ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Osteoporosis (ebi-a-GCST90038656)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Salted peanuts (ukb-b-1099) (👉 📊) Osteoporosis Weighted median 11 -0.025998181 0.009190859 0.004673752
Salted peanuts (ukb-b-1099) (👉 📊) Osteoporosis Inverse variance weighted 11 -0.020998628 0.007038521 0.002850778
Other fish (ukb-b-1252) (👉 📊) Osteoporosis Inverse variance weighted 22 -0.017791656 0.008963249 0.047149357
Double crust pastry (ukb-b-1255) (👉 📊) Osteoporosis Weighted median 11 -0.018914381 0.009583107 0.048413452
Vegetable pieces (ukb-b-12566) (👉 📊) Osteoporosis Inverse variance weighted 14 -0.005605608 0.002822205 0.047005475
Homemade soup (ukb-b-12658) (👉 📊) Osteoporosis Inverse variance weighted 16 0.011567437 0.004457745 0.009461636
Herbal tea (ukb-b-13344) (👉 📊) Osteoporosis Inverse variance weighted 91 -8.79e-05 4.45e-05 0.048186882
Sweetcorn (ukb-b-13567) (👉 📊) Osteoporosis Weighted median 18 0.011697202 0.00546924 0.032457915
Lamb/mutton (ukb-b-14179) (👉 📊) Osteoporosis Inverse variance weighted 128 -0.008227476 0.003337499 0.013695131
Cereal (ukb-b-15926) (👉 📊) Osteoporosis Inverse variance weighted 175 -0.004656446 0.002111771 0.027454398
Salted nuts (ukb-b-15960) (👉 📊) Osteoporosis MR Egger 20 0.040383817 0.014176309 0.010661905
Carrot (ukb-b-16710) (👉 📊) Osteoporosis Inverse variance weighted 5 0.007332343 0.003336975 0.027998871
Fruit smoothie (ukb-b-1780) (👉 📊) Osteoporosis MR Egger 21 -0.045583675 0.011466421 0.00081047
Boiled/baked potatoes (ukb-b-18007) (👉 📊) Osteoporosis Inverse variance weighted 8 0.007492123 0.002838634 0.00830675
Cheesecake (ukb-b-1814) (👉 📊) Osteoporosis MR Egger 21 -0.035240047 0.015196281 0.031692926
Other fruit (ukb-b-18659) (👉 📊) Osteoporosis Inverse variance weighted 15 -0.019031004 0.008109161 0.01893275
Oily fish (ukb-b-2209) (👉 📊) Osteoporosis MR Egger 171 -0.015525316 0.007262297 0.033970643
Oily fish (ukb-b-2209) (👉 📊) Osteoporosis Weighted mode 171 -0.015526461 0.007398975 0.037342298
White pasta (ukb-b-2512) (👉 📊) Osteoporosis Inverse variance weighted 7 -0.011968471 0.005816505 0.039621436
Standard tea (ukb-b-3291) (👉 📊) Osteoporosis MR Egger 15 -8.02e-05 3.31e-05 0.030696353
Sliced bread (ukb-b-4566) (👉 📊) Osteoporosis MR Egger 14 0.009874217 0.004124921 0.033899958
Coffee (ukb-b-5237) (👉 📊) Osteoporosis Inverse variance weighted 116 -0.006627206 0.002684781 0.013570534
Yorkshire pudding (ukb-b-5605) (👉 📊) Osteoporosis Weighted median 17 -0.021091087 0.007960855 0.008064686
Yorkshire pudding (ukb-b-5605) (👉 📊) Osteoporosis Inverse variance weighted 17 -0.017266886 0.005488066 0.001653725
Yorkshire pudding (ukb-b-5605) (👉 📊) Osteoporosis Simple mode 17 -0.034130124 0.014519395 0.031894226
Cauliflower (ukb-b-905) (👉 📊) Osteoporosis Inverse variance weighted 13 -0.007274075 0.003562404 0.041161402
Fortified wine (ukb-b-9524) (👉 📊) Osteoporosis Inverse variance weighted 17 0.018038044 0.008202102 0.027863863

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Salted peanuts (ukb-b-1099) Osteoporosis rs9421416 -0.0486919512901407 0.0236528584274458 0.0395318555926436
Salted peanuts (ukb-b-1099) Osteoporosis All - Inverse variance weighted -0.0209986277493053 0.0070385209151476 0.0028507781738571
Other fish (ukb-b-1252) Osteoporosis rs61993987 -0.0851498555329487 0.0430653492758066 0.048016280818504
Other fish (ukb-b-1252) Osteoporosis All - Inverse variance weighted -0.0177916556359758 0.0089632489599244 0.0471493567154899
Vegetable pieces (ukb-b-12566) Osteoporosis rs148090673 -0.0266387792472024 0.0103392878942014 0.0099817263571494
Vegetable pieces (ukb-b-12566) Osteoporosis rs72883121 -0.0222132009955142 0.0102289682717098 0.0298860426296552
Vegetable pieces (ukb-b-12566) Osteoporosis All - Inverse variance weighted -0.0056056077839962 0.0028222053308389 0.0470054753116304
Homemade soup (ukb-b-12658) Osteoporosis rs10110298 0.0420657242371114 0.0185990942217246 0.0237154366996067
Homemade soup (ukb-b-12658) Osteoporosis All - Inverse variance weighted 0.0115674365332721 0.0044577451396553 0.0094616364376131
Herbal tea (ukb-b-13344) Osteoporosis rs112849992 -0.0010079452994804 0.000470357808058 0.0321184734369339
Herbal tea (ukb-b-13344) Osteoporosis rs115494331 0.0009561588398954 0.0004679374631144 0.0410180517605134
Herbal tea (ukb-b-13344) Osteoporosis rs76631426 -0.0008952496429357 0.0004126251882408 0.0300338476306414
Herbal tea (ukb-b-13344) Osteoporosis All - Inverse variance weighted -8.78832548549932e-05 4.44817105974303e-05 0.0481868816322109
Sweetcorn (ukb-b-13567) Osteoporosis rs866596 -0.0420906011022868 0.0172631249462973 0.0147614331694534
Lamb/mutton (ukb-b-14179) Osteoporosis rs115145470 0.0758863880158835 0.0359077008487495 0.0345688013304314
Lamb/mutton (ukb-b-14179) Osteoporosis rs12494242 -0.0714952168405179 0.0356992297643419 0.0452083875121402
Lamb/mutton (ukb-b-14179) Osteoporosis rs141934869 -0.0912059553349876 0.036816448068061 0.0132374850387931
Lamb/mutton (ukb-b-14179) Osteoporosis rs2696532 -0.0927491772449459 0.0338715433602599 0.0061764752900795
Lamb/mutton (ukb-b-14179) Osteoporosis rs3964074 -0.0629245116151095 0.0314243003419677 0.0452400438887446
Lamb/mutton (ukb-b-14179) Osteoporosis rs41282441 0.117666142429248 0.0369819730821209 0.0014640521009979
Lamb/mutton (ukb-b-14179) Osteoporosis rs4315028 -0.121606147207635 0.0370116402792487 0.001017585616135
Lamb/mutton (ukb-b-14179) Osteoporosis rs4486004 -0.0778559439320503 0.0352937251432588 0.0273879949110118
Lamb/mutton (ukb-b-14179) Osteoporosis rs62398404 -0.0653212905823416 0.0294380995888534 0.026491005798595
Lamb/mutton (ukb-b-14179) Osteoporosis rs6829572 -0.0647236043328175 0.0305955243423402 0.0343907706600849
Lamb/mutton (ukb-b-14179) Osteoporosis rs77431173 -0.082423706894568 0.0339431259118125 0.0151702647411692
Lamb/mutton (ukb-b-14179) Osteoporosis rs77691530 -0.101082124360665 0.0380750152796989 0.0079351897324339
Lamb/mutton (ukb-b-14179) Osteoporosis rs942038 -0.101495551994412 0.0355035337503981 0.004253204395045
Lamb/mutton (ukb-b-14179) Osteoporosis All - Inverse variance weighted -0.0082274759313873 0.0033374990475205 0.0136951305053025
Cereal (ukb-b-15926) Osteoporosis rs10857964 -0.0559853335794301 0.0223160308378175 0.0121159334404355
Cereal (ukb-b-15926) Osteoporosis rs2472297 0.040295297694899 0.0185211774057205 0.0295826614804904
Cereal (ukb-b-15926) Osteoporosis rs3021529 -0.0640667155791966 0.029625318904137 0.0305745544289788
Cereal (ukb-b-15926) Osteoporosis rs396370 0.0654133391543029 0.0306969837005111 0.0330943305397035
Cereal (ukb-b-15926) Osteoporosis rs4988235 -0.0575715789473684 0.0266491228070175 0.030745159786415
Cereal (ukb-b-15926) Osteoporosis rs6545770 -0.0448172348484848 0.0214961392773893 0.0370786571512741
Cereal (ukb-b-15926) Osteoporosis rs68136852 -0.0538071971789098 0.024949582926173 0.0310339482993975
Cereal (ukb-b-15926) Osteoporosis rs8178823 0.104474370418269 0.030855373672484 0.0007093550703901
Cereal (ukb-b-15926) Osteoporosis rs9374896 -0.0374425013550909 0.0146370353464753 0.0105256136115821
Cereal (ukb-b-15926) Osteoporosis rs9846396 -0.0444698932098869 0.021483279576182 0.0384545044389756
Cereal (ukb-b-15926) Osteoporosis All - Inverse variance weighted -0.0046564455002775 0.0021117708067855 0.0274543978716791
Salted nuts (ukb-b-15960) Osteoporosis rs150856188 0.0650779008829105 0.032695563146851 0.0465446950025486
Salted nuts (ukb-b-15960) Osteoporosis rs9613266 -0.0737129041616969 0.0326725766416299 0.024063786569674
Salted nuts (ukb-b-15960) Osteoporosis All - MR Egger 0.0403838167657027 0.0141763094376925 0.0106619046998519
Carrot (ukb-b-16710) Osteoporosis All - Inverse variance weighted 0.00733234328366 0.0033369753692031 0.0279988714263902
Fruit smoothie (ukb-b-1780) Osteoporosis rs1379657 0.0641079452763511 0.0299072293127835 0.0320681457999938
Fruit smoothie (ukb-b-1780) Osteoporosis rs149304310 -0.0595641237258224 0.0270246362941956 0.0275195943213644
Fruit smoothie (ukb-b-1780) Osteoporosis rs183426795 -0.0670824467556227 0.030323194861495 0.0269494893420174
Fruit smoothie (ukb-b-1780) Osteoporosis rs3111807 0.060189221672035 0.0286125667035239 0.0354138838006482
Fruit smoothie (ukb-b-1780) Osteoporosis rs67791558 0.058862660944206 0.0275703385789223 0.0327610454426515
Fruit smoothie (ukb-b-1780) Osteoporosis All - MR Egger -0.0455836749347459 0.0114664210707757 0.0008104696775094
Boiled/baked potatoes (ukb-b-18007) Osteoporosis rs9962730 0.0235759261092462 0.0067781837489538 0.0005047799655386
Boiled/baked potatoes (ukb-b-18007) Osteoporosis All - Inverse variance weighted 0.0074921229488439 0.0028386344948442 0.0083067504859441
Cheesecake (ukb-b-1814) Osteoporosis rs28381866 -0.071366496021711 0.0319987047431074 0.0257279792979442
Cheesecake (ukb-b-1814) Osteoporosis rs73084384 -0.0827421907008943 0.0332543337901414 0.0128404999453426
Cheesecake (ukb-b-1814) Osteoporosis All - MR Egger -0.0352400474367274 0.0151962808383858 0.031692926482204
Other fruit (ukb-b-18659) Osteoporosis rs118011111 -0.0516205578858527 0.0232711857937171 0.0265399876060039
Other fruit (ukb-b-18659) Osteoporosis rs28541551 -0.0606390600372546 0.0231596621365929 0.0088367772005778
Other fruit (ukb-b-18659) Osteoporosis rs2980435 -0.0686995317907308 0.0229427065662392 0.0027498945222457
Other fruit (ukb-b-18659) Osteoporosis rs75464830 0.0638694352670559 0.0238771638084494 0.0074747716918777
Other fruit (ukb-b-18659) Osteoporosis All - Inverse variance weighted -0.0190310044247823 0.0081091609720654 0.0189327497786418
Oily fish (ukb-b-2209) Osteoporosis rs10864473 -0.0674769982794596 0.0290980942115573 0.020397798438946
Oily fish (ukb-b-2209) Osteoporosis rs1260326 0.0906298804934299 0.0278774854414212 0.0011499731380554
Oily fish (ukb-b-2209) Osteoporosis rs12906493 -0.0725288294909134 0.0285180144623788 0.0109822328011869
Oily fish (ukb-b-2209) Osteoporosis rs16891727 -0.0412269103144118 0.0159060264026681 0.0095446107465056
Oily fish (ukb-b-2209) Osteoporosis rs4970581 -0.0556583456637875 0.0260106362111993 0.0323684892253905
Oily fish (ukb-b-2209) Osteoporosis rs61882686 -0.0676491579730612 0.0232491053305595 0.0036171429590681
Oily fish (ukb-b-2209) Osteoporosis rs7404229 0.0824763819788599 0.0281493837816636 0.003390128681782
Oily fish (ukb-b-2209) Osteoporosis rs9606833 0.046174524302939 0.0175940208176338 0.0086790535468083
Oily fish (ukb-b-2209) Osteoporosis rs9958909 0.0458368069434135 0.0233623276677008 0.0497628826326867
Oily fish (ukb-b-2209) Osteoporosis All - MR Egger -0.0155253155062119 0.0072622968115969 0.0339706432947601
White pasta (ukb-b-2512) Osteoporosis rs6736155 -0.03009045389585 0.0143613380532688 0.0361496386816617
White pasta (ukb-b-2512) Osteoporosis All - Inverse variance weighted -0.0119684709832139 0.0058165048741206 0.0396214356318986
Standard tea (ukb-b-3291) Osteoporosis rs2472297 -6.25768307616948e-05 2.87625765368602e-05 0.0295826614804904
Standard tea (ukb-b-3291) Osteoporosis All - MR Egger -8.0228066573077e-05 3.31026437275174e-05 0.0306963525998412
Sliced bread (ukb-b-4566) Osteoporosis rs7965336 -0.0102206409389005 0.0047140459937969 0.0301491777007969
Sliced bread (ukb-b-4566) Osteoporosis All - MR Egger 0.0098742167110062 0.0041249207152538 0.0338999577083423
Coffee (ukb-b-5237) Osteoporosis rs10938398 -0.0741442652508467 0.0341583862204866 0.0299612623576507
Coffee (ukb-b-5237) Osteoporosis rs11206378 0.101390298637155 0.033447512448462 0.0024348258238287
Coffee (ukb-b-5237) Osteoporosis rs11678584 -0.0714822636817903 0.0294021215043394 0.0150491510226266
Coffee (ukb-b-5237) Osteoporosis rs13378244 -0.0816932771298721 0.0326459562150365 0.0123354080487534
Coffee (ukb-b-5237) Osteoporosis rs1338549 -0.0693703769147019 0.027036114952477 0.0102925945113567
Coffee (ukb-b-5237) Osteoporosis rs13387939 -0.0458931009072349 0.0203585450416168 0.0241809058442859
Coffee (ukb-b-5237) Osteoporosis rs1527961 -0.0685629276554924 0.0275757507625664 0.0129061494187538
Coffee (ukb-b-5237) Osteoporosis rs2472297 -0.0137452550849135 0.0063178167795691 0.0295826614804904
Coffee (ukb-b-5237) Osteoporosis rs56349356 -0.0971948005869113 0.0348182533845341 0.0052466004678397
Coffee (ukb-b-5237) Osteoporosis rs73123665 -0.105528621298917 0.0337797355212237 0.0017839739809915
Coffee (ukb-b-5237) Osteoporosis rs780093 -0.0671748598939331 0.0197026366269229 0.0006509757669024
Coffee (ukb-b-5237) Osteoporosis All - Inverse variance weighted -0.006627206068674 0.0026847805950272 0.0135705340731182
Yorkshire pudding (ukb-b-5605) Osteoporosis rs13058042 -0.0464900929222576 0.0221756613469832 0.0360425799143015
Yorkshire pudding (ukb-b-5605) Osteoporosis All - Inverse variance weighted -0.0172668860597687 0.0054880657147047 0.001653724673452
Cauliflower (ukb-b-905) Osteoporosis rs881150 -0.0249740519777705 0.0118487250735534 0.0350533378335431
Cauliflower (ukb-b-905) Osteoporosis All - Inverse variance weighted -0.0072740751711079 0.0035624043254954 0.0411614022440472
Fortified wine (ukb-b-9524) Osteoporosis All - Inverse variance weighted 0.0180380436216768 0.008202101621916 0.027863862622264