ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Total body bone mineral density (age 45-60) (ebi-a-GCST005350)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Tinned tomato (ukb-b-10565) (👉 📊) Total body bone mineral density (age 45-60) MR Egger 12 -0.92621271 0.408724593 0.046879838
Tinned tomato (ukb-b-10565) (👉 📊) Total body bone mineral density (age 45-60) Weighted median 12 -0.578568447 0.246225488 0.018786002
Tinned tomato (ukb-b-10565) (👉 📊) Total body bone mineral density (age 45-60) Inverse variance weighted 12 -0.349859705 0.173723953 0.044021825
Fried potatoes (ukb-b-12836) (👉 📊) Total body bone mineral density (age 45-60) MR Egger 19 -0.544401728 0.225039154 0.027057028
Cottage cheese (ukb-b-14171) (👉 📊) Total body bone mineral density (age 45-60) MR Egger 24 -1.557247237 0.735059982 0.045659477
Water (ukb-b-14898) (👉 📊) Total body bone mineral density (age 45-60) MR Egger 160 -0.677055955 0.293838454 0.022515185
Boiled/baked potatoes (ukb-b-18007) (👉 📊) Total body bone mineral density (age 45-60) Weighted median 9 -0.318918394 0.143179221 0.025920088
Low fat hard cheese (ukb-b-18079) (👉 📊) Total body bone mineral density (age 45-60) Inverse variance weighted 15 -0.672737442 0.266952777 0.01173343
Oily fish (ukb-b-2209) (👉 📊) Total body bone mineral density (age 45-60) Weighted median 170 0.292976755 0.127119822 0.02118175
Cake (ukb-b-3433) (👉 📊) Total body bone mineral density (age 45-60) Inverse variance weighted 10 -0.541138406 0.233719688 0.020594832
Sushi (ukb-b-5213) (👉 📊) Total body bone mineral density (age 45-60) MR Egger 69 -2.077611992 0.905661585 0.0249309
Sausage (ukb-b-5847) (👉 📊) Total body bone mineral density (age 45-60) Weighted median 15 0.447601502 0.214832289 0.037206338
Couscous (ukb-b-758) (👉 📊) Total body bone mineral density (age 45-60) MR Egger 17 1.75394319 0.762686189 0.03624588
Couscous (ukb-b-758) (👉 📊) Total body bone mineral density (age 45-60) Weighted median 17 1.302639145 0.589205723 0.02704697
Soft cheese (ukb-b-8007) (👉 📊) Total body bone mineral density (age 45-60) Inverse variance weighted 17 0.7668789 0.330267789 0.020233409
Cappuccino (ukb-b-8374) (👉 📊) Total body bone mineral density (age 45-60) Inverse variance weighted 21 0.33876156 0.170156374 0.04649367
Squash (ukb-b-8793) (👉 📊) Total body bone mineral density (age 45-60) Inverse variance weighted 19 -0.244390207 0.116608024 0.036097569
Other milk-based pudding (ukb-b-9857) (👉 📊) Total body bone mineral density (age 45-60) MR Egger 23 -1.781330379 0.812951952 0.03985563
Other milk-based pudding (ukb-b-9857) (👉 📊) Total body bone mineral density (age 45-60) Inverse variance weighted 23 -1.079870835 0.341794728 0.001580871

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Tinned tomato (ukb-b-10565) Total body bone mineral density (age 45-60) All - Inverse variance weighted -0.349859704783902 0.173723952938493 0.0440218252643999
Tinned tomato (ukb-b-10565) Total body bone mineral density (age 45-60) All - MR Egger -0.92621271039953 0.408724592610711 0.0468798377060366
Fried potatoes (ukb-b-12836) Total body bone mineral density (age 45-60) rs115451005 -1.3365501811564 0.462491443073481 0.0038537457017563
Fried potatoes (ukb-b-12836) Total body bone mineral density (age 45-60) All - MR Egger -0.544401727574596 0.225039154361164 0.0270570278474262
Cottage cheese (ukb-b-14171) Total body bone mineral density (age 45-60) rs73211402 -4.76685556016717 1.80400826802878 0.0082328301521494
Cottage cheese (ukb-b-14171) Total body bone mineral density (age 45-60) All - MR Egger -1.55724723658812 0.735059981686577 0.0456594770593437
Water (ukb-b-14898) Total body bone mineral density (age 45-60) rs118027723 -2.46175022499868 1.20109587590661 0.0404047718767537
Water (ukb-b-14898) Total body bone mineral density (age 45-60) rs12894578 -2.74739671061004 1.14537247063579 0.0164537115598896
Water (ukb-b-14898) Total body bone mineral density (age 45-60) rs1421085 -2.19816819317236 0.907577019150708 0.0154345711980951
Water (ukb-b-14898) Total body bone mineral density (age 45-60) rs182050989 -2.11936582809224 1.07442348008386 0.0485456028148166
Water (ukb-b-14898) Total body bone mineral density (age 45-60) rs197503 -2.53057598298758 1.22727504754333 0.039212791431774
Water (ukb-b-14898) Total body bone mineral density (age 45-60) rs3808058 -2.02927169875134 0.905535220410546 0.0250284163766885
Water (ukb-b-14898) Total body bone mineral density (age 45-60) rs6059662 2.57670128923916 1.29945711569389 0.0473779322561446
Water (ukb-b-14898) Total body bone mineral density (age 45-60) rs6503416 3.96294000463723 1.27760453880842 0.00192314176668
Water (ukb-b-14898) Total body bone mineral density (age 45-60) rs6747465 -2.7309436841972 1.17827005729476 0.0204625307563197
Water (ukb-b-14898) Total body bone mineral density (age 45-60) rs780093 -4.7555069717626 1.13627157732381 2.84933713946245e-05
Water (ukb-b-14898) Total body bone mineral density (age 45-60) rs8024871 3.61691476022726 1.2745318678896 0.0045420251844249
Water (ukb-b-14898) Total body bone mineral density (age 45-60) All - MR Egger -0.677055954936183 0.293838454440194 0.0225151851124428
Low fat hard cheese (ukb-b-18079) Total body bone mineral density (age 45-60) rs113861725 -2.26447112237415 1.0605928643874 0.0327528967318767
Low fat hard cheese (ukb-b-18079) Total body bone mineral density (age 45-60) rs27779 -2.63091032775733 1.00810582652384 0.0090606797853478
Low fat hard cheese (ukb-b-18079) Total body bone mineral density (age 45-60) All - Inverse variance weighted -0.672737441995059 0.266952777153307 0.0117334299238406
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs1053924 -3.11837844320953 0.991484428097389 0.0016599528606054
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs11747857 -3.16692696674417 1.20693959318915 0.0086921233035133
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs117551050 3.37076824240256 1.33366946140897 0.011489777374402
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs1260326 -4.76015249603142 1.15527296532897 3.78263842585848e-05
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs1361016 2.36014628895411 0.982837123162195 0.0163342337521372
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs1421085 -1.42846321166145 0.589782159360222 0.0154345711980951
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs154911 2.33594864479315 1.04315263908702 0.0251353469871306
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs275160 -1.97214245634881 0.98194540713602 0.0446004460046407
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs4002471 2.28124236771133 0.582002608618835 8.8680283733338e-05
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs4278546 1.74425550555533 0.868145434271833 0.0445186509567089
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs55701338 2.46961720933255 1.24564025909317 0.0474111553150719
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs61882686 2.92570826942837 1.00729402355752 0.0036781363266287
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs6709441 2.51680365935262 1.10859208804818 0.0231911897169439
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs7431970 -2.12805908493459 1.07967703573887 0.0487222181300751
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs7919624 -2.15229478467088 1.08611172004225 0.0475182727994274
Oily fish (ukb-b-2209) Total body bone mineral density (age 45-60) rs9860241 -3.51401802221217 1.2422165619922 0.0046718679056343
Cake (ukb-b-3433) Total body bone mineral density (age 45-60) rs35268725 -1.75407590686166 0.698095700967614 0.0119825357287868
Cake (ukb-b-3433) Total body bone mineral density (age 45-60) All - Inverse variance weighted -0.541138406437163 0.233719687981119 0.0205948320695517
Sushi (ukb-b-5213) Total body bone mineral density (age 45-60) rs2229360 -5.31907106571737 2.61073671574201 0.0416116583250717
Sushi (ukb-b-5213) Total body bone mineral density (age 45-60) All - MR Egger -2.07761199238324 0.905661585285485 0.0249308998312511
Sausage (ukb-b-5847) Total body bone mineral density (age 45-60) rs117524659 1.64731239553092 0.764273774962611 0.0311308838678233
Sausage (ukb-b-5847) Total body bone mineral density (age 45-60) rs4245952 -1.85470445612605 0.749480199216672 0.0133365168434353
Couscous (ukb-b-758) Total body bone mineral density (age 45-60) rs11839514 -3.60710944808232 1.66136576239476 0.0299182357013621
Couscous (ukb-b-758) Total body bone mineral density (age 45-60) All - MR Egger 1.75394319005719 0.762686188887115 0.0362458801048961
Soft cheese (ukb-b-8007) Total body bone mineral density (age 45-60) rs6029122 3.0526867943349 1.21247560000344 0.0118113658561585
Soft cheese (ukb-b-8007) Total body bone mineral density (age 45-60) All - Inverse variance weighted 0.766878900058294 0.330267788697385 0.0202334093036847
Cappuccino (ukb-b-8374) Total body bone mineral density (age 45-60) All - Inverse variance weighted 0.338761559805611 0.170156374325752 0.0464936696235953
Squash (ukb-b-8793) Total body bone mineral density (age 45-60) rs10097265 -0.977328495627189 0.494956062163126 0.0483162540733967
Squash (ukb-b-8793) Total body bone mineral density (age 45-60) rs12742072 -0.938566274836973 0.4529885840359 0.0382708088934747
Squash (ukb-b-8793) Total body bone mineral density (age 45-60) All - Inverse variance weighted -0.244390207491441 0.11660802422954 0.03609756930009
Other milk-based pudding (ukb-b-9857) Total body bone mineral density (age 45-60) rs16939038 -3.02606291513537 1.47510030682086 0.0402252290221024
Other milk-based pudding (ukb-b-9857) Total body bone mineral density (age 45-60) rs76865693 -3.97416498377952 1.73685728920735 0.0221296260301262
Other milk-based pudding (ukb-b-9857) Total body bone mineral density (age 45-60) rs77851248 -6.18895113720866 1.80424664555293 0.0006031065794616
Other milk-based pudding (ukb-b-9857) Total body bone mineral density (age 45-60) All - Inverse variance weighted -1.0798708346606 0.341794728466348 0.0015808709116745
Other milk-based pudding (ukb-b-9857) Total body bone mineral density (age 45-60) All - MR Egger -1.78133037859364 0.812951951926293 0.0398556298769583