ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Sweet pepper (ukb-b-10932) (👉 📊) Drug-induced osteoporosis Weighted median 9 5.25632617 2.645738675 0.046954095
Herbal tea (ukb-b-13344) (👉 📊) Drug-induced osteoporosis MR Egger 121 -0.102424567 0.032443131 0.002019599
Herbal tea (ukb-b-13344) (👉 📊) Drug-induced osteoporosis Inverse variance weighted 121 -0.036700207 0.015553351 0.018293003
Red wine (ukb-b-13556) (👉 📊) Drug-induced osteoporosis Weighted median 10 4.443642625 2.049396132 0.030138206
Red wine (ukb-b-13556) (👉 📊) Drug-induced osteoporosis Inverse variance weighted 10 3.922434048 1.502601817 0.009042897
Shellfish (ukb-b-143) (👉 📊) Drug-induced osteoporosis MR Egger 40 18.87278843 7.323307267 0.013970058
Lobster/crab (ukb-b-14746) (👉 📊) Drug-induced osteoporosis Weighted median 54 -16.45579556 7.275462696 0.023708454
Lobster/crab (ukb-b-14746) (👉 📊) Drug-induced osteoporosis Inverse variance weighted 54 -18.87069652 5.130690886 0.000235067
Dried fruit (ukb-b-16576) (👉 📊) Drug-induced osteoporosis Weighted median 155 -4.491343824 1.738111854 0.009765157
Powdered/instant soup (ukb-b-19931) (👉 📊) Drug-induced osteoporosis MR Egger 18 -15.19789706 7.110098415 0.048339524
Powdered/instant soup (ukb-b-19931) (👉 📊) Drug-induced osteoporosis Inverse variance weighted 18 -7.226393467 3.420044572 0.03460479
Beef (ukb-b-2862) (👉 📊) Drug-induced osteoporosis Inverse variance weighted 98 3.348950239 1.488122814 0.024420213
Other vegetables (ukb-b-3055) (👉 📊) Drug-induced osteoporosis Inverse variance weighted 14 -6.76740071 2.894993646 0.019406868
Standard tea (ukb-b-3291) (👉 📊) Drug-induced osteoporosis Weighted median 14 0.018672896 0.009158835 0.041471472
Crumbed or deep-fried poultry (ukb-b-39) (👉 📊) Drug-induced osteoporosis Inverse variance weighted 12 6.062146987 3.042825864 0.046340854
Dairy smoothie (ukb-b-4955) (👉 📊) Drug-induced osteoporosis Inverse variance weighted 18 5.279703945 2.177764197 0.015335016
Sushi (ukb-b-5213) (👉 📊) Drug-induced osteoporosis MR Egger 69 -16.68049718 7.752680219 0.035039045
Tofu (ukb-b-5522) (👉 📊) Drug-induced osteoporosis MR Egger 48 -16.24986499 6.67037401 0.018776811
Soft cheese (ukb-b-8007) (👉 📊) Drug-induced osteoporosis Inverse variance weighted 16 -7.99352852 3.324596096 0.016200775

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Herbal tea (ukb-b-13344) Drug-induced osteoporosis rs144114507 0.345409722907011 0.133832955329849 0.0098542591954484
Herbal tea (ukb-b-13344) Drug-induced osteoporosis rs145459923 2.00693769293806 0.986756114539489 0.0419642921093052
Herbal tea (ukb-b-13344) Drug-induced osteoporosis rs151338529 0.397324370360854 0.163123888780674 0.0148621204243462
Herbal tea (ukb-b-13344) Drug-induced osteoporosis rs4269839 0.452052719284957 0.223299500075746 0.0429266124979264
Herbal tea (ukb-b-13344) Drug-induced osteoporosis rs62167877 -0.336995746874597 0.155077973965717 0.0297748289189
Herbal tea (ukb-b-13344) Drug-induced osteoporosis rs78335902 -0.189641971657356 0.0832534060096134 0.0227332248307135
Herbal tea (ukb-b-13344) Drug-induced osteoporosis All - Inverse variance weighted -0.0367002065431067 0.0155533511451242 0.0182930034757718
Herbal tea (ukb-b-13344) Drug-induced osteoporosis All - MR Egger -0.102424567330434 0.0324431309686868 0.0020195994031551
Red wine (ukb-b-13556) Drug-induced osteoporosis All - Inverse variance weighted 3.92243404772901 1.50260181672852 0.0090428971555087
Shellfish (ukb-b-143) Drug-induced osteoporosis rs146163137 90.0888459236754 42.1711243075695 0.0326575320607333
Shellfish (ukb-b-143) Drug-induced osteoporosis rs182535176 30.8319095807596 12.1660439704861 0.0112685326094067
Shellfish (ukb-b-143) Drug-induced osteoporosis rs62100374 -77.3289692134226 27.1968322644988 0.00446479089796
Shellfish (ukb-b-143) Drug-induced osteoporosis rs73696164 183.106176726459 80.2228758440698 0.0224617027852593
Shellfish (ukb-b-143) Drug-induced osteoporosis All - MR Egger 18.8727884347518 7.32330726731687 0.0139700583156912
Lobster/crab (ukb-b-14746) Drug-induced osteoporosis rs1395502 -122.968685335908 51.5105531797489 0.0169748384559539
Lobster/crab (ukb-b-14746) Drug-induced osteoporosis rs217514 -103.018533912651 44.4921600236933 0.0205893476169188
Lobster/crab (ukb-b-14746) Drug-induced osteoporosis All - Inverse variance weighted -18.8706965216864 5.13069088562219 0.0002350671863513
Dried fruit (ukb-b-16576) Drug-induced osteoporosis rs13016580 36.8859177762801 15.4146705768775 0.0167153454474886
Dried fruit (ukb-b-16576) Drug-induced osteoporosis rs13071694 -31.2415533721571 15.6792814676744 0.0463121353808474
Dried fruit (ukb-b-16576) Drug-induced osteoporosis rs142119647 58.8762523154142 22.4112175593045 0.0086118928361955
Dried fruit (ukb-b-16576) Drug-induced osteoporosis rs193003548 -50.1312262675899 20.2116372570918 0.0131266375674905
Dried fruit (ukb-b-16576) Drug-induced osteoporosis rs2165150 -29.3701132918462 14.5404499760651 0.043394771749372
Dried fruit (ukb-b-16576) Drug-induced osteoporosis rs261809 40.1201423262828 13.2314422272028 0.0024279268321683
Dried fruit (ukb-b-16576) Drug-induced osteoporosis rs34162196 -24.1740748027975 9.84670971434704 0.0140868570988182
Dried fruit (ukb-b-16576) Drug-induced osteoporosis rs6126123 31.7496427474981 14.7318342348391 0.031148344770853
Dried fruit (ukb-b-16576) Drug-induced osteoporosis rs979678 39.629961751734 13.8993100671632 0.0043552111595725
Powdered/instant soup (ukb-b-19931) Drug-induced osteoporosis All - Inverse variance weighted -7.226393467313 3.42004457194617 0.0346047901320051
Powdered/instant soup (ukb-b-19931) Drug-induced osteoporosis All - MR Egger -15.1978970606416 7.11009841457614 0.0483395236374961
Beef (ukb-b-2862) Drug-induced osteoporosis rs1421085 22.1311204962386 10.5830143856408 0.0365108098054836
Beef (ukb-b-2862) Drug-induced osteoporosis rs1555302 45.2829605900353 15.5980770461169 0.0036947478450287
Beef (ukb-b-2862) Drug-induced osteoporosis rs61845699 34.239423897907 16.1744517799929 0.0342697688784899
Beef (ukb-b-2862) Drug-induced osteoporosis rs6739040 41.2000440766237 20.420235809937 0.0436320369701164
Beef (ukb-b-2862) Drug-induced osteoporosis rs7597864 33.2475911580249 16.876541607166 0.0488329095979492
Beef (ukb-b-2862) Drug-induced osteoporosis All - Inverse variance weighted 3.34895023914366 1.4881228136494 0.0244202128365045
Other vegetables (ukb-b-3055) Drug-induced osteoporosis rs117427411 -12.2830397059243 5.41203607480673 0.0232331806797956
Other vegetables (ukb-b-3055) Drug-induced osteoporosis rs1177387 -16.9544978617653 8.33848443945453 0.0420239493046738
Other vegetables (ukb-b-3055) Drug-induced osteoporosis rs189553395 -58.132584676689 22.0482831785132 0.0083740603874164
Other vegetables (ukb-b-3055) Drug-induced osteoporosis All - Inverse variance weighted -6.76740070998198 2.89499364611972 0.0194068679365448
Crumbed or deep-fried poultry (ukb-b-39) Drug-induced osteoporosis All - Inverse variance weighted 6.06214698663202 3.04282586358861 0.0463408538844354
Dairy smoothie (ukb-b-4955) Drug-induced osteoporosis rs141362991 19.9078111690412 8.01415711708692 0.0129886453798983
Dairy smoothie (ukb-b-4955) Drug-induced osteoporosis rs144950069 14.9077244375042 6.87567274301782 0.0301446807540215
Dairy smoothie (ukb-b-4955) Drug-induced osteoporosis All - Inverse variance weighted 5.27970394466423 2.17776419722308 0.0153350161056033
Sushi (ukb-b-5213) Drug-induced osteoporosis rs5996535 63.6148818218219 23.5059244178505 0.0068030590431479
Sushi (ukb-b-5213) Drug-induced osteoporosis All - MR Egger -16.6804971802212 7.75268021948943 0.0350390445494982
Tofu (ukb-b-5522) Drug-induced osteoporosis All - MR Egger -16.2498649909286 6.67037400976222 0.0187768107710519
Soft cheese (ukb-b-8007) Drug-induced osteoporosis All - Inverse variance weighted -7.99352852021007 3.32459609597406 0.0162007749702241