ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Sweet pepper (ukb-b-10932) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) Inverse variance weighted 9 -2.393019723 1.042840714 0.0217496
Beetroot (ukb-b-11880) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) MR Egger 10 -5.019311071 1.852631675 0.026687532
Beetroot (ukb-b-11880) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) Inverse variance weighted 10 -2.698224199 1.120605153 0.01604775
Beetroot (ukb-b-11880) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) Weighted mode 10 -4.022655897 1.696817416 0.041860474
Double crust pastry (ukb-b-1255) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) MR Egger 10 9.043949154 3.509604978 0.032773241
Dark chocolate (ukb-b-16139) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) MR Egger 21 -3.509110274 1.602490106 0.041220556
Non-oily fish (ukb-b-17627) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) Inverse variance weighted 67 -1.937466209 0.921596312 0.035527548
Mixed fruit (ukb-b-18956) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) Weighted median 16 -2.580657981 1.285233331 0.044650779
Butternut squash (ukb-b-20341) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) Inverse variance weighted 16 3.813224949 1.795706101 0.033709969
Cherry (ukb-b-2221) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) MR Egger 17 -10.35551242 4.494528235 0.035943412
Prune (ukb-b-3022) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) Inverse variance weighted 15 3.017214589 1.527551525 0.048245841
Drinking water (ukb-b-3975) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) Weighted median 24 0.750350694 0.30721606 0.014589157
Drinking water (ukb-b-3975) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) Weighted mode 24 0.846258222 0.386279036 0.038861784
Other cheese (ukb-b-4088) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) Weighted median 17 6.771234371 3.209202226 0.03486325
Other cheese (ukb-b-4088) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) Inverse variance weighted 17 5.376545145 2.369557871 0.023267855
Milk chocolate (ukb-b-4569) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) Weighted median 14 4.238394777 1.713105012 0.013357194
Milk chocolate (ukb-b-4569) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) Inverse variance weighted 14 3.692826602 1.272043653 0.003695288
Lamb (ukb-b-530) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) MR Egger 13 6.237604595 2.146739413 0.014300681
Cooked vegetable (ukb-b-8089) (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) MR Egger 94 5.02235881 2.509402233 0.048293569

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Sweet pepper (ukb-b-10932) Benign neoplasm: Long bones of lower limb (all cancers excluded) All - Inverse variance weighted -2.3930197230637 1.04284071383741 0.021749600385507
Beetroot (ukb-b-11880) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs189837126 -4.16807150226221 1.57476181727514 0.0081258626974944
Beetroot (ukb-b-11880) Benign neoplasm: Long bones of lower limb (all cancers excluded) All - Inverse variance weighted -2.69822419888013 1.12060515266834 0.0160477499443328
Beetroot (ukb-b-11880) Benign neoplasm: Long bones of lower limb (all cancers excluded) All - MR Egger -5.01931107090772 1.85263167503893 0.0266875323769281
Double crust pastry (ukb-b-1255) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs10789657 -13.9875587601173 6.15876718622981 0.0231371654025208
Double crust pastry (ukb-b-1255) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs75438658 7.57762096590526 3.25405891923703 0.0198766917232723
Double crust pastry (ukb-b-1255) Benign neoplasm: Long bones of lower limb (all cancers excluded) All - MR Egger 9.04394915375844 3.50960497830981 0.0327732413127168
Dark chocolate (ukb-b-16139) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs17143632 -5.75084641114888 2.76279454768738 0.0373852001535104
Dark chocolate (ukb-b-16139) Benign neoplasm: Long bones of lower limb (all cancers excluded) All - MR Egger -3.50911027426614 1.60249010577908 0.0412205561000118
Non-oily fish (ukb-b-17627) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs4415102 -18.9431133804661 7.05354804922755 0.0072396488788199
Non-oily fish (ukb-b-17627) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs78744083 -12.4555842652356 5.85468252556847 0.0333821454399142
Non-oily fish (ukb-b-17627) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs79262908 -16.7677315613073 8.27246837282291 0.042669358773401
Non-oily fish (ukb-b-17627) Benign neoplasm: Long bones of lower limb (all cancers excluded) All - Inverse variance weighted -1.93746620864824 0.921596312003591 0.0355275477577325
Mixed fruit (ukb-b-18956) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs139486419 -2.90922489502901 1.15093552736534 0.0114810943710167
Mixed fruit (ukb-b-18956) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs2229090 -11.9710323254935 5.28504399261725 0.0235079462478956
Mixed fruit (ukb-b-18956) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs79042385 6.30006028765826 3.12419257600551 0.043743506776636
Butternut squash (ukb-b-20341) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs5743134 31.730525436621 15.0884676380955 0.03546879382035
Butternut squash (ukb-b-20341) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs75010843 50.0415710639614 17.3776715048081 0.003981198204617
Butternut squash (ukb-b-20341) Benign neoplasm: Long bones of lower limb (all cancers excluded) All - Inverse variance weighted 3.81322494881761 1.79570610072349 0.033709969020076
Cherry (ukb-b-2221) Benign neoplasm: Long bones of lower limb (all cancers excluded) All - MR Egger -10.3555124242342 4.4945282345932 0.0359434116652946
Prune (ukb-b-3022) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs4712683 6.45027876975448 3.29009287022824 0.0499355432278634
Prune (ukb-b-3022) Benign neoplasm: Long bones of lower limb (all cancers excluded) All - Inverse variance weighted 3.01721458916846 1.52755152530288 0.0482458408713523
Drinking water (ukb-b-3975) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs377268 -2.78680269574875 1.24336927205127 0.0250046110230669
Drinking water (ukb-b-3975) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs76945478 -4.58651937041846 2.04868195964468 0.0251711502385015
Other cheese (ukb-b-4088) Benign neoplasm: Long bones of lower limb (all cancers excluded) All - Inverse variance weighted 5.37654514495101 2.36955787137944 0.0232678553335509
Milk chocolate (ukb-b-4569) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs189232607 15.3592530189425 7.05176822151476 0.0294007390295346
Milk chocolate (ukb-b-4569) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs2129730 9.31772081120902 4.24460343567997 0.0281498058375997
Milk chocolate (ukb-b-4569) Benign neoplasm: Long bones of lower limb (all cancers excluded) All - Inverse variance weighted 3.69282660224933 1.2720436525169 0.0036952882250297
Lamb (ukb-b-530) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs11687610 -11.8248664034268 5.18340751489445 0.0225311703015071
Lamb (ukb-b-530) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs142252464 4.7247916785788 1.81686852149844 0.0093084272742429
Lamb (ukb-b-530) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs78938647 14.4451358639286 6.25181497614603 0.0208576815423433
Lamb (ukb-b-530) Benign neoplasm: Long bones of lower limb (all cancers excluded) All - MR Egger 6.2376045950532 2.14673941300114 0.0143006813097392
Cooked vegetable (ukb-b-8089) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs17653477 17.7028356740317 8.59200286251006 0.039361729102213
Cooked vegetable (ukb-b-8089) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs2052063 15.3422397978335 7.21116991186935 0.033373085185064
Cooked vegetable (ukb-b-8089) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs28450747 -17.0760993661667 8.41502303058935 0.0424338750452499
Cooked vegetable (ukb-b-8089) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs4706990 -19.2670742792327 9.49110581093925 0.0423551525678076
Cooked vegetable (ukb-b-8089) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs4851029 -13.298081459349 6.66378361377575 0.0459801788832575
Cooked vegetable (ukb-b-8089) Benign neoplasm: Long bones of lower limb (all cancers excluded) rs7743389 17.8765135947931 7.77853230913052 0.0215512085218432
Cooked vegetable (ukb-b-8089) Benign neoplasm: Long bones of lower limb (all cancers excluded) All - MR Egger 5.02235881033727 2.50940223271543 0.0482935685769518