ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Bread (ukb-b-11348) (👉 📊) Ankylosing spondylitis, strict definition MR Egger 113 -4.561122816 2.239794794 0.044090197
Pineapple (ukb-b-1164) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 16 -3.94380188 1.382669233 0.004340269
Crisp (ukb-b-12602) (👉 📊) Ankylosing spondylitis, strict definition MR Egger 9 -8.803139834 2.740639397 0.014815355
Red wine (ukb-b-13556) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 10 -1.656803626 0.67949033 0.01475638
Cheese (ukb-b-1489) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 198 -0.786819597 0.378442648 0.037608285
Water (ukb-b-14898) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 153 1.052683779 0.467242164 0.024260879
Broccoli (ukb-b-15601) (👉 📊) Ankylosing spondylitis, strict definition MR Egger 8 -5.222627374 1.891591219 0.032811874
Mashed potato (ukb-b-15710) (👉 📊) Ankylosing spondylitis, strict definition Weighted median 11 2.603911705 1.180105909 0.027348535
Mashed potato (ukb-b-15710) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 11 2.106339958 0.84350946 0.012520841
Carrot (ukb-b-16710) (👉 📊) Ankylosing spondylitis, strict definition Weighted median 5 -2.116848277 0.983575223 0.031381791
Carrot (ukb-b-16710) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 5 -1.756960881 0.779069944 0.024120589
Low fat hard cheese (ukb-b-18079) (👉 📊) Ankylosing spondylitis, strict definition Weighted median 16 3.440485735 1.592653798 0.03075549
Low fat hard cheese (ukb-b-18079) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 16 2.747447933 1.161679067 0.018026847
Other savoury snack (ukb-b-18718) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 24 -3.001111199 1.513714307 0.047410561
Bran cereal (ukb-b-19498) (👉 📊) Ankylosing spondylitis, strict definition Weighted median 4 -3.320731126 1.58502593 0.036165283
Bran cereal (ukb-b-19498) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 4 -3.158839466 1.292884066 0.014555636
Cherry (ukb-b-2221) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 17 4.568940524 1.787148976 0.010571506
Indian snacks (ukb-b-282) (👉 📊) Ankylosing spondylitis, strict definition Weighted median 24 -3.692999253 1.883093862 0.049863402
Milk (ukb-b-2966) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 20 -2.208576706 1.041192064 0.033904967
Cabbage/kale (ukb-b-2975) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 20 -1.437661041 0.592096811 0.01517881
Seeds (ukb-b-4548) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 15 -4.887447646 2.228250472 0.028278473
Baguette (ukb-b-5277) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 13 -2.203085205 0.838791848 0.008626847
Tofu (ukb-b-5522) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 48 -4.526355146 1.722286205 0.008586111
Doughnut (ukb-b-6214) (👉 📊) Ankylosing spondylitis, strict definition MR Egger 31 5.604419662 2.693553631 0.046403932
Bread roll (ukb-b-6246) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 18 1.187943957 0.564424898 0.035317604
Pancake (ukb-b-6500) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 45 -2.754285714 1.244486437 0.026884506
Poultry (ukb-b-8006) (👉 📊) Ankylosing spondylitis, strict definition Inverse variance weighted 80 1.739601194 0.697127823 0.01258211

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Bread (ukb-b-11348) Ankylosing spondylitis, strict definition rs12117826 -15.2657609876417 7.0098534129104 0.0294240940129064
Bread (ukb-b-11348) Ankylosing spondylitis, strict definition rs12510662 15.0076742578444 6.4333820097502 0.0196596183810493
Bread (ukb-b-11348) Ankylosing spondylitis, strict definition rs2517678 -33.7489609310058 4.76838207511524 1.46614679215112e-12
Bread (ukb-b-11348) Ankylosing spondylitis, strict definition rs62272476 -16.4983994090126 7.31491808740241 0.0241053767178416
Bread (ukb-b-11348) Ankylosing spondylitis, strict definition rs73802707 -14.3945861791884 6.45339493772599 0.0257113002534194
Bread (ukb-b-11348) Ankylosing spondylitis, strict definition rs7802468 -5.17284939214738 2.59070685616652 0.0458584109655937
Bread (ukb-b-11348) Ankylosing spondylitis, strict definition rs8050588 -11.0229477730913 5.46592451558244 0.0437303107358599
Bread (ukb-b-11348) Ankylosing spondylitis, strict definition rs9564268 -11.4961432824038 4.7612782264033 0.015756486813504
Bread (ukb-b-11348) Ankylosing spondylitis, strict definition All - MR Egger -4.56112281638603 2.23979479409835 0.0440901967096237
Pineapple (ukb-b-1164) Ankylosing spondylitis, strict definition rs79943840 -12.2245061871248 5.05860411930465 0.0156672136665792
Pineapple (ukb-b-1164) Ankylosing spondylitis, strict definition All - Inverse variance weighted -3.94380187951344 1.38266923261174 0.0043402691150995
Crisp (ukb-b-12602) Ankylosing spondylitis, strict definition rs150252324 -6.53250709829848 3.15572043411881 0.0384474246558177
Crisp (ukb-b-12602) Ankylosing spondylitis, strict definition rs543197 6.62532914295422 2.85021282218258 0.020098534302167
Crisp (ukb-b-12602) Ankylosing spondylitis, strict definition rs72610845 -8.74727140591098 3.97937767684772 0.027938376066343
Crisp (ukb-b-12602) Ankylosing spondylitis, strict definition All - MR Egger -8.80313983395291 2.74063939675118 0.0148153552463262
Red wine (ukb-b-13556) Ankylosing spondylitis, strict definition All - Inverse variance weighted -1.65680362648436 0.679490329931314 0.014756380337606
Cheese (ukb-b-1489) Ankylosing spondylitis, strict definition rs11104660 -11.2653020352646 5.14031559535035 0.0284114055154902
Cheese (ukb-b-1489) Ankylosing spondylitis, strict definition rs11620149 -11.0441596650542 5.4145803275906 0.041379475547284
Cheese (ukb-b-1489) Ankylosing spondylitis, strict definition rs117309393 -12.90210487706 5.24449649616154 0.0138889522875006
Cheese (ukb-b-1489) Ankylosing spondylitis, strict definition rs1806771 -10.5613928937494 4.84948096104612 0.0294179618538975
Cheese (ukb-b-1489) Ankylosing spondylitis, strict definition rs1931805 9.41731361237071 4.55829633674414 0.0388311025264432
Cheese (ukb-b-1489) Ankylosing spondylitis, strict definition rs2245959 -44.7225799759705 5.63570199929121 2.0950912578720103e-15
Cheese (ukb-b-1489) Ankylosing spondylitis, strict definition rs6126641 -8.95962498109784 4.47603205806744 0.0453181698336477
Cheese (ukb-b-1489) Ankylosing spondylitis, strict definition rs61734410 -9.54125135102678 3.67479284256035 0.0094204889582718
Cheese (ukb-b-1489) Ankylosing spondylitis, strict definition rs6498981 13.4984286180426 5.46119631111645 0.0134473019064921
Cheese (ukb-b-1489) Ankylosing spondylitis, strict definition rs67238148 -9.72000580298854 4.26761448812805 0.0227492041948789
Cheese (ukb-b-1489) Ankylosing spondylitis, strict definition rs7012814 -7.23694514503594 3.52666058187199 0.0401631144436815
Cheese (ukb-b-1489) Ankylosing spondylitis, strict definition rs75499503 -11.9989535385246 4.90705583720453 0.0144753788900156
Cheese (ukb-b-1489) Ankylosing spondylitis, strict definition All - Inverse variance weighted -0.786819596665753 0.378442648195094 0.0376082847262991
Water (ukb-b-14898) Ankylosing spondylitis, strict definition rs10892517 12.7553308104013 6.07698142828054 0.0358205738968175
Water (ukb-b-14898) Ankylosing spondylitis, strict definition rs11770515 18.8976377952756 6.15450095765056 0.0021367247888687
Water (ukb-b-14898) Ankylosing spondylitis, strict definition rs12692772 20.7443974615763 9.09759173461199 0.0225953811097418
Water (ukb-b-14898) Ankylosing spondylitis, strict definition rs12981418 15.6582718924214 6.51309793283974 0.0162114310801086
Water (ukb-b-14898) Ankylosing spondylitis, strict definition rs1963510 9.15321489764632 4.32861394174407 0.0344654753930275
Water (ukb-b-14898) Ankylosing spondylitis, strict definition rs2274156 18.7113626469308 5.64214192424902 0.0009119891240308
Water (ukb-b-14898) Ankylosing spondylitis, strict definition rs2516491 -16.7450366007899 6.74977006574017 0.0131076623625385
Water (ukb-b-14898) Ankylosing spondylitis, strict definition rs2917704 14.4771395865598 6.73355329607434 0.031555214782181
Water (ukb-b-14898) Ankylosing spondylitis, strict definition rs4239466 -13.0795106458948 5.44039990227952 0.0162103386460619
Water (ukb-b-14898) Ankylosing spondylitis, strict definition rs6844845 16.9285116668216 8.54327414706703 0.0475350465078148
Water (ukb-b-14898) Ankylosing spondylitis, strict definition All - Inverse variance weighted 1.05268377936807 0.467242164428094 0.024260878622536
Broccoli (ukb-b-15601) Ankylosing spondylitis, strict definition rs113230204 -3.53022742113622 1.48174423385439 0.0171964213437132
Broccoli (ukb-b-15601) Ankylosing spondylitis, strict definition All - MR Egger -5.22262737416381 1.89159121866638 0.0328118743695595
Mashed potato (ukb-b-15710) Ankylosing spondylitis, strict definition rs55768233 5.71232839518034 2.18258982558079 0.008864791748922
Mashed potato (ukb-b-15710) Ankylosing spondylitis, strict definition All - Inverse variance weighted 2.10633995754711 0.843509459966752 0.0125208414277545
Carrot (ukb-b-16710) Ankylosing spondylitis, strict definition All - Inverse variance weighted -1.75696088126317 0.779069943547502 0.0241205891242476
Low fat hard cheese (ukb-b-18079) Ankylosing spondylitis, strict definition rs113861725 16.3808919094324 7.75005408321229 0.0345452811863674
Low fat hard cheese (ukb-b-18079) Ankylosing spondylitis, strict definition rs117864679 7.93733681462141 3.6629480180394 0.030240507126869
Low fat hard cheese (ukb-b-18079) Ankylosing spondylitis, strict definition All - Inverse variance weighted 2.74744793309666 1.1616790665282 0.0180268467235956
Other savoury snack (ukb-b-18718) Ankylosing spondylitis, strict definition All - Inverse variance weighted -3.0011111986374 1.51371430740009 0.047410560826045
Bran cereal (ukb-b-19498) Ankylosing spondylitis, strict definition rs8176599 -3.47084287682707 1.74904148894392 0.0472084036397042
Bran cereal (ukb-b-19498) Ankylosing spondylitis, strict definition All - Inverse variance weighted -3.1588394655066 1.29288406613172 0.0145556356679797
Cherry (ukb-b-2221) Ankylosing spondylitis, strict definition rs6676180 20.477325598093 5.66740381209493 0.0003024696233626
Cherry (ukb-b-2221) Ankylosing spondylitis, strict definition All - Inverse variance weighted 4.56894052413982 1.78714897632723 0.010571505938238
Indian snacks (ukb-b-282) Ankylosing spondylitis, strict definition rs72696787 18.3957479032419 7.78693794739173 0.0181577583239123
Milk (ukb-b-2966) Ankylosing spondylitis, strict definition rs13072001 31.9457402453612 15.4289563436606 0.0384050237910048
Milk (ukb-b-2966) Ankylosing spondylitis, strict definition rs3744761 -8.13276074436566 4.11797995938613 0.0482750289478643
Milk (ukb-b-2966) Ankylosing spondylitis, strict definition All - Inverse variance weighted -2.20857670587884 1.04119206398636 0.0339049672195226
Cabbage/kale (ukb-b-2975) Ankylosing spondylitis, strict definition rs117630679 -6.09568888986026 2.29590057897076 0.0079300948544324
Cabbage/kale (ukb-b-2975) Ankylosing spondylitis, strict definition All - Inverse variance weighted -1.43766104050487 0.592096810626627 0.0151788097065628
Seeds (ukb-b-4548) Ankylosing spondylitis, strict definition rs12778642 -24.3748307303422 7.82401974060365 0.0018370520434806
Seeds (ukb-b-4548) Ankylosing spondylitis, strict definition All - Inverse variance weighted -4.8874476464278 2.22825047234725 0.0282784734631213
Baguette (ukb-b-5277) Ankylosing spondylitis, strict definition rs2362311 -7.92084773870759 3.54442476881131 0.0254347948861202
Baguette (ukb-b-5277) Ankylosing spondylitis, strict definition All - Inverse variance weighted -2.20308520531693 0.83879184831685 0.0086268471265184
Tofu (ukb-b-5522) Ankylosing spondylitis, strict definition rs112346208 -31.2667674747573 13.3895907516707 0.0195353340150464
Tofu (ukb-b-5522) Ankylosing spondylitis, strict definition rs117633973 -35.4395604395604 16.4694280078895 0.0314100229197313
Tofu (ukb-b-5522) Ankylosing spondylitis, strict definition rs146578953 -17.5730125584542 8.82326990382636 0.04640764337158
Tofu (ukb-b-5522) Ankylosing spondylitis, strict definition rs74348216 40.164469390419 16.7667406343819 0.016598410382748
Tofu (ukb-b-5522) Ankylosing spondylitis, strict definition All - Inverse variance weighted -4.52635514637274 1.72228620486025 0.0085861105518457
Doughnut (ukb-b-6214) Ankylosing spondylitis, strict definition rs117118087 43.0032918092042 15.7598055035607 0.0063590508102785
Doughnut (ukb-b-6214) Ankylosing spondylitis, strict definition rs117309828 25.8853097714544 12.7752461126378 0.0427434429452994
Doughnut (ukb-b-6214) Ankylosing spondylitis, strict definition All - MR Egger 5.60441966158565 2.69355363146628 0.0464039315845063
Bread roll (ukb-b-6246) Ankylosing spondylitis, strict definition All - Inverse variance weighted 1.18794395747621 0.564424898041078 0.0353176041704351
Pancake (ukb-b-6500) Ankylosing spondylitis, strict definition rs140856674 62.9241419241675 29.3844673586336 0.0322411272052871
Pancake (ukb-b-6500) Ankylosing spondylitis, strict definition rs145580229 33.8031014356547 12.1123754397214 0.0052579504716475
Pancake (ukb-b-6500) Ankylosing spondylitis, strict definition rs561776 -11.2008584690635 4.45455604172559 0.0119210614279358
Pancake (ukb-b-6500) Ankylosing spondylitis, strict definition All - Inverse variance weighted -2.75428571401803 1.24448643749613 0.0268845063018756
Poultry (ukb-b-8006) Ankylosing spondylitis, strict definition rs11586828 13.0523252070213 6.36840139602571 0.0404088527544236
Poultry (ukb-b-8006) Ankylosing spondylitis, strict definition rs2965200 -16.0561244565583 6.20939182510053 0.009715877457773
Poultry (ukb-b-8006) Ankylosing spondylitis, strict definition rs7531243 -12.0798110491702 5.68602034243362 0.0336304005625124
Poultry (ukb-b-8006) Ankylosing spondylitis, strict definition All - Inverse variance weighted 1.73960119447597 0.697127822643008 0.0125821100235821