ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Fractures (ebi-a-GCST90038703)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Homemade soup (ukb-b-12658) (👉 📊) Fractures MR Egger 16 -0.026437019 0.010694063 0.026874278
Fried potatoes (ukb-b-12836) (👉 📊) Fractures Inverse variance weighted 19 -0.004347101 0.002052304 0.034161863
Mixed vegetable (ukb-b-13155) (👉 📊) Fractures Inverse variance weighted 13 0.006200605 0.003000817 0.038799598
Naan bread (ukb-b-13281) (👉 📊) Fractures Weighted median 18 0.027894378 0.014092215 0.047769022
Mozzarella (ukb-b-14505) (👉 📊) Fractures Weighted median 19 0.03094624 0.015364518 0.043995176
Mozzarella (ukb-b-14505) (👉 📊) Fractures Inverse variance weighted 19 0.027171729 0.010326592 0.008507424
Cereal (ukb-b-15926) (👉 📊) Fractures Inverse variance weighted 175 -0.004569282 0.002229147 0.040384982
Pea (ukb-b-15945) (👉 📊) Fractures Inverse variance weighted 11 -0.007358426 0.003313201 0.026354908
Cheesecake (ukb-b-1814) (👉 📊) Fractures MR Egger 21 -0.037672453 0.01607344 0.030116411
Cheesecake (ukb-b-1814) (👉 📊) Fractures Weighted median 21 -0.021708773 0.010885608 0.046123238
Cheesecake (ukb-b-1814) (👉 📊) Fractures Inverse variance weighted 21 -0.020126103 0.007944808 0.011301363
Other fruit (ukb-b-18659) (👉 📊) Fractures Inverse variance weighted 15 0.013315459 0.006050095 0.027745395
Butternut squash (ukb-b-20341) (👉 📊) Fractures Weighted median 14 -0.027238353 0.011256508 0.015529596
Parsnip (ukb-b-2468) (👉 📊) Fractures Inverse variance weighted 15 0.012788524 0.005669459 0.024090255
Fizzy drink (ukb-b-2832) (👉 📊) Fractures Weighted median 12 0.013027074 0.006056827 0.031491325
Cake (ukb-b-3433) (👉 📊) Fractures Weighted median 9 -0.014652433 0.006854685 0.032550914
Mushroom (ukb-b-4043) (👉 📊) Fractures Weighted median 9 -0.013833908 0.005397434 0.010375621
Danish pastry (ukb-b-447) (👉 📊) Fractures MR Egger 15 0.073172397 0.0270222 0.017923199
Pork (ukb-b-5185) (👉 📊) Fractures Inverse variance weighted 17 -0.010327208 0.004773287 0.030499518
Lamb (ukb-b-530) (👉 📊) Fractures Weighted median 14 -0.016312331 0.007725573 0.034731778
Cucumber (ukb-b-588) (👉 📊) Fractures MR Egger 15 -0.0129836 0.006001003 0.049707988
Pancake (ukb-b-6500) (👉 📊) Fractures Inverse variance weighted 33 -0.017413071 0.008449813 0.039325545
Other meat (ukb-b-770) (👉 📊) Fractures Inverse variance weighted 22 -0.021890316 0.009002868 0.015037179
Poultry (ukb-b-8006) (👉 📊) Fractures MR Egger 82 -0.025125928 0.011244033 0.02823319
Other milk-based pudding (ukb-b-9857) (👉 📊) Fractures Inverse variance weighted 21 0.017395541 0.007913091 0.027925991
Soya dessert (ukb-b-998) (👉 📊) Fractures Inverse variance weighted 21 0.031029833 0.013963735 0.026271628

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Homemade soup (ukb-b-12658) Fractures rs10110298 -0.0441186428746225 0.0196716805170512 0.0249130014074169
Homemade soup (ukb-b-12658) Fractures All - MR Egger -0.0264370191227084 0.0106940634422953 0.0268742781093875
Fried potatoes (ukb-b-12836) Fractures All - Inverse variance weighted -0.0043471009708937 0.0020523044994126 0.0341618630519684
Mixed vegetable (ukb-b-13155) Fractures rs2730078 0.0264526702881621 0.0111459072702175 0.017629558699099
Mixed vegetable (ukb-b-13155) Fractures rs72769311 0.0260488228778449 0.0101472152355774 0.0102555753631726
Mixed vegetable (ukb-b-13155) Fractures All - Inverse variance weighted 0.0062006050550429 0.0030008165054438 0.0387995982338036
Mozzarella (ukb-b-14505) Fractures rs116735069 0.130551789251006 0.0474511780448502 0.0059361686723885
Mozzarella (ukb-b-14505) Fractures All - Inverse variance weighted 0.027171728971574 0.0103265918325639 0.0085074237960681
Cereal (ukb-b-15926) Fractures rs10260232 -0.0643635846626747 0.0320269832018876 0.0444664005087334
Cereal (ukb-b-15926) Fractures rs11097340 -0.0629874104773961 0.023637175507656 0.0077043181237136
Cereal (ukb-b-15926) Fractures rs11119497 -0.0657883953576501 0.0276826967612205 0.0174769630611847
Cereal (ukb-b-15926) Fractures rs1500962 0.0567210144927536 0.0274437839673913 0.0387523103686554
Cereal (ukb-b-15926) Fractures rs1966434 -0.0704313797991003 0.0284762022144163 0.0133856072064575
Cereal (ukb-b-15926) Fractures rs2450126 -0.0533677584737517 0.024694300726753 0.0306847848228042
Cereal (ukb-b-15926) Fractures rs2656195 -0.0773201298625737 0.0315415944238221 0.0142313437879032
Cereal (ukb-b-15926) Fractures rs3195944 -0.0710257623594939 0.0311589570937638 0.0226394187499602
Cereal (ukb-b-15926) Fractures rs56246631 -0.0747303042337515 0.0303334006080769 0.0137537648472759
Cereal (ukb-b-15926) Fractures rs6510177 -0.0842459763413474 0.0267079644659926 0.0016086205883793
Cereal (ukb-b-15926) Fractures rs8178823 0.0932434616979554 0.0326353521651426 0.0042748997111533
Cereal (ukb-b-15926) Fractures rs9987289 -0.0571253476905512 0.0257838917835896 0.0267227452147115
Cereal (ukb-b-15926) Fractures All - Inverse variance weighted -0.0045692817365567 0.002229146877417 0.0403849822339848
Pea (ukb-b-15945) Fractures All - Inverse variance weighted -0.0073584260856653 0.0033132008657784 0.0263549078608436
Cheesecake (ukb-b-1814) Fractures rs1394426 0.088111386350047 0.035751654171403 0.0137189200881901
Cheesecake (ukb-b-1814) Fractures rs28381866 -0.0719795842842164 0.0338459877875779 0.0334466828956713
Cheesecake (ukb-b-1814) Fractures rs28694319 -0.0843567951983457 0.0376802932102657 0.0251721202400035
Cheesecake (ukb-b-1814) Fractures All - Inverse variance weighted -0.0201261029950119 0.0079448078397455 0.0113013627192904
Cheesecake (ukb-b-1814) Fractures All - MR Egger -0.0376724532131954 0.0160734395587156 0.0301164110400621
Other fruit (ukb-b-18659) Fractures rs4777390 0.0534346107463486 0.0245993568270133 0.0298409244342443
Other fruit (ukb-b-18659) Fractures All - Inverse variance weighted 0.0133154592372027 0.0060500954203703 0.0277453953084834
Butternut squash (ukb-b-20341) Fractures rs78400819 0.0685652478693938 0.0285150734238134 0.0161934349463239
Parsnip (ukb-b-2468) Fractures rs118084928 0.0506186252474214 0.0203495802699072 0.0128661439424665
Parsnip (ukb-b-2468) Fractures rs4001121 0.0488460919427022 0.0220704524107514 0.0268845886719891
Parsnip (ukb-b-2468) Fractures rs62136768 0.048638200238379 0.0225212753277712 0.0307993343789698
Parsnip (ukb-b-2468) Fractures All - Inverse variance weighted 0.0127885236507483 0.0056694590149218 0.0240902551755521
Mushroom (ukb-b-4043) Fractures rs182656582 -0.0242771524003332 0.0119712698453586 0.0425652173071377
Danish pastry (ukb-b-447) Fractures rs77949626 0.0724359720508565 0.0330936948142433 0.0286102968720683
Danish pastry (ukb-b-447) Fractures All - MR Egger 0.0731723966542856 0.0270222001238987 0.0179231987981652
Pork (ukb-b-5185) Fractures rs11015253 -0.0455341765763492 0.019792553806685 0.0214158881626653
Pork (ukb-b-5185) Fractures All - Inverse variance weighted -0.0103272075755275 0.0047732873251543 0.030499517501458
Cucumber (ukb-b-588) Fractures All - MR Egger -0.0129835998317528 0.0060010027662545 0.0497079876940657
Pancake (ukb-b-6500) Fractures All - Inverse variance weighted -0.0174130714170368 0.0084498128277999 0.039325545442663
Other meat (ukb-b-770) Fractures All - Inverse variance weighted -0.0218903158870104 0.0090028683052706 0.0150371786192747
Poultry (ukb-b-8006) Fractures rs4428348 0.070227504446013 0.0290112151870293 0.0154905733773513
Poultry (ukb-b-8006) Fractures rs7531243 -0.0646903703468075 0.0281240904355571 0.0214382257635122
Poultry (ukb-b-8006) Fractures rs77118273 -0.0748553271185371 0.0316479030323436 0.0180177121559324
Poultry (ukb-b-8006) Fractures All - MR Egger -0.0251259284476955 0.0112440330316253 0.0282331900055708
Other milk-based pudding (ukb-b-9857) Fractures All - Inverse variance weighted 0.0173955410620374 0.0079130907036469 0.0279259906170526
Soya dessert (ukb-b-998) Fractures All - Inverse variance weighted 0.0310298330025943 0.0139637352126037 0.0262716278386086