ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Instant coffee | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | rs148251241 | 1.74153001623899 | 0.661026792484935 | 0.0084240680211981 |
| Instant coffee | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | All - Inverse variance weighted | 0.330999184543245 | 0.141017799730291 | 0.0189143047219215 |
| Instant coffee | Cervical spondylosis (ebi-a-GCST90038693) | rs11649454 | 0.00791327965561 | 0.0033062923649111 | 0.0166930378533148 |
| Instant coffee | Cervical spondylosis (ebi-a-GCST90038693) | rs117947931 | 0.0107290717719443 | 0.0033264565317935 | 0.0012580749184883 |
| Instant coffee | Cervical spondylosis (ebi-a-GCST90038693) | rs76197902 | 0.007285493556588 | 0.0032551174717278 | 0.0252102258468586 |
| Instant coffee | Cervical spondylosis (ebi-a-GCST90038693) | All - Inverse variance weighted | 0.0022982055422105 | 0.0008701723344534 | 0.0082639177019677 |
| Instant coffee | Cervical spondylosis (ebi-a-GCST90038693) | All - MR Egger | 0.0059766984636656 | 0.0023631087873446 | 0.0216159103304219 |
| Instant coffee | Neck injury (ebi-a-GCST90038700) | rs11649454 | 0.0085077078473009 | 0.0035038425551441 | 0.0151778262844075 |
| Instant coffee | Neck injury (ebi-a-GCST90038700) | rs117947931 | 0.0116549172401228 | 0.0035252157176026 | 0.000945850149007 |
| Instant coffee | Neck injury (ebi-a-GCST90038700) | rs2960876 | 0.0065873975144694 | 0.003348586504415 | 0.0491581570854819 |
| Instant coffee | Neck injury (ebi-a-GCST90038700) | rs76197902 | 0.0067730888927851 | 0.0034496033137547 | 0.0495950778135144 |
| Instant coffee | Neck injury (ebi-a-GCST90038700) | All - Inverse variance weighted | 0.0021117833030476 | 0.000970767278815 | 0.0296019928981441 |
| Instant coffee | Neck injury (ebi-a-GCST90038700) | All - MR Egger | 0.0056985222395683 | 0.0026864285531439 | 0.0489049577950288 |
| Instant coffee | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | rs2726351 | 4.10222509718198 | 1.99737603594871 | 0.0399943648562743 |
| Instant coffee | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | All - Inverse variance weighted | 1.50402988407343 | 0.488041555892304 | 0.0020577651537612 |
| Instant coffee | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | rs2726351 | 4.13162809466548 | 2.00041772534356 | 0.038886807372544 |
| Instant coffee | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | All - Inverse variance weighted | 1.50904594972716 | 0.488334346525235 | 0.0020002844272173 |
| Instant coffee | Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) | rs143523613 | 3.02413574631805 | 1.39915831053315 | 0.0306647313575859 |
| Instant coffee | Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) | All - MR Egger | 1.65735061787985 | 0.742674436549267 | 0.0378823626511851 |
| Instant coffee | Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) | All - MR Egger | -0.945268308870287 | 0.438845229014617 | 0.044289905879411 |
| Instant coffee | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | rs144845508 | 0.585663308533863 | 0.226967723581761 | 0.0098691229051787 |
| Instant coffee | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | rs76197902 | 0.439423161216797 | 0.164920662750942 | 0.0077113910210013 |
| Instant coffee | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | All - MR Egger | 0.279361181143018 | 0.0977945991116378 | 0.0100951146681826 |
| Instant coffee | Osteonecrosis (finn-b-M13_OSTEONECROSIS) | rs2960876 | 2.37002720324167 | 1.06193629013425 | 0.025628321888748 |
| Instant coffee | Osteonecrosis (finn-b-M13_OSTEONECROSIS) | All - Inverse variance weighted | 0.491137346790104 | 0.218616641182073 | 0.0246675916981072 |
| Instant coffee | Patellar tendinitis (finn-b-M13_PATELLARTEND) | All - MR Egger | 1.75167266840958 | 0.827356769591684 | 0.0476610254959893 |
| Instant coffee | Shoulder lesions (finn-b-M13_SHOULDER) | rs11649454 | 0.534664298342678 | 0.23012612841038 | 0.0201601810361454 |
| Instant coffee | Shoulder lesions (finn-b-M13_SHOULDER) | All - Inverse variance weighted | 0.0920202033209041 | 0.0449713765631514 | 0.0407371946561994 |
| Instant coffee | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | rs112601576 | 1.74664247304707 | 0.759913644671664 | 0.0215347722683216 |
| Instant coffee | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | All - Inverse variance weighted | 0.388430284158523 | 0.160501750407328 | 0.0155162400068582 |
| Instant coffee | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs12510185 | 1.58786008787362 | 0.60988262466055 | 0.0092263729038735 |
| Instant coffee | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | All - Inverse variance weighted | 0.267049741381342 | 0.1224329462139 | 0.0291692312422478 |
| Instant coffee | Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) | All - MR Egger | -1.31909913112935 | 0.509506166103104 | 0.0180035280739959 |
| Instant coffee | Fracture of femur (finn-b-ST19_FRACT_FEMUR) | rs6968554 | 0.714675855097432 | 0.335598738040049 | 0.0332083980029684 |
| Instant coffee | Fracture of femur (finn-b-ST19_FRACT_FEMUR) | rs76197902 | 0.699680021039712 | 0.336964144823354 | 0.0378548676470315 |
| Instant coffee | Fracture of femur (finn-b-ST19_FRACT_FEMUR) | All - Inverse variance weighted | 0.20802370982217 | 0.0874945607593942 | 0.0174275307849826 |
| Instant coffee | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | rs12510185 | -0.869714275403506 | 0.283288674768362 | 0.0021401312449528 |
| Instant coffee | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | rs143523613 | -0.564547813129365 | 0.245640239693905 | 0.0215463759829523 |
| Instant coffee | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | rs144845508 | -0.619059104374231 | 0.29685151858105 | 0.0370314952707351 |
| Instant coffee | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | rs2171275 | -0.636703083043343 | 0.294739790360218 | 0.0307555656478594 |
| Instant coffee | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | All - Inverse variance weighted | -0.137835717966223 | 0.0688855860769209 | 0.0453991795569755 |
| Instant coffee | Fracture of neck (finn-b-ST19_FRACT_NECK) | rs11649454 | 2.23098324488865 | 1.06381659360966 | 0.0359802760938305 |
| Instant coffee | Fracture of neck (finn-b-ST19_FRACT_NECK) | rs34667201 | 2.12568070124314 | 0.946411330790506 | 0.0247012431761335 |
| Instant coffee | Fracture of neck (finn-b-ST19_FRACT_NECK) | All - Inverse variance weighted | 0.49890713427907 | 0.206986291878656 | 0.0159377033630565 |
| Instant coffee | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | rs143523613 | 0.911417315867156 | 0.367398514124314 | 0.0131112844938725 |
| Instant coffee | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | rs148251241 | 0.481251179083884 | 0.219355841042847 | 0.0282405016958183 |
| Instant coffee | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | All - MR Egger | 0.46478685367039 | 0.193471161577594 | 0.0266739375719408 |
| Instant coffee | Four-jointed box protein 1 (prot-a-1112) | rs2171275 | 1.28480494250946 | 0.499917765970093 | 0.0101688953002789 |
| Instant coffee | Four-jointed box protein 1 (prot-a-1112) | All - Inverse variance weighted | 0.200179723510577 | 0.101440721466477 | 0.0484538191710523 |
| Instant coffee | Bone morphogenetic protein 6 (prot-a-256) | All - Inverse variance weighted | 0.218709476460811 | 0.101449737903727 | 0.0310961042947891 |
| Instant coffee | Alkaline phosphatase, bone (prot-c-2795_23_3) | rs2171275 | 2.59403583449628 | 0.868441836114906 | 0.0028172964815036 |
| Instant coffee | Alkaline phosphatase, bone (prot-c-2795_23_3) | rs2960876 | 2.1522750367654 | 0.832924127571211 | 0.0097662103336281 |
| Instant coffee | Alkaline phosphatase, bone (prot-c-2795_23_3) | All - Inverse variance weighted | 1.49481053600678 | 0.471154440418616 | 0.0015105185488258 |
| Instant coffee | Fractured bone site(s): Ankle (ukb-a-438) | All - Inverse variance weighted | -0.0024569220293922 | 0.0011853022285162 | 0.0381887309082908 |
| Instant coffee | Fractured bone site(s): Wrist (ukb-a-439) | rs143523613 | 0.0185891613898849 | 0.0067887670912868 | 0.0061772085214162 |
| Instant coffee | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | All - MR Egger | -0.0241285722224822 | 0.0103307799129034 | 0.0312845703469353 |
| Instant coffee | Pain type(s) experienced in last month: Knee pain (ukb-a-476) | rs112601576 | 0.0400976133082567 | 0.0194254787952637 | 0.0390010019700289 |
| Instant coffee | Pain type(s) experienced in last month: Knee pain (ukb-a-476) | rs117671135 | 0.0386435924621225 | 0.019417254732074 | 0.0465724692493605 |
| Instant coffee | Pain type(s) experienced in last month: Knee pain (ukb-a-476) | rs2472297 | 0.0599428325252843 | 0.015404856500065 | 9.9764217268069e-05 |
| Instant coffee | Pain type(s) experienced in last month: Knee pain (ukb-a-476) | rs6968554 | 0.0322233212590252 | 0.0140971850466985 | 0.0222660626681285 |
| Instant coffee | Pain type(s) experienced in last month: Knee pain (ukb-a-476) | All - Inverse variance weighted | 0.0184341359176485 | 0.0048763547632057 | 0.0001566327939328 |
| Instant coffee | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | All - Inverse variance weighted | -0.0025518142819015 | 0.000988449327778 | 0.0098333840118714 |
| Instant coffee | Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC (ukb-b-10298) | rs2472297 | 0.0038710312711557 | 0.001759513666172 | 0.0278028143545181 |
| Instant coffee | Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC (ukb-b-10298) | All - Inverse variance weighted | 0.0023733448329229 | 0.000951256037306 | 0.0125971676766826 |
| Instant coffee | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | rs12510185 | -0.0095961061340117 | 0.0043522342815384 | 0.0274632934769489 |
| Instant coffee | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | rs167978 | -0.0116944059177069 | 0.0043733626136538 | 0.0074950699203326 |
| Instant coffee | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | rs2472297 | 0.016522904600067 | 0.0033964865252979 | 1.14627710302124e-06 |
| Instant coffee | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | All - MR Egger | 0.0266575292076536 | 0.0119808608292405 | 0.0479433169869106 |
| Instant coffee | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | rs112601576 | 0.0352846613334746 | 0.0166445921962332 | 0.0340155419393254 |
| Instant coffee | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | rs167978 | -0.0365878794883649 | 0.017012405609493 | 0.0315031421405342 |
| Instant coffee | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | rs2472297 | 0.0594258634955586 | 0.0132155063356059 | 6.90237193148396e-06 |
| Instant coffee | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | rs6968554 | 0.0326048440349023 | 0.012016160370001 | 0.0066593411871583 |
| Instant coffee | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | All - Inverse variance weighted | 0.0142301161719314 | 0.0044567117386154 | 0.001408209355703 |
| Instant coffee | Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) | rs112601576 | 0.0062415234033535 | 0.0026030436279833 | 0.0164948128968451 |
| Instant coffee | Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) | All - Inverse variance weighted | 0.0023499517078237 | 0.0008424090200047 | 0.0052779483293585 |
| Instant coffee | Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) | rs12510185 | -0.0062806903582609 | 0.0024431212277045 | 0.0101474180558083 |
| Instant coffee | Ankle spacing width (left) (ukb-b-2122) | rs6968554 | 0.131702531800358 | 0.043436802817399 | 0.0024289945085369 |
| Instant coffee | Ankle spacing width (left) (ukb-b-2122) | All - Inverse variance weighted | 0.027523690526428 | 0.0124968667314706 | 0.0276337270838145 |
| Instant coffee | Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) | rs11649454 | 0.0083296150279251 | 0.0034347082565672 | 0.0153028936393089 |
| Instant coffee | Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) | All - Inverse variance weighted | 0.0021367672053077 | 0.0010877331369195 | 0.0494811415433962 |
| Instant coffee | Ankle spacing width (ukb-b-4080) | rs144845508 | 0.142190022078332 | 0.0438347650234698 | 0.0011795776068087 |
| Instant coffee | Ankle spacing width (ukb-b-4080) | rs148251241 | 0.0875773571505195 | 0.0408597417297669 | 0.032083768189906 |
| Instant coffee | Ankle spacing width (ukb-b-4080) | rs2472297 | -0.0830309702742808 | 0.0350386017218625 | 0.0178025295440844 |
| Instant coffee | Ankle spacing width (ukb-b-4080) | rs6968554 | 0.0938707713879657 | 0.0318458745811809 | 0.0032019028669756 |
| Instant coffee | Ankle spacing width (ukb-b-4080) | All - Inverse variance weighted | 0.030841333416497 | 0.0125131760153085 | 0.0137124692656519 |
| Instant coffee | Ankle spacing width (ukb-b-4080) | All - MR Egger | 0.0653996908229817 | 0.0309686839539458 | 0.0481739748233527 |
| Instant coffee | Non-cancer illness code, self-reported: joint pain (ukb-b-4122) | All - Inverse variance weighted | -0.0019432503349631 | 0.0008573403351911 | 0.0234144773131041 |
| Instant coffee | Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) | rs2171275 | 0.0119138708453495 | 0.0036722623802924 | 0.0011774529682391 |
| Instant coffee | Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) | rs2960876 | 0.0078051528367742 | 0.0034747249695462 | 0.0246870435449758 |
| Instant coffee | Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) | All - Inverse variance weighted | 0.0025563312248164 | 0.0011371010199056 | 0.0245690055367209 |
| Instant coffee | Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) | All - MR Egger | 0.0200164753023205 | 0.0066414672316274 | 0.0195550846449142 |
| Instant coffee | Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) | rs167978 | -0.005628640776699 | 0.0027927839420557 | 0.0438603545565988 |
| Instant coffee | Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) | rs2472297 | 0.0048813774899649 | 0.0021688902261397 | 0.0244087455230745 |
| Instant coffee | Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) | All - MR Egger | 0.0260855941965765 | 0.0068578376027134 | 0.0066819412698621 |
| Instant coffee | Ankle spacing width (right) (ukb-b-8607) | rs6968554 | 0.11082163266748 | 0.0439719944891155 | 0.0117262314809196 |
| Instant coffee | Ankle spacing width (right) (ukb-b-8607) | rs76197902 | 0.116123871307092 | 0.0583550670640835 | 0.0465960555074676 |
| Instant coffee | Ankle spacing width (right) (ukb-b-8607) | All - Inverse variance weighted | 0.0272215911886193 | 0.0126510280317045 | 0.0314186592616889 |
| Instant coffee | Fractured bone site(s): Wrist (ukb-b-9571) | rs6968554 | -0.0101697151350955 | 0.0040927149258557 | 0.012961204165929 |
| Instant coffee | Fractured bone site(s): Wrist (ukb-b-9571) | All - Inverse variance weighted | -0.0030837298599082 | 0.0014151209205435 | 0.0293221482148911 |
| Instant coffee | Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) | rs117671135 | 0.0105971476452683 | 0.0040703626435012 | 0.0092280012119925 |
| Instant coffee | Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) | All - MR Egger | 0.0055968978661676 | 0.0022249791931463 | 0.0216008486268535 |
| Instant coffee | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | rs117671135 | -0.0100385710105605 | 0.0051124259455597 | 0.0495807785103468 |
| Instant coffee | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | rs2960876 | -0.0109251153455317 | 0.0049435264489986 | 0.0271062588481424 |
| Instant coffee | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | All - MR Egger | -0.0073125120217469 | 0.0026660151127871 | 0.0133744126095142 |
| Instant coffee | Ankle spacing width (left) (ukb-e-4100_CSA) | rs2599415 | 0.821650912969948 | 0.355431609169225 | 0.020794273831785 |
| Instant coffee | Ankle spacing width (left) (ukb-e-4100_CSA) | All - Inverse variance weighted | 0.172255238357825 | 0.0805007916538482 | 0.0323712903913021 |
| Instant coffee | Fractured bone site(s) (ukb-e-6151_p7_CSA) | rs167978 | -5.0046232085067 | 2.02650639543843 | 0.0135271106958593 |
| Instant coffee | Fractured bone site(s) (ukb-e-6151_p7_CSA) | rs2171275 | -4.11821508188392 | 1.76192515563401 | 0.0194216025141163 |
| Instant coffee | Fractured bone site(s) (ukb-e-6151_p7_CSA) | rs2960876 | -3.17318555640412 | 1.59053756382663 | 0.0460385520274292 |
| Instant coffee | Fractured bone site(s) (ukb-e-6151_p7_CSA) | All - Inverse variance weighted | -1.22562799650193 | 0.473461082013742 | 0.0096351219261388 |
| Instant coffee | Internal derangement of knee (ukb-e-835_CSA) | rs2171275 | -2.61683338734182 | 1.32746893426326 | 0.0486900986317814 |
| Instant coffee | Internal derangement of knee (ukb-e-835_CSA) | All - MR Egger | 2.14153397488259 | 0.957819781323019 | 0.0409866892417161 |