ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
Intake (exposure) | Outcome | SNP | b | se | P-value |
---|---|---|---|---|---|
Cappuccino | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | All - Inverse variance weighted | 0.338761559805611 | 0.170156374325752 | 0.0464936696235953 |
Cappuccino | Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (ebi-a-GCST005528) | rs62626322 | 10.2636580767787 | 3.55956210539355 | 0.0039340167301526 |
Cappuccino | Bone mineral density (ebi-a-GCST90014022) | rs55678878 | -0.289062801712877 | 0.143161932022551 | 0.0434735281023489 |
Cappuccino | Bone mineral density (ebi-a-GCST90014022) | rs7145645 | 1.05345105141362 | 0.144957993761948 | 3.66784486853717e-13 |
Cappuccino | Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) | rs115619469 | -15.4158271478632 | 6.60653450117794 | 0.0196260537626727 |
Cappuccino | Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) | rs13084063 | 21.5182996098059 | 10.0539466679838 | 0.0323318349239398 |
Cappuccino | Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) | All - MR Egger | -9.57412052617993 | 3.85902860651871 | 0.0226293451942522 |
Cappuccino | Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) | rs115619469 | -15.4454060487112 | 6.60131469514593 | 0.0192968085521949 |
Cappuccino | Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) | rs13084063 | 21.6061070042861 | 10.0649225922938 | 0.031819249110266 |
Cappuccino | Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) | All - MR Egger | -9.56481428615111 | 3.86463991845838 | 0.0229170590983839 |
Cappuccino | Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) | All - Inverse variance weighted | -3.81350934674153 | 1.76504724637239 | 0.0307285175675815 |
Cappuccino | Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) | All - Inverse variance weighted | -3.86780510273181 | 1.767569277438 | 0.0286546247919473 |
Cappuccino | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | rs17815776 | 12.6432410430711 | 6.06833975572147 | 0.0372078450655553 |
Cappuccino | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | All - MR Egger | 8.7283411570587 | 3.45961240321365 | 0.020713301852852 |
Cappuccino | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | rs11586839 | -21.0880893219333 | 9.12719375476903 | 0.0208622568347533 |
Cappuccino | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | rs62555921 | -11.1604262391241 | 5.68579528790693 | 0.0496623190253659 |
Cappuccino | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | All - Inverse variance weighted | -4.73408288962078 | 1.46720015245323 | 0.0012526601051719 |
Cappuccino | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | rs78001300 | 12.8391320815973 | 6.33948379416698 | 0.0428402019222263 |
Cappuccino | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | All - Inverse variance weighted | 3.63095847839201 | 1.73673991807366 | 0.0365572204191242 |
Cappuccino | Other juvenile arthritis (finn-b-M13_JUVEARTH) | rs115619469 | 6.64133320805799 | 2.95441021411644 | 0.0245800957287863 |
Cappuccino | Other juvenile arthritis (finn-b-M13_JUVEARTH) | rs62626322 | 7.2969530865918 | 3.13168968013409 | 0.019804191265879 |
Cappuccino | Other juvenile arthritis (finn-b-M13_JUVEARTH) | All - Inverse variance weighted | 1.59276581495462 | 0.769421014973333 | 0.0384445175604844 |
Cappuccino | Recurrent dislocation and subluxation of joint (finn-b-M13_RECUDISLOCATIO) | rs855066 | -5.83128452921036 | 2.81627763046576 | 0.0383995110674024 |
Cappuccino | Recurrent dislocation and subluxation of joint (finn-b-M13_RECUDISLOCATIO) | All - Inverse variance weighted | -1.10077004124229 | 0.559860490378438 | 0.0492812164317203 |
Cappuccino | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | rs1482868 | 11.1197195620698 | 5.1629537429827 | 0.0312596620849598 |
Cappuccino | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | rs7145645 | 12.2874534661435 | 6.22547539993963 | 0.0484116131596806 |
Cappuccino | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | rs73056156 | 15.069873893537 | 5.00939735661453 | 0.0026269574028259 |
Cappuccino | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | All - Inverse variance weighted | 3.10070119239063 | 1.34840522974225 | 0.0214747392709793 |
Cappuccino | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | rs185911612 | -0.858121764954559 | 0.368066933497666 | 0.0197307724209959 |
Cappuccino | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | All - Inverse variance weighted | -0.19919637660719 | 0.0952841701425234 | 0.0365683703174197 |
Cappuccino | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | rs62555921 | -9.23257405415974 | 4.34842115553818 | 0.033736975457938 |
Cappuccino | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | All - Inverse variance weighted | -2.71802832863918 | 1.12251393545018 | 0.0154618741732781 |
Cappuccino | Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) | All - Inverse variance weighted | -0.443674177771811 | 0.199918555723206 | 0.0264680468435588 |
Cappuccino | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | rs7145645 | -5.5086024750981 | 2.11288862058557 | 0.0091301259769146 |
Cappuccino | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | All - Inverse variance weighted | -0.993183803600779 | 0.37077219680975 | 0.0073910769692246 |
Cappuccino | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | All - MR Egger | -1.95955054310592 | 0.825424363560493 | 0.0282921725711301 |
Cappuccino | Fracture of neck (finn-b-ST19_FRACT_NECK) | rs13084063 | -10.169193873239 | 4.37390583754534 | 0.0200736375402664 |
Cappuccino | Fracture of neck (finn-b-ST19_FRACT_NECK) | rs7145645 | -9.15585068920415 | 4.31381426702888 | 0.0338000528329359 |
Cappuccino | Fracture of neck (finn-b-ST19_FRACT_NECK) | All - Inverse variance weighted | -1.63152730162958 | 0.755551455233273 | 0.0308202262519486 |
Cappuccino | Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) | rs185911612 | -2.19367892364609 | 0.999038819493666 | 0.0281070154410939 |
Cappuccino | Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) | rs7145645 | -3.96795452258779 | 1.47147600362209 | 0.0070055316014797 |
Cappuccino | Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) | All - Inverse variance weighted | -0.807118379632563 | 0.26725230814578 | 0.0025272344760089 |
Cappuccino | Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) | All - MR Egger | -1.34413154720522 | 0.594560007891389 | 0.035706190850922 |
Cappuccino | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs6797227 | -1.4336570027565 | 0.664884407075478 | 0.0310641492060577 |
Cappuccino | Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) | rs73056156 | -16.6083121134958 | 8.24921183460652 | 0.0440808616808104 |
Cappuccino | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | All - Inverse variance weighted | -4.75427962554994 | 1.98350118956434 | 0.0165338525779911 |
Cappuccino | Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) | rs62626322 | 10.6802618386773 | 4.72269642739628 | 0.0237298337307438 |
Cappuccino | Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) | rs7649045 | -12.3923322444238 | 5.34669173448928 | 0.0204625307563197 |
Cappuccino | Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -2.45835066359274 | 1.17178261336399 | 0.0359088590456529 |
Cappuccino | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | rs17815776 | 3.43600241248073 | 1.52859770101283 | 0.0245880903454385 |
Cappuccino | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | All - Inverse variance weighted | 0.770174314145274 | 0.384100056251539 | 0.044948102488653 |
Cappuccino | Knee and hip osteoarthritis (ieu-a-1170) | All - Inverse variance weighted | 1.31730108644416 | 0.538224278642 | 0.0143853228228379 |
Cappuccino | Knee osteoarthritis (ieu-a-1171) | rs11653897 | 4.15823129329659 | 1.88870234868757 | 0.0276911727374648 |
Cappuccino | Knee osteoarthritis (ieu-a-1171) | All - Inverse variance weighted | 1.53399220936178 | 0.696278912381025 | 0.0275856632616074 |
Cappuccino | Femoral neck bone mineral density (ieu-a-980) | rs115619469 | -1.82903743296899 | 0.5719341469271 | 0.0013839096679094 |
Cappuccino | Femoral neck bone mineral density (ieu-a-980) | rs11586839 | -1.31964417313951 | 0.548479453216203 | 0.0161280547369957 |
Cappuccino | Femoral neck bone mineral density (ieu-a-980) | All - MR Egger | -0.752471055281433 | 0.289401360567245 | 0.0180957543816878 |
Cappuccino | Psoriatic arthritis (ieu-b-5116) | rs115241046 | -3.76294333213035 | 1.36826304836905 | 0.0059566035248516 |
Cappuccino | Psoriatic arthritis (ieu-b-5116) | All - MR Egger | -1.92088082972199 | 0.859804879994697 | 0.0391985022924258 |
Cappuccino | Osteocrin (prot-a-2157) | rs6797227 | -4.5503026609228 | 1.72454393085202 | 0.0083260385626392 |
Cappuccino | Osteocrin (prot-a-2157) | rs73056156 | -4.42206256820662 | 1.89462834970292 | 0.0195957219200614 |
Cappuccino | Osteocrin (prot-a-2157) | All - MR Egger | 1.9227200773489 | 0.905277239573505 | 0.0477942238962049 |
Cappuccino | Osteocalcin (prot-a-246) | rs142375406 | 3.80530073946078 | 1.60883541280207 | 0.0180178194625014 |
Cappuccino | Osteocalcin (prot-a-246) | rs73056156 | 3.95977325087911 | 1.89462834970292 | 0.036617799703318 |
Cappuccino | Osteocalcin (prot-a-246) | All - Inverse variance weighted | 0.803071493878948 | 0.383263334217045 | 0.0361397362925495 |
Cappuccino | Osteocalcin (prot-a-246) | All - MR Egger | 2.14298506531025 | 0.905184662267253 | 0.0293171544564154 |
Cappuccino | Neck/shoulder pain for 3+ months (ukb-a-341) | All - Inverse variance weighted | -0.0690751601088532 | 0.034906415281847 | 0.0478309605619223 |
Cappuccino | Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) | All - Inverse variance weighted | -0.0106316605405812 | 0.0038801859754992 | 0.0061441546605073 |
Cappuccino | Neck/shoulder pain for 3+ months (ukb-b-16118) | All - Inverse variance weighted | -0.0604790292954697 | 0.0295433975172338 | 0.0406458074223072 |
Cappuccino | Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint (ukb-b-19054) | All - Inverse variance weighted | -0.0065926909703075 | 0.0033167730807767 | 0.0468468435556594 |
Cappuccino | Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) | rs13084063 | -0.0276338651168662 | 0.0125405972000417 | 0.0275558264274582 |
Cappuccino | Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) | rs855066 | -0.0231847216938547 | 0.0116041994333377 | 0.0457210399115619 |
Cappuccino | Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) | All - Inverse variance weighted | -0.0084952785637983 | 0.0042748166143474 | 0.0468908325951582 |
Cappuccino | Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) | rs55678878 | 0.0203102412945778 | 0.0094902637846106 | 0.0323455983183411 |
Cappuccino | Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) | rs855066 | -0.0185828331980082 | 0.0086980393938189 | 0.0326436235835051 |
Cappuccino | Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) | All - Inverse variance weighted | -0.0044698668903503 | 0.0021092743204961 | 0.0340778638262605 |
Cappuccino | Ohter specific/unspecified arthritis (ukb-d-M13_ARTHRITISNAS) | rs855066 | -0.0203086549435325 | 0.0082198399945491 | 0.0134853649169492 |
Cappuccino | Ohter specific/unspecified arthritis (ukb-d-M13_ARTHRITISNAS) | All - Inverse variance weighted | -0.0044300543407292 | 0.0020237526730271 | 0.0285946945557492 |
Cappuccino | Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) | rs55678878 | 0.0203102412945778 | 0.0094902637846106 | 0.0323455983183411 |
Cappuccino | Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) | rs855066 | -0.0185828331980082 | 0.0086980393938189 | 0.0326436235835051 |
Cappuccino | Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) | All - Inverse variance weighted | -0.0044698668903503 | 0.0021092743204961 | 0.0340778638262605 |
Cappuccino | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | All - MR Egger | 1.40415681269 | 0.61008995784078 | 0.0342803080449152 |
Cappuccino | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | All - MR Egger | 1.44627756006243 | 0.613255429239565 | 0.0305912437041037 |
Cappuccino | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | rs115241046 | 3.38093211741871 | 1.16905199237989 | 0.0038276276776196 |
Cappuccino | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | rs13084063 | -3.68406899466021 | 1.40162553439031 | 0.0085781017131864 |
Cappuccino | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | rs62626322 | -1.9935972623845 | 1.00841181912847 | 0.0480453186036145 |
Cappuccino | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | All - MR Egger | 1.56805024237784 | 0.691125311780807 | 0.0365892179647284 |
Cappuccino | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) | rs115241046 | 3.5712554336409 | 1.1722838977497 | 0.0023159308483735 |
Cappuccino | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) | rs13084063 | -3.98426052453942 | 1.40821108897633 | 0.0046649026887199 |
Cappuccino | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) | rs62626322 | -2.12327786100562 | 1.01305709430296 | 0.0360900557855939 |
Cappuccino | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) | All - MR Egger | 1.57691379830706 | 0.728723996055838 | 0.0449979280084719 |