ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Chocolate sweet | Frozen shoulder (ebi-a-GCST90000512) | All - Inverse variance weighted | -0.421174895239794 | 0.203903192355384 | 0.0388697585576702 |
| Chocolate sweet | Neck circumference (ebi-a-GCST90017134) | rs7959426 | 10.5399360748593 | 2.83207225426096 | 0.0001979378682179 |
| Chocolate sweet | Neck circumference (ebi-a-GCST90017134) | All - Inverse variance weighted | 3.63774984378267 | 1.64940405789053 | 0.027419487018148 |
| Chocolate sweet | Neck circumference (BMI adjusted) (ebi-a-GCST90017137) | rs7959426 | 10.5399360748593 | 2.83207225426096 | 0.0001979378682179 |
| Chocolate sweet | Neck circumference (BMI adjusted) (ebi-a-GCST90017137) | All - Inverse variance weighted | 3.63774984378267 | 1.64940405789053 | 0.027419487018148 |
| Chocolate sweet | Heel bone mineral density (ebi-a-GCST90029004) | rs138083296 | -0.259844944805278 | 0.117832779905855 | 0.0274400045311054 |
| Chocolate sweet | Heel bone mineral density (ebi-a-GCST90029004) | rs72704169 | 0.242018347952146 | 0.111714940475319 | 0.0302812484384704 |
| Chocolate sweet | Heel bone mineral density (ebi-a-GCST90029004) | All - Inverse variance weighted | 0.0562012858214542 | 0.0273705873626214 | 0.0400390334202553 |
| Chocolate sweet | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | rs117567632 | -0.0266199476043378 | 0.0107312654060422 | 0.0131162474065379 |
| Chocolate sweet | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | rs6486647 | -0.0371530095334365 | 0.0117320298001875 | 0.0015412548578791 |
| Chocolate sweet | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | All - Inverse variance weighted | -0.0064632012680502 | 0.0032917761002066 | 0.0495951967189055 |
| Chocolate sweet | Fracture of forearm or wrist (ebi-a-GCST90038705) | rs117567632 | -0.0173261279218564 | 0.0078537372427689 | 0.0273770148530728 |
| Chocolate sweet | Fracture of forearm or wrist (ebi-a-GCST90038705) | rs6486647 | -0.0177431103463442 | 0.0085861500889298 | 0.0387831469817512 |
| Chocolate sweet | Fracture of forearm or wrist (ebi-a-GCST90038705) | All - Inverse variance weighted | -0.0041607661359505 | 0.002107916970324 | 0.0483958757418604 |
| Chocolate sweet | Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) | All - Inverse variance weighted | -2.95632634263278 | 1.35451734484588 | 0.0290676313948666 |
| Chocolate sweet | Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) | All - Inverse variance weighted | -2.94542911774096 | 1.35217654946729 | 0.0293846478832506 |
| Chocolate sweet | Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) | rs148822130 | 16.2561883900688 | 7.36297207437093 | 0.0272561472099836 |
| Chocolate sweet | Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) | rs185656352 | 66.9769390778624 | 24.0575849632612 | 0.0053688750595927 |
| Chocolate sweet | Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) | rs186365856 | 6.15263370111066 | 3.0909790696822 | 0.0465344647706792 |
| Chocolate sweet | Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) | All - Inverse variance weighted | 3.55210260496332 | 1.46005534725383 | 0.0149803084099509 |
| Chocolate sweet | Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) | rs148822130 | 15.8258071971956 | 7.28327185346849 | 0.029787991392171 |
| Chocolate sweet | Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) | rs185656352 | 65.2874010445505 | 23.6400640498032 | 0.0057496548023418 |
| Chocolate sweet | Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) | rs186365856 | 6.19295480370954 | 3.09922656794106 | 0.0456921746123108 |
| Chocolate sweet | Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) | All - Inverse variance weighted | 3.57274008114756 | 1.46412456049361 | 0.0146795952735683 |
| Chocolate sweet | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | rs117585054 | 45.1476070016557 | 13.051348363072 | 0.0005417234556761 |
| Chocolate sweet | Other bursitis of elbow (finn-b-M13_BURSELBOWOTH) | rs114815025 | 24.2255463738306 | 11.4099761264508 | 0.0337379397556763 |
| Chocolate sweet | Other bursitis of elbow (finn-b-M13_BURSELBOWOTH) | rs185905470 | 14.2582265160854 | 7.16537013209307 | 0.046604159127241 |
| Chocolate sweet | Other bursitis of elbow (finn-b-M13_BURSELBOWOTH) | rs2240193 | -13.1798119362886 | 5.36813151666347 | 0.0140808017710588 |
| Chocolate sweet | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | All - Inverse variance weighted | -3.24078610345447 | 1.35931844087764 | 0.0171197510797136 |
| Chocolate sweet | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs115654287 | -8.06167654335194 | 3.92957827512801 | 0.0402146476344393 |
| Chocolate sweet | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs148822130 | 14.4987985191699 | 7.37758378153638 | 0.0493852782595474 |
| Chocolate sweet | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs7959426 | -14.5973830109941 | 5.73269693827711 | 0.0108859783155104 |
| Chocolate sweet | Pyogenic arthritis (finn-b-M13_PYOGARTH) | rs7959426 | -4.18169821506611 | 2.01372762405847 | 0.0378388859855027 |
| Chocolate sweet | Pyogenic arthritis (finn-b-M13_PYOGARTH) | All - MR Egger | 2.79931454567755 | 0.981096623759371 | 0.0105576377783764 |
| Chocolate sweet | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | rs138083296 | 6.03517678641519 | 1.90524213765303 | 0.0015366627577873 |
| Chocolate sweet | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | All - Inverse variance weighted | 2.0137467274443 | 0.808122960102685 | 0.0127068391084622 |
| Chocolate sweet | Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) | rs138083296 | 0.773556958144838 | 0.386778479072419 | 0.0455002638963584 |
| Chocolate sweet | Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) | rs150503648 | -3.11480789380109 | 1.56267970552826 | 0.0462343186725949 |
| Chocolate sweet | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | rs114815025 | 4.37482190619635 | 1.79590390237945 | 0.0148506845269724 |
| Chocolate sweet | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | rs115654287 | -1.91013175306369 | 0.795121109257235 | 0.016291651181461 |
| Chocolate sweet | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | rs138083296 | -1.38237493446254 | 0.648928337110392 | 0.0331515710969006 |
| Chocolate sweet | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | rs2240193 | 1.95995650227084 | 0.836691613893686 | 0.0191546415378861 |
| Chocolate sweet | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | All - MR Egger | -1.45206367043613 | 0.565395230162923 | 0.0193474163104065 |
| Chocolate sweet | Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) | rs185905470 | 1.65769800890739 | 0.79765122910803 | 0.037688723235488 |
| Chocolate sweet | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | rs117585054 | -4.62984763695063 | 2.07005799552837 | 0.025313887813821 |
| Chocolate sweet | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | rs185656352 | -11.738473280158 | 4.33383715187884 | 0.0067575172077356 |
| Chocolate sweet | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | rs185905470 | 2.70661780701562 | 1.27995197228963 | 0.034461963319341 |
| Chocolate sweet | Four-jointed box protein 1 (prot-a-1112) | rs117567632 | 2.7371048856657 | 1.33529111523417 | 0.040382112361969 |
| Chocolate sweet | Four-jointed box protein 1 (prot-a-1112) | All - Inverse variance weighted | 0.732578281136979 | 0.355646213163413 | 0.0394127675672831 |
| Chocolate sweet | Bone morphogenetic protein 6 (prot-a-256) | All - Inverse variance weighted | 0.723023764022466 | 0.355668483329276 | 0.0420668025029609 |
| Chocolate sweet | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | rs114815025 | 0.0514792261809265 | 0.0171486074561141 | 0.0026825808078269 |
| Chocolate sweet | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | rs185905470 | 0.0513839164506713 | 0.0188996123044026 | 0.0065522873683428 |
| Chocolate sweet | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | All - MR Egger | 0.019581471540086 | 0.0090518810270991 | 0.0450586530886627 |
| Chocolate sweet | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | rs148574253 | -0.0318727290937062 | 0.0151057443975418 | 0.0348605888034277 |
| Chocolate sweet | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | All - Inverse variance weighted | -0.0065878149469207 | 0.0033090428146273 | 0.046497145914255 |
| Chocolate sweet | Diagnoses - main ICD10: N32.0 Bladder-neck obstruction (ukb-b-123) | rs7959426 | -0.0185937325941096 | 0.0067267928602644 | 0.0057074726534069 |
| Chocolate sweet | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs117567632 | 0.280210356730762 | 0.142617315726198 | 0.0494407556605618 |
| Chocolate sweet | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs2240193 | 0.352431395125696 | 0.165693341009403 | 0.033419251387505 |
| Chocolate sweet | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs72704169 | 0.376769998974975 | 0.152980627022594 | 0.0137833392507696 |
| Chocolate sweet | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | All - Inverse variance weighted | 0.0824923767858629 | 0.0396640088210369 | 0.0375457984451455 |
| Chocolate sweet | Non-cancer illness code, self-reported: joint pain (ukb-b-4122) | rs7959426 | -0.0156187285238091 | 0.0071407638454485 | 0.0287233304097392 |
| Chocolate sweet | Operative procedures - main OPCS: W15.1 Osteotomy of neck of first metatarsal bone (ukb-b-6551) | rs7959426 | 0.0109975663887437 | 0.0048197071097438 | 0.0225016568659589 |
| Chocolate sweet | Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) | rs7959426 | -0.0137379926134757 | 0.0066432874317689 | 0.0386446348602041 |
| Chocolate sweet | Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) | All - Inverse variance weighted | -0.0126820792961533 | 0.0063133479162466 | 0.0445612723340965 |
| Chocolate sweet | Heel bone mineral density (BMD) (ukb-b-8875) | rs117567632 | 0.283777180552162 | 0.142587078155653 | 0.0465686167143465 |
| Chocolate sweet | Heel bone mineral density (BMD) (ukb-b-8875) | rs2240193 | 0.340249472270198 | 0.165663660205975 | 0.0399895317880563 |
| Chocolate sweet | Heel bone mineral density (BMD) (ukb-b-8875) | rs72704169 | 0.377136079424814 | 0.152937795609963 | 0.0136652597029218 |
| Chocolate sweet | Heel bone mineral density (BMD) (ukb-b-8875) | All - Inverse variance weighted | 0.0802678667290842 | 0.0394658659948952 | 0.0419661716219763 |
| Chocolate sweet | Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) | All - Inverse variance weighted | 0.0141118759073893 | 0.0065769115335102 | 0.0318993874603197 |
| Chocolate sweet | Fractured bone site(s): Wrist (ukb-b-9571) | rs72704169 | -0.0371352008317348 | 0.0173632689519849 | 0.0324582106381375 |
| Chocolate sweet | Fractured bone site(s): Wrist (ukb-b-9571) | All - Inverse variance weighted | -0.0172756336915397 | 0.0071759157266786 | 0.0160645127486698 |
| Chocolate sweet | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | rs114815025 | 0.0426213492266838 | 0.0202325336372801 | 0.0351544370421205 |
| Chocolate sweet | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | rs185905470 | 0.0546763778876914 | 0.022323273034498 | 0.0143134438628336 |
| Chocolate sweet | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | All - MR Egger | 0.0238537721390602 | 0.010528165870295 | 0.0368172139302538 |
| Chocolate sweet | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | rs185905470 | 0.0518471612553985 | 0.0218541259479486 | 0.017671998890853 |
| Chocolate sweet | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | All - MR Egger | 0.0239213557284706 | 0.0100919171454984 | 0.0298617053389582 |
| Chocolate sweet | Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) | rs12966891 | -0.025557300753092 | 0.011641584735983 | 0.0281388228178799 |
| Chocolate sweet | Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) | All - Inverse variance weighted | -0.0062621409553303 | 0.002538297937096 | 0.0136226382746393 |
| Chocolate sweet | Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) | All - Inverse variance weighted | 2.55087224553882 | 1.20231063625338 | 0.0338678473646062 |
| Chocolate sweet | Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) | rs115654287 | 1.3716126805132 | 0.674184454289166 | 0.041903538045736 |
| Chocolate sweet | Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) | rs148574253 | 3.09984353014384 | 1.19560702259044 | 0.0095227369512407 |
| Chocolate sweet | Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) | All - Inverse variance weighted | 1.17158714723193 | 0.485455929216134 | 0.0158055533507978 |
| Chocolate sweet | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | rs138083296 | -2.18458215031644 | 0.762096855061211 | 0.0041498393861456 |
| Chocolate sweet | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | All - MR Egger | -1.95116560534845 | 0.840646907819451 | 0.0488409328289551 |
| Chocolate sweet | M51 Other intervertebral disk disorders (ukb-e-M51_CSA) | All - Inverse variance weighted | -3.69670330041812 | 1.75220396562846 | 0.034880338712561 |