ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Neck circumference (ebi-a-GCST90017134)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Beetroot (ukb-b-11880) (👉 📊) Neck circumference Weighted median 8 4.194591177 2.032010674 0.038993406
Beetroot (ukb-b-11880) (👉 📊) Neck circumference Inverse variance weighted 8 3.800637272 1.539991805 0.013588573
Mixed vegetable (ukb-b-13155) (👉 📊) Neck circumference Weighted median 11 -2.541498712 1.095401292 0.020332596
Mixed vegetable (ukb-b-13155) (👉 📊) Neck circumference Inverse variance weighted 11 -1.905842044 0.910298674 0.036291638
Scotch egg (ukb-b-13516) (👉 📊) Neck circumference Inverse variance weighted 42 8.698021275 4.057196603 0.032044901
Cheese (ukb-b-1489) (👉 📊) Neck circumference Inverse variance weighted 199 0.766224799 0.373579684 0.040263592
Other savoury snack (ukb-b-18718) (👉 📊) Neck circumference Inverse variance weighted 11 6.69907737 2.508890811 0.007582074
Parsnip (ukb-b-2468) (👉 📊) Neck circumference Inverse variance weighted 11 -3.819499129 1.834881959 0.037378581
Leek (ukb-b-2530) (👉 📊) Neck circumference Weighted median 10 -5.823276767 2.225706372 0.008886957
Leek (ukb-b-2530) (👉 📊) Neck circumference Inverse variance weighted 10 -5.331396289 1.663770044 0.00135341
Standard tea (ukb-b-3291) (👉 📊) Neck circumference Weighted median 14 0.01173809 0.004759499 0.013653791
Standard tea (ukb-b-3291) (👉 📊) Neck circumference Weighted mode 14 0.012972214 0.005645199 0.038808337
Drinking water (ukb-b-3975) (👉 📊) Neck circumference Inverse variance weighted 20 -0.489086577 0.2424723 0.043686929
Coffee (ukb-b-5237) (👉 📊) Neck circumference MR Egger 116 3.903632017 1.24648687 0.002208599
Coffee (ukb-b-5237) (👉 📊) Neck circumference Weighted median 116 2.158794297 0.960490656 0.024602007
Coffee (ukb-b-5237) (👉 📊) Neck circumference Inverse variance weighted 116 1.395625865 0.572955568 0.014857414
Coffee (ukb-b-5237) (👉 📊) Neck circumference Weighted mode 116 2.662276992 1.132787 0.020467365
Lamb (ukb-b-530) (👉 📊) Neck circumference Inverse variance weighted 11 -3.450203995 1.721877957 0.045097405
Sausage (ukb-b-5847) (👉 📊) Neck circumference Weighted median 10 -3.23963324 1.403965795 0.02102767
Bread roll (ukb-b-6246) (👉 📊) Neck circumference MR Egger 15 -3.256011991 1.218705133 0.019202132
Bread roll (ukb-b-6246) (👉 📊) Neck circumference Weighted median 15 -2.075092871 0.914579732 0.023274214
Onion (ukb-b-8124) (👉 📊) Neck circumference Weighted median 12 2.237586469 1.032999882 0.030303145
Berry (ukb-b-8887) (👉 📊) Neck circumference Weighted median 11 -3.17907752 1.424561713 0.025640223
Chocolate sweet (ukb-b-9835) (👉 📊) Neck circumference Inverse variance weighted 10 3.637749844 1.649404058 0.027419487

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Beetroot (ukb-b-11880) Neck circumference rs117786423 8.70541536716756 3.94896512616955 0.027490592060875
Beetroot (ukb-b-11880) Neck circumference All - Inverse variance weighted 3.80063727155509 1.53999180473565 0.0135885725708314
Mixed vegetable (ukb-b-13155) Neck circumference rs2730078 -5.91376180166427 2.61090086780353 0.0235110029084736
Mixed vegetable (ukb-b-13155) Neck circumference rs80030163 7.6303185675391 3.85738985273952 0.0479169675239884
Mixed vegetable (ukb-b-13155) Neck circumference All - Inverse variance weighted -1.90584204432153 0.910298674431173 0.0362916376847065
Scotch egg (ukb-b-13516) Neck circumference rs149736097 52.5125470553005 25.616776467492 0.0403714585051402
Scotch egg (ukb-b-13516) Neck circumference All - Inverse variance weighted 8.69802127532352 4.05719660309496 0.0320449008909377
Cheese (ukb-b-1489) Neck circumference rs10499731 11.3438663612246 5.14055845515591 0.0273323595942053
Cheese (ukb-b-1489) Neck circumference rs11104660 -12.17487086626 5.62430634945801 0.0304115539278636
Cheese (ukb-b-1489) Neck circumference rs12951057 12.7625179029765 4.86393737857882 0.0086927592371487
Cheese (ukb-b-1489) Neck circumference rs28415940 -13.5822528061848 5.20352140346406 0.0090488221933257
Cheese (ukb-b-1489) Neck circumference rs376580 13.2624234495573 6.48427279449406 0.0408231588817089
Cheese (ukb-b-1489) Neck circumference rs4776970 9.31286018379108 4.03665437931572 0.0210506976257935
Cheese (ukb-b-1489) Neck circumference rs62034322 10.7423486778372 4.82221664095296 0.0259019569682269
Cheese (ukb-b-1489) Neck circumference rs77742462 15.098974441083 6.81950331600192 0.0268227866401828
Cheese (ukb-b-1489) Neck circumference rs7925389 12.9458259469481 5.1962203392587 0.0127243358194819
Cheese (ukb-b-1489) Neck circumference All - Inverse variance weighted 0.766224799375349 0.373579683665728 0.0402635924088068
Other savoury snack (ukb-b-18718) Neck circumference rs17151237 18.6266985689134 6.30671301521376 0.0031422139235193
Other savoury snack (ukb-b-18718) Neck circumference rs17810066 19.2339874220627 9.71686145375044 0.0477659887397646
Other savoury snack (ukb-b-18718) Neck circumference All - Inverse variance weighted 6.69907736962123 2.50889081054995 0.0075820737279222
Parsnip (ukb-b-2468) Neck circumference rs142276527 -14.244950913625 6.7071913863415 0.0336841540211137
Parsnip (ukb-b-2468) Neck circumference All - Inverse variance weighted -3.8194991288478 1.83488195860236 0.0373785808049572
Leek (ukb-b-2530) Neck circumference rs12766168 -9.88467874794069 4.73396669944195 0.036794856883592
Leek (ukb-b-2530) Neck circumference rs3862773 -11.2183998648725 5.47547998423512 0.0404774511634766
Leek (ukb-b-2530) Neck circumference All - Inverse variance weighted -5.33139628923974 1.66377004382017 0.0013534103068107
Standard tea (ukb-b-3291) Neck circumference rs2472297 0.0151457261817291 0.0076414401175606 0.047473501351992
Standard tea (ukb-b-3291) Neck circumference rs729009 0.0363452844432004 0.0135075532032198 0.007129419674339
Drinking water (ukb-b-3975) Neck circumference rs2472297 -1.57181869386543 0.793026249168847 0.047473501351992
Drinking water (ukb-b-3975) Neck circumference All - Inverse variance weighted -0.489086576614666 0.24247229994133 0.0436869288033419
Coffee (ukb-b-5237) Neck circumference rs12514566 12.3188151475801 5.43993261502825 0.0235423888837264
Coffee (ukb-b-5237) Neck circumference rs17842490 7.1798141617019 3.14601169404206 0.0224777925856407
Coffee (ukb-b-5237) Neck circumference rs2472297 3.32682028284428 1.67847336391885 0.047473501351992
Coffee (ukb-b-5237) Neck circumference rs73075167 -13.0790156811235 6.23758863040731 0.0360107179544502
Coffee (ukb-b-5237) Neck circumference rs73228435 -21.0436222567471 8.27976295689872 0.0110354888252174
Coffee (ukb-b-5237) Neck circumference rs7590617 -16.6200256636672 7.86983558712975 0.0346980810555838
Coffee (ukb-b-5237) Neck circumference All - Inverse variance weighted 1.39562586476417 0.572955567942057 0.0148574141852441
Coffee (ukb-b-5237) Neck circumference All - MR Egger 3.90363201666726 1.24648687001656 0.0022085992906015
Lamb (ukb-b-530) Neck circumference All - Inverse variance weighted -3.45020399504126 1.7218779567791 0.0450974050488127
Sausage (ukb-b-5847) Neck circumference rs116938798 -7.92685097729591 3.39692266451095 0.0196198822457891
Bread roll (ukb-b-6246) Neck circumference rs80081868 -8.94385343710142 3.28645078890395 0.0064999690990196
Bread roll (ukb-b-6246) Neck circumference All - MR Egger -3.2560119909296 1.21870513320191 0.0192021319712579
Berry (ukb-b-8887) Neck circumference rs12964409 8.62221672948979 3.16793342808297 0.0064943826692894
Berry (ukb-b-8887) Neck circumference rs1498885 -9.74088062341636 2.98800019123201 0.0011141221380492
Chocolate sweet (ukb-b-9835) Neck circumference rs7959426 10.5399360748593 2.83207225426096 0.0001979378682179
Chocolate sweet (ukb-b-9835) Neck circumference All - Inverse variance weighted 3.63774984378267 1.64940405789053 0.027419487018148