ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Tinned tomato (ukb-b-10565) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) MR Egger 13 11.51510316 4.020859956 0.01541039
Beef (ukb-b-10829) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Inverse variance weighted 8 5.40891261 2.597968935 0.037344534
Scotch egg (ukb-b-13516) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Weighted median 106 -12.83126513 6.500605575 0.048398017
Red wine (ukb-b-13556) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Inverse variance weighted 10 -3.183967806 1.539405992 0.038610943
Dark chocolate (ukb-b-16139) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Simple mode 21 -11.31962628 5.370949567 0.047886921
Fruit smoothie (ukb-b-1780) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) MR Egger 24 10.39803109 4.4065435 0.02757922
White pasta (ukb-b-2512) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Inverse variance weighted 10 -5.511328439 2.681581433 0.039854569
White pasta (ukb-b-2512) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Weighted mode 10 -11.87469518 4.737201868 0.033492177
Orange juice (ukb-b-2763) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Inverse variance weighted 12 -3.749230853 1.79830441 0.037081106
Hard cheese (ukb-b-3542) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Inverse variance weighted 12 3.449863864 1.569636657 0.027958074
Drinking water (ukb-b-3975) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) MR Egger 24 1.537160357 0.712461817 0.042149396
Green tea (ukb-b-4078) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Inverse variance weighted 126 -0.030627406 0.014854058 0.039218385
Sliced bread (ukb-b-4566) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Weighted median 15 2.235481353 1.011830513 0.027150745
Milk chocolate (ukb-b-4569) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Inverse variance weighted 14 5.203766583 2.265612131 0.021627445
Oat crunch (ukb-b-5186) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Inverse variance weighted 13 -10.21232021 4.765105182 0.032101308
Lamb (ukb-b-530) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Weighted median 13 9.687871912 3.674016174 0.008367698
Lamb (ukb-b-530) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Inverse variance weighted 13 6.565334495 2.805448739 0.019272986
Eggs in sandwiches (ukb-b-5382) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) MR Egger 15 24.28084822 10.08885128 0.031684973
Yorkshire pudding (ukb-b-5605) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Weighted median 15 -9.560891009 4.190023452 0.022499805
Cucumber (ukb-b-588) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) MR Egger 17 4.999643432 2.2106243 0.039005137
Processed meat (ukb-b-6324) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Weighted median 125 3.183357311 1.593747934 0.045781395
Instant coffee (ukb-b-930) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Weighted median 21 1.966254908 0.721763597 0.006445029
Instant coffee (ukb-b-930) (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) Inverse variance weighted 21 1.50904595 0.488334347 0.002000284

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Tinned tomato (ukb-b-10565) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs137930953 13.9468072767503 5.13101897700811 0.0065650851874515
Tinned tomato (ukb-b-10565) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs58393161 -14.2467125263773 6.78755508927542 0.035821649239708
Tinned tomato (ukb-b-10565) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - MR Egger 11.5151031593268 4.02085995618148 0.0154103895128808
Beef (ukb-b-10829) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - Inverse variance weighted 5.40891261030805 2.59796893497608 0.037344534019167
Scotch egg (ukb-b-13516) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs139110217 50.133505868947 24.0310564104545 0.0369608268065375
Scotch egg (ukb-b-13516) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs148914642 359.462365591398 145.122887864823 0.0132509879391808
Scotch egg (ukb-b-13516) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs193041511 179.276031250649 81.7734535565259 0.0283542436980919
Scotch egg (ukb-b-13516) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs7532469 601.93425020225 298.852688092962 0.0439937492569025
Scotch egg (ukb-b-13516) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs76631139 81.4378307266245 32.6589268431659 0.0126460076793293
Red wine (ukb-b-13556) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - Inverse variance weighted -3.1839678060626 1.53940599165304 0.0386109431089632
Fruit smoothie (ukb-b-1780) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs143438158 -28.5749942328128 13.5803076085271 0.0353654288267699
Fruit smoothie (ukb-b-1780) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs6429985 54.0871085648385 24.2324755164107 0.0256143541444792
Fruit smoothie (ukb-b-1780) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs685117 17.5721441260292 4.90874461510115 0.0003439054958029
Fruit smoothie (ukb-b-1780) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - MR Egger 10.3980310915241 4.40654349956215 0.0275792202705248
White pasta (ukb-b-2512) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - Inverse variance weighted -5.51132843874028 2.68158143295823 0.0398545688344318
Orange juice (ukb-b-2763) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - Inverse variance weighted -3.74923085330876 1.79830441047127 0.0370811056777089
Hard cheese (ukb-b-3542) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs12652998 8.65398654119271 4.09914035297293 0.0347576101582332
Hard cheese (ukb-b-3542) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - Inverse variance weighted 3.44986386366129 1.56963665708016 0.027958074119571
Drinking water (ukb-b-3975) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs28444545 -5.43440383285411 2.48399254444828 0.0286863759103458
Drinking water (ukb-b-3975) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - MR Egger 1.537160357251 0.712461816922393 0.0421493956537513
Green tea (ukb-b-4078) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs115172153 0.59376605497723 0.27433747499788 0.030436452336569
Green tea (ukb-b-4078) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs117077082 -0.351774231339981 0.16057900080706 0.0284762986552493
Green tea (ukb-b-4078) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs117914662 0.327990738857082 0.166937913530375 0.0494435451870589
Green tea (ukb-b-4078) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs138759868 0.562231364195624 0.228811308584963 0.0140031152799188
Green tea (ukb-b-4078) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs146320720 3.46339405635264 1.46481960075059 0.018060147746073
Green tea (ukb-b-4078) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs181929142 0.786792005687653 0.361892724543803 0.0296974116013773
Green tea (ukb-b-4078) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs186917540 -0.207287478909326 0.0938925573353886 0.0272645390153575
Green tea (ukb-b-4078) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs62059726 0.634710802381627 0.298766657215764 0.0336336575849444
Green tea (ukb-b-4078) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs72703007 0.511537588186011 0.222569354725048 0.0215430747646129
Green tea (ukb-b-4078) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - Inverse variance weighted -0.0306274055767351 0.014854057674911 0.0392183854862101
Sliced bread (ukb-b-4566) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs79885987 5.8986051691206 2.35831436203579 0.0123774845559527
Milk chocolate (ukb-b-4569) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - Inverse variance weighted 5.20376658272706 2.26561213141008 0.0216274450254005
Oat crunch (ukb-b-5186) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs141655467 -33.5474054017767 16.8900624314708 0.0470087328302687
Oat crunch (ukb-b-5186) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - Inverse variance weighted -10.2123202086344 4.76510518166854 0.0321013077066476
Lamb (ukb-b-530) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs142252464 9.94084966900786 3.58822781220791 0.0055986371050254
Lamb (ukb-b-530) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs147244930 36.9100054558278 13.749351288773 0.0072640407548174
Lamb (ukb-b-530) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - Inverse variance weighted 6.56533449504129 2.80544873872626 0.0192729860118247
Eggs in sandwiches (ukb-b-5382) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs114267116 35.1979408697416 17.1044748678968 0.0396073570840057
Eggs in sandwiches (ukb-b-5382) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs920644 -62.3197777039898 19.4159486901662 0.0013286387893559
Eggs in sandwiches (ukb-b-5382) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - MR Egger 24.2808482150834 10.0888512810125 0.0316849728759963
Cucumber (ukb-b-588) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - MR Egger 4.99964343154619 2.21062429979145 0.0390051367583463
Processed meat (ukb-b-6324) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs117665299 32.6404413631123 14.9975381284271 0.0295263631910342
Processed meat (ukb-b-6324) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs11887120 26.7344362611916 11.0014127954122 0.0150950245737561
Processed meat (ukb-b-6324) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs12788387 25.8982226175995 12.5542383035893 0.0391214911117089
Processed meat (ukb-b-6324) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs6909218 -26.7253169703915 12.1335896203748 0.0276236953736129
Processed meat (ukb-b-6324) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs77165542 36.5215799944508 15.0714610403027 0.0153832864016041
Processed meat (ukb-b-6324) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs78553019 -40.0603261381846 17.0735539007761 0.0189589123886999
Instant coffee (ukb-b-930) Malignant neoplasm of bone and articular cartilage (all cancers excluded) rs2726351 4.13162809466548 2.00041772534356 0.038886807372544
Instant coffee (ukb-b-930) Malignant neoplasm of bone and articular cartilage (all cancers excluded) All - Inverse variance weighted 1.50904594972716 0.488334346525235 0.0020002844272173