ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Tinned tomato (ukb-b-10565) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 10 0.655223008 0.222518665 0.00323398
Beef (ukb-b-10829) (👉 📊) Medication use (drugs affecting bone structure and mineralization) MR Egger 7 2.034613183 0.700850594 0.033670416
Homemade soup (ukb-b-12658) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Weighted median 15 0.780189316 0.333104553 0.019171699
Homemade soup (ukb-b-12658) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 15 0.478208886 0.238259353 0.044739669
Lamb/mutton (ukb-b-14179) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 123 -0.390169833 0.18362386 0.033600643
Plum (ukb-b-14182) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 11 0.326729317 0.153240612 0.032995941
Vegetarian alternatives (ukb-b-14425) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 6 2.072512698 1.048544876 0.048091297
Cheese (ukb-b-1489) (👉 📊) Medication use (drugs affecting bone structure and mineralization) MR Egger 194 0.80844774 0.281525252 0.004541876
Dried fruit (ukb-b-16576) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 155 0.292887744 0.133098609 0.027769174
Boiled/baked potatoes (ukb-b-18007) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 9 0.346388184 0.17024041 0.041881055
Cheesecake (ukb-b-1814) (👉 📊) Medication use (drugs affecting bone structure and mineralization) MR Egger 20 -1.83059399 0.708173734 0.018680704
Goat's cheese (ukb-b-20122) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 27 0.805758855 0.337865335 0.017085989
Indian snacks (ukb-b-282) (👉 📊) Medication use (drugs affecting bone structure and mineralization) MR Egger 17 -1.577880377 0.723605629 0.045550704
Cabbage/kale (ukb-b-2975) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 13 -0.294998126 0.124376008 0.017700472
Wholemeal pasta (ukb-b-4150) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 13 1.044250621 0.52654033 0.047341735
Other bread (ukb-b-4964) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 13 -0.401613511 0.18701131 0.031750638
Chocolate-covered biscuits (ukb-b-5068) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Weighted median 7 -0.505689383 0.242456243 0.037006405
Chocolate-covered biscuits (ukb-b-5068) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 7 -0.430916432 0.197820315 0.029382039
Coffee (ukb-b-5237) (👉 📊) Medication use (drugs affecting bone structure and mineralization) MR Egger 116 -0.811816448 0.296307478 0.007137871
Coffee (ukb-b-5237) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 116 -0.485626893 0.13177348 0.000228419
Other meat (ukb-b-770) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Inverse variance weighted 21 1.051245239 0.477321981 0.027638351
Onion (ukb-b-8124) (👉 📊) Medication use (drugs affecting bone structure and mineralization) Weighted median 12 -0.487626633 0.216178186 0.02409131

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Tinned tomato (ukb-b-10565) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 0.655223007985937 0.222518665350669 0.0032339804313978
Beef (ukb-b-10829) Medication use (drugs affecting bone structure and mineralization) rs143363049 1.88622726464283 0.75261871998652 0.0122030043620267
Beef (ukb-b-10829) Medication use (drugs affecting bone structure and mineralization) All - MR Egger 2.03461318315457 0.70085059375242 0.0336704161924095
Homemade soup (ukb-b-12658) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 0.478208885990512 0.238259352917083 0.0447396691454408
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs10905778 -3.76962114636728 1.83785799662746 0.0402577068136143
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs115145470 8.16286203586954 2.24419895741197 0.0002754932623881
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs11756299 3.66011413742209 1.78381013917683 0.0401840623174183
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs2018466 4.93882062673848 2.30905899431929 0.0324446681305199
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs2696532 -4.19925631491217 2.13702611445912 0.0494142375450078
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs35797675 4.03694077310181 1.82491843167616 0.0269582908252502
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs4315028 -4.22657384586275 1.6955441590961 0.0126756767232983
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs4486004 -5.0734499805 1.82920305419388 0.0055442370550052
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs4759074 4.94357872111768 1.77682249686548 0.0053982096721511
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs62106258 3.5459353502478 1.7244248834973 0.0397535824818032
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs62169335 -4.9836818094267 2.1955138782069 0.0232113056292954
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs6581296 -4.04195650655196 1.68664357927724 0.016554765315408
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs6829572 -3.0353529341745 1.4760147601476 0.0397390057234327
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs7039466 -4.42663827641274 2.06389674912915 0.0319691307708373
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs7649005 3.45648882308655 1.72124747060585 0.0446294704412077
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) rs77691530 -5.83523659407469 2.35468202142375 0.0132068543933111
Lamb/mutton (ukb-b-14179) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted -0.390169833407608 0.183623860347505 0.0336006432067558
Plum (ukb-b-14182) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 0.326729316586787 0.153240611820865 0.0329959406325069
Vegetarian alternatives (ukb-b-14425) Medication use (drugs affecting bone structure and mineralization) rs72733403 6.50632236924376 3.04474138727842 0.0326057386220767
Vegetarian alternatives (ukb-b-14425) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 2.07251269768144 1.04854487601921 0.0480912969609506
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs11104660 -3.57986264676185 1.0597728581323 0.0007302762594092
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs1473781 3.09718368420606 1.43403847296116 0.0307909970243097
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs6706648 3.1830421279927 1.45387599900207 0.0285714752776448
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs71386942 2.76021417601727 1.15527761251851 0.0168841168853418
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs7185391 -2.69217464543007 1.17312638180752 0.0217404726393954
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs75499503 9.17067928076986 2.8706983716211 0.0014003384662757
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs7730004 2.63236930904722 1.21018320583715 0.029616444413498
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) rs79398870 -3.40882983100112 1.47466619648324 0.0208000564063569
Cheese (ukb-b-1489) Medication use (drugs affecting bone structure and mineralization) All - MR Egger 0.808447740454896 0.281525252420469 0.0045418764748188
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs142119647 4.58103451709921 2.03955623717808 0.0246980035992342
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs1549212 3.64620584234367 1.44913309118787 0.0118651734770967
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs1801140 6.06738223017293 1.76654740608229 0.0005934309207618
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs1812195 3.6768117695567 1.56235132700013 0.0186034384187887
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs2328887 -3.29846634508819 1.39854973031739 0.0183494261814845
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs3101339 2.49658122655072 1.14309758406676 0.0289586417915695
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs536421612 -6.96824401878821 1.70949911675879 4.57795233048881e-05
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs57499472 2.53220490481028 1.28123515103946 0.0481119866890885
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs58563230 -2.65868530399758 1.20198048174741 0.0269721564626072
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs62007687 4.5537083344162 1.54803484321345 0.0032651524109023
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs72842424 -3.03006375964784 1.46074734992795 0.0380492002276673
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs7730004 3.63546308846009 1.67133705744642 0.029616444413498
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs8081370 2.58601034404138 0.972003888015552 0.0078026157481021
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs9300104 3.77145246974125 1.69279714813469 0.0258844378736712
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) rs9310545 4.71069962948536 1.74386476668448 0.0069069276508631
Dried fruit (ukb-b-16576) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 0.292887744347264 0.133098608828559 0.0277691740241272
Boiled/baked potatoes (ukb-b-18007) Medication use (drugs affecting bone structure and mineralization) rs1614617 1.03211912703207 0.464847545762534 0.0263957655841366
Boiled/baked potatoes (ukb-b-18007) Medication use (drugs affecting bone structure and mineralization) rs9962730 1.06942407089097 0.428969543162435 0.0126666351544814
Boiled/baked potatoes (ukb-b-18007) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 0.346388184463534 0.170240409798933 0.0418810548148372
Cheesecake (ukb-b-1814) Medication use (drugs affecting bone structure and mineralization) rs145639946 -4.23660319906772 1.9284626806759 0.0280289395967334
Cheesecake (ukb-b-1814) Medication use (drugs affecting bone structure and mineralization) All - MR Egger -1.83059398979538 0.708173734483658 0.0186807040324719
Goat's cheese (ukb-b-20122) Medication use (drugs affecting bone structure and mineralization) rs149866188 7.26577256375941 3.3742418633788 0.0312947000804928
Goat's cheese (ukb-b-20122) Medication use (drugs affecting bone structure and mineralization) rs151088223 10.9082439409428 3.41179160035024 0.0013875967283974
Goat's cheese (ukb-b-20122) Medication use (drugs affecting bone structure and mineralization) rs79888670 1.68672173349142 0.648487190740389 0.0092949717114573
Goat's cheese (ukb-b-20122) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 0.80575885472371 0.337865334664182 0.0170859886615491
Indian snacks (ukb-b-282) Medication use (drugs affecting bone structure and mineralization) rs11649662 4.29685819138538 2.07773686507619 0.0386355720221448
Indian snacks (ukb-b-282) Medication use (drugs affecting bone structure and mineralization) rs146057934 -4.28486897142741 2.09142414081576 0.040483584585415
Indian snacks (ukb-b-282) Medication use (drugs affecting bone structure and mineralization) rs146431609 -4.0594608802313 2.02973044011565 0.0455002638963584
Indian snacks (ukb-b-282) Medication use (drugs affecting bone structure and mineralization) All - MR Egger -1.57788037730472 0.723605628723442 0.0455507042640398
Cabbage/kale (ukb-b-2975) Medication use (drugs affecting bone structure and mineralization) rs117630679 -1.97951174125221 0.775360802961566 0.0106793322620394
Cabbage/kale (ukb-b-2975) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted -0.294998126152765 0.124376007976613 0.0177004716764257
Wholemeal pasta (ukb-b-4150) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 1.04425062123663 0.526540329577324 0.0473417351227619
Other bread (ukb-b-4964) Medication use (drugs affecting bone structure and mineralization) rs9992062 -1.81129909318688 0.864924406382599 0.0362448032383334
Other bread (ukb-b-4964) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted -0.401613510609756 0.18701130953455 0.0317506381966445
Chocolate-covered biscuits (ukb-b-5068) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted -0.430916432330996 0.197820314677908 0.0293820389927696
Coffee (ukb-b-5237) Medication use (drugs affecting bone structure and mineralization) rs10992783 3.51586995479221 1.61362688223672 0.0293419371476866
Coffee (ukb-b-5237) Medication use (drugs affecting bone structure and mineralization) rs11206378 3.42537345385946 1.58675387936137 0.0308711076071626
Coffee (ukb-b-5237) Medication use (drugs affecting bone structure and mineralization) rs13387939 -3.87175491368584 1.06307155196366 0.0002704802977162
Coffee (ukb-b-5237) Medication use (drugs affecting bone structure and mineralization) rs1421085 -2.66952854507998 0.717267265647752 0.0001978041379517
Coffee (ukb-b-5237) Medication use (drugs affecting bone structure and mineralization) rs1527961 -3.5299143377476 1.5663526466863 0.0242220664148456
Coffee (ukb-b-5237) Medication use (drugs affecting bone structure and mineralization) rs2472297 -0.852148015528031 0.389491895986297 0.0286808725922352
Coffee (ukb-b-5237) Medication use (drugs affecting bone structure and mineralization) rs62121718 -6.00075379487898 1.79908747550451 0.0008516359928664
Coffee (ukb-b-5237) Medication use (drugs affecting bone structure and mineralization) rs6691876 -2.97954916037833 1.39700473453636 0.0329401104302035
Coffee (ukb-b-5237) Medication use (drugs affecting bone structure and mineralization) rs7224815 -3.99624316310934 1.37198209977717 0.0035825937165183
Coffee (ukb-b-5237) Medication use (drugs affecting bone structure and mineralization) rs73123665 -4.4691166311053 2.0970000061137 0.0330730531563771
Coffee (ukb-b-5237) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted -0.485626893392413 0.131773480091868 0.0002284191995724
Coffee (ukb-b-5237) Medication use (drugs affecting bone structure and mineralization) All - MR Egger -0.811816447820676 0.296307478037333 0.0071378707262003
Other meat (ukb-b-770) Medication use (drugs affecting bone structure and mineralization) rs74883734 5.45087564510086 2.59853273546937 0.0359339161630593
Other meat (ukb-b-770) Medication use (drugs affecting bone structure and mineralization) All - Inverse variance weighted 1.0512452393903 0.477321981375605 0.0276383511440434
Onion (ukb-b-8124) Medication use (drugs affecting bone structure and mineralization) rs11961853 -1.05980228799538 0.47102323910906 0.0244489453100894
Onion (ukb-b-8124) Medication use (drugs affecting bone structure and mineralization) rs1467978 -1.05154332570935 0.467352589204155 0.0244489453100894