weighted | 1.79110641308608 | 0.667167736525099 | 0.0072607569527657 |
| Soft cheese | Rheumatoid Arthritis (bbj-a-74) | rs115801985 | -4.4570249072994 | 2.19086071208856 | 0.0419141386825373 |
| Soft cheese | Rheumatoid Arthritis (bbj-a-74) | rs62224239 | 4.91039581912843 | 2.20906722579781 | 0.0262268098259301 |
| Soft cheese | Rheumatoid Arthritis (bbj-a-74) | All - Inverse variance weighted | 1.25640349344806 | 0.637827550007349 | 0.0488593578860474 |
| Soft cheese | Rheumatoid arthritis (ebi-a-GCST002318) | rs17713345 | 4.24877022822478 | 2.0716309467939 | 0.0402737561085304 |
| Soft cheese | Rheumatoid arthritis (ebi-a-GCST002318) | rs62224239 | 4.81690951298049 | 2.18968418812346 | 0.0278197189024643 |
| Soft cheese | Rheumatoid arthritis (ebi-a-GCST002318) | All - Inverse variance weighted | 1.52049152881817 | 0.592475999632786 | 0.0102779694125708 |
| Soft cheese | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | rs6029122 | 3.0526867943349 | 1.21247560000344 | 0.0118113658561585 |
| Soft cheese | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | All - Inverse variance weighted | 0.766878900058294 | 0.330267788697385 | 0.0202334093036847 |
| Soft cheese | Osteoprotegerin levels (ebi-a-GCST90000490) | All - Inverse variance weighted | -4.0729315135215 | 1.7889129147732 | 0.0228003561070334 |
| Soft cheese | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | rs17713345 | 0.0415438633084772 | 0.0165634179833481 | 0.0121358364345476 |
| Soft cheese | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | All - Inverse variance weighted | 0.0101759345217085 | 0.0051049221925597 | 0.0462223231482104 |
| Soft cheese | Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) | All - Inverse variance weighted | -8.52925890488027 | 3.34126309702979 | 0.0106889996433139 |
| Soft cheese | Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) | All - Inverse variance weighted | -8.53657599048356 | 3.34469510295308 | 0.0107022533273489 |
| Soft cheese | Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) | rs117772192 | 48.1264087513751 | 20.3039697620092 | 0.0177738719910208 |
| Soft cheese | Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) | All - Inverse variance weighted | -7.99352852021007 | 3.32459609597406 | 0.0162007749702241 |
| Soft cheese | Bicipital tendinitis (finn-b-M13_BICIPITALTEND) | rs140800890 | 4.88479760061097 | 2.45957000044155 | 0.047029189698417 |
| Soft cheese | Bicipital tendinitis (finn-b-M13_BICIPITALTEND) | All - Inverse variance weighted | 2.82018515267042 | 1.41639561311512 | 0.0464699063098649 |
| Soft cheese | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | rs117772192 | 5.88502280927141 | 2.53607301018276 | 0.0203124517838971 |
| Soft cheese | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | rs140800890 | 1.08750934195055 | 0.528218823233124 | 0.039511146777562 |
| Soft cheese | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | All - MR Egger | 1.09488245183674 | 0.509258416078238 | 0.0495211975405127 |
| Soft cheese | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | rs2284636 | -9.01534681451989 | 3.14328183954525 | 0.0041290339818925 |
| Soft cheese | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | rs6029122 | -6.38054535604647 | 3.22466914894532 | 0.0478535482890884 |
| Soft cheese | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | All - Inverse variance weighted | -2.45039581105259 | 0.700573200794312 | 0.0004692863688638 |
| Soft cheese | Seronegative rheumatoid arthritis (finn-b-RHEUMA_SERONEG) | rs6029122 | -8.0831706666896 | 3.98999062696167 | 0.0427789212015214 |
| Soft cheese | Seronegative rheumatoid arthritis (finn-b-RHEUMA_SERONEG) | rs79474565 | -10.5452530298528 | 4.88310269775361 | 0.0308083383558928 |
| Soft cheese | Seronegative rheumatoid arthritis (finn-b-RHEUMA_SERONEG) | All - Inverse variance weighted | -2.27598538351091 | 0.925538936208413 | 0.0139288922861554 |
| Soft cheese | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs115966909 | 21.2772636522307 | 8.18275802893892 | 0.0093154305466652 |
| Soft cheese | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | All - Inverse variance weighted | 3.38515638880554 | 1.69869912952759 | 0.0462840763961374 |
| Soft cheese | Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) | rs117772192 | -18.4756380569937 | 8.28262469453013 | 0.0257043117809233 |
| Soft cheese | Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) | rs140800890 | 3.92811645017327 | 1.73837959472697 | 0.0238434463191616 |
| Soft cheese | Rheumatoid arthritis (ieu-a-832) | rs62224239 | 4.81690951298049 | 2.16371927307697 | 0.0259996224512677 |
| Soft cheese | Rheumatoid arthritis (ieu-a-832) | All - Inverse variance weighted | 3.6908072625116 | 1.116997959655 | 0.0009524098050144 |
| Soft cheese | Rheumatoid arthritis (ieu-a-833) | rs17713345 | 4.24877022822478 | 2.11968156298343 | 0.0450231644048622 |
| Soft cheese | Rheumatoid arthritis (ieu-a-833) | rs62224239 | 4.81690951298049 | 2.22359859218767 | 0.0302907465649204 |
| Soft cheese | Rheumatoid arthritis (ieu-a-833) | All - Inverse variance weighted | 2.47910827093296 | 0.818113639177665 | 0.0024433218497427 |
| Soft cheese | Alkaline phosphatase, bone (prot-c-2795_23_3) | All - Inverse variance weighted | 5.47342883158481 | 2.74266615699724 | 0.0459709561694568 |
| Soft cheese | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs114909308 | -0.0139326557682656 | 0.0059991993499199 | 0.0202103743890645 |
| Soft cheese | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs62224239 | -0.0119285688949146 | 0.0059038257654881 | 0.0433334995512845 |
| Soft cheese | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | All - Inverse variance weighted | -0.0042487597611554 | 0.0014508852420174 | 0.0034072091474939 |
| Soft cheese | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | All - MR Egger | -0.006538245578162 | 0.0026534143490754 | 0.0272935091579947 |
| Soft cheese | Operation code: knee replacement/revision (ukb-b-11120) | rs12468108 | -0.0597291125206374 | 0.0265585018136828 | 0.024514791242234 |
| Soft cheese | Operation code: knee replacement/revision (ukb-b-11120) | rs9645975 | -0.0770887945468796 | 0.0266762441492395 | 0.0038549691160174 |
| Soft cheese | Operation code: knee replacement/revision (ukb-b-11120) | All - Inverse variance weighted | -0.0425530578780802 | 0.011622759792343 | 0.0002510527356015 |
| Soft cheese | Operation code: bone surgery/joint surgery (ukb-b-12974) | rs11691751 | 0.0416354312619578 | 0.01980302643892 | 0.0355114078605852 |
| Soft cheese | Operation code: bone surgery/joint surgery (ukb-b-12974) | All - Inverse variance weighted | 0.0211197748482124 | 0.0095069015471122 | 0.0263157408210783 |
| Soft cheese | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | rs12468108 | -0.0676034682916836 | 0.0254587432363492 | 0.007921145024762 |
| Soft cheese | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | All - Inverse variance weighted | -0.0311260158274361 | 0.0112169686046 | 0.005521793219559 |
| Soft cheese | Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint (ukb-b-19054) | All - Inverse variance weighted | -0.016823235936215 | 0.0074024682156242 | 0.023047145178719 |
| Soft cheese | Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) | rs2284636 | -0.0284632805960491 | 0.0142255955252562 | 0.0454085739889833 |
| Soft cheese | Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) | All - Inverse variance weighted | -0.0150709198003831 | 0.0069598727875714 | 0.0303569422017346 |
| Soft cheese | Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint (ukb-b-7012) | rs12468108 | -0.0281706307920351 | 0.0122384420404835 | 0.0213456011646706 |
| Soft cheese | Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint (ukb-b-7012) | All - Inverse variance weighted | -0.0163261489263258 | 0.0068149939933264 | 0.0165921955802838 |
| Soft cheese | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | rs143439425 | 0.0610248934269762 | 0.0298834642282082 | 0.0411420405932021 |
| Soft cheese | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | rs2284636 | -0.0856307115906503 | 0.0305398039651407 | 0.0050487765701842 |
| Soft cheese | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | rs6029122 | 0.0630716048533421 | 0.0298857177253614 | 0.0348216526119019 |
| Soft cheese | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | rs79571040 | 0.0598948287086586 | 0.0299161733613091 | 0.0452752067393934 |
| Soft cheese | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | All - MR Egger | 0.0334152219381694 | 0.0156357462695507 | 0.0494681709974768 |
| Soft cheese | Osteoarthrosis (ukb-e-740_CSA) | All - Inverse variance weighted | 3.84955917203159 | 1.62611092874078 | 0.0179164136161222 |
| Soft cheese | Pain in joint (ukb-e-745_AFR) | All - MR Egger | 11.9595282588675 | 4.80229328367281 | 0.0415735271896175 |
| Soft cheese | Internal derangement of knee (ukb-e-835_CSA) | rs112482846 | -17.3592683558989 | 6.5536946299199 | 0.0080783881160585 |
| Soft cheese | Internal derangement of knee (ukb-e-835_CSA) | rs9645975 | -25.2365994160825 | 10.6185132872459 | 0.0174701667140575 |
| Soft cheese | Internal derangement of knee (ukb-e-835_CSA) | All - Inverse variance weighted | -4.93153896990318 | 1.94297916457995 | 0.0111445715200445 |
| Soft cheese | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | rs112482846 | -14.5791935623218 | 5.61877491576466 | 0.009466575550914 |
| Soft cheese | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | rs2284636 | 16.1654494605184 | 7.16276788417985 | 0.0240160812602914 |
| Soft cheese | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | rs9645975 | -20.7937489799578 | 9.0337958867869 | 0.0213479674545211 |
| Soft cheese | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | All - MR Egger | -8.30535183216567 | 3.63529920812089 | 0.0431825901931865 |