ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Osteoarthritis of the knee (hospital diagnosed) (ebi-a-GCST005813)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Chocolate-covered raisin (ukb-b-1160) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Inverse variance weighted 51 1.010729374 0.457512713 0.027161905
Flavoured milk (ukb-b-12763) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Inverse variance weighted 21 1.519763814 0.747989838 0.04217417
Lamb/mutton (ukb-b-14179) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Weighted median 128 -1.045382885 0.414387761 0.011645221
Cheese (ukb-b-1489) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Weighted median 202 -0.445957084 0.204092253 0.028883275
Cheese (ukb-b-1489) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Inverse variance weighted 202 -0.490614322 0.143768731 0.000643641
Broad bean (ukb-b-15212) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Weighted median 22 1.193746457 0.607412251 0.049379685
Broad bean (ukb-b-15212) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Inverse variance weighted 22 1.543006559 0.450787959 0.000619546
Cereal (ukb-b-15926) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Weighted median 172 -0.737698467 0.288807514 0.010640425
Cereal (ukb-b-15926) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Inverse variance weighted 172 -0.680075208 0.198670139 0.000619028
Dried fruit (ukb-b-16576) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Weighted median 156 -0.624833492 0.318424344 0.04973144
Fruitcake (ukb-b-17775) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Weighted median 14 -1.960131493 0.801545736 0.014467578
Fruitcake (ukb-b-17775) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Inverse variance weighted 14 -2.008424484 0.710098771 0.00467852
Butternut squash (ukb-b-20341) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Inverse variance weighted 16 1.37354033 0.65663951 0.03645889
Porridge (ukb-b-29) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Inverse variance weighted 14 -0.913380931 0.358111994 0.010755449
Baked bean (ukb-b-4058) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Weighted median 15 -0.716855187 0.362802866 0.048168289
Coffee (ukb-b-5237) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) MR Egger 116 1.768189449 0.480830892 0.000361032
Coffee (ukb-b-5237) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Inverse variance weighted 116 0.737546667 0.229574013 0.001315051
Breaded fish (ukb-b-5753) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) MR Egger 20 -2.625312473 1.089092775 0.026838953
Tea (ukb-b-6066) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Weighted median 140 0.616668769 0.276681479 0.025826953
Tea (ukb-b-6066) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Inverse variance weighted 140 0.416759395 0.182372432 0.022300488
Tea (ukb-b-6066) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Weighted mode 140 0.980754528 0.388015909 0.012602905
Processed meat (ukb-b-6324) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) MR Egger 128 -1.480532076 0.717635239 0.041159911
Berry (ukb-b-8887) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) MR Egger 13 1.501333626 0.678203869 0.048902018
Berry (ukb-b-8887) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Weighted median 13 1.003700868 0.417327862 0.016169565
Berry (ukb-b-8887) (👉 📊) Osteoarthritis of the knee (hospital diagnosed) Inverse variance weighted 13 1.13462506 0.304644594 0.000195763

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Chocolate-covered raisin (ukb-b-1160) Osteoarthritis of the knee (hospital diagnosed) rs186113223 8.0133572785432 3.19796829625101 0.0122186771665084
Chocolate-covered raisin (ukb-b-1160) Osteoarthritis of the knee (hospital diagnosed) rs8177156 9.15959306047226 3.09748029761249 0.0031053630568416
Chocolate-covered raisin (ukb-b-1160) Osteoarthritis of the knee (hospital diagnosed) All - Inverse variance weighted 1.01072937366931 0.457512713062897 0.0271619048584104
Flavoured milk (ukb-b-12763) Osteoarthritis of the knee (hospital diagnosed) rs10880014 6.7820613347273 3.43954521693675 0.0486335687337412
Flavoured milk (ukb-b-12763) Osteoarthritis of the knee (hospital diagnosed) All - Inverse variance weighted 1.51976381425264 0.747989837506333 0.0421741695590239
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs10932201 8.71417267513002 3.2978530281131 0.0082326237534153
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs114210747 -7.17654079420624 3.60122435392597 0.0462827159705518
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs146908007 -9.36808604965377 3.12325831785171 0.0027045930025333
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs1711171 9.7910338230984 3.15149849026339 0.0018913276507863
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs17235152 -7.23074674850212 3.21894880413074 0.0246843601120716
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs17270057 -5.95793982597425 3.02766867141378 0.0490875029037634
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs2018466 7.47894587180874 3.52828490367162 0.0340303876933248
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs2396885 6.25091378410065 3.16438261692003 0.0482230464893684
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs416769 6.24544204674517 3.10378748697264 0.044198829123855
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs4486004 9.21398339451768 3.36702211494988 0.0062089455427611
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs56394517 8.11599358253054 3.06330354485332 0.0080628820255096
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs6476606 -8.14187517495469 3.49735482648736 0.0199116005309421
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs660880 -5.28613325686728 2.62900049046038 0.0443570748169397
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs77691530 -6.83848554057966 3.43433589603371 0.0464577549855568
Lamb/mutton (ukb-b-14179) Osteoarthritis of the knee (hospital diagnosed) rs942038 -6.83129680421585 3.30146280830431 0.0385298809613467
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs1873036 -5.20250973303671 2.2086415461624 0.0184965669127998
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs1931805 -4.58229861589231 1.89675775345631 0.0156981542633251
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs2245959 4.86127702241315 2.13454806337572 0.0227607496335845
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs34423638 -4.7393206235217 2.04747656094155 0.0206286435600454
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs3733421 -4.69557197273641 2.25952058142645 0.037697612686628
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs61734410 -3.3734598294704 1.69171370241383 0.0461402530498423
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs61757207 -4.07623009913507 1.90364955059731 0.0322521682221014
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs6544743 4.95020536981668 2.24606626196732 0.0275282479406519
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs66510028 5.46356680253057 2.16383061188767 0.0115714340798592
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs683996 -4.24680116861557 2.08645000398721 0.0418086739139924
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs6873324 -5.0026609813571 1.93055800458458 0.0095613232919758
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs7299943 -5.50656476178704 2.06503646326892 0.0076629593447681
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs73024305 -3.27836052776352 1.63651870314992 0.0451501705412826
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs7515509 -4.3058158306765 1.97107092733659 0.0289251031318715
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) rs75499503 -5.10720573574019 2.12904708369571 0.016447892132581
Cheese (ukb-b-1489) Osteoarthritis of the knee (hospital diagnosed) All - Inverse variance weighted -0.490614321536264 0.143768731204585 0.0006436413449859
Broad bean (ukb-b-15212) Osteoarthritis of the knee (hospital diagnosed) rs11014050 5.05687151322028 2.18791907542275 0.0208179512510448
Broad bean (ukb-b-15212) Osteoarthritis of the knee (hospital diagnosed) All - Inverse variance weighted 1.54300655861235 0.450787958601507 0.0006195461328878
Cereal (ukb-b-15926) Osteoarthritis of the knee (hospital diagnosed) rs10260232 -6.98881849202395 2.78231075097997 0.0120091413161565
Cereal (ukb-b-15926) Osteoarthritis of the knee (hospital diagnosed) rs10931025 7.50615052225063 2.9037110970405 0.0097373420681123
Cereal (ukb-b-15926) Osteoarthritis of the knee (hospital diagnosed) rs1397440 -5.94208690402141 2.73904407080464 0.0300521989062901
Cereal (ukb-b-15926) Osteoarthritis of the knee (hospital diagnosed) rs2212484 -5.94443838703229 2.66547638517872 0.0257368333770339
Cereal (ukb-b-15926) Osteoarthritis of the knee (hospital diagnosed) rs2472297 -5.15969795228302 1.66473838933118 0.0019390996331414
Cereal (ukb-b-15926) Osteoarthritis of the knee (hospital diagnosed) rs2903760 -6.68359650322431 2.5833955753795 0.0096777298498201
Cereal (ukb-b-15926) Osteoarthritis of the knee (hospital diagnosed) rs6918737 -4.37252503185873 2.06719825232114 0.0344134288250044
Cereal (ukb-b-15926) Osteoarthritis of the knee (hospital diagnosed) rs72655538 -5.39918323280212 2.4900290249646 0.0301342409712146
Cereal (ukb-b-15926) Osteoarthritis of the knee (hospital diagnosed) rs75756987 6.10786511848904 2.96387420561858 0.0393249211122632
Cereal (ukb-b-15926) Osteoarthritis of the knee (hospital diagnosed) rs78959390 -5.19000300637668 2.45367806452634 0.0344134895091144
Cereal (ukb-b-15926) Osteoarthritis of the knee (hospital diagnosed) rs9973711 -6.02578696764444 2.84606936242518 0.0342402272132023
Cereal (ukb-b-15926) Osteoarthritis of the knee (hospital diagnosed) All - Inverse variance weighted -0.680075208010004 0.198670138990751 0.0006190275003031
Dried fruit (ukb-b-16576) Osteoarthritis of the knee (hospital diagnosed) rs10129747 -6.50127898006415 2.56993787811117 0.0114146529225668
Dried fruit (ukb-b-16576) Osteoarthritis of the knee (hospital diagnosed) rs10178071 5.88959937939824 2.6426552889677 0.0258360507447113
Dried fruit (ukb-b-16576) Osteoarthritis of the knee (hospital diagnosed) rs11134477 7.05219494024131 3.01465398044031 0.0193196573739274
Dried fruit (ukb-b-16576) Osteoarthritis of the knee (hospital diagnosed) rs11632215 -5.29154941527497 2.55526959571249 0.0383739364262247
Dried fruit (ukb-b-16576) Osteoarthritis of the knee (hospital diagnosed) rs17175518 5.04820723369461 2.40886553817783 0.0361107381822351
Dried fruit (ukb-b-16576) Osteoarthritis of the knee (hospital diagnosed) rs1812195 6.57644185644928 2.86861800040175 0.0218740933646488
Dried fruit (ukb-b-16576) Osteoarthritis of the knee (hospital diagnosed) rs3819391 -7.50768190564043 2.99469273005815 0.0121762180452506
Dried fruit (ukb-b-16576) Osteoarthritis of the knee (hospital diagnosed) rs4963390 -5.50550489751357 2.72106469023419 0.0430431845652246
Dried fruit (ukb-b-16576) Osteoarthritis of the knee (hospital diagnosed) rs62023502 7.83243301809402 3.17526738588698 0.0136364437119933
Dried fruit (ukb-b-16576) Osteoarthritis of the knee (hospital diagnosed) rs75641275 -5.65458679640993 2.35823688503174 0.016493746224994
Dried fruit (ukb-b-16576) Osteoarthritis of the knee (hospital diagnosed) rs7582086 -5.66431351206507 2.46659555618334 0.0216524772769149
Dried fruit (ukb-b-16576) Osteoarthritis of the knee (hospital diagnosed) rs7742849 -6.29321169688552 2.97757605448907 0.0345549885181676
Dried fruit (ukb-b-16576) Osteoarthritis of the knee (hospital diagnosed) rs7923809 7.09911082458552 2.82673851431074 0.0120248563843113
Dried fruit (ukb-b-16576) Osteoarthritis of the knee (hospital diagnosed) rs862227 -5.26950439735504 2.58732514239574 0.0416840181257935
Fruitcake (ukb-b-17775) Osteoarthritis of the knee (hospital diagnosed) rs595711 -8.10481296128544 2.06219278575565 8.487816430343e-05
Fruitcake (ukb-b-17775) Osteoarthritis of the knee (hospital diagnosed) All - Inverse variance weighted -2.00842448356233 0.710098771280786 0.0046785200071902
Butternut squash (ukb-b-20341) Osteoarthritis of the knee (hospital diagnosed) rs146267276 6.38453268650264 2.68821663727107 0.0175486287866495
Butternut squash (ukb-b-20341) Osteoarthritis of the knee (hospital diagnosed) All - Inverse variance weighted 1.37354033041449 0.656639510022354 0.0364588904310656
Porridge (ukb-b-29) Osteoarthritis of the knee (hospital diagnosed) rs4906184 -3.56948115175963 1.28128364837226 0.0053385372238448
Porridge (ukb-b-29) Osteoarthritis of the knee (hospital diagnosed) All - Inverse variance weighted -0.913380931190329 0.358111994368469 0.0107554487802052
Baked bean (ukb-b-4058) Osteoarthritis of the knee (hospital diagnosed) rs9824684 -0.988598044107692 0.44654985554874 0.0268385373198942
Coffee (ukb-b-5237) Osteoarthritis of the knee (hospital diagnosed) rs12930957 -5.88454836796979 3.00176183356796 0.0499531619091195
Coffee (ukb-b-5237) Osteoarthritis of the knee (hospital diagnosed) rs13387939 6.05038717549137 1.95583420915933 0.0019780576433774
Coffee (ukb-b-5237) Osteoarthritis of the knee (hospital diagnosed) rs13437947 -6.45132615798578 3.23800691908514 0.046329856368706
Coffee (ukb-b-5237) Osteoarthritis of the knee (hospital diagnosed) rs1421085 4.20403826863547 1.29756884147854 0.0011955709088763
Coffee (ukb-b-5237) Osteoarthritis of the knee (hospital diagnosed) rs2126069 -5.35247007479039 2.72746102026403 0.0497116434254603
Coffee (ukb-b-5237) Osteoarthritis of the knee (hospital diagnosed) rs2472297 1.76004071373852 0.567864121125524 0.0019390996331414
Coffee (ukb-b-5237) Osteoarthritis of the knee (hospital diagnosed) rs2595223 -6.31926499102985 3.00253097270295 0.0353221287861021
Coffee (ukb-b-5237) Osteoarthritis of the knee (hospital diagnosed) rs35303290 6.26840979060181 2.8803132883196 0.0295332511377526
Coffee (ukb-b-5237) Osteoarthritis of the knee (hospital diagnosed) rs476828 3.19125336530978 1.58791889819614 0.0444620992736353
Coffee (ukb-b-5237) Osteoarthritis of the knee (hospital diagnosed) rs516636 7.46021564311835 2.44299331146642 0.002260235123843
Coffee (ukb-b-5237) Osteoarthritis of the knee (hospital diagnosed) rs56113850 3.82886623982569 1.90122131257549 0.0440202192274703
Coffee (ukb-b-5237) Osteoarthritis of the knee (hospital diagnosed) rs780093 3.9126640839508 1.8344980629631 0.0329390509475982
Coffee (ukb-b-5237) Osteoarthritis of the knee (hospital diagnosed) All - Inverse variance weighted 0.737546666564746 0.229574012631923 0.0013150505484362
Coffee (ukb-b-5237) Osteoarthritis of the knee (hospital diagnosed) All - MR Egger 1.7681894485768 0.480830892137922 0.0003610318218551
Breaded fish (ukb-b-5753) Osteoarthritis of the knee (hospital diagnosed) rs4880869 5.00083894293191 2.42214809340231 0.0389580488545357
Breaded fish (ukb-b-5753) Osteoarthritis of the knee (hospital diagnosed) All - MR Egger -2.62531247274946 1.08909277515687 0.0268389528573943
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) rs12446615 5.05795752969617 2.06842727699612 0.0144725427640599
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) rs1394094 4.90761727559765 2.34815253345362 0.0366186229416887
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) rs145322337 8.24311490978158 3.0244166607803 0.0064199848721048
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) rs16895478 -5.22532391348704 2.26590236686391 0.0211068583173852
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) rs2273447 -6.46630226368657 1.73586698337292 0.0001952270367953
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) rs2472297 1.53322785699959 0.494684630136113 0.0019390996331414
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) rs323065 5.19557600136305 2.48586202043099 0.0366133053692247
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) rs4451355 -5.54665042777332 2.46055291028078 0.0241817473680204
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) rs4817505 3.31809131935227 1.60615874701354 0.0388421588151193
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) rs58864227 4.84354971817879 2.40824568488701 0.0443005656164885
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) rs73187605 5.20685909098938 2.34962286481426 0.0266887383933779
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) rs7757102 -4.01249587000906 2.01921398859699 0.0469049651993043
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) rs9478663 5.21010888782406 2.36378281918673 0.027514481242945
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) rs9937354 -5.34240684629195 1.70684700155404 0.001748147642794
Tea (ukb-b-6066) Osteoarthritis of the knee (hospital diagnosed) All - Inverse variance weighted 0.416759395431893 0.182372431905962 0.0223004880979159
Processed meat (ukb-b-6324) Osteoarthritis of the knee (hospital diagnosed) rs10084188 5.13790188679245 2.4975879245283 0.0396722272317961
Processed meat (ukb-b-6324) Osteoarthritis of the knee (hospital diagnosed) rs10109400 -4.37364932509407 2.08796216384161 0.0361978830823574
Processed meat (ukb-b-6324) Osteoarthritis of the knee (hospital diagnosed) rs114687117 -4.99898133119639 2.4477796415644 0.0411266030308262
Processed meat (ukb-b-6324) Osteoarthritis of the knee (hospital diagnosed) rs17755786 -6.89433918865538 2.36440004200231 0.0035467131622641
Processed meat (ukb-b-6324) Osteoarthritis of the knee (hospital diagnosed) rs3733421 -4.46272791023843 2.14747545582048 0.037697612686628
Processed meat (ukb-b-6324) Osteoarthritis of the knee (hospital diagnosed) rs62396185 4.85609000170828 2.2471467733932 0.0306951391991872
Processed meat (ukb-b-6324) Osteoarthritis of the knee (hospital diagnosed) rs62504693 -5.64895856569262 2.41318592460406 0.0192387786898173
Processed meat (ukb-b-6324) Osteoarthritis of the knee (hospital diagnosed) rs6878756 -5.87439685112294 2.41569807825886 0.0150256788708704
Processed meat (ukb-b-6324) Osteoarthritis of the knee (hospital diagnosed) rs7096909 6.06556363809252 2.29095548265424 0.0081062250723945
Processed meat (ukb-b-6324) Osteoarthritis of the knee (hospital diagnosed) rs78553019 -4.76425047915292 2.41263706915512 0.0483014471488095
Processed meat (ukb-b-6324) Osteoarthritis of the knee (hospital diagnosed) rs871974 4.73726783608491 2.39532355542453 0.047960843052639
Processed meat (ukb-b-6324) Osteoarthritis of the knee (hospital diagnosed) rs9341169 -4.3684347549393 2.05237732501519 0.0332976831348703
Processed meat (ukb-b-6324) Osteoarthritis of the knee (hospital diagnosed) All - MR Egger -1.48053207626649 0.717635238508568 0.0411599106209421
Berry (ukb-b-8887) Osteoarthritis of the knee (hospital diagnosed) rs72791977 3.10575635876841 1.10219086002431 0.0048353515535781
Berry (ukb-b-8887) Osteoarthritis of the knee (hospital diagnosed) All - Inverse variance weighted 1.134625060466 0.304644594054968 0.0001957631439136
Berry (ukb-b-8887) Osteoarthritis of the knee (hospital diagnosed) All - MR Egger 1.50133362635012 0.678203869062663 0.0489020178560053