ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Osteoarthritis (ebi-a-GCST90038686)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Beef (ukb-b-10829) (👉 📊) Osteoarthritis Weighted median 7 0.033613379 0.01464692 0.021738227
Beef (ukb-b-10829) (👉 📊) Osteoarthritis Inverse variance weighted 7 0.02656402 0.013547572 0.049902874
Chocolate bar (ukb-b-117) (👉 📊) Osteoarthritis MR Egger 11 -0.038722967 0.015280153 0.032013978
Other alcohol (ukb-b-12901) (👉 📊) Osteoarthritis Inverse variance weighted 41 -0.02592064 0.012787936 0.042666462
Cheese (ukb-b-1489) (👉 📊) Osteoarthritis Weighted median 202 -0.012971738 0.004932966 0.008548492
Cheese (ukb-b-1489) (👉 📊) Osteoarthritis Inverse variance weighted 202 -0.014047507 0.004020095 0.000475267
Water (ukb-b-14898) (👉 📊) Osteoarthritis MR Egger 160 -0.041386122 0.01629323 0.012047658
Cereal (ukb-b-15926) (👉 📊) Osteoarthritis MR Egger 175 -0.034385425 0.016939548 0.043899542
Cereal (ukb-b-15926) (👉 📊) Osteoarthritis Weighted median 175 -0.013574402 0.00649333 0.036571576
Cereal (ukb-b-15926) (👉 📊) Osteoarthritis Inverse variance weighted 175 -0.02068466 0.004756538 1.37e-05
Pea (ukb-b-15945) (👉 📊) Osteoarthritis Inverse variance weighted 11 -0.017657051 0.006746699 0.008867017
Rose wine (ukb-b-16124) (👉 📊) Osteoarthritis Weighted median 13 -0.034489206 0.016625913 0.038039879
Powdered/instant soup (ukb-b-19931) (👉 📊) Osteoarthritis Weighted median 16 0.054839961 0.024109012 0.022925947
Salad / raw vegetable (ukb-b-1996) (👉 📊) Osteoarthritis Weighted median 108 -0.022903099 0.010866134 0.035052581
Salad / raw vegetable (ukb-b-1996) (👉 📊) Osteoarthritis Inverse variance weighted 108 -0.018587802 0.008207366 0.023526754
Oily fish (ukb-b-2209) (👉 📊) Osteoarthritis Inverse variance weighted 171 -0.013838101 0.004799532 0.00393634
Green bean (ukb-b-2299) (👉 📊) Osteoarthritis Weighted median 14 0.020264863 0.009139992 0.026611873
Drinking water (ukb-b-3975) (👉 📊) Osteoarthritis Inverse variance weighted 23 -0.005259288 0.002019001 0.009190209
Oat crunch (ukb-b-5186) (👉 📊) Osteoarthritis Weighted median 12 -0.053115247 0.023397822 0.023201901
Oat crunch (ukb-b-5186) (👉 📊) Osteoarthritis Inverse variance weighted 12 -0.042642444 0.01861029 0.021943937
Sushi (ukb-b-5213) (👉 📊) Osteoarthritis Inverse variance weighted 47 0.045677361 0.021987284 0.037760559
Coffee (ukb-b-5237) (👉 📊) Osteoarthritis Inverse variance weighted 116 0.011832123 0.005931789 0.046075905
Coffee (ukb-b-5237) (👉 📊) Osteoarthritis Weighted mode 116 0.031612828 0.011375777 0.006371471
Tofu (ukb-b-5522) (👉 📊) Osteoarthritis Inverse variance weighted 35 -0.044526362 0.021818346 0.041273072
Tea (ukb-b-6066) (👉 📊) Osteoarthritis MR Egger 139 0.036584783 0.011516015 0.00183993
Tea (ukb-b-6066) (👉 📊) Osteoarthritis Weighted median 139 0.017568767 0.007249696 0.015376843
Tea (ukb-b-6066) (👉 📊) Osteoarthritis Inverse variance weighted 139 0.014720298 0.004420371 0.000868133
Tea (ukb-b-6066) (👉 📊) Osteoarthritis Weighted mode 139 0.022173647 0.010031509 0.02872447
Watercress (ukb-b-6181) (👉 📊) Osteoarthritis Inverse variance weighted 12 -0.026760476 0.012885983 0.037828141
Poultry (ukb-b-8006) (👉 📊) Osteoarthritis Inverse variance weighted 82 0.016915071 0.008437846 0.044998658
Other milk-based pudding (ukb-b-9857) (👉 📊) Osteoarthritis Inverse variance weighted 21 -0.03836504 0.019450633 0.048560376

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Beef (ukb-b-10829) Osteoarthritis rs2602248 0.0754261201143947 0.0276712106768351 0.006414631684179
Beef (ukb-b-10829) Osteoarthritis All - Inverse variance weighted 0.0265640195944607 0.0135475721675953 0.0499028741473517
Chocolate bar (ukb-b-117) Osteoarthritis rs4656997 0.0519838879190175 0.0250594308882312 0.038039938971595
Chocolate bar (ukb-b-117) Osteoarthritis rs79174915 -0.0423041184807494 0.0199760153635853 0.0341966194038111
Chocolate bar (ukb-b-117) Osteoarthritis All - MR Egger -0.0387229671229892 0.0152801525171775 0.0320139777991857
Other alcohol (ukb-b-12901) Osteoarthritis rs115331905 -0.148737463482215 0.0677035207661958 0.028028012265429
Other alcohol (ukb-b-12901) Osteoarthritis rs1321865 -0.194275888295498 0.0777872389676097 0.0125062221127022
Other alcohol (ukb-b-12901) Osteoarthritis rs358054 -0.234270696751036 0.077860655481258 0.0026224228372369
Other alcohol (ukb-b-12901) Osteoarthritis All - Inverse variance weighted -0.0259206398648789 0.0127879359492879 0.0426664618779351
Cheese (ukb-b-1489) Osteoarthritis rs12447542 0.149504749944297 0.042839281735502 0.0004832038295074
Cheese (ukb-b-1489) Osteoarthritis rs13107325 -0.266533968364999 0.0362907567232092 2.06678417655021e-13
Cheese (ukb-b-1489) Osteoarthritis rs150830434 -0.155459570206487 0.0485115475471496 0.0013525548060672
Cheese (ukb-b-1489) Osteoarthritis rs2352974 -0.0988170129404299 0.0378375134508733 0.0090115706981008
Cheese (ukb-b-1489) Osteoarthritis rs2372904 -0.12554745807358 0.0485623847572219 0.009729938719727
Cheese (ukb-b-1489) Osteoarthritis rs2802530 -0.0959251822662214 0.0449641909956729 0.0328945207084998
Cheese (ukb-b-1489) Osteoarthritis rs2960578 -0.0761601343653469 0.0321344593086762 0.0177858908035973
Cheese (ukb-b-1489) Osteoarthritis rs531358 -0.0883181686995883 0.0434725745446812 0.0421958302028141
Cheese (ukb-b-1489) Osteoarthritis rs61734410 -0.158525279212201 0.0384998799087306 3.82917211240601e-05
Cheese (ukb-b-1489) Osteoarthritis rs62048491 -0.118516228493227 0.0482275204247356 0.0139931258323408
Cheese (ukb-b-1489) Osteoarthritis rs6539284 0.120465046828208 0.046240553477067 0.009182553107565
Cheese (ukb-b-1489) Osteoarthritis rs660240 0.103105213211158 0.0514630750322811 0.0451258512813844
Cheese (ukb-b-1489) Osteoarthritis rs683996 -0.10000579958098 0.047203514546074 0.0341235086746287
Cheese (ukb-b-1489) Osteoarthritis rs7299943 -0.146255476357244 0.0468210347053411 0.0017858453487965
Cheese (ukb-b-1489) Osteoarthritis rs7925389 0.0971441117634622 0.0473261827703417 0.0401064880079
Cheese (ukb-b-1489) Osteoarthritis rs79398870 0.124207500494227 0.0506183446337645 0.0141353972703409
Cheese (ukb-b-1489) Osteoarthritis rs9504123 -0.107221994834375 0.0430477185158003 0.0127466363462461
Cheese (ukb-b-1489) Osteoarthritis rs992903 0.108937829906525 0.052949493244827 0.0396485955930855
Cheese (ukb-b-1489) Osteoarthritis All - Inverse variance weighted -0.0140475074450715 0.0040200951920815 0.0004752672515084
Water (ukb-b-14898) Osteoarthritis rs10140117 0.140429825215113 0.0633019381689148 0.0265267042093366
Water (ukb-b-14898) Osteoarthritis rs1055253 0.136063977309955 0.0622033038787591 0.0287127846038046
Water (ukb-b-14898) Osteoarthritis rs10822004 0.185247527351199 0.064976086601764 0.0043580483494116
Water (ukb-b-14898) Osteoarthritis rs11167599 -0.146215318289329 0.0601082245123968 0.0149935710216883
Water (ukb-b-14898) Osteoarthritis rs146394874 0.141449167811062 0.049181199530256 0.0040264496391372
Water (ukb-b-14898) Osteoarthritis rs2229357 -0.120526643507898 0.0528903126433768 0.0226787330900205
Water (ukb-b-14898) Osteoarthritis rs2472297 -0.0778992001484199 0.0189231178950707 3.84476720355261e-05
Water (ukb-b-14898) Osteoarthritis rs2516491 -0.143799214827067 0.0661220845791475 0.0296486160983258
Water (ukb-b-14898) Osteoarthritis rs2826576 0.186521283233668 0.0639873181045696 0.003557196966519
Water (ukb-b-14898) Osteoarthritis rs3746410 -0.0947829753371617 0.0399194731309868 0.017579669606388
Water (ukb-b-14898) Osteoarthritis rs3808058 0.154986716998424 0.0463437106214917 0.0008249404054852
Water (ukb-b-14898) Osteoarthritis rs4803217 -0.174385190280847 0.0656313152680723 0.0078829517764476
Water (ukb-b-14898) Osteoarthritis rs58959216 -0.140084692100681 0.0573479499762546 0.0145772477809223
Water (ukb-b-14898) Osteoarthritis rs6503416 0.265810356167754 0.0649120109022254 4.22289911770681e-05
Water (ukb-b-14898) Osteoarthritis rs7513076 0.143353556332333 0.0603092480814936 0.0174552857375235
Water (ukb-b-14898) Osteoarthritis rs8024871 0.196532814028577 0.0650945909326818 0.0025345311981308
Water (ukb-b-14898) Osteoarthritis All - MR Egger -0.041386122427416 0.0162932298581907 0.0120476576375406
Cereal (ukb-b-15926) Osteoarthritis rs10124390 -0.132620068938639 0.0663456086524184 0.0456161868877935
Cereal (ukb-b-15926) Osteoarthritis rs10260232 -0.131059587708331 0.0652192355777817 0.0444816431509764
Cereal (ukb-b-15926) Osteoarthritis rs11670024 0.202748666575065 0.0544507663289906 0.0001964621573727
Cereal (ukb-b-15926) Osteoarthritis rs117477397 -0.124766743566834 0.0604030813408189 0.0388691764796564
Cereal (ukb-b-15926) Osteoarthritis rs17599026 0.176972940050465 0.0666503523884103 0.0079251090241722
Cereal (ukb-b-15926) Osteoarthritis rs2236950 0.159883180077999 0.0645553508175606 0.0132609392660487
Cereal (ukb-b-15926) Osteoarthritis rs2472297 -0.164226775508144 0.0398936398390088 3.84476720355263e-05
Cereal (ukb-b-15926) Osteoarthritis rs2494936 -0.146564370780067 0.0562825407528224 0.0092120620634213
Cereal (ukb-b-15926) Osteoarthritis rs2880666 0.159111880046136 0.0627559360458179 0.0112316540060396
Cereal (ukb-b-15926) Osteoarthritis rs34234069 -0.140586599461198 0.0586442165638307 0.0165173026181512
Cereal (ukb-b-15926) Osteoarthritis rs3766823 -0.203698839630548 0.0617942093849092 0.0009793017098448
Cereal (ukb-b-15926) Osteoarthritis rs6510177 -0.119262163032972 0.0543885879988339 0.0283232931704197
Cereal (ukb-b-15926) Osteoarthritis rs6918737 -0.130399417440379 0.046860149280903 0.0053902671540018
Cereal (ukb-b-15926) Osteoarthritis rs79598313 -0.141925574590099 0.0637709197948846 0.0260441239495991
Cereal (ukb-b-15926) Osteoarthritis rs834233 -0.208209217992407 0.0576678997255972 0.0003056222994662
Cereal (ukb-b-15926) Osteoarthritis rs9866512 0.136339710273139 0.0651040583877032 0.0362438211102286
Cereal (ukb-b-15926) Osteoarthritis All - Inverse variance weighted -0.0206846597485339 0.0047565375807027 1.36959395022231e-05
Cereal (ukb-b-15926) Osteoarthritis All - MR Egger -0.0343854246072838 0.0169395478600025 0.0438995423871843
Pea (ukb-b-15945) Osteoarthritis rs61995486 -0.0456292654793129 0.0232053334798072 0.0492608911127873
Pea (ukb-b-15945) Osteoarthritis All - Inverse variance weighted -0.0176570505772556 0.0067466990172834 0.0088670168978647
Rose wine (ukb-b-16124) Osteoarthritis rs591596 0.0846470680392781 0.0431696408265992 0.0499022599197413
Powdered/instant soup (ukb-b-19931) Osteoarthritis rs117037603 0.147383829527694 0.0688952845652423 0.0324159060721091
Powdered/instant soup (ukb-b-19931) Osteoarthritis rs189989746 0.224231539212638 0.0701998134419952 0.0014022381538585
Salad / raw vegetable (ukb-b-1996) Osteoarthritis rs10819082 -0.179272757031016 0.0635504514580321 0.0047881404524248
Salad / raw vegetable (ukb-b-1996) Osteoarthritis rs2395441 -0.203112109616397 0.0834595163946653 0.0149470164320299
Salad / raw vegetable (ukb-b-1996) Osteoarthritis rs2776307 0.1970719571765 0.0805856085647 0.0144652188151163
Salad / raw vegetable (ukb-b-1996) Osteoarthritis rs3095337 -0.110687065236337 0.0535095628198831 0.0385885814209134
Salad / raw vegetable (ukb-b-1996) Osteoarthritis rs62258905 -0.230298863056832 0.0820208968175233 0.0049880082802009
Salad / raw vegetable (ukb-b-1996) Osteoarthritis rs6824864 0.209242393779174 0.0838003390806784 0.0125278686571753
Salad / raw vegetable (ukb-b-1996) Osteoarthritis rs7458242 -0.252360759618667 0.079455113827125 0.001492476460529
Salad / raw vegetable (ukb-b-1996) Osteoarthritis rs9531213 -0.19539269086268 0.073681173488648 0.0080048007371645
Salad / raw vegetable (ukb-b-1996) Osteoarthritis All - Inverse variance weighted -0.0185878024676821 0.008207366197933 0.0235267544919237
Oily fish (ukb-b-2209) Osteoarthritis rs10819087 -0.156567563787488 0.0591757078063498 0.0081496047451889
Oily fish (ukb-b-2209) Osteoarthritis rs10828250 -0.0625676306201666 0.0296987024848358 0.035139579311202
Oily fish (ukb-b-2209) Osteoarthritis rs11607886 -0.103002820568453 0.048126274679974 0.0323336265285806
Oily fish (ukb-b-2209) Osteoarthritis rs116900901 0.17167302065786 0.0613179852429786 0.0051147387146066
Oily fish (ukb-b-2209) Osteoarthritis rs13058717 -0.12626054407078 0.0604427473589379 0.0367142098053306
Oily fish (ukb-b-2209) Osteoarthritis rs17050031 0.173994954021844 0.0455123991634299 0.0001318254162087
Oily fish (ukb-b-2209) Osteoarthritis rs1821849 -0.184618171492358 0.060825540748284 0.0024036980538208
Oily fish (ukb-b-2209) Osteoarthritis rs28623270 -0.118640931317572 0.0438396662330088 0.0068048570129407
Oily fish (ukb-b-2209) Osteoarthritis rs4419275 -0.164685218349635 0.055089544014327 0.0027951703639427
Oily fish (ukb-b-2209) Osteoarthritis rs4579097 0.133693571072093 0.0596559139784946 0.0250210070386225
Oily fish (ukb-b-2209) Osteoarthritis rs573057 -0.156705160259894 0.0562318646675642 0.0053236579572799
Oily fish (ukb-b-2209) Osteoarthritis rs6033437 -0.123315929196442 0.0505995203836931 0.0148057153746433
Oily fish (ukb-b-2209) Osteoarthritis rs61882686 -0.146912567891111 0.0500742562981185 0.0033473833721024
Oily fish (ukb-b-2209) Osteoarthritis rs631490 -0.145819627736166 0.039875361629612 0.0002552984494161
Oily fish (ukb-b-2209) Osteoarthritis rs6465487 -0.139949002307038 0.0451982838871575 0.0019592925088322
Oily fish (ukb-b-2209) Osteoarthritis rs6903171 -0.225529592814183 0.0615743314332375 0.0002495503572209
Oily fish (ukb-b-2209) Osteoarthritis rs7243428 -0.112523115330087 0.0507033994945448 0.0264702629387989
Oily fish (ukb-b-2209) Osteoarthritis All - Inverse variance weighted -0.0138381007028763 0.0047995319774349 0.0039363395293803
Green bean (ukb-b-2299) Osteoarthritis rs117462537 -0.0544747370898416 0.024388754895004 0.0255093657044128
Green bean (ukb-b-2299) Osteoarthritis rs7047957 0.0595304349382175 0.0250919356137541 0.0176685106232341
Drinking water (ukb-b-3975) Osteoarthritis rs2472297 -0.0264676577461381 0.0064294704821396 3.84476720355261e-05
Drinking water (ukb-b-3975) Osteoarthritis All - Inverse variance weighted -0.0052592879094 0.0020190009174781 0.0091902085228418
Oat crunch (ukb-b-5186) Osteoarthritis All - Inverse variance weighted -0.042642444280872 0.018610290224298 0.0219439373318501
Sushi (ukb-b-5213) Osteoarthritis rs189242249 0.298303256178894 0.151388779913692 0.0487873987844722
Sushi (ukb-b-5213) Osteoarthritis All - Inverse variance weighted 0.0456773608621629 0.0219872840417044 0.0377605586786186
Coffee (ukb-b-5237) Osteoarthritis rs117968677 -0.130760331164458 0.0611858239955656 0.0325897171526457
Coffee (ukb-b-5237) Osteoarthritis rs13054099 -0.131662599627008 0.0579992020560973 0.0232029690646981
Coffee (ukb-b-5237) Osteoarthritis rs2231142 0.195405216173639 0.0687254745954203 0.0044652947787889
Coffee (ukb-b-5237) Osteoarthritis rs2472297 0.0560199092763628 0.0136082443168613 3.84476720355263e-05
Coffee (ukb-b-5237) Osteoarthritis rs35303290 0.184075118098394 0.0666244710354147 0.0057294617802316
Coffee (ukb-b-5237) Osteoarthritis rs442355 0.146162410659771 0.0560751355816543 0.0091460584171463
Coffee (ukb-b-5237) Osteoarthritis rs763030 -0.176455460856118 0.0670900339701653 0.0085352410504118
Coffee (ukb-b-5237) Osteoarthritis rs7743687 -0.150709629698118 0.0689139162811208 0.0287479324519113
Coffee (ukb-b-5237) Osteoarthritis rs9296406 0.144122318891404 0.0709508104567748 0.0422246605336663
Coffee (ukb-b-5237) Osteoarthritis All - Inverse variance weighted 0.0118321226989908 0.0059317886167645 0.0460759047719993
Tofu (ukb-b-5522) Osteoarthritis All - Inverse variance weighted -0.0445263617393189 0.0218183456620806 0.0412730718411875
Tea (ukb-b-6066) Osteoarthritis rs1433071 0.123313340569978 0.0506444906444906 0.014896661430464
Tea (ukb-b-6066) Osteoarthritis rs1453548 0.0943431723807097 0.0434399688188646 0.0298703207181156
Tea (ukb-b-6066) Osteoarthritis rs1481012 0.0915236153714253 0.0331316325947377 0.0057373926126368
Tea (ukb-b-6066) Osteoarthritis rs16895478 -0.117321720057131 0.0507152876963885 0.0207039353201927
Tea (ukb-b-6066) Osteoarthritis rs2416721 0.125868815968981 0.0553868385151145 0.0230539040333106
Tea (ukb-b-6066) Osteoarthritis rs2472297 0.0488007378344484 0.0118545776291445 3.84476720355261e-05
Tea (ukb-b-6066) Osteoarthritis rs2645929 0.0993853525713752 0.0464100185528757 0.0322366931154932
Tea (ukb-b-6066) Osteoarthritis rs323065 0.125812091176449 0.0554588824440148 0.0232947793995702
Tea (ukb-b-6066) Osteoarthritis rs4135060 0.10830079873921 0.0525102976467639 0.0391632189075801
Tea (ukb-b-6066) Osteoarthritis rs56188862 0.0802339307473599 0.0356936053005686 0.0245856489990857
Tea (ukb-b-6066) Osteoarthritis rs56348300 0.0945631642572911 0.0442726540069511 0.0326853511928604
Tea (ukb-b-6066) Osteoarthritis rs57462170 0.0931197618861126 0.0459591133390773 0.0427500745416932
Tea (ukb-b-6066) Osteoarthritis rs6265 0.12631799252233 0.0497569402566813 0.0111264878181372
Tea (ukb-b-6066) Osteoarthritis rs9438548 0.133698481561822 0.0493555159590951 0.0067509468415024
Tea (ukb-b-6066) Osteoarthritis rs984616 -0.178911064718163 0.0541002087682672 0.000942904740854
Tea (ukb-b-6066) Osteoarthritis All - Inverse variance weighted 0.0147202981029875 0.004420370619267 0.0008681325422448
Tea (ukb-b-6066) Osteoarthritis All - MR Egger 0.0365847830076289 0.0115160154095778 0.00183993034266
Watercress (ukb-b-6181) Osteoarthritis All - Inverse variance weighted -0.0267604762494224 0.0128859828221144 0.0378281405648428
Poultry (ukb-b-8006) Osteoarthritis rs1062633 0.135621106552929 0.0595865077814677 0.0228437849953458
Poultry (ukb-b-8006) Osteoarthritis rs113631743 0.15950819971511 0.0616677928339238 0.0096935854490556
Poultry (ukb-b-8006) Osteoarthritis rs11698621 0.164785689535287 0.0641113981865412 0.0101609734655034
Poultry (ukb-b-8006) Osteoarthritis rs1367228 -0.137447943452974 0.0647550208109567 0.0337887626835482
Poultry (ukb-b-8006) Osteoarthritis rs146301131 0.162889164825595 0.0654606440792763 0.012833641886702
Poultry (ukb-b-8006) Osteoarthritis rs2565017 0.150425055928412 0.0520602657170251 0.0038592766375532
Poultry (ukb-b-8006) Osteoarthritis rs28418529 -0.152044468861219 0.0643706557382643 0.0181758957549459
Poultry (ukb-b-8006) Osteoarthritis rs4437085 -0.154439000534328 0.0593776433403671 0.0092962720819765
Poultry (ukb-b-8006) Osteoarthritis rs6803184 0.152591357883629 0.0647604228977773 0.018460787220013
Poultry (ukb-b-8006) Osteoarthritis rs76536752 0.187287289313523 0.0599110697272715 0.0017714840088794
Poultry (ukb-b-8006) Osteoarthritis All - Inverse variance weighted 0.0169150712246523 0.0084378458702548 0.0449986579448702
Other milk-based pudding (ukb-b-9857) Osteoarthritis rs111689342 -0.174468587623996 0.0770787408807012 0.02360419949163
Other milk-based pudding (ukb-b-9857) Osteoarthritis rs73223239 -0.253196181546196 0.0795027990685193 0.0014488136263342
Other milk-based pudding (ukb-b-9857) Osteoarthritis All - Inverse variance weighted -0.0383650400305435 0.0194506330525463 0.0485603764695449