ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Osteoarthritis (self-reported) (ebi-a-GCST005811)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Flavoured milk (ukb-b-12763) (👉 📊) Osteoarthritis (self-reported) Weighted median 21 1.36591336 0.638494208 0.032413573
Snackpot (ukb-b-12912) (👉 📊) Osteoarthritis (self-reported) MR Egger 120 3.565055735 1.3201905 0.007944266
Red wine (ukb-b-13556) (👉 📊) Osteoarthritis (self-reported) Inverse variance weighted 11 0.264403727 0.134849847 0.049910884
Mozzarella (ukb-b-14505) (👉 📊) Osteoarthritis (self-reported) MR Egger 22 -1.814546274 0.867661779 0.049469704
Cheese (ukb-b-1489) (👉 📊) Osteoarthritis (self-reported) Weighted median 202 -0.492111744 0.128471901 0.000127883
Cheese (ukb-b-1489) (👉 📊) Osteoarthritis (self-reported) Inverse variance weighted 202 -0.438139467 0.098371074 8.43e-06
Mashed potato (ukb-b-15710) (👉 📊) Osteoarthritis (self-reported) MR Egger 11 1.088321577 0.375401446 0.017621541
Cereal (ukb-b-15926) (👉 📊) Osteoarthritis (self-reported) Weighted median 171 -0.444977387 0.176961726 0.011918769
Cereal (ukb-b-15926) (👉 📊) Osteoarthritis (self-reported) Inverse variance weighted 171 -0.433928562 0.127235897 0.000648616
Cereal (ukb-b-15926) (👉 📊) Osteoarthritis (self-reported) Simple mode 171 -1.19886679 0.517400832 0.021690927
Dried fruit (ukb-b-16576) (👉 📊) Osteoarthritis (self-reported) Inverse variance weighted 155 -0.346085463 0.134360232 0.010000766
Fruit smoothie (ukb-b-1780) (👉 📊) Osteoarthritis (self-reported) MR Egger 23 1.913872967 0.570320414 0.002992795
Espresso (ukb-b-19142) (👉 📊) Osteoarthritis (self-reported) MR Egger 33 0.89369518 0.435440376 0.048656426
Oily fish (ukb-b-2209) (👉 📊) Osteoarthritis (self-reported) Inverse variance weighted 169 -0.376180816 0.122597301 0.002151892
Porridge (ukb-b-29) (👉 📊) Osteoarthritis (self-reported) Weighted median 14 -0.549860491 0.267296701 0.039675008
Porridge (ukb-b-29) (👉 📊) Osteoarthritis (self-reported) Inverse variance weighted 14 -0.524919356 0.200589962 0.008873818
Mushroom (ukb-b-4043) (👉 📊) Osteoarthritis (self-reported) Inverse variance weighted 11 -0.390562463 0.198168121 0.048739407
Wholemeal pasta (ukb-b-4150) (👉 📊) Osteoarthritis (self-reported) MR Egger 22 1.648628019 0.736395612 0.036700104
Other bread (ukb-b-4964) (👉 📊) Osteoarthritis (self-reported) MR Egger 15 0.928181243 0.425527063 0.048124787
Other bread (ukb-b-4964) (👉 📊) Osteoarthritis (self-reported) Inverse variance weighted 15 0.647747774 0.237436583 0.006370271
Coffee (ukb-b-5237) (👉 📊) Osteoarthritis (self-reported) MR Egger 114 0.701562886 0.282957963 0.014650187
Coffee (ukb-b-5237) (👉 📊) Osteoarthritis (self-reported) Weighted median 114 0.511732155 0.217189561 0.018465237
Coffee (ukb-b-5237) (👉 📊) Osteoarthritis (self-reported) Inverse variance weighted 114 0.318256889 0.132831482 0.01657759
Coffee (ukb-b-5237) (👉 📊) Osteoarthritis (self-reported) Weighted mode 114 0.624196215 0.236372659 0.009443249
Pork (ukb-b-5640) (👉 📊) Osteoarthritis (self-reported) Weighted median 82 0.653170857 0.297375865 0.028059837
Tea (ukb-b-6066) (👉 📊) Osteoarthritis (self-reported) MR Egger 140 0.580613178 0.250375757 0.021865478
Tea (ukb-b-6066) (👉 📊) Osteoarthritis (self-reported) Weighted median 140 0.419864995 0.162493246 0.009769239
Tea (ukb-b-6066) (👉 📊) Osteoarthritis (self-reported) Inverse variance weighted 140 0.232233658 0.098294685 0.018145932
Tea (ukb-b-6066) (👉 📊) Osteoarthritis (self-reported) Weighted mode 140 0.582912313 0.202360867 0.004599384
Liver (ukb-b-6373) (👉 📊) Osteoarthritis (self-reported) Inverse variance weighted 28 -0.960504073 0.406147867 0.018034343
Crumble (ukb-b-7641) (👉 📊) Osteoarthritis (self-reported) Inverse variance weighted 25 0.862780448 0.363389404 0.017584226
Stewed fruit (ukb-b-8676) (👉 📊) Osteoarthritis (self-reported) Inverse variance weighted 9 -1.000050611 0.483476801 0.038597141
Berry (ukb-b-8887) (👉 📊) Osteoarthritis (self-reported) Weighted median 13 0.627547396 0.247431857 0.011204885
Berry (ukb-b-8887) (👉 📊) Osteoarthritis (self-reported) Inverse variance weighted 13 0.699465962 0.203745983 0.000596877

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Snackpot (ukb-b-12912) Osteoarthritis (self-reported) rs112869543 16.7729797125779 5.39737514413889 0.0018860172805377
Snackpot (ukb-b-12912) Osteoarthritis (self-reported) rs147606020 -18.0778440973587 7.65404102337837 0.0181830541448584
Snackpot (ukb-b-12912) Osteoarthritis (self-reported) rs41303053 -19.0124955095779 7.45324621105469 0.0107444746465671
Snackpot (ukb-b-12912) Osteoarthritis (self-reported) All - MR Egger 3.56505573492567 1.32019049970446 0.0079442658047179
Red wine (ukb-b-13556) Osteoarthritis (self-reported) All - Inverse variance weighted 0.264403727288075 0.134849846544771 0.0499108844141948
Mozzarella (ukb-b-14505) Osteoarthritis (self-reported) rs116735069 -5.83222710461493 2.5545968239996 0.0224284648445607
Mozzarella (ukb-b-14505) Osteoarthritis (self-reported) rs147986150 -6.40330038499593 2.63163824097023 0.0149660596931708
Mozzarella (ukb-b-14505) Osteoarthritis (self-reported) rs1714348 4.84596442952343 2.38349777474274 0.0420392383110507
Mozzarella (ukb-b-14505) Osteoarthritis (self-reported) All - MR Egger -1.81454627353982 0.867661778834475 0.0494697044031926
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs111423440 -3.75002968611877 1.41716517356484 0.0081414035495865
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs113829457 -2.7419029806969 1.32002981387035 0.037787503611696
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs114964798 2.96883223170087 1.29796363760365 0.0221783183434838
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs11669334 2.4888028485498 1.2675286064922 0.0495871493214488
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs12786959 -2.41581213599482 1.09518268704266 0.0273942862676485
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs13107325 -2.93831757755307 0.89392708108312 0.0010126917596407
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs150830434 -3.8264007277898 1.18800599356304 0.0012780666070417
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs17342130 2.60441497875383 1.29452149397551 0.0442331521611485
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs2352974 -3.18321468973319 0.978416521811108 0.0011401875260605
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs28415940 -2.84109082799707 1.24143808340501 0.0221056194953215
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs2960578 -2.24891650321232 0.828243736860032 0.0066219069114906
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs34198643 -1.9911200795181 1.00277834329306 0.0470773795680402
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs35760956 3.03451612608747 1.31841377358663 0.0213553861679269
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs4721694 -4.4239813524075 1.34372357686419 0.0009936097195385
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs61734410 -2.25888675393299 1.00766782754894 0.0249809100578672
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs62048491 -3.72632090948812 1.2504225096662 0.0028820185690568
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs77742462 -2.08579680955952 1.05321403591563 0.0476573492063414
Cheese (ukb-b-1489) Osteoarthritis (self-reported) rs79398870 3.24507242427643 1.33635746763482 0.0151699275120342
Cheese (ukb-b-1489) Osteoarthritis (self-reported) All - Inverse variance weighted -0.43813946657042 0.0983710744946949 8.4306261391898e-06
Mashed potato (ukb-b-15710) Osteoarthritis (self-reported) rs264633 1.325777975588 0.644015486478545 0.0395314272000412
Mashed potato (ukb-b-15710) Osteoarthritis (self-reported) rs4756830 -1.34784284024927 0.631424863696558 0.0327932668017106
Mashed potato (ukb-b-15710) Osteoarthritis (self-reported) All - MR Egger 1.08832157683668 0.375401445841401 0.0176215409627539
Cereal (ukb-b-15926) Osteoarthritis (self-reported) rs10260232 -5.91490726727517 1.65224523176131 0.0003436982071388
Cereal (ukb-b-15926) Osteoarthritis (self-reported) rs11258417 -3.97696087483175 1.67185215380631 0.0173702532945097
Cereal (ukb-b-15926) Osteoarthritis (self-reported) rs11670024 2.90108297837791 1.36204204504291 0.0331756491216742
Cereal (ukb-b-15926) Osteoarthritis (self-reported) rs17662627 3.39600050948924 1.68037702203541 0.0432823187645107
Cereal (ukb-b-15926) Osteoarthritis (self-reported) rs2450126 -3.22044168864373 1.28214522980291 0.0120130601035111
Cereal (ukb-b-15926) Osteoarthritis (self-reported) rs2456141 4.23329703058321 1.66649626600284 0.0110777078314135
Cereal (ukb-b-15926) Osteoarthritis (self-reported) rs2472297 -2.33268146204217 0.994442271540141 0.0189904528214186
Cereal (ukb-b-15926) Osteoarthritis (self-reported) rs3766823 -5.10646368121377 1.59721442210491 0.0013881394466733
Cereal (ukb-b-15926) Osteoarthritis (self-reported) rs491711 -2.75380929973906 1.32143559909313 0.0371644689120334
Cereal (ukb-b-15926) Osteoarthritis (self-reported) rs7040561 -3.85772505147985 1.23677659280204 0.0018135700581173
Cereal (ukb-b-15926) Osteoarthritis (self-reported) rs75756987 3.90398378571004 1.73429055057314 0.0243820405550521
Cereal (ukb-b-15926) Osteoarthritis (self-reported) rs977915 -4.22916214293512 1.69538861303291 0.0126131530056854
Cereal (ukb-b-15926) Osteoarthritis (self-reported) All - Inverse variance weighted -0.433928562115101 0.127235897228519 0.0006486157597547
Dried fruit (ukb-b-16576) Osteoarthritis (self-reported) rs10026792 -2.96597980915503 1.44300926566173 0.0398391439303611
Dried fruit (ukb-b-16576) Osteoarthritis (self-reported) rs10896126 -2.08762076087681 1.01866879872077 0.0404267652432695
Dried fruit (ukb-b-16576) Osteoarthritis (self-reported) rs11082011 -3.53821833939177 1.63373800494857 0.0303326240668527
Dried fruit (ukb-b-16576) Osteoarthritis (self-reported) rs11085749 -3.34767903238655 1.55666622890396 0.0315122189431775
Dried fruit (ukb-b-16576) Osteoarthritis (self-reported) rs11692435 -3.67529711375212 1.46929235049991 0.0123701178052985
Dried fruit (ukb-b-16576) Osteoarthritis (self-reported) rs11772627 -2.380324864458 1.01802681386292 0.01937817086567
Dried fruit (ukb-b-16576) Osteoarthritis (self-reported) rs12727104 -4.21083951295432 1.83641551466325 0.0218499256136973
Dried fruit (ukb-b-16576) Osteoarthritis (self-reported) rs142119647 4.47706495110244 1.73319258270759 0.0097907899682564
Dried fruit (ukb-b-16576) Osteoarthritis (self-reported) rs4800488 -3.27602723722421 1.17777629426883 0.005410231929683
Dried fruit (ukb-b-16576) Osteoarthritis (self-reported) rs6765212 -3.17388257989372 1.45802394991628 0.0294926238890368
Dried fruit (ukb-b-16576) Osteoarthritis (self-reported) rs7582086 -2.99808583319225 1.46306530497361 0.0404444053297095
Dried fruit (ukb-b-16576) Osteoarthritis (self-reported) All - Inverse variance weighted -0.346085463347246 0.134360231706794 0.010000765998321
Fruit smoothie (ukb-b-1780) Osteoarthritis (self-reported) rs148801832 3.86494573001878 1.587088882725 0.0148818272323753
Fruit smoothie (ukb-b-1780) Osteoarthritis (self-reported) All - MR Egger 1.91387296714078 0.570320414343928 0.0029927953510928
Espresso (ukb-b-19142) Osteoarthritis (self-reported) rs28692629 -2.74520547945205 1.29117199391172 0.033492051848813
Espresso (ukb-b-19142) Osteoarthritis (self-reported) rs76762868 2.69135008595973 1.29263244043269 0.0373361567983879
Espresso (ukb-b-19142) Osteoarthritis (self-reported) All - MR Egger 0.893695179975452 0.435440376388881 0.0486564259525164
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs10137526 3.62012531152375 1.37773351117975 0.0085990895677933
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs10819087 -5.06773362105137 1.53596475454055 0.0009689814464064
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs10828250 -1.76707766228867 0.757130376944535 0.0196001926192941
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs11648715 -5.02247791742283 1.55665414128331 0.0012533298780828
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs12906493 -3.72265621455855 1.60164040030122 0.0201106436797708
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs13058717 -3.48728167474855 1.55500367556437 0.0249213571474344
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs1821849 -6.00096938126059 1.59515113535108 0.0001685554795805
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs4419275 -3.86481805837089 1.40310550449688 0.0058786505914057
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs4970581 -3.04149973193207 1.44543434548675 0.0353599921973665
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs4974084 -3.76563508274181 1.59828490061916 0.0184705576012248
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs510161 2.77579249190251 1.36175861519673 0.0415111401586661
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs573057 -5.25006898743174 1.47930795153319 0.0003866920499404
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs631490 -2.4921927634447 1.03067411722744 0.0156051302510914
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs6903171 -5.24952497605251 1.58136649864167 0.0009014227605296
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs7243428 -3.3154780250262 1.28586728718486 0.009925951346731
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs7254235 -2.75683887718242 1.34798314268513 0.0408392567051586
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs9301837 -3.50759712376451 1.26333307924893 0.0054953946661722
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs957523 -3.87320679994102 1.71240968170041 0.0237069264873049
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) rs9831061 4.3064322082022 1.62418310089606 0.0080148158672168
Oily fish (ukb-b-2209) Osteoarthritis (self-reported) All - Inverse variance weighted -0.376180816464527 0.122597301183015 0.0021518920537164
Porridge (ukb-b-29) Osteoarthritis (self-reported) rs138894584 -1.59624074391421 0.727850784230606 0.0283010470337598
Porridge (ukb-b-29) Osteoarthritis (self-reported) rs718911 -1.91131452334059 0.77160835861509 0.0132472361674408
Porridge (ukb-b-29) Osteoarthritis (self-reported) All - Inverse variance weighted -0.524919355637658 0.200589961909002 0.0088738184336921
Mushroom (ukb-b-4043) Osteoarthritis (self-reported) rs2410501 -2.09465562547756 0.645570996378275 0.0011759270260531
Mushroom (ukb-b-4043) Osteoarthritis (self-reported) All - Inverse variance weighted -0.3905624627175 0.198168120936982 0.0487394065887653
Wholemeal pasta (ukb-b-4150) Osteoarthritis (self-reported) rs184803792 3.57614162975847 1.7982674930194 0.0467388054999227
Wholemeal pasta (ukb-b-4150) Osteoarthritis (self-reported) rs189429947 3.88692466370585 1.72009028829134 0.0238385534364081
Wholemeal pasta (ukb-b-4150) Osteoarthritis (self-reported) All - MR Egger 1.64862801883009 0.736395611810083 0.0367001040701151
Other bread (ukb-b-4964) Osteoarthritis (self-reported) rs4530746 2.50957707005775 0.862507548573174 0.0036185789338371
Other bread (ukb-b-4964) Osteoarthritis (self-reported) rs74006323 2.04078880384399 0.840877222753133 0.0152252647401531
Other bread (ukb-b-4964) Osteoarthritis (self-reported) All - Inverse variance weighted 0.647747773966287 0.237436582638488 0.0063702707224324
Other bread (ukb-b-4964) Osteoarthritis (self-reported) All - MR Egger 0.928181242835705 0.425527062728411 0.0481247866156315
Coffee (ukb-b-5237) Osteoarthritis (self-reported) rs11206378 -4.11046073791611 1.84575996695522 0.0259489651074131
Coffee (ukb-b-5237) Osteoarthritis (self-reported) rs11236225 -4.14317925591883 1.75355129650507 0.0181405737370008
Coffee (ukb-b-5237) Osteoarthritis (self-reported) rs13387939 3.2333925270902 1.14584616871429 0.004774925631116
Coffee (ukb-b-5237) Osteoarthritis (self-reported) rs2472297 0.795708272721795 0.339217314959071 0.0189904528214186
Coffee (ukb-b-5237) Osteoarthritis (self-reported) rs6937318 4.2482925635317 1.65460125298301 0.0102416247411161
Coffee (ukb-b-5237) Osteoarthritis (self-reported) rs7743687 -4.0038809448453 1.78286386228691 0.0247195070022
Coffee (ukb-b-5237) Osteoarthritis (self-reported) All - Inverse variance weighted 0.318256889334342 0.132831482143539 0.0165775899320317
Coffee (ukb-b-5237) Osteoarthritis (self-reported) All - MR Egger 0.701562885594583 0.282957962543037 0.0146501870674948
Pork (ukb-b-5640) Osteoarthritis (self-reported) rs10137783 -5.52061434475974 2.08433754055834 0.0080821581002749
Pork (ukb-b-5640) Osteoarthritis (self-reported) rs2314715 6.22614328082922 2.09558512568518 0.0029675805235468
Pork (ukb-b-5640) Osteoarthritis (self-reported) rs34161520 -3.50021135448028 1.67986266272138 0.0371938839661229
Pork (ukb-b-5640) Osteoarthritis (self-reported) rs4605770 4.2152846275453 1.91452390925428 0.0276836515974375
Tea (ukb-b-6066) Osteoarthritis (self-reported) rs1285244 -2.79225892931944 1.32421085946736 0.0349773020558659
Tea (ukb-b-6066) Osteoarthritis (self-reported) rs16895478 -3.04159227708631 1.32252346459906 0.0214572901233482
Tea (ukb-b-6066) Osteoarthritis (self-reported) rs2279844 -2.97070379299127 1.20850190608864 0.0139646838947243
Tea (ukb-b-6066) Osteoarthritis (self-reported) rs2472297 0.693166970660958 0.295503071498333 0.0189904528214186
Tea (ukb-b-6066) Osteoarthritis (self-reported) rs323065 3.50214458741694 1.4617048543977 0.0165781918122516
Tea (ukb-b-6066) Osteoarthritis (self-reported) rs4135060 2.87192115285887 1.32870685435247 0.0306613084098127
Tea (ukb-b-6066) Osteoarthritis (self-reported) rs62183766 3.19482097692065 1.40084571609232 0.0225699188167608
Tea (ukb-b-6066) Osteoarthritis (self-reported) rs6265 3.17475328655651 1.28715954963711 0.0136448348001484
Tea (ukb-b-6066) Osteoarthritis (self-reported) rs7840343 -4.09489768970887 1.40931401564478 0.0036655395153625
Tea (ukb-b-6066) Osteoarthritis (self-reported) All - Inverse variance weighted 0.232233658130072 0.0982946850626212 0.0181459321953823
Tea (ukb-b-6066) Osteoarthritis (self-reported) All - MR Egger 0.580613178058831 0.250375756643559 0.021865478487558
Liver (ukb-b-6373) Osteoarthritis (self-reported) rs34717472 -5.43846325867351 2.22911267536884 0.0146976918294035
Liver (ukb-b-6373) Osteoarthritis (self-reported) All - Inverse variance weighted -0.960504073285901 0.406147867350151 0.0180343426228211
Crumble (ukb-b-7641) Osteoarthritis (self-reported) rs78006365 4.65161674439703 1.89683597238564 0.0141945038507723
Crumble (ukb-b-7641) Osteoarthritis (self-reported) All - Inverse variance weighted 0.862780448095467 0.363389404005201 0.0175842262188487
Stewed fruit (ukb-b-8676) Osteoarthritis (self-reported) rs148674336 -4.11762536873156 1.47036276162382 0.0051037007210548
Stewed fruit (ukb-b-8676) Osteoarthritis (self-reported) All - Inverse variance weighted -1.00005061057203 0.483476801310116 0.0385971406740659
Berry (ukb-b-8887) Osteoarthritis (self-reported) rs696217 2.75154224503651 0.687233511596019 6.23343289323382e-05
Berry (ukb-b-8887) Osteoarthritis (self-reported) rs7658609 1.24224475088464 0.603217082196329 0.0394591900834379
Berry (ukb-b-8887) Osteoarthritis (self-reported) All - Inverse variance weighted 0.699465962436749 0.203745982835068 0.0005968772289588