ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Osteoprotegerin levels (ebi-a-GCST90010243)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Pineapple (ukb-b-1164) (👉 📊) Osteoprotegerin levels MR Egger 15 -6.418492897 2.810011602 0.039811633
Red wine (ukb-b-13556) (👉 📊) Osteoprotegerin levels Inverse variance weighted 11 0.626177127 0.312939013 0.045397156
Vegetarian alternatives (ukb-b-14425) (👉 📊) Osteoprotegerin levels Inverse variance weighted 6 -6.93424742 3.268988259 0.033903186
Mozzarella (ukb-b-14505) (👉 📊) Osteoprotegerin levels Inverse variance weighted 20 -3.386417001 1.438227956 0.018543852
White rice (ukb-b-14690) (👉 📊) Osteoprotegerin levels Inverse variance weighted 14 1.314443099 0.62705829 0.036063956
Water (ukb-b-14898) (👉 📊) Osteoprotegerin levels MR Egger 153 -3.411651637 1.027905294 0.001132258
Rose wine (ukb-b-16124) (👉 📊) Osteoprotegerin levels MR Egger 13 -3.596996783 1.285690467 0.017345488
Rose wine (ukb-b-16124) (👉 📊) Osteoprotegerin levels Weighted median 13 -2.762791431 0.930601204 0.002989415
Rose wine (ukb-b-16124) (👉 📊) Osteoprotegerin levels Weighted mode 13 -2.85688089 1.070690572 0.020476492
Non-oily fish (ukb-b-17627) (👉 📊) Osteoprotegerin levels Weighted mode 68 3.079852461 1.374417712 0.028355421
Other savoury snack (ukb-b-18718) (👉 📊) Osteoprotegerin levels Inverse variance weighted 21 2.47204964 1.170329601 0.034663478
Plain cereal (ukb-b-20023) (👉 📊) Osteoprotegerin levels Weighted median 13 2.851196793 1.14576556 0.012829609
Plain cereal (ukb-b-20023) (👉 📊) Osteoprotegerin levels Inverse variance weighted 13 2.199582003 0.939194772 0.01918138
Green bean (ukb-b-2299) (👉 📊) Osteoprotegerin levels MR Egger 16 -1.575848902 0.702023473 0.041464238
Green bean (ukb-b-2299) (👉 📊) Osteoprotegerin levels Weighted median 16 -1.208367306 0.555938387 0.029737943
Green bean (ukb-b-2299) (👉 📊) Osteoprotegerin levels Inverse variance weighted 16 -0.825425324 0.418709844 0.048683399
Green bean (ukb-b-2299) (👉 📊) Osteoprotegerin levels Weighted mode 16 -1.24269596 0.563420537 0.04342647
Parsnip (ukb-b-2468) (👉 📊) Osteoprotegerin levels Inverse variance weighted 19 -1.466447738 0.68804414 0.03306213
Fizzy drink (ukb-b-2832) (👉 📊) Osteoprotegerin levels Inverse variance weighted 12 1.751747415 0.700770094 0.012428229
Other vegetables (ukb-b-3055) (👉 📊) Osteoprotegerin levels Weighted median 13 2.676839934 1.042323627 0.010224389
Other vegetables (ukb-b-3055) (👉 📊) Osteoprotegerin levels Inverse variance weighted 13 2.201037814 0.845492848 0.009234186
Mushroom (ukb-b-4043) (👉 📊) Osteoprotegerin levels MR Egger 10 -2.238592165 0.941551613 0.04471589
Whole egg (ukb-b-4075) (👉 📊) Osteoprotegerin levels Inverse variance weighted 5 -1.965266446 0.816764691 0.016121207
Beer/cider (ukb-b-4961) (👉 📊) Osteoprotegerin levels MR Egger 13 2.198381508 0.958626208 0.042532991
Beer/cider (ukb-b-4961) (👉 📊) Osteoprotegerin levels Weighted mode 13 1.383641247 0.574819097 0.033087985
Sausage (ukb-b-5847) (👉 📊) Osteoprotegerin levels Inverse variance weighted 13 1.288653089 0.596870497 0.030848908
Liver (ukb-b-6373) (👉 📊) Osteoprotegerin levels Inverse variance weighted 27 -2.587825527 1.276099501 0.042568587
Crumble (ukb-b-7641) (👉 📊) Osteoprotegerin levels Inverse variance weighted 21 -2.977832866 1.491480569 0.045872825
Yogurt (ukb-b-7753) (👉 📊) Osteoprotegerin levels Inverse variance weighted 10 1.2343233 0.586834646 0.035434494
Poultry (ukb-b-8006) (👉 📊) Osteoprotegerin levels MR Egger 79 -4.344407535 2.136749434 0.045480093
Stewed fruit (ukb-b-8676) (👉 📊) Osteoprotegerin levels Weighted median 8 -3.712508134 1.464887261 0.011266249
Other grain (ukb-b-8765) (👉 📊) Osteoprotegerin levels Weighted mode 69 4.941230372 2.196760189 0.027733542

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Pineapple (ukb-b-1164) Osteoprotegerin levels rs149078766 -8.70192952794998 4.43649196253656 0.0498272781359294
Pineapple (ukb-b-1164) Osteoprotegerin levels rs62007226 11.0014055086621 4.18387314701931 0.0085515877710397
Pineapple (ukb-b-1164) Osteoprotegerin levels All - MR Egger -6.41849289673058 2.81001160195567 0.039811632928458
Red wine (ukb-b-13556) Osteoprotegerin levels rs1229984 1.05429461504228 0.501438670363904 0.0355060426356564
Red wine (ukb-b-13556) Osteoprotegerin levels All - Inverse variance weighted 0.626177126661905 0.312939013067075 0.0453971556313865
Vegetarian alternatives (ukb-b-14425) Osteoprotegerin levels rs551343 -18.7693079411205 7.24733191496722 0.0096025250307559
Vegetarian alternatives (ukb-b-14425) Osteoprotegerin levels All - Inverse variance weighted -6.93424742038036 3.26898825871511 0.0339031862699487
Mozzarella (ukb-b-14505) Osteoprotegerin levels rs116968441 -18.0571857872749 8.95550275976591 0.0437662160887972
Mozzarella (ukb-b-14505) Osteoprotegerin levels rs352863 -16.8703566591422 6.96541760722348 0.0154346479773603
Mozzarella (ukb-b-14505) Osteoprotegerin levels All - Inverse variance weighted -3.38641700102423 1.43822795626036 0.0185438521814866
White rice (ukb-b-14690) Osteoprotegerin levels rs12609624 6.79916062914311 2.67521866637575 0.0110367042416309
White rice (ukb-b-14690) Osteoprotegerin levels All - Inverse variance weighted 1.3144430994814 0.627058290175291 0.0360639563899779
Water (ukb-b-14898) Osteoprotegerin levels rs12692772 -9.60042082262731 3.65634841955476 0.0086474689885063
Water (ukb-b-14898) Osteoprotegerin levels rs13409451 10.4521013057467 4.82021933341415 0.0301292481967768
Water (ukb-b-14898) Osteoprotegerin levels rs4410790 -2.77013352164139 1.34616505892185 0.0396096882503111
Water (ukb-b-14898) Osteoprotegerin levels rs55938136 8.60335100453551 4.38837785171507 0.0499390749181677
Water (ukb-b-14898) Osteoprotegerin levels rs7624543 -9.86091160220995 4.47972573007103 0.0277196675938537
Water (ukb-b-14898) Osteoprotegerin levels rs78493248 -10.2306596040893 4.50581179823875 0.0231743861869109
Water (ukb-b-14898) Osteoprotegerin levels All - MR Egger -3.41165163724311 1.02790529406303 0.0011322577545769
Rose wine (ukb-b-16124) Osteoprotegerin levels rs13224220 -3.00126783406193 0.985314941506747 0.0023190899194795
Rose wine (ukb-b-16124) Osteoprotegerin levels All - MR Egger -3.59699678273226 1.2856904669646 0.017345488032587
Non-oily fish (ukb-b-17627) Osteoprotegerin levels rs1445978 10.4909888448964 4.98595344099624 0.0353689515697087
Non-oily fish (ukb-b-17627) Osteoprotegerin levels rs2400169 11.8139107046173 4.86562610978826 0.0151808763435179
Non-oily fish (ukb-b-17627) Osteoprotegerin levels rs35287743 -13.5430465442698 3.5081820282862 0.0001131935535381
Non-oily fish (ukb-b-17627) Osteoprotegerin levels rs55774808 10.8547983966046 5.28920537609054 0.0401448828391187
Non-oily fish (ukb-b-17627) Osteoprotegerin levels rs776472 -12.3757599594433 5.31941601402629 0.0199905041053693
Other savoury snack (ukb-b-18718) Osteoprotegerin levels rs12061341 11.8107940727762 5.42408954276997 0.0294454928476899
Other savoury snack (ukb-b-18718) Osteoprotegerin levels All - Inverse variance weighted 2.47204963997699 1.17032960113992 0.0346634781472673
Plain cereal (ukb-b-20023) Osteoprotegerin levels rs113962416 7.11973875765107 3.01216932493626 0.0180954983909645
Plain cereal (ukb-b-20023) Osteoprotegerin levels rs833365 6.97108824722499 3.02625044559993 0.0212484923591059
Plain cereal (ukb-b-20023) Osteoprotegerin levels All - Inverse variance weighted 2.19958200275845 0.93919477231671 0.0191813799914707
Green bean (ukb-b-2299) Osteoprotegerin levels rs115617710 -4.417328358894 1.97518681467591 0.0253248997060336
Green bean (ukb-b-2299) Osteoprotegerin levels rs146548702 -1.66670861781455 0.73592958499827 0.0235270165941654
Green bean (ukb-b-2299) Osteoprotegerin levels All - Inverse variance weighted -0.825425323672198 0.418709844018145 0.0486833993167307
Green bean (ukb-b-2299) Osteoprotegerin levels All - MR Egger -1.57584890217551 0.702023473345805 0.0414642379952986
Parsnip (ukb-b-2468) Osteoprotegerin levels All - Inverse variance weighted -1.46644773790223 0.688044139596092 0.0330621301301443
Fizzy drink (ukb-b-2832) Osteoprotegerin levels rs2212808 5.1234296096401 2.50030726480883 0.0404503827593612
Fizzy drink (ukb-b-2832) Osteoprotegerin levels All - Inverse variance weighted 1.75174741472204 0.700770093875775 0.0124282290639094
Other vegetables (ukb-b-3055) Osteoprotegerin levels rs10915244 7.48942930465599 2.80618966149334 0.0076100934033861
Other vegetables (ukb-b-3055) Osteoprotegerin levels rs116068692 5.59257783596107 2.64070806534236 0.0341892406903907
Other vegetables (ukb-b-3055) Osteoprotegerin levels All - Inverse variance weighted 2.20103781405719 0.845492847966499 0.0092341862364498
Mushroom (ukb-b-4043) Osteoprotegerin levels rs35350431 -2.8547293725884 1.21070748982504 0.018378553854613
Mushroom (ukb-b-4043) Osteoprotegerin levels rs61068241 -3.32841890071679 1.59305313637391 0.0366777345150125
Mushroom (ukb-b-4043) Osteoprotegerin levels All - MR Egger -2.23859216494341 0.94155161282742 0.0447158896822249
Whole egg (ukb-b-4075) Osteoprotegerin levels rs2184358 -4.80382821099715 1.97587930040361 0.0150474239555529
Whole egg (ukb-b-4075) Osteoprotegerin levels All - Inverse variance weighted -1.96526644565521 0.816764690882829 0.0161212068879231
Beer/cider (ukb-b-4961) Osteoprotegerin levels rs1229984 1.13202414975051 0.538408027862269 0.0355060426356564
Beer/cider (ukb-b-4961) Osteoprotegerin levels All - MR Egger 2.19838150821902 0.958626208063952 0.0425329911956049
Sausage (ukb-b-5847) Osteoprotegerin levels rs4245952 3.75309980865805 1.47856555706756 0.011138021143473
Sausage (ukb-b-5847) Osteoprotegerin levels All - Inverse variance weighted 1.28865308885318 0.596870497083214 0.0308489080180455
Liver (ukb-b-6373) Osteoprotegerin levels rs12548207 -17.2648347388515 6.18827849008579 0.0052720203281657
Liver (ukb-b-6373) Osteoprotegerin levels rs4372557 -8.55127153846984 4.30629133713842 0.0470597095559379
Liver (ukb-b-6373) Osteoprotegerin levels rs74798467 -19.8089997268079 7.61760917925301 0.009310913928144
Liver (ukb-b-6373) Osteoprotegerin levels All - Inverse variance weighted -2.58782552650667 1.27609950123433 0.0425685874628363
Crumble (ukb-b-7641) Osteoprotegerin levels rs116756799 -18.9044609371614 5.83503940320274 0.0011960635700816
Crumble (ukb-b-7641) Osteoprotegerin levels rs143152334 -19.5566245794649 6.61611261582964 0.0031174939887001
Crumble (ukb-b-7641) Osteoprotegerin levels rs150982043 -30.4508012885862 12.2304978999307 0.0127835356635561
Crumble (ukb-b-7641) Osteoprotegerin levels All - Inverse variance weighted -2.97783286602361 1.49148056869027 0.0458728252147027
Yogurt (ukb-b-7753) Osteoprotegerin levels All - Inverse variance weighted 1.23432329986719 0.586834646228692 0.0354344940704215
Poultry (ukb-b-8006) Osteoprotegerin levels rs10224539 11.3068442811208 4.70984914292991 0.016364605564323
Poultry (ukb-b-8006) Osteoprotegerin levels rs2696187 -12.23415806942 4.64840313866227 0.0084907460888899
Poultry (ukb-b-8006) Osteoprotegerin levels rs76141078 -15.469625413324 7.87914097355414 0.0496038395997717
Poultry (ukb-b-8006) Osteoprotegerin levels All - MR Egger -4.34440753535694 2.13674943388362 0.0454800927790176
Stewed fruit (ukb-b-8676) Osteoprotegerin levels rs117969658 10.6525097152892 5.21093965951773 0.0409279783527224
Other grain (ukb-b-8765) Osteoprotegerin levels rs10093198 24.4136905743476 11.2135150151331 0.0294681379303711
Other grain (ukb-b-8765) Osteoprotegerin levels rs72732838 21.8252600501219 10.8251570599746 0.0437831376273871
Other grain (ukb-b-8765) Osteoprotegerin levels rs73173015 -22.3784188649229 9.97451229816433 0.0248607120735662