ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Total body bone mineral density (age 15-30) (ebi-a-GCST005344)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Sponge pudding (ukb-b-12067) (👉 📊) Total body bone mineral density (age 15-30) Inverse variance weighted 15 -1.819825975 0.875190805 0.037585405
Other sweets (ukb-b-139) (👉 📊) Total body bone mineral density (age 15-30) Weighted median 25 1.540611258 0.529807255 0.003638982
Other sweets (ukb-b-139) (👉 📊) Total body bone mineral density (age 15-30) Inverse variance weighted 25 1.030288293 0.402303829 0.010438018
Vegetarian alternatives (ukb-b-14425) (👉 📊) Total body bone mineral density (age 15-30) Weighted median 6 -5.171965076 2.389339885 0.030418332
Vegetarian alternatives (ukb-b-14425) (👉 📊) Total body bone mineral density (age 15-30) Inverse variance weighted 6 -4.700243604 1.904940957 0.013609977
Lobster/crab (ukb-b-14746) (👉 📊) Total body bone mineral density (age 15-30) MR Egger 42 5.722056847 2.564911305 0.031360871
Rose wine (ukb-b-16124) (👉 📊) Total body bone mineral density (age 15-30) Weighted median 12 1.227472447 0.608587008 0.043703667
Rose wine (ukb-b-16124) (👉 📊) Total body bone mineral density (age 15-30) Inverse variance weighted 12 0.88702127 0.410714516 0.030795688
Dark chocolate (ukb-b-16139) (👉 📊) Total body bone mineral density (age 15-30) MR Egger 19 2.024261664 0.943350793 0.046618867
Dark chocolate (ukb-b-16139) (👉 📊) Total body bone mineral density (age 15-30) Inverse variance weighted 19 1.268943052 0.564872345 0.024676833
Fruitcake (ukb-b-17775) (👉 📊) Total body bone mineral density (age 15-30) MR Egger 13 4.354964845 1.809608549 0.034824752
Espresso (ukb-b-19142) (👉 📊) Total body bone mineral density (age 15-30) MR Egger 29 1.605124569 0.694237396 0.028637894
Milk-based pudding (ukb-b-20554) (👉 📊) Total body bone mineral density (age 15-30) Inverse variance weighted 15 1.585682951 0.646994922 0.014252212
Oily fish (ukb-b-2209) (👉 📊) Total body bone mineral density (age 15-30) MR Egger 169 1.463738534 0.71687172 0.042740369
Milk (ukb-b-2966) (👉 📊) Total body bone mineral density (age 15-30) Weighted median 20 -1.445995449 0.608173319 0.017425518
Milk (ukb-b-2966) (👉 📊) Total body bone mineral density (age 15-30) Inverse variance weighted 20 -1.231649861 0.461880199 0.007662275
Pizza (ukb-b-3852) (👉 📊) Total body bone mineral density (age 15-30) Inverse variance weighted 14 0.775568379 0.379908304 0.041204924
Mushroom (ukb-b-4043) (👉 📊) Total body bone mineral density (age 15-30) MR Egger 10 2.168137635 0.866962838 0.036893565
White fish (ukb-b-5427) (👉 📊) Total body bone mineral density (age 15-30) Inverse variance weighted 6 -1.899035241 0.882921078 0.031487644
Tofu (ukb-b-5522) (👉 📊) Total body bone mineral density (age 15-30) Inverse variance weighted 35 2.517826393 1.061580893 0.017703076
Doughnut (ukb-b-6214) (👉 📊) Total body bone mineral density (age 15-30) Weighted median 28 -2.216659206 1.048441437 0.03449458
Sweet potato (ukb-b-9686) (👉 📊) Total body bone mineral density (age 15-30) Inverse variance weighted 18 1.639649038 0.697750532 0.018778089
Soya dessert (ukb-b-998) (👉 📊) Total body bone mineral density (age 15-30) MR Egger 19 7.532944435 2.584300082 0.009653006
Soya dessert (ukb-b-998) (👉 📊) Total body bone mineral density (age 15-30) Inverse variance weighted 19 3.186602824 1.405125238 0.023338804

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Sponge pudding (ukb-b-12067) Total body bone mineral density (age 15-30) rs1468548 -7.86683935338418 3.01668771952266 0.0091133140886449
Sponge pudding (ukb-b-12067) Total body bone mineral density (age 15-30) All - Inverse variance weighted -1.81982597526335 0.875190804689847 0.0375854050425064
Other sweets (ukb-b-139) Total body bone mineral density (age 15-30) rs720112 -6.23709566414315 2.27259692590044 0.0060606940569954
Other sweets (ukb-b-139) Total body bone mineral density (age 15-30) rs76694902 3.25501015674742 1.12300275899706 0.0037496651276254
Other sweets (ukb-b-139) Total body bone mineral density (age 15-30) All - Inverse variance weighted 1.03028829258131 0.402303828699174 0.0104380177721053
Vegetarian alternatives (ukb-b-14425) Total body bone mineral density (age 15-30) All - Inverse variance weighted -4.70024360436196 1.90494095667283 0.0136099768832284
Lobster/crab (ukb-b-14746) Total body bone mineral density (age 15-30) rs117123413 25.2288380588764 11.6187245497058 0.0299013417240028
Lobster/crab (ukb-b-14746) Total body bone mineral density (age 15-30) rs143695299 30.5175468355385 10.3283199517509 0.0031292806081428
Lobster/crab (ukb-b-14746) Total body bone mineral density (age 15-30) rs186181876 29.1908396946565 10.0424088210348 0.0036519705452261
Lobster/crab (ukb-b-14746) Total body bone mineral density (age 15-30) All - MR Egger 5.72205684732583 2.56491130525718 0.0313608707279129
Rose wine (ukb-b-16124) Total body bone mineral density (age 15-30) rs12456862 3.61618412972776 1.7360716262215 0.0372540099287419
Rose wine (ukb-b-16124) Total body bone mineral density (age 15-30) rs13224220 1.23078696271415 0.520717561148295 0.0180965654136911
Rose wine (ukb-b-16124) Total body bone mineral density (age 15-30) All - Inverse variance weighted 0.887021270070393 0.410714515924221 0.030795688076005
Dark chocolate (ukb-b-16139) Total body bone mineral density (age 15-30) rs112868306 4.65152838427948 1.23144104803493 0.0001585345644671
Dark chocolate (ukb-b-16139) Total body bone mineral density (age 15-30) rs145537395 5.4621891509482 2.05620985555635 0.0078971522665663
Dark chocolate (ukb-b-16139) Total body bone mineral density (age 15-30) All - Inverse variance weighted 1.26894305240282 0.564872345032503 0.0246768330893036
Dark chocolate (ukb-b-16139) Total body bone mineral density (age 15-30) All - MR Egger 2.02426166364861 0.943350793152833 0.0466188673653536
Fruitcake (ukb-b-17775) Total body bone mineral density (age 15-30) All - MR Egger 4.35496484477446 1.8096085490497 0.0348247517399219
Espresso (ukb-b-19142) Total body bone mineral density (age 15-30) rs10000963 -5.11161724447478 2.21083009993249 0.0207732455112812
Espresso (ukb-b-19142) Total body bone mineral density (age 15-30) rs1370699 -4.15333814879785 2.10676572765109 0.048674875673469
Espresso (ukb-b-19142) Total body bone mineral density (age 15-30) All - MR Egger 1.60512456890918 0.694237395549634 0.0286378942015733
Milk-based pudding (ukb-b-20554) Total body bone mineral density (age 15-30) All - Inverse variance weighted 1.58568295138094 0.646994922124126 0.0142522117117273
Oily fish (ukb-b-2209) Total body bone mineral density (age 15-30) rs10744777 -8.91654330324627 2.55679193514772 0.0004877504791989
Oily fish (ukb-b-2209) Total body bone mineral density (age 15-30) rs116900901 -6.82192077705864 2.76324733280137 0.0135564803035852
Oily fish (ukb-b-2209) Total body bone mineral density (age 15-30) rs1260326 -5.75497088284249 2.46030353727467 0.0193286839874062
Oily fish (ukb-b-2209) Total body bone mineral density (age 15-30) rs17050031 -3.74298708627959 1.8756431962288 0.0459801788832574
Oily fish (ukb-b-2209) Total body bone mineral density (age 15-30) rs2827161 -4.59323711186213 2.17525253468267 0.0347218041880297
Oily fish (ukb-b-2209) Total body bone mineral density (age 15-30) rs4002471 3.02433498407287 1.21596973586435 0.0128760418357853
Oily fish (ukb-b-2209) Total body bone mineral density (age 15-30) rs45501495 5.82259267998699 1.63262182483754 0.0003619101961009
Oily fish (ukb-b-2209) Total body bone mineral density (age 15-30) rs4817505 -5.25460710567684 2.6437584811443 0.046861274144571
Oily fish (ukb-b-2209) Total body bone mineral density (age 15-30) rs55930451 -4.5268237763796 2.14027289945408 0.0344241100784836
Oily fish (ukb-b-2209) Total body bone mineral density (age 15-30) rs77869596 7.98920705761244 2.75897786743479 0.003782986484107
Oily fish (ukb-b-2209) Total body bone mineral density (age 15-30) rs7965154 -7.05408449628682 2.31954334586969 0.0023567461698702
Oily fish (ukb-b-2209) Total body bone mineral density (age 15-30) rs9860241 -6.74825753947115 2.6411090867582 0.0106161947509127
Oily fish (ukb-b-2209) Total body bone mineral density (age 15-30) All - MR Egger 1.46373853364288 0.716871720212485 0.0427403688356684
Milk (ukb-b-2966) Total body bone mineral density (age 15-30) rs2807888 -3.73241976199062 1.88724606322875 0.0479617694093487
Milk (ukb-b-2966) Total body bone mineral density (age 15-30) All - Inverse variance weighted -1.23164986051901 0.461880199341132 0.0076622747652934
Pizza (ukb-b-3852) Total body bone mineral density (age 15-30) rs2990534 3.37839367796572 1.48993501347282 0.0233610899495301
Pizza (ukb-b-3852) Total body bone mineral density (age 15-30) All - Inverse variance weighted 0.775568378942139 0.379908303986897 0.0412049238955806
Mushroom (ukb-b-4043) Total body bone mineral density (age 15-30) All - MR Egger 2.16813763494038 0.866962837830119 0.0368935651519971
White fish (ukb-b-5427) Total body bone mineral density (age 15-30) rs10089529 -4.76316485842816 2.29820891951556 0.0382136935485458
White fish (ukb-b-5427) Total body bone mineral density (age 15-30) All - Inverse variance weighted -1.89903524057003 0.882921078192277 0.0314876441123882
Tofu (ukb-b-5522) Total body bone mineral density (age 15-30) rs11960530 8.14143195063285 3.86129648614042 0.0349902622338844
Tofu (ukb-b-5522) Total body bone mineral density (age 15-30) rs79406768 15.9197928793592 6.52291011450713 0.0146630198319869
Tofu (ukb-b-5522) Total body bone mineral density (age 15-30) All - Inverse variance weighted 2.51782639295444 1.06158089285385 0.017703076304257
Doughnut (ukb-b-6214) Total body bone mineral density (age 15-30) rs117309828 -9.99234702751592 4.7613664034508 0.0358495175831096
Doughnut (ukb-b-6214) Total body bone mineral density (age 15-30) rs118029434 8.98765650871354 4.50767245723526 0.046167630308472
Sweet potato (ukb-b-9686) Total body bone mineral density (age 15-30) rs28360770 7.68459026191645 2.90980830093035 0.0082679619641864
Sweet potato (ukb-b-9686) Total body bone mineral density (age 15-30) All - Inverse variance weighted 1.63964903845058 0.697750532161891 0.0187780892533404
Soya dessert (ukb-b-998) Total body bone mineral density (age 15-30) All - Inverse variance weighted 3.18660282390582 1.40512523845698 0.0233388040788791
Soya dessert (ukb-b-998) Total body bone mineral density (age 15-30) All - MR Egger 7.53294443490569 2.58430008154934 0.0096530060451451