ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Soya dessert | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | All - Inverse variance weighted | 3.18660282390582 | 1.40512523845698 | 0.0233388040788791 |
| Soya dessert | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | All - MR Egger | 7.53294443490569 | 2.58430008154934 | 0.0096530060451451 |
| Soya dessert | Rheumatoid arthritis (ebi-a-GCST005569) | rs117586700 | 11.5546464444888 | 4.85652231756802 | 0.0173501765913149 |
| Soya dessert | Osteoclast-associated immunoglobulin-like receptor levels (ebi-a-GCST90010135) | rs72835369 | 29.457310648925 | 11.7170367190853 | 0.0119350782124589 |
| Soya dessert | Osteoclast-associated immunoglobulin-like receptor levels (ebi-a-GCST90010135) | All - MR Egger | -6.44202239723016 | 2.79844385174039 | 0.0299433550593511 |
| Soya dessert | Juvenile rheumatoid arthritis (ebi-a-GCST90018873) | All - Inverse variance weighted | -7.45319420138247 | 3.37702838207036 | 0.0273121444945304 |
| Soya dessert | Heel bone mineral density T score (ebi-a-GCST90025982) | All - Inverse variance weighted | 0.371398377289669 | 0.169813142468613 | 0.0287352016986049 |
| Soya dessert | Rheumatoid arthritis (ebi-a-GCST90038685) | rs34374711 | -0.118032263944586 | 0.0449752261956053 | 0.0086805856428747 |
| Soya dessert | Rheumatoid arthritis (ebi-a-GCST90038685) | All - Inverse variance weighted | -0.0244322323049193 | 0.0111584974505845 | 0.0285559503839785 |
| Soya dessert | Rheumatoid arthritis (ebi-a-GCST90038685) | All - MR Egger | -0.0498713597991369 | 0.0229386332577457 | 0.042539049882045 |
| Soya dessert | Fractures (ebi-a-GCST90038703) | All - Inverse variance weighted | 0.0310298330025943 | 0.0139637352126037 | 0.0262716278386086 |
| Soya dessert | Fracture of pelvis or lower limb (ebi-a-GCST90038706) | All - MR Egger | 0.055855168778552 | 0.0197797469515882 | 0.0108445447589659 |
| Soya dessert | Fracture of lower leg or ankle (ebi-a-GCST90038707) | rs184459654 | 0.11737123708002 | 0.0372455194461434 | 0.0016255393426024 |
| Soya dessert | Fracture of lower leg or ankle (ebi-a-GCST90038707) | rs34374711 | 0.0646646008020416 | 0.0310575265966261 | 0.0373341461313854 |
| Soya dessert | Fracture of lower leg or ankle (ebi-a-GCST90038707) | All - Inverse variance weighted | 0.0178335769546484 | 0.0078437377892891 | 0.022989627666373 |
| Soya dessert | Fracture of lower leg or ankle (ebi-a-GCST90038707) | All - MR Egger | 0.0336180130012371 | 0.0160154921642814 | 0.0494030211496905 |
| Soya dessert | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | rs117586700 | 50.4822723341981 | 24.8320361870551 | 0.0420576383758493 |
| Soya dessert | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | rs144004344 | 60.6629279682283 | 29.2949571213477 | 0.0383809026805534 |
| Soya dessert | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | rs144278273 | 62.419876930966 | 23.8766745721428 | 0.0089420502916163 |
| Soya dessert | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | rs146214493 | 34.8328542887488 | 16.3989215926561 | 0.0336622671686129 |
| Soya dessert | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | rs72835369 | 32.1535880126429 | 11.4332539899325 | 0.004919063825972 |
| Soya dessert | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | All - Inverse variance weighted | 9.31867480006837 | 3.76878453057486 | 0.0134136354738158 |
| Soya dessert | Benign neoplasm: Skin of upper limb, including shoulder (finn-b-CD2_BENIGN_SKIN_UPPERLIMB) | rs117586700 | 69.2942193840218 | 27.8387547395729 | 0.0128056910849495 |
| Soya dessert | Benign neoplasm: Skin of upper limb, including shoulder (finn-b-CD2_BENIGN_SKIN_UPPERLIMB) | rs147317193 | -27.1782447026397 | 12.4126368200279 | 0.0285559776786867 |
| Soya dessert | Benign neoplasm: Skin of upper limb, including shoulder (finn-b-CD2_BENIGN_SKIN_UPPERLIMB) | All - MR Egger | -13.0802101484795 | 6.27541749429459 | 0.0470943259151811 |
| Soya dessert | Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) | rs74836046 | -69.4256745285261 | 33.5549503908293 | 0.0385447382906702 |
| Soya dessert | Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) | All - Inverse variance weighted | -13.4982918208666 | 4.46912057622465 | 0.0025248581545536 |
| Soya dessert | Bicipital tendinitis (finn-b-M13_BICIPITALTEND) | rs11694725 | 31.1926049401424 | 13.662676163055 | 0.0224272848073009 |
| Soya dessert | Bicipital tendinitis (finn-b-M13_BICIPITALTEND) | rs117949207 | 82.7633748749696 | 26.7948059437881 | 0.0020097732441378 |
| Soya dessert | Bicipital tendinitis (finn-b-M13_BICIPITALTEND) | rs148405974 | 40.8934346651166 | 20.678609635589 | 0.0479770365298603 |
| Soya dessert | Bicipital tendinitis (finn-b-M13_BICIPITALTEND) | rs77263279 | 26.1195403314266 | 11.7640996193968 | 0.0264000825428577 |
| Soya dessert | Bicipital tendinitis (finn-b-M13_BICIPITALTEND) | All - Inverse variance weighted | 6.08044375538594 | 2.43452171927061 | 0.0125039756023677 |
| Soya dessert | Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) | rs10840617 | 67.9502458301734 | 31.2227536074869 | 0.0295324355021775 |
| Soya dessert | Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) | rs147659323 | 10.093064627476 | 4.88556104296107 | 0.0388382308400826 |
| Soya dessert | Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) | rs75749401 | 24.1085135917778 | 11.7899594590868 | 0.0408711961471615 |
| Soya dessert | Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) | All - Inverse variance weighted | 6.41737448990239 | 2.83581561376616 | 0.0236373467107278 |
| Soya dessert | Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) | All - MR Egger | -14.0791019313001 | 6.47448645190843 | 0.0389505878268849 |
| Soya dessert | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | rs34374711 | 127.253670500116 | 62.2907897789414 | 0.0410626307096832 |
| Soya dessert | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | rs74836046 | 169.60835580064 | 47.5922065045399 | 0.0003655464496522 |
| Soya dessert | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | rs147659323 | -7.15575381020657 | 3.47166905634326 | 0.0392853493360038 |
| Soya dessert | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | rs74836046 | -30.0778942078492 | 15.1713740483936 | 0.0474185528617627 |
| Soya dessert | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | All - Inverse variance weighted | -4.11017998477619 | 2.04311021729882 | 0.0442487229871815 |
| Soya dessert | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs117949207 | 151.212457084156 | 61.4383678912889 | 0.0138470976339087 |
| Soya dessert | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs13250489 | -62.3579978558291 | 30.1708451770908 | 0.0387502070622713 |
| Soya dessert | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs74857779 | 217.20514570483 | 89.534748960171 | 0.0152691624043728 |
| Soya dessert | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs75749401 | 44.1859182378952 | 20.2290883350647 | 0.0289419511393098 |
| Soya dessert | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | All - MR Egger | 20.476129421459 | 9.53679344803439 | 0.0412871331643192 |
| Soya dessert | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs116362645 | -28.2096516248166 | 11.0189658109794 | 0.0104642122984548 |
| Soya dessert | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs34374711 | -44.6591323368575 | 17.8885095946707 | 0.0125416414349386 |
| Soya dessert | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | All - Inverse variance weighted | -3.45104538704757 | 1.6838140802454 | 0.0404092781618576 |
| Soya dessert | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs75398225 | -12.4872109897731 | 5.15841249320417 | 0.0154886576498631 |
| Soya dessert | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs75749401 | 8.62298789288374 | 3.43816361613914 | 0.0121409317328588 |
| Soya dessert | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs76224945 | 12.1241343034979 | 5.18102919260103 | 0.0192784985690654 |
| Soya dessert | Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) | rs13250489 | -12.0732558940111 | 6.07351162081616 | 0.0468278116924262 |
| Soya dessert | Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) | rs147659323 | -3.43184111305826 | 1.71923955180288 | 0.0459187953908214 |
| Soya dessert | Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) | rs148405974 | 22.7192619022589 | 9.04689171557018 | 0.0120294855382431 |
| Soya dessert | Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) | rs72835369 | -7.50185351387209 | 3.47289967612284 | 0.0307639724533713 |
| Soya dessert | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | rs147659323 | 2.42950454038553 | 1.05544049705273 | 0.0213415572302346 |
| Soya dessert | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | rs117586700 | -8.94033127120335 | 3.76505022284308 | 0.0175699611217908 |
| Soya dessert | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | rs117608723 | 14.9633018681302 | 6.89833577649392 | 0.0300737532528164 |
| Soya dessert | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | rs146111071 | 10.6390801524166 | 4.97693696102681 | 0.0325430249128644 |
| Soya dessert | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | rs147659323 | 2.55894535606181 | 0.843024799532685 | 0.0024019052605923 |
| Soya dessert | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | rs17091776 | -6.86349630740638 | 3.38283962894733 | 0.0424668811709887 |
| Soya dessert | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | rs75398225 | -6.39985616376782 | 3.00514985081272 | 0.0332022028607256 |
| Soya dessert | Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) | rs117608723 | 23.4036185828992 | 11.402543254087 | 0.0401219588053104 |
| Soya dessert | Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) | rs147659323 | 3.20283043916945 | 1.38402102915405 | 0.020659567867126 |
| Soya dessert | Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) | rs17091776 | -11.2571121146416 | 5.48590619344952 | 0.0401690847986297 |
| Soya dessert | Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) | rs34374711 | -24.2103867696285 | 9.25910582308687 | 0.0089288839252352 |
| Soya dessert | Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) | rs76224945 | 13.7634785657929 | 5.03199789602875 | 0.0062343968520784 |
| Soya dessert | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs116362645 | 43.4548442231492 | 17.5808836056474 | 0.0134468582387953 |
| Soya dessert | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs147659323 | 11.8156231745526 | 4.56693749668101 | 0.0096756799438761 |
| Soya dessert | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs183468306 | -46.1991533222897 | 19.5522313136891 | 0.0181345987837642 |
| Soya dessert | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | All - MR Egger | 12.6029537643453 | 4.80609243220518 | 0.0144098610579379 |
| Soya dessert | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | rs146214493 | 65.0126631165378 | 30.4731772167881 | 0.0328887349827916 |
| Soya dessert | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | rs77263279 | -63.6056450009938 | 30.9046872354366 | 0.0395783357698289 |
| Soya dessert | Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) | rs117586700 | 48.6928756735183 | 21.3197631876538 | 0.0223755654129043 |
| Soya dessert | Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) | rs147659323 | -11.6861823588763 | 4.94198396261484 | 0.0180459345036906 |
| Soya dessert | Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) | All - Inverse variance weighted | -5.71108165337766 | 2.84008333563978 | 0.044337579989013 |
| Soya dessert | Forearm bone mineral density (ieu-a-977) | rs61922525 | 8.03555871332268 | 3.82594500410228 | 0.0357041499922878 |
| Soya dessert | Forearm bone mineral density (ieu-a-977) | All - Inverse variance weighted | 1.43364733682423 | 0.73094811024606 | 0.049837847813202 |
| Soya dessert | Osteomyelitis (ieu-b-4975) | rs144278273 | 12.3202839561567 | 5.40774629831421 | 0.0227107403853147 |
| Soya dessert | Osteomyelitis (ieu-b-4975) | All - MR Egger | 4.03713341340198 | 1.78810859187733 | 0.0322526855143936 |
| Soya dessert | Alkaline phosphatase, bone (prot-c-2795_23_3) | rs61922525 | 25.0873319969212 | 11.7946831096112 | 0.0334197942084144 |
| Soya dessert | Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) | All - Inverse variance weighted | -0.0727732075694561 | 0.0358501659235114 | 0.0423639947018116 |
| Soya dessert | Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint (ukb-b-19054) | rs13250489 | 0.0855679102202201 | 0.0327952415142961 | 0.0090765780528081 |
| Soya dessert | Operative procedures - main OPCS: W26.2 Manipulation of fracture of bone NEC (ukb-b-1935) | rs13250489 | -0.064607164284801 | 0.0250752426945737 | 0.0099796978271887 |
| Soya dessert | Fractured bone site(s): Leg (ukb-b-3798) | rs13250489 | -0.0886656470379951 | 0.0420041113001741 | 0.0347826100025787 |
| Soya dessert | Non-cancer illness code, self-reported: other joint disorder (ukb-b-5316) | rs13250489 | 0.0998325481208998 | 0.0410222679033353 | 0.0149487433679981 |
| Soya dessert | Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint (ukb-b-7012) | rs13250489 | 0.0564917724818286 | 0.0264057597545023 | 0.0324054625728179 |
| Soya dessert | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | rs13250489 | 0.174819269998328 | 0.0685436358450296 | 0.0107574256437368 |
| Soya dessert | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | rs148405974 | 0.155000525622554 | 0.0635799224552139 | 0.0147734818128465 |
| Soya dessert | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | All - Inverse variance weighted | 0.0308652637166938 | 0.0123889607724435 | 0.012725792914563 |
| Soya dessert | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | rs116362645 | 0.0892767051918289 | 0.0427345720739287 | 0.0366989104905113 |
| Soya dessert | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | rs184459654 | 0.119542256235769 | 0.0419899467010686 | 0.0044143671209319 |
| Soya dessert | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | All - Inverse variance weighted | 0.0320120001404506 | 0.008424110343897 | 0.0001446696936894 |
| Soya dessert | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | All - MR Egger | 0.0464496816992626 | 0.0166100105689828 | 0.0108144807906423 |
| Soya dessert | Ankle spacing width (ukb-e-3143_CSA) | rs144278273 | -6.52602397282225 | 2.76344465098391 | 0.0181985176993577 |
| Soya dessert | Ankle spacing width (ukb-e-3143_CSA) | rs72835369 | -35.5386896632458 | 14.1257267725446 | 0.0118734262095109 |
| Soya dessert | Ankle spacing width (ukb-e-3143_CSA) | rs76224945 | -15.2450249846585 | 5.97790830191987 | 0.0107652704829578 |
| Soya dessert | Ankle spacing width (ukb-e-3143_CSA) | All - Inverse variance weighted | -2.46427822828921 | 1.17221270034334 | 0.0355318242162199 |
| Soya dessert | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | All - MR Egger | 17.8122714965981 | 6.89631277843388 | 0.0207957521237214 |