ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Fortified wine | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs188390104 | -10.3225818267061 | 5.19249787558238 | 0.0468139040844606 |
| Fortified wine | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs79482515 | -8.8240385286522 | 4.17460040483004 | 0.0345370979183439 |
| Fortified wine | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | All - Inverse variance weighted | -2.09598077207376 | 0.952837236072077 | 0.0278263461706788 |
| Fortified wine | Rheumatoid arthritis (ebi-a-GCST90018910) | rs12686701 | -2.83415899243707 | 1.36660817169568 | 0.0380919770617308 |
| Fortified wine | Rheumatoid arthritis (ebi-a-GCST90018910) | rs6042162 | -3.77468558584836 | 1.7685589807821 | 0.0328159114906078 |
| Fortified wine | Rheumatoid arthritis (ebi-a-GCST90018910) | rs77439809 | -5.4489033818966 | 2.37732078051859 | 0.0219036006303085 |
| Fortified wine | Rheumatoid arthritis (ebi-a-GCST90018910) | All - Inverse variance weighted | -0.918189543477305 | 0.451835240770201 | 0.0421401396204885 |
| Fortified wine | Bone disorder (ebi-a-GCST90038652) | rs11024916 | 0.0875343844347534 | 0.0415686850050319 | 0.0352237200227752 |
| Fortified wine | Bone disorder (ebi-a-GCST90038652) | All - Inverse variance weighted | 0.0211968244452506 | 0.0096168372574113 | 0.027514728117071 |
| Fortified wine | Osteoporosis (ebi-a-GCST90038656) | All - Inverse variance weighted | 0.0180380436216768 | 0.008202101621916 | 0.027863862622264 |
| Fortified wine | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | All - Inverse variance weighted | 0.0134497678728604 | 0.0057414985681371 | 0.0191522851564348 |
| Fortified wine | Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) | All - Inverse variance weighted | -8.34542665736058 | 3.92138674469603 | 0.033321954952681 |
| Fortified wine | Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) | All - Inverse variance weighted | -8.31027018288975 | 3.92566537484378 | 0.0342677053328227 |
| Fortified wine | Cervicalgia (finn-b-M13_CERVICALGIA) | rs7171089 | -6.79404656126286 | 3.3913709956387 | 0.045141521920307 |
| Fortified wine | Cervicalgia (finn-b-M13_CERVICALGIA) | All - Inverse variance weighted | 1.32658458771287 | 0.676170357576518 | 0.0497731008876027 |
| Fortified wine | Cervicalgia (finn-b-M13_CERVICALGIA) | All - MR Egger | 2.74657310956815 | 1.20029658062277 | 0.0344370402442872 |
| Fortified wine | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | rs182287655 | 5.47173408078398 | 2.41933016561115 | 0.0237176047053017 |
| Fortified wine | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | All - Inverse variance weighted | 0.63864826239005 | 0.308168596307078 | 0.0382282551498033 |
| Fortified wine | Loose body in joint (finn-b-M13_LOOSEJOINT) | rs149716734 | 46.6613577072058 | 15.8558668228921 | 0.0032521124547986 |
| Fortified wine | Loose body in joint (finn-b-M13_LOOSEJOINT) | All - MR Egger | 7.49939961086521 | 3.54634392060603 | 0.0486680845665922 |
| Fortified wine | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | rs113146569 | -3.90174006267524 | 1.71119907636484 | 0.0226005437753925 |
| Fortified wine | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | rs4279116 | -4.91327099620757 | 2.17747237331926 | 0.024044949905368 |
| Fortified wine | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | rs79482515 | -4.28212465973337 | 2.15676694353319 | 0.0470958847263899 |
| Fortified wine | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | All - Inverse variance weighted | -0.913741348180074 | 0.455536745270305 | 0.0448715589318368 |
| Fortified wine | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | rs77439809 | -9.45668752958502 | 3.03301250021915 | 0.0018213280562095 |
| Fortified wine | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | All - Inverse variance weighted | -1.22664280489976 | 0.518398361688942 | 0.0179709274283874 |
| Fortified wine | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | rs117118865 | -3.00836337930879 | 1.49449811654503 | 0.0441189466647759 |
| Fortified wine | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | rs77439809 | -8.74138747172987 | 2.95236592506881 | 0.0030683355155144 |
| Fortified wine | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | All - Inverse variance weighted | -1.25590601606424 | 0.504229354064772 | 0.0127476090501269 |
| Fortified wine | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | rs6042162 | -6.59910067456007 | 3.24675753188356 | 0.0421010082754536 |
| Fortified wine | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | rs77439809 | -11.0100106944371 | 3.50286645979067 | 0.0016714408111333 |
| Fortified wine | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | All - Inverse variance weighted | -1.78956177957551 | 0.595183893994242 | 0.002640676168909 |
| Fortified wine | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | rs77439809 | -10.9328704921194 | 3.48884096846018 | 0.0017263586110183 |
| Fortified wine | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | All - Inverse variance weighted | -1.79447620698024 | 0.593559720952776 | 0.00250080040473 |
| Fortified wine | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs12686701 | -8.91401239265137 | 4.44147655801096 | 0.044750407590066 |
| Fortified wine | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | rs6042162 | -6.53310966781447 | 3.22036112918531 | 0.0424900254521254 |
| Fortified wine | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | rs77439809 | -11.020529812935 | 3.46780273146444 | 0.0014831647304989 |
| Fortified wine | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | All - Inverse variance weighted | -1.85974835734451 | 0.590156045496545 | 0.0016255523889866 |
| Fortified wine | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | rs4279116 | -32.173550131416 | 11.5992278347968 | 0.0055411426348759 |
| Fortified wine | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | All - Inverse variance weighted | -6.62736551044961 | 2.17019903517226 | 0.0022595860888517 |
| Fortified wine | Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) | rs77439809 | 51.789126737846 | 22.6722067357422 | 0.0223564837612276 |
| Fortified wine | Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) | All - MR Egger | 18.2773684357004 | 7.01309488866645 | 0.0178657626153034 |
| Fortified wine | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | All - MR Egger | -14.2792293584025 | 5.85187336982062 | 0.0252537540628402 |
| Fortified wine | Bone morphogenetic protein 10 (prot-a-254) | rs77439809 | 7.48961237048335 | 3.34157330949 | 0.0250038574202007 |
| Fortified wine | Bone morphogenetic protein 10 (prot-a-254) | All - MR Egger | 3.27621392950826 | 1.31918528927286 | 0.0230849857454487 |
| Fortified wine | Bone morphogenetic protein 6 (prot-a-256) | rs4279116 | 7.59323699413897 | 3.50349721604574 | 0.0302096489594229 |
| Fortified wine | Bone morphogenetic protein 6 (prot-a-256) | All - MR Egger | -3.05966307223056 | 1.31925543922117 | 0.0323424104552878 |
| Fortified wine | Fractured bone site(s): Other bones (ukb-a-441) | rs6042162 | -0.17543445179291 | 0.0769527728761124 | 0.0226214652011485 |
| Fortified wine | Fractured bone site(s): Other bones (ukb-a-441) | All - MR Egger | 0.0600733135828008 | 0.0280248728776309 | 0.0452216462265516 |
| Fortified wine | Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) | rs274958 | -0.0539606462806023 | 0.0187569879268615 | 0.0040169324619247 |
| Fortified wine | Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) | rs77439809 | -0.0423962551938148 | 0.0183428531355739 | 0.0208150299889506 |
| Fortified wine | Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) | rs79482515 | -0.0370098415578977 | 0.0158004816081524 | 0.0191640888470036 |
| Fortified wine | Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) | All - Inverse variance weighted | -0.0108274149598055 | 0.0038019539238636 | 0.0044014920224167 |
| Fortified wine | Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) | rs4279116 | -0.054845085402979 | 0.0258200765744451 | 0.0336596431596159 |
| Fortified wine | Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) | All - Inverse variance weighted | -0.0251017614844677 | 0.0126840328441429 | 0.0478154693677273 |
| Fortified wine | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs151034857 | 0.337877054676802 | 0.119528234372623 | 0.0047022263635992 |
| Fortified wine | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs182287655 | 0.270708454241006 | 0.119621756085392 | 0.0236334115275697 |
| Fortified wine | Knee pain for 3+ months (ukb-b-8906) | rs149716734 | 0.562959356026599 | 0.221405589286046 | 0.0110011907026917 |
| Fortified wine | Knee pain for 3+ months (ukb-b-8906) | All - MR Egger | 0.217281746646572 | 0.0962724294425533 | 0.0353554562691696 |
| Fortified wine | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | rs117887999 | 0.0464181146769511 | 0.0213341147663524 | 0.0295725057907609 |
| Fortified wine | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | rs7171089 | -0.0536450455461125 | 0.0208710623356598 | 0.0101608314660967 |
| Fortified wine | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | All - MR Egger | 0.0192040087264888 | 0.0090560601154382 | 0.0489673263688377 |
| Fortified wine | Fractured/broken bones in last 5 years (ukb-e-2463_CSA) | rs11489423 | -9.59455010618772 | 4.08828104995664 | 0.0189332762225347 |
| Fortified wine | Fractured/broken bones in last 5 years (ukb-e-2463_CSA) | All - Inverse variance weighted | -4.58433185934902 | 2.17538641177844 | 0.0350860058293634 |
| Fortified wine | Fractured/broken bones in last 5 years (ukb-e-2463_CSA) | All - MR Egger | -12.0798892859993 | 4.42515860910126 | 0.0232313593324565 |
| Fortified wine | Ankle spacing width (ukb-e-3143_AFR) | rs11489423 | 3.24265239067614 | 1.57441854960699 | 0.0394380149467997 |
| Fortified wine | Ankle spacing width (ukb-e-3143_AFR) | All - MR Egger | 4.6894425226574 | 1.70383138015964 | 0.0284098913501776 |
| Fortified wine | Heel bone mineral density (BMD) (ukb-e-3148_CSA) | All - Inverse variance weighted | 2.00589545102893 | 0.974664774739781 | 0.0395866524789096 |
| Fortified wine | Other disorders of synovium, tendon, and bursa (ukb-e-727_AFR) | rs79482515 | -14.8321351294758 | 6.87862078592867 | 0.031062911867349 |
| Fortified wine | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) | All - Inverse variance weighted | 1.96755071370739 | 0.971135479197433 | 0.0427615945268708 |