ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Chocolate biscuits (ukb-b-9886)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Chocolate biscuits (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) Weighted median 5 -0.153041118 0.075204663 0.04185137
Chocolate biscuits (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) Inverse variance weighted 5 -0.122106344 0.05968344 0.04076622
Chocolate biscuits (👉 📊) Rheumatoid arthritis (ebi-a-GCST90018910) Inverse variance weighted 9 0.418197072 0.185910335 0.024483515
Chocolate biscuits (👉 📊) Arthritis (not osteoarthritis) (ebi-a-GCST90038699) Inverse variance weighted 9 -0.003883524 0.001794315 0.030437528
Chocolate biscuits (👉 📊) Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) Inverse variance weighted 8 -1.106280838 0.517390765 0.032501157
Chocolate biscuits (👉 📊) Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) Inverse variance weighted 8 1.64467638 0.691637015 0.017409313
Chocolate biscuits (👉 📊) Cervicalgia (finn-b-M13_CERVICALGIA) MR Egger 8 1.396153248 0.548589946 0.043785588
Chocolate biscuits (👉 📊) Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) Weighted median 8 -1.213106771 0.610530878 0.046925679
Chocolate biscuits (👉 📊) Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) Inverse variance weighted 8 -0.991543703 0.453875285 0.028916934
Chocolate biscuits (👉 📊) Osteomalacia (finn-b-M13_OSTEOMALACIA) Weighted median 8 3.594780983 1.528371396 0.018671085
Chocolate biscuits (👉 📊) Contusion of ankle (finn-b-ST19_CONTU_ANKLE) MR Egger 8 -3.128757842 1.241778454 0.045312911
Chocolate biscuits (👉 📊) Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) Weighted median 8 -1.432187393 0.729042587 0.049474801
Chocolate biscuits (👉 📊) Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) Inverse variance weighted 8 -1.572964977 0.560066717 0.004976802
Chocolate biscuits (👉 📊) Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) Inverse variance weighted 8 -1.489508449 0.622354154 0.016695516
Chocolate biscuits (👉 📊) Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) MR Egger 8 2.024866247 0.508459528 0.007263685
Chocolate biscuits (👉 📊) Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) Weighted median 8 0.590640725 0.289463524 0.04130385
Chocolate biscuits (👉 📊) Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) MR Egger 8 0.901224794 0.354521184 0.043956835
Chocolate biscuits (👉 📊) Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) Weighted median 8 -3.590466039 1.727377444 0.037657364
Chocolate biscuits (👉 📊) Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) Inverse variance weighted 8 -3.162863531 1.310865612 0.015830272
Chocolate biscuits (👉 📊) Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) Weighted median 8 3.690482837 1.750622629 0.035022574
Chocolate biscuits (👉 📊) Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) Inverse variance weighted 8 3.390794332 1.279049935 0.008024772
Chocolate biscuits (👉 📊) Lumbar spine bone mineral density (ieu-a-982) Weighted median 9 0.240206474 0.118227546 0.042180978
Chocolate biscuits (👉 📊) Fractured bone site(s): Ankle (ukb-a-438) Weighted median 9 0.009868412 0.004221177 0.019395846
Chocolate biscuits (👉 📊) Non-cancer illness code self-reported: osteoporosis (ukb-a-87) Weighted median 9 -0.007838225 0.003730437 0.035627427
Chocolate biscuits (👉 📊) Non-cancer illness code self-reported: osteoporosis (ukb-a-87) Inverse variance weighted 9 -0.006028129 0.003020808 0.045984536
Chocolate biscuits (👉 📊) Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) Inverse variance weighted 2 0.012346814 0.004850389 0.010911185
Chocolate biscuits (👉 📊) Heel bone ultrasound T-score, manual entry (ukb-b-17612) Inverse variance weighted 9 -0.148766504 0.068694952 0.03034097
Chocolate biscuits (👉 📊) Fractured bone site(s): Other bones (ukb-b-17738) MR Egger 9 -0.024953566 0.009666139 0.036390336
Chocolate biscuits (👉 📊) Diagnoses - main ICD10: M54.56 Low back pain (Lumbar region) (ukb-b-19813) Inverse variance weighted 2 0.00514901 0.002586931 0.046547621
Chocolate biscuits (👉 📊) Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) Inverse variance weighted 2 -0.008865319 0.004072168 0.029476738
Chocolate biscuits (👉 📊) Operative procedures - main OPCS: W90.1 Aspiration of joint (ukb-b-9333) Inverse variance weighted 2 0.005003636 0.002364108 0.034302234
Chocolate biscuits (👉 📊) Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) Inverse variance weighted 9 0.003083252 0.001508737 0.040993198
Chocolate biscuits (👉 📊) Rheumatoid arthritis (ukb-d-M13_RHEUMA) Inverse variance weighted 9 0.003173652 0.001570825 0.04334474
Chocolate biscuits (👉 📊) Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) Inverse variance weighted 9 -0.005976639 0.002743227 0.029354782
Chocolate biscuits (👉 📊) Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) Inverse variance weighted 9 0.003169032 0.001404077 0.024006706

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Chocolate biscuits Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) All - Inverse variance weighted -0.122106344426626 0.059683440230648 0.0407662201497505
Chocolate biscuits Rheumatoid arthritis (ebi-a-GCST90018910) rs118080427 1.1624950478657 0.549908644209107 0.0345171041403269
Chocolate biscuits Rheumatoid arthritis (ebi-a-GCST90018910) rs4679314 1.06100318750534 0.50127904833409 0.0342944957623473
Chocolate biscuits Rheumatoid arthritis (ebi-a-GCST90018910) rs72667801 0.959150513267796 0.442893863066999 0.030338388220556
Chocolate biscuits Rheumatoid arthritis (ebi-a-GCST90018910) All - Inverse variance weighted 0.418197071970106 0.1859103352465 0.0244835152984463
Chocolate biscuits Arthritis (not osteoarthritis) (ebi-a-GCST90038699) All - Inverse variance weighted -0.0038835239219114 0.0017943145177642 0.0304375281955333
Chocolate biscuits Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) rs118143545 -2.48278707942015 0.934579439252336 0.0078937210025747
Chocolate biscuits Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) All - Inverse variance weighted -1.10628083755924 0.517390764950758 0.0325011566570163
Chocolate biscuits Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) All - Inverse variance weighted 1.64467637978513 0.691637015204559 0.0174093133624605
Chocolate biscuits Cervicalgia (finn-b-M13_CERVICALGIA) rs118143545 1.2929749887285 0.404245726381428 0.0013815042018458
Chocolate biscuits Cervicalgia (finn-b-M13_CERVICALGIA) All - MR Egger 1.39615324789892 0.548589945963079 0.0437855879687082
Chocolate biscuits Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) rs118143545 -1.71250410741168 0.822246505834435 0.0372773229403954
Chocolate biscuits Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) All - Inverse variance weighted -0.9915437029066 0.45387528486643 0.0289169339892407
Chocolate biscuits Osteomalacia (finn-b-M13_OSTEOMALACIA) rs118143545 5.03664193304346 2.04033287228433 0.0135665744327826
Chocolate biscuits Contusion of ankle (finn-b-ST19_CONTU_ANKLE) rs12908565 4.30570505920344 2.12401968322313 0.0426471441590264
Chocolate biscuits Contusion of ankle (finn-b-ST19_CONTU_ANKLE) All - MR Egger -3.12875784215538 1.24177845422468 0.0453129107177107
Chocolate biscuits Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) rs11704431 -3.54565094303321 1.48697454277594 0.0171035938416358
Chocolate biscuits Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) rs12963907 -4.34860667092381 1.86266849193218 0.0195637423970206
Chocolate biscuits Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) All - Inverse variance weighted -1.57296497741912 0.560066716535713 0.0049768023878271
Chocolate biscuits Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) All - Inverse variance weighted -1.48950844881672 0.622354154485265 0.016695516029494
Chocolate biscuits Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) rs12908565 -3.6169203957148 0.868189040955456 3.09920499786664e-05
Chocolate biscuits Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) All - MR Egger 2.02486624741647 0.508459527854226 0.007263685424213
Chocolate biscuits Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) rs118143545 0.76569795431794 0.388198164464585 0.0485592915932612
Chocolate biscuits Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) rs118143545 0.590703112462842 0.299554489114404 0.0486165961251971
Chocolate biscuits Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) rs12908565 -1.52173355887026 0.605489773950484 0.0119632155585965
Chocolate biscuits Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) All - MR Egger 0.901224794237707 0.35452118407665 0.0439568353043175
Chocolate biscuits Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) All - Inverse variance weighted -3.16286353091388 1.31086561193538 0.0158302722407675
Chocolate biscuits Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) All - Inverse variance weighted 3.39079433219487 1.27904993464228 0.0080247719359776
Chocolate biscuits Fractured bone site(s): Ankle (ukb-a-438) rs118080427 0.0257818459191457 0.0089445420088813 0.0039464465429626
Chocolate biscuits Fractured bone site(s): Ankle (ukb-a-438) rs12908565 0.0243363319493567 0.009276615920857 0.0087055406467313
Chocolate biscuits Non-cancer illness code self-reported: osteoporosis (ukb-a-87) All - Inverse variance weighted -0.0060281288537953 0.0030208080396623 0.0459845361785307
Chocolate biscuits Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) All - Inverse variance weighted 0.0123468140797028 0.004850389486138 0.0109111850401844
Chocolate biscuits Heel bone ultrasound T-score, manual entry (ukb-b-17612) rs8076469 -0.4889141494035 0.216281459373346 0.02378739588971
Chocolate biscuits Heel bone ultrasound T-score, manual entry (ukb-b-17612) All - Inverse variance weighted -0.14876650430052 0.068694952466715 0.0303409700899351
Chocolate biscuits Fractured bone site(s): Other bones (ukb-b-17738) All - MR Egger -0.024953566004785 0.0096661394089199 0.036390335594085
Chocolate biscuits Diagnoses - main ICD10: M54.56 Low back pain (Lumbar region) (ukb-b-19813) All - Inverse variance weighted 0.0051490102983751 0.0025869310040222 0.0465476205618855
Chocolate biscuits Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) All - Inverse variance weighted -0.0088653194455724 0.0040721683095051 0.0294767376192912
Chocolate biscuits Operative procedures - main OPCS: W90.1 Aspiration of joint (ukb-b-9333) All - Inverse variance weighted 0.0050036357600085 0.0023641076185351 0.0343022338560785
Chocolate biscuits Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) rs8076469 0.0134729132310656 0.0047001822676787 0.0041508258521249
Chocolate biscuits Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) All - Inverse variance weighted 0.0030832524798844 0.0015087366847256 0.0409931978372724
Chocolate biscuits Rheumatoid arthritis (ukb-d-M13_RHEUMA) rs8076469 0.0139797909661307 0.0048936211912074 0.0042801971087936
Chocolate biscuits Rheumatoid arthritis (ukb-d-M13_RHEUMA) All - Inverse variance weighted 0.003173651586926 0.0015708248031966 0.0433447404631475
Chocolate biscuits Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) rs11704431 -0.0176374145882922 0.0086061468943945 0.0404232767467132
Chocolate biscuits Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) All - Inverse variance weighted -0.005976639251194 0.0027432273874642 0.0293547817070928
Chocolate biscuits Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) rs8076469 0.0118169931712616 0.0043741443078447 0.0069015981685912
Chocolate biscuits Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) All - Inverse variance weighted 0.0031690324932674 0.0014040769810628 0.0240067064640887