ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Bread (ukb-b-11348) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Weighted median 104 0.20463665 0.103400399 0.047808101
Grape (ukb-b-12051) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Inverse variance weighted 8 0.233571947 0.119012346 0.049694316
Vegetable pieces (ukb-b-12566) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Weighted median 11 -0.313260857 0.127627163 0.014108071
Fried potatoes (ukb-b-12836) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Inverse variance weighted 17 0.208073767 0.059567333 0.000477474
Mixed vegetable (ukb-b-13155) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Inverse variance weighted 12 0.221662197 0.098045401 0.023770915
Cheese (ukb-b-1489) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) MR Egger 181 0.443240245 0.194393878 0.023780216
Cheese (ukb-b-1489) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Weighted median 181 0.152532065 0.07404692 0.039404468
Cereal (ukb-b-15926) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Weighted median 150 -0.214705616 0.090346215 0.017478897
Cereal (ukb-b-15926) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Inverse variance weighted 150 -0.203743324 0.06775717 0.002638716
Boiled/baked potatoes (ukb-b-18007) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Inverse variance weighted 9 0.215547772 0.102856013 0.03611535
Other savoury snack (ukb-b-18718) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Inverse variance weighted 21 0.513845044 0.254782766 0.043716732
Cheesy biscuits (ukb-b-19847) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Inverse variance weighted 21 -0.641917263 0.268033688 0.016624326
Powdered/instant soup (ukb-b-19931) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) MR Egger 16 1.577760919 0.535823941 0.010660238
Plain cereal (ukb-b-20023) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) MR Egger 12 -0.924940275 0.314571963 0.014777579
Cherry (ukb-b-2221) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Weighted median 16 0.854753066 0.280693621 0.002325674
Cherry (ukb-b-2221) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Simple mode 16 1.012888596 0.427325913 0.031604877
Indian snacks (ukb-b-282) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Weighted median 23 -0.629704446 0.289114744 0.029402809
Beef (ukb-b-2862) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) MR Egger 90 0.771023497 0.312223586 0.015462463
Spirits (ukb-b-3751) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Inverse variance weighted 18 -0.198918402 0.092291174 0.031135626
Fresh fruit (ukb-b-3881) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) MR Egger 131 -0.793016199 0.381576939 0.039667646
Fresh fruit (ukb-b-3881) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Weighted median 131 -0.351353549 0.160798044 0.028884368
Mango (ukb-b-6218) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Weighted median 24 -0.76144124 0.357845134 0.033349413
Mango (ukb-b-6218) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Inverse variance weighted 24 -0.630783019 0.282893422 0.025763713
Blue cheese (ukb-b-7429) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) MR Egger 20 0.998586071 0.454718083 0.041432901
Other meat (ukb-b-770) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) MR Egger 20 1.628878551 0.687768491 0.029263478
Other grain (ukb-b-8765) (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) Inverse variance weighted 64 0.64437237 0.271963902 0.017820321

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Bread (ukb-b-11348) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs11060853 1.21129095316287 0.583648447884901 0.0379515465023945
Bread (ukb-b-11348) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs1884010 1.92695443849227 0.759077743794299 0.0111313888260484
Bread (ukb-b-11348) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs596878 -1.5332311099753 0.632288099497402 0.0153128910302856
Bread (ukb-b-11348) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs61878484 1.64077347378037 0.787107847547598 0.0371092655903873
Bread (ukb-b-11348) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs7923705 -1.5638562675517 0.772581056931325 0.0429498848319995
Bread (ukb-b-11348) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs8050588 -2.40662834446256 0.693599402392253 0.0005209099620414
Bread (ukb-b-11348) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs9755262 -1.62528208106796 0.732172952591337 0.02643192389662
Grape (ukb-b-12051) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - Inverse variance weighted 0.233571946658742 0.119012346135146 0.0496943160667957
Vegetable pieces (ukb-b-12566) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs75462991 0.564409773541647 0.280322420170006 0.0440693360441445
Fried potatoes (ukb-b-12836) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs10495468 0.552044828397779 0.257003571873572 0.0317133981347132
Fried potatoes (ukb-b-12836) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs10742742 0.538987358233946 0.246040304095976 0.0284773753959563
Fried potatoes (ukb-b-12836) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs72864648 0.624274233554916 0.237204087707114 0.0084933301564041
Fried potatoes (ukb-b-12836) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs9596491 0.553398218818996 0.258686633975848 0.0324145390020211
Fried potatoes (ukb-b-12836) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - Inverse variance weighted 0.208073767380675 0.059567333458975 0.0004774742479608
Mixed vegetable (ukb-b-13155) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs11134553 0.879730746089049 0.29236198856799 0.0026206921553682
Mixed vegetable (ukb-b-13155) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - Inverse variance weighted 0.221662196720696 0.0980454006469952 0.0237709148499567
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs1073242 1.07751780264496 0.478982706002035 0.0244745730062521
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs114121746 1.42827598249463 0.659316373637167 0.0302883945546315
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs11620149 -1.54435486152366 0.593120031684065 0.0092201563771519
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs11735256 1.93039532508414 0.641531738191317 0.0026207371676953
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs13107325 -0.991726072301715 0.475197075836908 0.0368900796302622
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs150702313 1.60652297080921 0.658150018475182 0.0146479627365812
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs34205186 -1.64262174335924 0.700036827543225 0.0189517320869097
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs35625885 -1.59111502115614 0.66717537150415 0.0170859586083897
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs4140685 2.59725720901851 0.621563688138563 2.93327320778683e-05
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs4655801 1.39075925024142 0.651131158230094 0.032686537746582
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs504675 0.562929545437981 0.280910144378284 0.045075545776118
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs683996 -1.73598857482547 0.640038857192568 0.0066814567454636
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs71386942 1.56676397747555 0.571234279231291 0.0060923427891451
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs7386207 -1.18500648134812 0.59691775889385 0.0471212282279925
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs75499503 1.46069052316003 0.634354340340383 0.0212990316216715
Cheese (ukb-b-1489) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - MR Egger 0.443240244615274 0.194393878465752 0.0237802160335478
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs10857964 -1.50348558204251 0.648865588573538 0.0204983583139917
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs143747365 1.90673504436393 0.905154098871898 0.0351582651965231
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs17599026 -1.77873488210215 0.896117926854027 0.0471518223205556
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs184643 -1.21695313720171 0.612057244786401 0.0467785718356578
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs2339515 -1.94033066783411 0.861551370714167 0.0243136928580536
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs2582404 2.17991726485205 0.76829904139473 0.0045492686975961
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs2817377 -1.50397340023675 0.744450975876794 0.0433579753119934
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs396370 2.31629693446997 0.887981942609265 0.009094119753812
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs62009152 1.77665054634645 0.879602015145114 0.0434005513640658
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs62462533 -1.98690010732904 0.820736545538179 0.0154832251387946
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs68136852 -1.60066420246137 0.71948421634023 0.0260988012608421
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs78959390 1.8457728761531 0.77754236617668 0.0176034593124478
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs834233 -2.04073951157915 0.774857132449956 0.0084460628484971
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs844137 1.73578365387393 0.868077854101552 0.0455465643152037
Cereal (ukb-b-15926) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - Inverse variance weighted -0.203743324446654 0.0677571702165538 0.0026387161392775
Boiled/baked potatoes (ukb-b-18007) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs16841871 0.590934380625102 0.218244275770049 0.006775651469975
Boiled/baked potatoes (ukb-b-18007) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs9962730 0.599129461808212 0.199647825004425 0.0026915503992923
Boiled/baked potatoes (ukb-b-18007) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - Inverse variance weighted 0.21554777191578 0.102856013331858 0.0361153497599513
Other savoury snack (ukb-b-18718) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs11061369 2.06550543784393 0.973398616346751 0.0338417434272262
Other savoury snack (ukb-b-18718) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs113470581 1.76634521206868 0.864349559035679 0.0409976031549236
Other savoury snack (ukb-b-18718) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - Inverse variance weighted 0.513845044302778 0.254782765844919 0.0437167322780069
Cheesy biscuits (ukb-b-19847) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs9560935 -3.10516476097668 1.23923104416333 0.0122202697974114
Cheesy biscuits (ukb-b-19847) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - Inverse variance weighted -0.641917263117067 0.268033688163933 0.0166243264267361
Powdered/instant soup (ukb-b-19931) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs6555009 -2.36346315217928 0.88777629695444 0.0077625217096706
Powdered/instant soup (ukb-b-19931) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - MR Egger 1.57776091868886 0.535823941104214 0.0106602383418696
Plain cereal (ukb-b-20023) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs113962416 -1.16210819680042 0.518991948781057 0.025145233643615
Plain cereal (ukb-b-20023) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs117581586 -1.22213010675071 0.540684862648685 0.0238003310778098
Plain cereal (ukb-b-20023) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - MR Egger -0.92494027535199 0.3145719625161 0.0147775790317524
Cherry (ukb-b-2221) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs4488206 -2.70984928837473 0.823069032995404 0.0009934617323999
Indian snacks (ukb-b-282) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs12784972 -2.10499248358256 0.934965681620381 0.0243594867120192
Indian snacks (ukb-b-282) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs143452328 -2.10847132615048 1.02183781525433 0.0390736014919803
Beef (ukb-b-2862) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs10123094 -1.81982733759978 0.913886008455181 0.0464471786133278
Beef (ukb-b-2862) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs140748046 2.20859933617828 0.934846846846847 0.0181509020055198
Beef (ukb-b-2862) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs187160427 2.35073233885685 0.824971793125322 0.0043792141561199
Beef (ukb-b-2862) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs4714375 1.83935728393017 0.90053533202724 0.0411004334114305
Beef (ukb-b-2862) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs61845699 -2.10690460038972 0.908823787441261 0.0204343124056678
Beef (ukb-b-2862) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs7174015 -3.20219707320344 0.903309859407911 0.0003926730767185
Beef (ukb-b-2862) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs803370 -2.17163603649916 0.840190745861507 0.0097465436562021
Beef (ukb-b-2862) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - MR Egger 0.771023497265897 0.312223585923887 0.0154624627638527
Spirits (ukb-b-3751) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs141415334 -0.829972306996073 0.352818748083256 0.0186524934948279
Spirits (ukb-b-3751) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - Inverse variance weighted -0.198918402274693 0.0922911744199054 0.031135625545341
Fresh fruit (ukb-b-3881) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs10838724 -2.53924145033559 0.858509934656771 0.0030991244060184
Fresh fruit (ukb-b-3881) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs10875917 -3.66119517825083 1.23707710601786 0.0030808576930615
Fresh fruit (ukb-b-3881) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs11075545 3.16585386758089 1.28933704735376 0.0140723138790372
Fresh fruit (ukb-b-3881) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs11896330 -1.84339430737881 0.908504594662117 0.0424539758885246
Fresh fruit (ukb-b-3881) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs139042899 -2.65077927489929 1.04392554521461 0.0111093045198783
Fresh fruit (ukb-b-3881) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs17056301 3.67037299069145 1.30244129250713 0.0048313014813253
Fresh fruit (ukb-b-3881) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs2143081 -1.80553869672493 0.886565241270898 0.0416946763443665
Fresh fruit (ukb-b-3881) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs4953150 -2.39087544924229 0.919986586422189 0.0093546022531102
Fresh fruit (ukb-b-3881) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs6477901 -2.33490286796783 1.15386947318021 0.0430173402071711
Fresh fruit (ukb-b-3881) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs7313901 3.7024753249259 1.18843983451261 0.0018369045244008
Fresh fruit (ukb-b-3881) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - MR Egger -0.793016198779839 0.381576938655167 0.0396676464556464
Mango (ukb-b-6218) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs1051412 -2.70609019640041 1.05392022241915 0.0102392738958456
Mango (ukb-b-6218) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs10976627 -2.03865532058303 0.959193417024742 0.0335544991434689
Mango (ukb-b-6218) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs17837122 -2.60329457410871 1.30861482390283 0.0466624432847038
Mango (ukb-b-6218) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs2622567 -3.23772544154029 1.07543992087279 0.0026072727458102
Mango (ukb-b-6218) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - Inverse variance weighted -0.630783018812894 0.282893422172062 0.025763713220878
Blue cheese (ukb-b-7429) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs10509498 -2.73139051419792 1.07609205517967 0.0111408411273143
Blue cheese (ukb-b-7429) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs168389 -2.06914762170622 0.983388096175143 0.0353696602496188
Blue cheese (ukb-b-7429) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs34065485 -3.00242675182239 0.948256478425442 0.0015441259963096
Blue cheese (ukb-b-7429) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs79603758 2.16633957069165 0.978124859157526 0.0267745932837509
Blue cheese (ukb-b-7429) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - MR Egger 0.99858607058165 0.454718082874835 0.0414329013245559
Other meat (ukb-b-770) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs138358390 2.65653394678815 1.16923416929947 0.023084758490561
Other meat (ukb-b-770) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - MR Egger 1.62887855124903 0.687768491137685 0.0292634775859772
Other grain (ukb-b-8765) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) rs76400165 5.27873950450917 2.20545247227117 0.0166887079788987
Other grain (ukb-b-8765) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) All - Inverse variance weighted 0.644372369791905 0.271963901792319 0.0178203208189807