ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Sweets (ukb-b-10217) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Inverse variance weighted 21 1.997850281 0.924035856 0.030611106
Beef (ukb-b-10829) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Inverse variance weighted 8 -4.611884071 2.005410276 0.021464033
Sponge pudding (ukb-b-12067) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Weighted median 15 -9.459402933 4.814572316 0.049443854
Unsalted nuts (ukb-b-12217) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist MR Egger 15 -15.95751487 5.715221538 0.01525846
Naan bread (ukb-b-13281) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Weighted median 18 12.6636475 6.045583623 0.036198206
Naan bread (ukb-b-13281) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Inverse variance weighted 18 9.798984461 4.253057175 0.021223426
Other sweets (ukb-b-139) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Inverse variance weighted 26 3.432906529 1.619161997 0.033991303
Battered fish (ukb-b-14166) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist MR Egger 15 -12.86560414 5.232899059 0.028744557
Battered fish (ukb-b-14166) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Inverse variance weighted 15 -6.681174208 3.05648911 0.02882305
Non-oily fish (ukb-b-17627) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist MR Egger 67 -7.527283791 3.453145632 0.032897829
Low fat hard cheese (ukb-b-18079) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Inverse variance weighted 16 4.117220953 2.0908897 0.048938861
Beef (ukb-b-2862) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Weighted median 98 3.600554291 1.742712912 0.038822552
Beef (ukb-b-2862) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Inverse variance weighted 98 2.313886807 1.168231471 0.047627738
Vegetarian sausages/burgers (ukb-b-3383) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Inverse variance weighted 34 5.027639963 2.158138725 0.019826322
Crumbed or deep-fried poultry (ukb-b-39) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Weighted median 12 -7.025324538 3.397934018 0.038684406
Crumbed or deep-fried poultry (ukb-b-39) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Inverse variance weighted 12 -5.534355869 2.400228505 0.02112393
Danish pastry (ukb-b-447) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Inverse variance weighted 16 -7.729690491 3.485508237 0.026577665
Sushi (ukb-b-5213) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Weighted median 69 -9.147219586 3.630759854 0.011756577
Coffee (ukb-b-5237) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Simple mode 117 8.105452162 3.295839407 0.015396679
Lamb (ukb-b-530) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist MR Egger 13 -8.861946197 2.946534063 0.011917229
Lamb (ukb-b-530) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Weighted median 13 -6.840839843 2.69795751 0.01122669
Lamb (ukb-b-530) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Inverse variance weighted 13 -4.531323304 1.994847685 0.023115915
Lamb (ukb-b-530) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Weighted mode 13 -6.882523604 2.724542052 0.026608346
Cucumber (ukb-b-588) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Weighted median 17 -2.895356338 1.299847613 0.025916661
Cucumber (ukb-b-588) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Inverse variance weighted 17 -1.949098076 0.942284766 0.038594821
Garlic bread (ukb-b-602) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist MR Egger 23 6.435448504 2.928193804 0.039321369
Pulses (ukb-b-621) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Weighted median 6 -6.111912193 2.58544783 0.018080445
Pulses (ukb-b-621) (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist Inverse variance weighted 6 -4.963787902 2.067687419 0.016366109

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Sweets (ukb-b-10217) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs62559005 4.64598081883913 2.34697585505116 0.0477529293240851
Sweets (ukb-b-10217) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - Inverse variance weighted 1.99785028102041 0.924035855991688 0.0306111064788813
Beef (ukb-b-10829) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs7697997 -13.5267377230152 4.91224010682556 0.0058929341058557
Beef (ukb-b-10829) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - Inverse variance weighted -4.61188407057199 2.00541027561687 0.0214640331259205
Sponge pudding (ukb-b-12067) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs1468548 -34.4200870895359 14.9128838148841 0.0209948431671656
Sponge pudding (ukb-b-12067) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs148036230 54.784418824164 22.4219592772384 0.0145521125824404
Sponge pudding (ukb-b-12067) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs79889442 -14.146925957065 6.50171342489837 0.0295644906187285
Unsalted nuts (ukb-b-12217) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs2178664 -22.1434813998556 9.7212194905701 0.0227355064363118
Unsalted nuts (ukb-b-12217) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs2664108 18.6604439172104 8.37417663034995 0.0258583986035682
Unsalted nuts (ukb-b-12217) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - MR Egger -15.9575148672007 5.71522153814521 0.0152584603964254
Naan bread (ukb-b-13281) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - Inverse variance weighted 9.79898446053668 4.25305717504102 0.021223425896241
Other sweets (ukb-b-139) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs117902110 42.6993098988818 16.7675619028507 0.0108795946082104
Other sweets (ukb-b-139) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs146890637 26.8009814578208 8.56868615597806 0.0017613082656136
Other sweets (ukb-b-139) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs76004663 34.0993127109345 13.733003451619 0.0130274026647806
Other sweets (ukb-b-139) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - Inverse variance weighted 3.43290652920409 1.61916199678919 0.0339913032934109
Battered fish (ukb-b-14166) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs186654512 49.1197011243333 22.9192733984683 0.0321001438715892
Battered fish (ukb-b-14166) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - Inverse variance weighted -6.68117420822736 3.05648910972433 0.0288230500227875
Battered fish (ukb-b-14166) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - MR Egger -12.8656041411896 5.23289905873928 0.0287445572354532
Non-oily fish (ukb-b-17627) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs112858262 -28.8276324918706 12.5508872199486 0.0216267498688108
Non-oily fish (ukb-b-17627) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - MR Egger -7.52728379092772 3.45314563168998 0.0328978290200332
Low fat hard cheese (ukb-b-18079) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs117864679 19.3971042012817 6.66508426299549 0.0036113234886943
Low fat hard cheese (ukb-b-18079) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs9895448 19.9837321803159 8.90449077443384 0.0248175572814151
Low fat hard cheese (ukb-b-18079) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - Inverse variance weighted 4.11722095314472 2.09088970047144 0.0489388610081657
Beef (ukb-b-2862) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs71559014 34.5503633927216 14.9581817821756 0.0208993955244718
Beef (ukb-b-2862) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs7220792 38.6616748021421 10.8620444528695 0.0003717924519387
Beef (ukb-b-2862) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - Inverse variance weighted 2.31388680667886 1.16823147075744 0.047627738032738
Vegetarian sausages/burgers (ukb-b-3383) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs16871519 35.4445090063916 13.957743518736 0.0111037892612706
Vegetarian sausages/burgers (ukb-b-3383) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs72737216 27.0960777258006 8.55523569629363 0.0015391843215866
Vegetarian sausages/burgers (ukb-b-3383) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - Inverse variance weighted 5.02763996330017 2.15813872493043 0.0198263219184182
Crumbed or deep-fried poultry (ukb-b-39) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs142223998 -11.267761027007 5.13030663629988 0.0280695218422518
Crumbed or deep-fried poultry (ukb-b-39) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - Inverse variance weighted -5.53435586850301 2.40022850541768 0.0211239302080234
Danish pastry (ukb-b-447) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs76394359 -21.1601077632514 9.19375898715766 0.0213592623301883
Danish pastry (ukb-b-447) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - Inverse variance weighted -7.72969049106955 3.48550823738942 0.0265776654123608
Sushi (ukb-b-5213) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs112365162 190.917606020477 77.5061098371069 0.0137680501972612
Sushi (ukb-b-5213) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs115129823 33.8494521200572 14.4294902334445 0.0189836311136322
Sushi (ukb-b-5213) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs115384920 112.678871462389 56.3810761123707 0.0456600003092012
Sushi (ukb-b-5213) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs115486703 -55.5426922186384 26.8424935249552 0.0385266077055275
Sushi (ukb-b-5213) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs117165655 227.081948409129 76.3500567004262 0.002937333571365
Sushi (ukb-b-5213) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs561262254 -50.6951015357741 20.6073950069146 0.013891992506553
Sushi (ukb-b-5213) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs8086196 -85.1116790016926 43.4187381766287 0.0499663146689631
Coffee (ukb-b-5237) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs10053913 -25.5832820790186 12.8993349303939 0.0473336601679641
Coffee (ukb-b-5237) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs56791931 30.816708338433 13.3058241393177 0.0205565468057746
Coffee (ukb-b-5237) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs641727 -29.2753471714895 11.3368648609448 0.0098140189278477
Coffee (ukb-b-5237) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs73228435 36.0495297280703 16.5827836749123 0.0297116662879534
Coffee (ukb-b-5237) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs77350503 27.0296849940993 10.4926317063576 0.0099932307539252
Coffee (ukb-b-5237) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs78308709 -26.732058971253 11.7410701096109 0.0227982196401161
Lamb (ukb-b-530) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs142252464 -7.88943357344315 2.72355242721732 0.0037705755615842
Lamb (ukb-b-530) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - Inverse variance weighted -4.53132330376516 1.99484768504462 0.0231159150125546
Lamb (ukb-b-530) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - MR Egger -8.86194619678682 2.94653406269513 0.011917229155374
Cucumber (ukb-b-588) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs183032803 -8.13490514482005 3.67241783121243 0.0267507273777046
Cucumber (ukb-b-588) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - Inverse variance weighted -1.94909807612387 0.94228476582383 0.0385948212760621
Garlic bread (ukb-b-602) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist rs146515099 20.5491222040639 8.70781985368899 0.0182824755950042
Garlic bread (ukb-b-602) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - MR Egger 6.4354485037502 2.92819380425609 0.0393213693377247
Pulses (ukb-b-621) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist All - Inverse variance weighted -4.96378790204486 2.06768741871515 0.0163661092550955