ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Sweets (ukb-b-10217) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Inverse variance weighted 12 -0.110794896 0.051822549 0.032519429
Grape (ukb-b-12051) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Inverse variance weighted 3 0.332021 0.157118432 0.034584562
Herbal tea (ukb-b-13344) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) MR Egger 41 -0.004841485 0.002370223 0.047890394
Scotch egg (ukb-b-13516) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Inverse variance weighted 37 -0.304776696 0.141333983 0.031050185
Dark chocolate (ukb-b-16139) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Weighted median 12 0.216027426 0.094196168 0.021826248
Dark chocolate (ukb-b-16139) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Weighted mode 12 0.221666979 0.09255458 0.035546471
Garlic (ukb-b-17223) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) MR Egger 11 -0.515963359 0.222105822 0.045259101
Butternut squash (ukb-b-20341) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Weighted median 7 -0.508713269 0.227658543 0.025447232
Butternut squash (ukb-b-20341) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Inverse variance weighted 7 -0.451332048 0.176388447 0.01050525
Crumbed or deep-fried poultry (ukb-b-39) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Inverse variance weighted 5 -0.267409585 0.134015947 0.046004016
Yorkshire pudding (ukb-b-5605) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Inverse variance weighted 11 0.20960099 0.098168261 0.032751232
Pork (ukb-b-5640) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Simple mode 67 -0.73281509 0.287065383 0.013006972
Peach/nectarine (ukb-b-6154) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Inverse variance weighted 10 -0.19055102 0.088432151 0.031179772
Watercress (ukb-b-6181) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) MR Egger 7 0.582827959 0.22278245 0.047318211
Pulses (ukb-b-621) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Inverse variance weighted 4 -0.558517027 0.202218916 0.005745859
Doughnut (ukb-b-6214) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) MR Egger 13 0.777358227 0.325396829 0.035927759
Poultry (ukb-b-8006) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Inverse variance weighted 67 0.209193213 0.086777006 0.015921997
Chocolate biscuits (ukb-b-9886) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Weighted median 5 -0.153041118 0.075204663 0.04185137
Chocolate biscuits (ukb-b-9886) (👉 📊) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) Inverse variance weighted 5 -0.122106344 0.05968344 0.04076622

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Sweets (ukb-b-10217) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) All - Inverse variance weighted -0.110794896119252 0.0518225494654475 0.0325194286994007
Grape (ukb-b-12051) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs10497191 0.663269920709096 0.283397147939341 0.0192617792731853
Grape (ukb-b-12051) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) All - Inverse variance weighted 0.332021000220432 0.157118431615715 0.0345845623867471
Herbal tea (ukb-b-13344) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs2216667 0.0110544168213315 0.0054690272695008 0.0432511405161693
Herbal tea (ukb-b-13344) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs855736 0.0332184528505585 0.0147822115184985 0.0246278224022572
Herbal tea (ukb-b-13344) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs9621390 0.0406844756177938 0.0144836733199346 0.0049697381034436
Herbal tea (ukb-b-13344) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs9792589 0.0193413838339668 0.0074842746140132 0.0097585462516864
Herbal tea (ukb-b-13344) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) All - MR Egger -0.0048414847164526 0.0023702232228122 0.0478903936171743
Scotch egg (ukb-b-13516) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs150494806 -2.81397170720287 1.00177392776422 0.0049697381034436
Scotch egg (ukb-b-13516) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) All - Inverse variance weighted -0.304776696197093 0.14133398331216 0.031050184512101
Dark chocolate (ukb-b-16139) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs259386 -1.92940225280682 0.817699049999081 0.0182970872732547
Garlic (ukb-b-17223) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs72780997 0.628001599751444 0.294169170409887 0.0327747794725053
Garlic (ukb-b-17223) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs78818759 -0.279540024246419 0.132413695695672 0.0347627626222285
Garlic (ukb-b-17223) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) All - MR Egger -0.515963359128209 0.222105821566431 0.045259101467641
Butternut squash (ukb-b-20341) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs6852243 -0.592513590780489 0.263668547897317 0.0246278224022572
Butternut squash (ukb-b-20341) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs74413219 -0.930855348659031 0.318638946271745 0.0034851994094175
Butternut squash (ukb-b-20341) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) All - Inverse variance weighted -0.451332047824297 0.176388447313521 0.0105052497245725
Crumbed or deep-fried poultry (ukb-b-39) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) All - Inverse variance weighted -0.267409585049622 0.13401594651063 0.0460040157331578
Yorkshire pudding (ukb-b-5605) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) All - Inverse variance weighted 0.209600990252992 0.098168261076097 0.0327512321026385
Pork (ukb-b-5640) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs1051921 2.12342563156745 0.899928005759539 0.0182970872732547
Pork (ukb-b-5640) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs13335365 -1.2045290291496 0.595572686635081 0.0431276226781775
Pork (ukb-b-5640) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs838133 -2.29475693934498 0.872007636951094 0.0084989118692023
Peach/nectarine (ukb-b-6154) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs7006940 -0.599838043728193 0.296586588287829 0.0431276226781775
Peach/nectarine (ukb-b-6154) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs7032259 -0.677446273891528 0.274057810801573 0.0134393303230719
Peach/nectarine (ukb-b-6154) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) All - Inverse variance weighted -0.190551019874846 0.0884321511879685 0.0311797719099941
Watercress (ukb-b-6181) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs116023894 0.535359132289918 0.251618792176262 0.0333653189448041
Watercress (ukb-b-6181) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) All - MR Egger 0.582827958763125 0.222782450229882 0.0473182111195562
Pulses (ukb-b-621) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs7115225 -1.05404288689698 0.375239267735326 0.0049697381034436
Pulses (ukb-b-621) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) All - Inverse variance weighted -0.558517027367611 0.202218916214853 0.0057458589356758
Doughnut (ukb-b-6214) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs4467081 -3.25807745993422 1.52615207333761 0.0327747794725053
Doughnut (ukb-b-6214) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) All - MR Egger 0.777358226946918 0.325396828607929 0.0359277592437954
Poultry (ukb-b-8006) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs1062633 -3.68995680579974 0.965900457988756 0.0001333301410487
Poultry (ukb-b-8006) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs1256428 1.93577308664113 0.906756866900318 0.0327747794725053
Poultry (ukb-b-8006) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs144438383 0.520212742239541 0.220471114568186 0.0182970872732546
Poultry (ukb-b-8006) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs4627402 2.71137421483122 0.804374350399928 0.0007495391775294
Poultry (ukb-b-8006) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs77779142 1.74076799518915 0.704219779871974 0.0134393303230719
Poultry (ukb-b-8006) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) rs78974715 2.01010277655497 0.894495735566959 0.0246278224022572
Poultry (ukb-b-8006) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) All - Inverse variance weighted 0.209193212710133 0.0867770055940347 0.0159219966979719
Chocolate biscuits (ukb-b-9886) Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) All - Inverse variance weighted -0.122106344426626 0.059683440230648 0.0407662201497505