ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Sweets (ukb-b-10217) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 10 0.603031124 0.234123766 0.01000392
Flavoured milk (ukb-b-12763) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Weighted median 6 3.91321998 1.648680582 0.017618176
Flavoured milk (ukb-b-12763) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 6 3.823393047 1.263040381 0.002468841
Vegetarian alternatives (ukb-b-14425) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 5 3.416317345 1.718752369 0.046847888
Cheese (ukb-b-1489) (👉 📊) Medication use (drugs affecting bone structure and mineralization) MR Egger 166 1.319971157 0.452712046 0.004045778
Hot chocolate (ukb-b-16449) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Weighted median 10 1.361357833 0.626150979 0.029692471
Hot chocolate (ukb-b-16449) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 10 1.218166046 0.487329028 0.012430595
Goat's cheese (ukb-b-20122) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 15 0.810727595 0.363809659 0.025851262
Leek (ukb-b-2530) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Weighted median 5 -1.76817167 0.875235986 0.043360285
Apple (ukb-b-4070) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 10 -0.581098468 0.219054035 0.007983587
Tofu (ukb-b-5522) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 15 1.061555963 0.460675955 0.02120333
Filtered coffee (ukb-b-748) (👉 📊) Medication use (drugs affecting bone structure and mineralization) MR Egger 13 1.970819426 0.795667513 0.030740401

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Sweets (ukb-b-10217) Medication use (drugs affecting bone structure and mineralization) rs73112179 1.19567341353616 0.507575253373656 0.0184899606962464
Sweets (ukb-b-10217) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 0.603031123906142 0.234123765538282 0.0100039202942219
Flavoured milk (ukb-b-12763) Medication use (drugs affecting bone structure and mineralization) rs9872037 5.88058053627622 2.49287461758827 0.0183264483646077
Flavoured milk (ukb-b-12763) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 3.82339304674392 1.26304038098141 0.0024688412221273
Vegetarian alternatives (ukb-b-14425) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 3.41631734514694 1.71875236934688 0.0468478883586612
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs1032001 -3.9337756784528 1.91217351823678 0.0396643609334103
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs17207890 -3.33240271307207 1.67852493833927 0.0471093053627024
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs2330698 12.8780639985738 5.97426686870488 0.0311157715496519
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs2870681 -3.52803452065654 1.70678161540818 0.038727699393106
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs35392738 -6.82113358017659 3.24934621061081 0.0357963992289297
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs4776970 -3.96448133534084 1.45361741342609 0.0063850885185917
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs6498981 -4.1508011471947 2.04700407013687 0.0425863362433274
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs7185391 -5.0930153860037 2.33682263231512 0.0292973881970918
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs75499503 9.17046716020053 2.87357614067836 0.0014163010159281
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs919109 2.72241726936233 1.14140694746768 0.0170725454881624
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs9377684 3.22701424922606 1.62108182876046 0.0465188561984309
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) All - MR Egger 1.31997115681851 0.452712046337974 0.0040457777827807
Hot chocolate (ukb-b-16449) Medication use (drugs affecting bone structure and mineralization) rs1789571 4.08520216896506 2.00371535680814 0.0414686320231659
Hot chocolate (ukb-b-16449) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 1.21816604582585 0.487329027835128 0.0124305948986385
Goat's cheese (ukb-b-20122) Medication use (drugs affecting bone structure and mineralization) rs79888670 1.68695754701532 0.649371491455035 0.0093814588163878
Goat's cheese (ukb-b-20122) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 0.810727594854885 0.363809658716578 0.0258512616497213
Apple (ukb-b-4070) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted -0.581098467749022 0.219054034721942 0.007983587336429
Tofu (ukb-b-5522) Medication use (drugs affecting bone structure and mineralization) rs7697383 4.46754448882037 2.23707645388095 0.0458201907992241
Tofu (ukb-b-5522) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 1.06155596323671 0.460675955175248 0.0212033299108277
Filtered coffee (ukb-b-748) Medication use (drugs affecting bone structure and mineralization) rs10932789 1.03549506218288 0.410088912719881 0.0115681786526528
Filtered coffee (ukb-b-748) Medication use (drugs affecting bone structure and mineralization) All - MR Egger 1.97081942623947 0.795667512532817 0.0307404009873428