ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Crispbread (ukb-b-8759)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Crispbread (👉 📊) Osteoprotegerin levels (ebi-a-GCST90000490) Weighted median 12 -1.744800407 0.64189476 0.006563751
Crispbread (👉 📊) Bone mineral density (ebi-a-GCST90014022) Inverse variance weighted 16 0.041654721 0.018942335 0.027875942
Crispbread (👉 📊) Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) Inverse variance weighted 14 1.106512746 0.537900458 0.039677017
Crispbread (👉 📊) Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) Inverse variance weighted 14 1.123072002 0.530571141 0.034283385
Crispbread (👉 📊) Achilles tendinitis (finn-b-M13_ACHILLESTEND) Inverse variance weighted 14 0.530059827 0.241530087 0.028192929
Crispbread (👉 📊) Loose body in joint (finn-b-M13_LOOSEJOINT) Inverse variance weighted 14 -0.993398098 0.505773812 0.049516719
Crispbread (👉 📊) Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) Inverse variance weighted 14 0.254635352 0.127609023 0.045995592
Crispbread (👉 📊) Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) Weighted median 14 0.441755345 0.198342852 0.02593184
Crispbread (👉 📊) Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) Inverse variance weighted 14 0.329082018 0.150187753 0.028441844
Crispbread (👉 📊) Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) Inverse variance weighted 14 0.651267218 0.320527123 0.042167522
Crispbread (👉 📊) Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) Weighted median 14 0.418596941 0.205924501 0.042075867
Crispbread (👉 📊) Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) Inverse variance weighted 14 0.30443043 0.149291031 0.041432637
Crispbread (👉 📊) Burn and corrosion of head and neck (finn-b-ST19_BURN_CORROSION_HEAD_NECK) Inverse variance weighted 14 -1.221742324 0.547251269 0.025581469
Crispbread (👉 📊) Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) MR Egger 14 -0.81110632 0.289229643 0.015914802
Crispbread (👉 📊) Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) Weighted median 14 -0.513880571 0.231542457 0.026460921
Crispbread (👉 📊) Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) Inverse variance weighted 14 -0.509656966 0.164582634 0.001957122
Crispbread (👉 📊) Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) Weighted median 14 -0.317369804 0.125701825 0.011576982
Crispbread (👉 📊) Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) Weighted median 14 0.268252593 0.130480905 0.039794447
Crispbread (👉 📊) Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) Inverse variance weighted 14 0.253928718 0.09070286 0.005117122
Crispbread (👉 📊) Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) Inverse variance weighted 14 1.34241058 0.62727198 0.032348513
Crispbread (👉 📊) Rheumatoid arthritis (ieu-a-831) Inverse variance weighted 4 0.487796443 0.235545752 0.03836626
Crispbread (👉 📊) Femoral neck bone mineral density (ieu-a-980) Inverse variance weighted 15 0.118363987 0.059697807 0.047398805
Crispbread (👉 📊) Psoriatic arthritis (ieu-b-5116) Inverse variance weighted 12 -0.552821731 0.238284782 0.020340642
Crispbread (👉 📊) Four-jointed box protein 1 (prot-a-1112) Inverse variance weighted 15 0.387312088 0.185768548 0.037076794
Crispbread (👉 📊) Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) Inverse variance weighted 15 0.072524271 0.03160978 0.021769729
Crispbread (👉 📊) Heel bone mineral density (BMD) (left) (ukb-b-1096) Weighted median 16 0.078489911 0.033564078 0.019360839
Crispbread (👉 📊) Heel bone mineral density (BMD) (left) (ukb-b-1096) Inverse variance weighted 16 0.070414292 0.025553361 0.005858845
Crispbread (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) Weighted median 16 0.074480795 0.035089951 0.033790099
Crispbread (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) Inverse variance weighted 16 0.070673647 0.025562824 0.005697443
Crispbread (👉 📊) Fractured heel (ukb-b-18389) Weighted median 16 -0.003084425 0.001471332 0.03605123
Crispbread (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) Inverse variance weighted 16 0.077694106 0.025443724 0.002261385
Crispbread (👉 📊) Heel bone mineral density (BMD) (right) (ukb-b-4657) Weighted median 16 0.071814506 0.034798853 0.039045863
Crispbread (👉 📊) Heel bone mineral density (BMD) (right) (ukb-b-4657) Inverse variance weighted 16 0.077763149 0.025630445 0.002413227
Crispbread (👉 📊) Knee pain for 3+ months (ukb-b-8906) Inverse variance weighted 16 0.027932688 0.013698947 0.041446132
Crispbread (👉 📊) Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) Inverse variance weighted 13 -0.002727396 0.001118841 0.014781109

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Crispbread Osteoprotegerin levels (ebi-a-GCST90000490) rs34233785 -2.95041616737377 1.31227281209469 0.0245554544246758
Crispbread Bone mineral density (ebi-a-GCST90014022) rs150099736 0.138172458311501 0.0619906764691583 0.0258190137438609
Crispbread Bone mineral density (ebi-a-GCST90014022) rs2977195 0.153427725204074 0.0621619515088378 0.0135796887211169
Crispbread Bone mineral density (ebi-a-GCST90014022) rs416284 0.152088702600214 0.0633523751621181 0.0163646947635154
Crispbread Bone mineral density (ebi-a-GCST90014022) rs6892373 0.175319151346269 0.0626740181919099 0.0051528809188468
Crispbread Bone mineral density (ebi-a-GCST90014022) All - Inverse variance weighted 0.0416547212776464 0.0189423345525262 0.0278759418796506
Crispbread Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) rs117670274 5.54114410261907 2.70697109372209 0.0406590176777751
Crispbread Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) All - Inverse variance weighted 1.10651274607264 0.537900458463469 0.0396770166245402
Crispbread Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) All - Inverse variance weighted 1.12307200161628 0.53057114115187 0.0342833854146527
Crispbread Achilles tendinitis (finn-b-M13_ACHILLESTEND) rs78576559 1.49788765842562 0.549458790590706 0.0064084734133157
Crispbread Achilles tendinitis (finn-b-M13_ACHILLESTEND) All - Inverse variance weighted 0.530059826825441 0.241530087286049 0.028192928609892
Crispbread Loose body in joint (finn-b-M13_LOOSEJOINT) All - Inverse variance weighted -0.993398097659833 0.505773811887344 0.0495167187621582
Crispbread Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) rs79252206 1.938519291965 0.889394391408114 0.0292875188364838
Crispbread Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) All - Inverse variance weighted 0.254635352406553 0.127609023004482 0.045995592096304
Crispbread Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) rs79252206 2.24741447891806 1.04663882259348 0.0317719193454948
Crispbread Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) All - Inverse variance weighted 0.329082018018999 0.150187753412836 0.0284418440083811
Crispbread Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs13021209 2.68018532754358 1.20504456587231 0.0261391655470776
Crispbread Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs79252206 5.26054097056484 1.91179395385839 0.0059300295122588
Crispbread Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs79463892 2.71142672692059 1.37508069722402 0.0486289038215588
Crispbread Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) All - Inverse variance weighted 0.651267218151682 0.320527123041029 0.0421675220097398
Crispbread Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) rs79252206 2.13864856801909 1.04042362768496 0.0398253754995506
Crispbread Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) All - Inverse variance weighted 0.304430430299138 0.149291031235811 0.0414326374412456
Crispbread Burn and corrosion of head and neck (finn-b-ST19_BURN_CORROSION_HEAD_NECK) rs16986341 -4.86820973794174 2.35723038749305 0.0389017718416567
Crispbread Burn and corrosion of head and neck (finn-b-ST19_BURN_CORROSION_HEAD_NECK) All - Inverse variance weighted -1.22174232398275 0.547251269169469 0.0255814689032038
Crispbread Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) rs112606199 -0.666071100134003 0.331721800362595 0.0446517093345081
Crispbread Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) rs117670274 -1.71365276735627 0.840390181155536 0.0414384870096436
Crispbread Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) rs34233785 -1.52216860446287 0.766482063240168 0.0470427081309213
Crispbread Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) All - Inverse variance weighted -0.509656966245497 0.1645826343238 0.0019571218123262
Crispbread Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) All - MR Egger -0.811106319971291 0.289229643366617 0.0159148015896158
Crispbread Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) rs112606199 0.602354239470296 0.16224808849418 0.0002051810171153
Crispbread Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) All - Inverse variance weighted 0.253928718043345 0.0907028600395597 0.0051171223473703
Crispbread Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) rs16986341 5.63314888532002 2.69517365260346 0.03660993621522
Crispbread Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) All - Inverse variance weighted 1.34241057960876 0.627271979838516 0.0323485132159957
Crispbread Rheumatoid arthritis (ieu-a-831) All - Inverse variance weighted 0.487796442742981 0.23554575249066 0.038366259708938
Crispbread Femoral neck bone mineral density (ieu-a-980) rs13021209 0.703496706904074 0.228780382111915 0.0021051171048384
Crispbread Femoral neck bone mineral density (ieu-a-980) All - Inverse variance weighted 0.118363986533019 0.0596978065599767 0.0473988050874196
Crispbread Psoriatic arthritis (ieu-b-5116) rs112606199 -2.73334165374813 0.865380067789485 0.0015855897420007
Crispbread Psoriatic arthritis (ieu-b-5116) All - Inverse variance weighted -0.552821731429995 0.238284781848507 0.0203406417925366
Crispbread Four-jointed box protein 1 (prot-a-1112) rs150099736 1.48495864911437 0.751932498933142 0.0482844553253291
Crispbread Four-jointed box protein 1 (prot-a-1112) All - Inverse variance weighted 0.387312087656756 0.185768547923729 0.0370767942011937
Crispbread Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) All - Inverse variance weighted 0.0725242709294505 0.0316097804962579 0.0217697290031212
Crispbread Heel bone mineral density (BMD) (left) (ukb-b-1096) rs6892373 0.308299634122858 0.105327023934935 0.0034217120805339
Crispbread Heel bone mineral density (BMD) (left) (ukb-b-1096) All - Inverse variance weighted 0.0704142921903961 0.0255533613657645 0.0058588450629687
Crispbread Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) rs6892373 0.305733963140427 0.105364404571765 0.0037116547648148
Crispbread Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) All - Inverse variance weighted 0.070673647421399 0.0255628240306836 0.0056974431483844
Crispbread Fractured heel (ukb-b-18389) rs416284 0.0095944634098445 0.0045329611504533 0.0342938506259146
Crispbread Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) rs6892373 0.267500651329278 0.104897996171317 0.0107691225414209
Crispbread Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) All - Inverse variance weighted 0.0776941056178578 0.0254437240347706 0.0022613852818593
Crispbread Heel bone mineral density (BMD) (right) (ukb-b-4657) rs6892373 0.266869145116163 0.104911589130164 0.0109668677218157
Crispbread Heel bone mineral density (BMD) (right) (ukb-b-4657) rs79252206 0.204735357000796 0.0993324880668258 0.0392923813555287
Crispbread Heel bone mineral density (BMD) (right) (ukb-b-4657) All - Inverse variance weighted 0.0777631485831908 0.0256304454192577 0.0024132265799559
Crispbread Knee pain for 3+ months (ukb-b-8906) rs35152605 0.131376398811135 0.0562698939653428 0.0195562394682331
Crispbread Knee pain for 3+ months (ukb-b-8906) All - Inverse variance weighted 0.0279326881315512 0.013698947239716 0.0414461320856235
Crispbread Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) rs66569168 -0.0075874950632712 0.003857654499321 0.04919849412368
Crispbread Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) All - Inverse variance weighted -0.002727396368803 0.0011188408670226 0.0147811086970615