ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Squash | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | rs10097265 | -0.977328495627189 | 0.494956062163126 | 0.0483162540733967 |
| Squash | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | rs12742072 | -0.938566274836973 | 0.4529885840359 | 0.0382708088934747 |
| Squash | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | All - Inverse variance weighted | -0.244390207491441 | 0.11660802422954 | 0.03609756930009 |
| Squash | Menstruation quality of life impact (stiff neck) (ebi-a-GCST006652) | rs10097265 | -6.3033073970764 | 2.61090161699629 | 0.0157686643644542 |
| Squash | Rheumatoid arthritis (ebi-a-GCST90018910) | rs116156344 | 1.80949597290122 | 0.777404100958233 | 0.0199326569686771 |
| Squash | Rheumatoid arthritis (ebi-a-GCST90018910) | rs35350688 | 1.45115836474765 | 0.680745159755517 | 0.0330298362741532 |
| Squash | Rheumatoid arthritis (ebi-a-GCST90018910) | All - MR Egger | 0.820910020145193 | 0.367332642718212 | 0.0391444933768736 |
| Squash | Heel bone mineral density T score (ebi-a-GCST90025982) | All - Inverse variance weighted | -0.0779314418178219 | 0.0325375999455386 | 0.0166149468342099 |
| Squash | Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) | All - Inverse variance weighted | -3.29480046236666 | 1.58647702731743 | 0.037819732854266 |
| Squash | Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) | All - MR Egger | -9.70207271327293 | 3.98260954149348 | 0.0269099846130075 |
| Squash | Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) | All - Inverse variance weighted | -3.3235128698854 | 1.5876641922347 | 0.0363192689053093 |
| Squash | Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) | All - MR Egger | -9.77784280538897 | 3.9866475695787 | 0.0260344039736119 |
| Squash | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | rs4362145 | 10.2538674378201 | 3.44445159409977 | 0.0029115705211528 |
| Squash | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | rs73213334 | -6.17631315280199 | 3.08815657640099 | 0.0455002638963584 |
| Squash | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs10097265 | -15.368805184455 | 5.72135651517376 | 0.0072266136044611 |
| Squash | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs116063249 | 10.5094890969647 | 4.81760196066109 | 0.0291481350450236 |
| Squash | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | All - MR Egger | 8.91066902933401 | 3.27723818291502 | 0.0151709570707155 |
| Squash | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | rs117062976 | 1.26753502274942 | 0.418908163168784 | 0.0024797097832326 |
| Squash | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | All - Inverse variance weighted | 0.260354054831151 | 0.125459774454658 | 0.0379680536780832 |
| Squash | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | All - MR Egger | 1.0400473722577 | 0.316413576761087 | 0.0046448870708897 |
| Squash | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | rs35350688 | 2.94806573216704 | 1.13000036599202 | 0.0090831955511743 |
| Squash | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | All - MR Egger | 1.60310205765303 | 0.593259701672725 | 0.0157013256120969 |
| Squash | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | rs35350688 | 2.88950700874721 | 1.0979760641218 | 0.0084967180778159 |
| Squash | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | All - MR Egger | 1.4213078200099 | 0.599992239750179 | 0.0307637368439731 |
| Squash | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | All - Inverse variance weighted | 0.661832387901289 | 0.287768619765769 | 0.0214551977553245 |
| Squash | Seronegative rheumatoid arthritis (finn-b-RHEUMA_SERONEG) | All - MR Egger | 2.022980617953 | 0.889534526372623 | 0.0370760974295242 |
| Squash | Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) | All - MR Egger | 1.65518498867327 | 0.724928829644469 | 0.0364250290050421 |
| Squash | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | rs117062976 | -6.76469117684816 | 2.44318051293278 | 0.0056262244183954 |
| Squash | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | rs12562325 | -6.31616619351843 | 3.06861213613128 | 0.0395600363631376 |
| Squash | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | All - MR Egger | -4.18536524604658 | 1.79561650267192 | 0.0331654797795516 |
| Squash | Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) | rs9427097 | -2.23649521382947 | 0.891767078932003 | 0.0121438485606677 |
| Squash | Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) | All - Inverse variance weighted | -0.574455776430952 | 0.232909815169413 | 0.013646736475218 |
| Squash | Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) | rs116063249 | 5.64239929617294 | 2.74304028153082 | 0.0396874379171162 |
| Squash | Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) | All - Inverse variance weighted | 2.32865925533156 | 0.745017435127456 | 0.0017741620118708 |
| Squash | Bone morphogenetic protein 7 (prot-a-257) | rs12562325 | -2.31657244004237 | 1.1316867452399 | 0.0406572453570408 |
| Squash | Bone morphogenetic protein 7 (prot-a-257) | All - Inverse variance weighted | -0.507443444890952 | 0.244326848511609 | 0.0378104069400262 |
| Squash | Bone morphogenetic protein receptor type-1A (prot-a-259) | rs16850360 | -3.10755961440893 | 1.17512758528069 | 0.0081825137622402 |
| Squash | Operation code: knee surgery (not replacement) (ukb-b-1508) | rs2111822 | -0.0364017752251664 | 0.0162945829526172 | 0.0254843777360504 |
| Squash | Operation code: knee surgery (not replacement) (ukb-b-1508) | rs76503826 | -0.0331414067514137 | 0.0166903757623139 | 0.0470711211862253 |
| Squash | Operation code: knee surgery (not replacement) (ukb-b-1508) | All - Inverse variance weighted | -0.0120597138825164 | 0.0041664764550639 | 0.0037980710418049 |
| Squash | Fracture resulting from simple fall (ukb-b-15251) | rs16850360 | 0.322201331065151 | 0.141259289103769 | 0.0225531002208622 |
| Squash | Fracture resulting from simple fall (ukb-b-15251) | rs2424181 | -0.276518533844411 | 0.138366255771409 | 0.0456675119371145 |
| Squash | Fracture resulting from simple fall (ukb-b-15251) | All - Inverse variance weighted | 0.0700758515092048 | 0.0344610880556768 | 0.0420042918343869 |
| Squash | Fracture resulting from simple fall (ukb-b-15251) | All - MR Egger | 0.201227567234697 | 0.08098012612064 | 0.0244038579669256 |
| Squash | Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) | rs10097265 | 0.0163770055158239 | 0.0079301608607202 | 0.0389084064126987 |
| Squash | Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) | All - MR Egger | -0.0594301161919247 | 0.0219347937110214 | 0.0423065012204503 |
| Squash | Non-cancer illness code, self-reported: other joint disorder (ukb-b-5316) | rs10097265 | -0.0197337304167278 | 0.007422243660997 | 0.0078436152897894 |
| Squash | Non-cancer illness code, self-reported: other joint disorder (ukb-b-5316) | rs11144503 | -0.0175522962449108 | 0.0071558523069808 | 0.0141725906608681 |
| Squash | Non-cancer illness code, self-reported: other joint disorder (ukb-b-5316) | All - MR Egger | 0.0987563345973867 | 0.0326634085113428 | 0.0390305358003518 |
| Squash | Knee pain for 3+ months (ukb-b-8906) | rs72709147 | -0.182622482784141 | 0.0836869691579861 | 0.0290940888970016 |
| Squash | Knee pain for 3+ months (ukb-b-8906) | rs73213334 | -0.168710454439397 | 0.0799407073937331 | 0.0348200565407316 |
| Squash | Knee pain for 3+ months (ukb-b-8906) | All - MR Egger | 0.10898784320288 | 0.0430184816965725 | 0.0214239112840329 |
| Squash | Shoulder lesions (ukb-d-M13_SHOULDER) | All - MR Egger | 0.0166049008038457 | 0.0078125374649716 | 0.0494745373645565 |
| Squash | Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) | All - MR Egger | 0.0166564240043425 | 0.0078130661353546 | 0.0488660123391119 |
| Squash | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | rs116156344 | -5.78868919481068 | 2.35040428651647 | 0.0137838222692449 |
| Squash | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | rs16850360 | -2.74569492941773 | 1.15889963291253 | 0.0178253662895017 |
| Squash | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | All - MR Egger | -4.09589773510412 | 1.76951661009664 | 0.0409584561321542 |
| Squash | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | rs116156344 | -5.69530367878293 | 2.33585069960305 | 0.0147600366834712 |
| Squash | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | rs16850360 | -2.64683498970364 | 1.15125197719879 | 0.0214996772773896 |
| Squash | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | All - MR Egger | -4.00701736148917 | 1.74261846096654 | 0.0420745975320014 |