ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Sciatica (ebi-a-GCST90038692)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Beetroot (ukb-b-11880) (👉 📊) Sciatica MR Egger 10 -0.020745581 0.008664759 0.043566051
Vegetable pieces (ukb-b-12566) (👉 📊) Sciatica Inverse variance weighted 14 -0.00479379 0.002143823 0.025345599
Cheese (ukb-b-1489) (👉 📊) Sciatica Inverse variance weighted 202 -0.002337919 0.001160233 0.043900232
Rose wine (ukb-b-16124) (👉 📊) Sciatica Inverse variance weighted 13 0.010284325 0.004930227 0.036980973
Low fat hard cheese (ukb-b-18079) (👉 📊) Sciatica Weighted median 16 -0.014069629 0.00582058 0.015639506
Low fat hard cheese (ukb-b-18079) (👉 📊) Sciatica Inverse variance weighted 16 -0.00879938 0.00434054 0.042636366
Bran cereal (ukb-b-19498) (👉 📊) Sciatica Inverse variance weighted 3 0.01925741 0.00825067 0.019593532
Melon (ukb-b-19862) (👉 📊) Sciatica MR Egger 14 -0.034324726 0.011008838 0.008889022
Milk-based pudding (ukb-b-20554) (👉 📊) Sciatica Weighted median 15 0.017282932 0.007567401 0.022379382
Milk-based pudding (ukb-b-20554) (👉 📊) Sciatica Inverse variance weighted 15 0.011758167 0.005529111 0.033453927
Oily fish (ukb-b-2209) (👉 📊) Sciatica MR Egger 171 0.011656053 0.005365761 0.031225957
Other vegetables (ukb-b-3055) (👉 📊) Sciatica MR Egger 12 0.020741972 0.009237708 0.048560658
Other vegetables (ukb-b-3055) (👉 📊) Sciatica Inverse variance weighted 12 0.009228633 0.003855343 0.016678224
Croissant (ukb-b-4007) (👉 📊) Sciatica Inverse variance weighted 22 -0.012344148 0.00509719 0.015445732
Beer/cider (ukb-b-4961) (👉 📊) Sciatica Inverse variance weighted 15 0.004122431 0.001720273 0.016557815
White fish (ukb-b-5427) (👉 📊) Sciatica Inverse variance weighted 5 0.019273977 0.007807042 0.013556925
Pork (ukb-b-5640) (👉 📊) Sciatica MR Egger 84 0.025001328 0.009683373 0.011604623
Other cereal (ukb-b-8917) (👉 📊) Sciatica Weighted median 13 -0.025284525 0.01065896 0.017685479
Other cereal (ukb-b-8917) (👉 📊) Sciatica Inverse variance weighted 13 -0.024015663 0.007898127 0.002360459

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Beetroot (ukb-b-11880) Sciatica rs2045966 -0.0260638715094533 0.0121914408071194 0.0325262572243137
Beetroot (ukb-b-11880) Sciatica All - MR Egger -0.0207455805128028 0.008664758646017 0.0435660513284455
Vegetable pieces (ukb-b-12566) Sciatica rs55998069 -0.0172914949097787 0.0080806750651899 0.0323662669813635
Vegetable pieces (ukb-b-12566) Sciatica All - Inverse variance weighted -0.0047937899520179 0.0021438228692586 0.0253455992174646
Cheese (ukb-b-1489) Sciatica rs11104660 -0.0433512187387869 0.0175185460250173 0.0133389209123257
Cheese (ukb-b-1489) Sciatica rs113367286 -0.0337153566934788 0.0147114896868845 0.021918895224986
Cheese (ukb-b-1489) Sciatica rs1514755 -0.0281802026271916 0.0142008806160648 0.047211461093272
Cheese (ukb-b-1489) Sciatica rs1647396 -0.0432736343022057 0.0165022469593898 0.008734174181422
Cheese (ukb-b-1489) Sciatica rs35270670 -0.0324030184255834 0.0147393066901107 0.0279200021679425
Cheese (ukb-b-1489) Sciatica rs3911016 0.0327971700542672 0.0143095335084491 0.0219067753381043
Cheese (ukb-b-1489) Sciatica rs4675530 -0.046659896206156 0.018076861130995 0.0098459065775783
Cheese (ukb-b-1489) Sciatica rs4721694 -0.0466342161993342 0.018797809212581 0.013107594762027
Cheese (ukb-b-1489) Sciatica rs66510028 -0.035428533920132 0.0176075867070091 0.0442075489156504
Cheese (ukb-b-1489) Sciatica rs72752436 -0.0399755537604694 0.0173784277879342 0.0214313719836786
Cheese (ukb-b-1489) Sciatica rs7730004 0.0419304630496617 0.0186522799144922 0.0245757188268794
Cheese (ukb-b-1489) Sciatica rs78370515 -0.0410209808614993 0.01694662488752 0.0154949654696152
Cheese (ukb-b-1489) Sciatica All - Inverse variance weighted -0.002337918729635 0.0011602331621465 0.0439002324679952
Rose wine (ukb-b-16124) Sciatica rs117158232 0.0347911417491256 0.015316102942332 0.0231143033566604
Rose wine (ukb-b-16124) Sciatica rs71641030 0.0384080783073538 0.0152243620994442 0.0116423343039989
Rose wine (ukb-b-16124) Sciatica All - Inverse variance weighted 0.0102843248824664 0.0049302266359429 0.0369809726638904
Low fat hard cheese (ukb-b-18079) Sciatica All - Inverse variance weighted -0.0087993803959309 0.0043405400192709 0.0426363659878428
Bran cereal (ukb-b-19498) Sciatica rs558086810 0.0329385879189543 0.0144507323371416 0.022644989053764
Bran cereal (ukb-b-19498) Sciatica All - Inverse variance weighted 0.0192574096277844 0.0082506703433244 0.019593532215827
Melon (ukb-b-19862) Sciatica rs142872754 -0.0409761908172083 0.018349398683262 0.0255418166319185
Melon (ukb-b-19862) Sciatica rs79508714 -0.0506773375769174 0.0199078298191153 0.010909064667102
Melon (ukb-b-19862) Sciatica All - MR Egger -0.0343247255725317 0.0110088382720891 0.0088890218174638
Milk-based pudding (ukb-b-20554) Sciatica rs75406904 0.0491326160698102 0.0213326341956032 0.0212694567652973
Milk-based pudding (ukb-b-20554) Sciatica rs9365376 0.0391090946934964 0.0193502022355608 0.0432672698488449
Milk-based pudding (ukb-b-20554) Sciatica All - Inverse variance weighted 0.0117581673837763 0.0055291107543135 0.0334539272934777
Oily fish (ukb-b-2209) Sciatica rs11265908 0.0618851534519263 0.0200901319825079 0.0020673966035034
Oily fish (ukb-b-2209) Sciatica rs114497213 0.0435695855064507 0.0161832189587336 0.0070967589855045
Oily fish (ukb-b-2209) Sciatica rs2092910 -0.0558092879366897 0.022466079013595 0.0129858208826952
Oily fish (ukb-b-2209) Sciatica rs3124402 0.0198527820956848 0.0100564964047742 0.0483675185291378
Oily fish (ukb-b-2209) Sciatica rs4579097 -0.047878317680686 0.02155247039608 0.026318669567934
Oily fish (ukb-b-2209) Sciatica rs6960970 0.0432976759953294 0.0190256506836416 0.0228608149355132
Oily fish (ukb-b-2209) Sciatica rs703987 0.0419709939038645 0.0184311891959935 0.0227759372468418
Oily fish (ukb-b-2209) Sciatica rs74575358 -0.0514019936054166 0.0209635508745533 0.0142076586307475
Oily fish (ukb-b-2209) Sciatica All - MR Egger 0.0116560526342771 0.0053657611188923 0.031225957352715
Other vegetables (ukb-b-3055) Sciatica rs10047705 0.0290977484925841 0.013466282340129 0.030711907649342
Other vegetables (ukb-b-3055) Sciatica All - Inverse variance weighted 0.0092286328546867 0.0038553429345372 0.0166782236866515
Other vegetables (ukb-b-3055) Sciatica All - MR Egger 0.0207419715440499 0.0092377083024801 0.0485606583879568
Croissant (ukb-b-4007) Sciatica rs12572321 -0.0704497004204045 0.0250148962229799 0.0048578779290669
Croissant (ukb-b-4007) Sciatica rs2350305 -0.0512973831103158 0.025477113155438 0.0440652900970029
Croissant (ukb-b-4007) Sciatica All - Inverse variance weighted -0.0123441476274475 0.0050971895286626 0.0154457317185348
Beer/cider (ukb-b-4961) Sciatica rs12473044 0.0147899300504699 0.0070766978256194 0.0366224763846366
Beer/cider (ukb-b-4961) Sciatica rs1450627 0.0166428364925336 0.0063653589924078 0.0089333284742993
Beer/cider (ukb-b-4961) Sciatica All - Inverse variance weighted 0.004122431439963 0.0017202729315243 0.0165578146592821
White fish (ukb-b-5427) Sciatica rs151062788 0.0431833631579505 0.0170401414639828 0.0112699918288427
White fish (ukb-b-5427) Sciatica All - Inverse variance weighted 0.019273977469991 0.0078070417032608 0.0135569248666712
Pork (ukb-b-5640) Sciatica rs10137783 0.0787922540518671 0.0249658476989838 0.0015994801015192
Pork (ukb-b-5640) Sciatica rs10896701 -0.0560269819126031 0.0278764713313819 0.0444491330585006
Pork (ukb-b-5640) Sciatica rs12097622 -0.0621767273121914 0.028503965085542 0.0291585680410062
Pork (ukb-b-5640) Sciatica rs1323058 0.0625802829097354 0.0270045528037288 0.0204820889058031
Pork (ukb-b-5640) Sciatica rs1451077 -0.0567310343278946 0.0249884916659701 0.0231902079392431
Pork (ukb-b-5640) Sciatica rs2555050 -0.060947626579568 0.0285138784996031 0.0325595931706544
Pork (ukb-b-5640) Sciatica rs36124222 0.0607773490222193 0.0239926986033403 0.011303928041205
Pork (ukb-b-5640) Sciatica All - MR Egger 0.0250013276852794 0.0096833733722442 0.0116046231859172
Other cereal (ukb-b-8917) Sciatica rs74383428 -0.058661902099844 0.0289205552328024 0.0425213870574944
Other cereal (ukb-b-8917) Sciatica All - Inverse variance weighted -0.0240156629106593 0.0078981268716933 0.0023604589351213