ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Onion | Osteoarthritis (hip) (ebi-a-GCST007091) | All - Inverse variance weighted | -0.278115630510072 | 0.121906602733449 | 0.0225258030754718 |
| Onion | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | rs11961853 | -0.947934268706982 | 0.294389524443162 | 0.0012819059673201 |
| Onion | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | All - Inverse variance weighted | -0.191880568183062 | 0.082890000204172 | 0.0206193915387749 |
| Onion | Osteopontin levels (ebi-a-GCST90010244) | All - MR Egger | -2.10192524445325 | 0.84005258965047 | 0.0293945954362136 |
| Onion | Compression fracture (ebi-a-GCST90018608) | All - Inverse variance weighted | -0.819964649349331 | 0.314874762003057 | 0.0092116488839189 |
| Onion | Compression fracture (ebi-a-GCST90018828) | rs113181638 | 3.08188236470489 | 1.37012228728286 | 0.0244903392214374 |
| Onion | Compression fracture (ebi-a-GCST90018828) | rs4378921 | -1.71034249185047 | 0.733810310034856 | 0.0197655314031897 |
| Onion | Compression fracture (ebi-a-GCST90018828) | All - MR Egger | 1.61879802572296 | 0.65708014832971 | 0.0298398863196727 |
| Onion | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | rs11961853 | -1.05980228799538 | 0.47102323910906 | 0.0244489453100894 |
| Onion | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | rs1467978 | -1.05154332570935 | 0.467352589204155 | 0.0244489453100894 |
| Onion | Benign neoplasm: Skin of upper limb, including shoulder (finn-b-CD2_BENIGN_SKIN_UPPERLIMB) | rs9640159 | -9.24467274735881 | 3.5854015530093 | 0.009925314480646 |
| Onion | Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) | rs144108770 | 10.4847829150328 | 4.06790477865264 | 0.0099534988519446 |
| Onion | Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) | All - MR Egger | 3.01217885388694 | 1.336120942464 | 0.0455355402898776 |
| Onion | Cervicalgia (finn-b-M13_CERVICALGIA) | All - Inverse variance weighted | 0.618245129495013 | 0.292553722856698 | 0.0345776287801395 |
| Onion | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs113181638 | -1.53320374111236 | 0.643993186290206 | 0.0172761977418935 |
| Onion | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs4378921 | -1.71598718654305 | 0.677363363109098 | 0.0112983455111213 |
| Onion | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -0.48342869211438 | 0.228398938573321 | 0.0342939965509246 |
| Onion | Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) | rs4378921 | -16.6264482169821 | 5.53744549341688 | 0.0026772937930413 |
| Onion | Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) | All - Inverse variance weighted | -3.60306951067372 | 1.81292739709782 | 0.0468745696427932 |
| Onion | Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) | rs6890703 | 14.5300454738543 | 5.11145620791231 | 0.0044741147702703 |
| Onion | Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) | All - Inverse variance weighted | 3.02628607000117 | 1.47358043578406 | 0.0400051355563117 |
| Onion | Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) | rs4378921 | 1.44504184129941 | 0.623738763529628 | 0.0205177857632471 |
| Onion | Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) | All - Inverse variance weighted | 0.42417263674531 | 0.202346925760719 | 0.0360587517508241 |
| Onion | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | All - Inverse variance weighted | 0.0248501091278758 | 0.0106085247890891 | 0.0191567769147323 |
| Onion | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | All - Inverse variance weighted | -0.0089968702055931 | 0.0036573319496953 | 0.0138954629070297 |
| Onion | Diagnoses - main ICD10: M51.2 Other specified intervertebral disk displacement (ukb-b-12872) | rs1467978 | -0.0083656467522535 | 0.0042517047747856 | 0.0491142845670747 |
| Onion | Diagnoses - main ICD10: M51.2 Other specified intervertebral disk displacement (ukb-b-12872) | rs7511986 | -0.0096580555297613 | 0.0046628284891819 | 0.0383319934998437 |
| Onion | Diagnoses - main ICD10: M51.2 Other specified intervertebral disk displacement (ukb-b-12872) | All - Inverse variance weighted | -0.0065754972494498 | 0.0021105006418585 | 0.0018356476867612 |
| Onion | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs11961853 | 0.0737021837814923 | 0.0340900125409937 | 0.0306191333881182 |
| Onion | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | All - Inverse variance weighted | 0.023344768481947 | 0.009919957751291 | 0.0186069493663043 |
| Onion | Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) | rs1467978 | -0.0150026200069395 | 0.0068268883522988 | 0.0279791886995616 |
| Onion | Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) | rs783494 | 0.0085178790917324 | 0.0040982420106093 | 0.0376704467328848 |
| Onion | Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) | rs9640159 | 0.0091174887033927 | 0.0040627106273854 | 0.0248202719302025 |
| Onion | Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) | rs1467978 | -0.0133141671564427 | 0.0052269492497574 | 0.0108586293764952 |
| Onion | Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) | All - Inverse variance weighted | -0.0045200827531732 | 0.0022758427002832 | 0.0470206815176454 |
| Onion | Non-cancer illness code, self-reported: joint disorder (ukb-b-8201) | rs6890703 | -0.0111957255969749 | 0.0055417865026915 | 0.0433587453878661 |
| Onion | Non-cancer illness code, self-reported: joint disorder (ukb-b-8201) | All - Inverse variance weighted | -0.0050210859635749 | 0.0024452705859241 | 0.0400350935441776 |
| Onion | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | All - Inverse variance weighted | -0.0072017146146162 | 0.0035866854732606 | 0.0446536568532916 |
| Onion | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | All - Inverse variance weighted | -0.006985261865097 | 0.0035113152438592 | 0.0466617398784038 |
| Onion | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | rs188458079 | 0.0201815640133802 | 0.0094809366106941 | 0.0332835053252534 |
| Onion | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | rs9640159 | -0.0240377444274724 | 0.0110533662493669 | 0.0296526805793013 |
| Onion | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | All - MR Egger | 0.0141075525416649 | 0.0058563054217492 | 0.0329758257486812 |
| Onion | Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) | rs7511986 | -5.49726065558548 | 2.68957191939827 | 0.040961788305996 |
| Onion | Neck/shoulder pain for 3+ months (ukb-e-3404_AFR) | All - Inverse variance weighted | -2.30552261891119 | 1.06080624803381 | 0.0297526124707508 |