ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Contracture of joint (finn-b-M13_CONTRACTUREJOINT)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Double crust pastry (ukb-b-1255) (👉 📊) Contracture of joint Weighted median 10 -10.47273924 3.947657635 0.007980361
Double crust pastry (ukb-b-1255) (👉 📊) Contracture of joint Weighted mode 10 -11.17351229 4.74535769 0.042978579
Battered fish (ukb-b-14166) (👉 📊) Contracture of joint MR Egger 15 -12.39365826 5.17613732 0.032424024
Side salad (ukb-b-1604) (👉 📊) Contracture of joint Inverse variance weighted 17 -1.778102673 0.680783304 0.009005422
Rose wine (ukb-b-16124) (👉 📊) Contracture of joint MR Egger 14 -11.09064907 3.485776058 0.007896426
Rose wine (ukb-b-16124) (👉 📊) Contracture of joint Weighted median 14 -5.917695608 2.537495778 0.019695396
Rose wine (ukb-b-16124) (👉 📊) Contracture of joint Weighted mode 14 -5.349383062 2.324489722 0.038564621
Dark chocolate (ukb-b-16139) (👉 📊) Contracture of joint Inverse variance weighted 21 3.271090993 1.583348567 0.03883487
Other dessert (ukb-b-17441) (👉 📊) Contracture of joint MR Egger 16 10.82938119 4.325574596 0.025291573
Goat's cheese (ukb-b-20122) (👉 📊) Contracture of joint Inverse variance weighted 35 5.56486556 2.712610809 0.040220271
Single crust pastry (ukb-b-2024) (👉 📊) Contracture of joint Weighted median 15 7.718960673 3.055934714 0.011540499
Single crust pastry (ukb-b-2024) (👉 📊) Contracture of joint Inverse variance weighted 15 4.631638008 2.272553364 0.041542265
Fresh fruit (ukb-b-3881) (👉 📊) Contracture of joint MR Egger 141 14.78764699 4.54345289 0.001425514
Baked bean (ukb-b-4058) (👉 📊) Contracture of joint Inverse variance weighted 13 -4.060755717 2.047581632 0.04734554
Baked bean (ukb-b-4058) (👉 📊) Contracture of joint Simple mode 13 -12.32986978 4.859502802 0.026068791
Apple (ukb-b-4070) (👉 📊) Contracture of joint Weighted median 18 -2.624955474 1.27188016 0.039033014
Green tea (ukb-b-4078) (👉 📊) Contracture of joint Inverse variance weighted 126 -0.027638064 0.012070372 0.022036155
Oatcakes (ukb-b-6298) (👉 📊) Contracture of joint MR Egger 15 -4.109510393 1.817030638 0.041503488
Crumble (ukb-b-7641) (👉 📊) Contracture of joint MR Egger 24 -10.72497952 4.015252616 0.013954523
Other egg (ukb-b-8266) (👉 📊) Contracture of joint Inverse variance weighted 21 8.047435827 3.86543951 0.037352141

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Double crust pastry (ukb-b-1255) Contracture of joint rs184629495 33.3160057363924 14.8033404820555 0.024412563683709
Double crust pastry (ukb-b-1255) Contracture of joint rs75438658 -12.2929090302868 5.07604039697333 0.0154459039270273
Battered fish (ukb-b-14166) Contracture of joint rs138104392 -26.9572589841729 13.1156599679828 0.0398453048593312
Battered fish (ukb-b-14166) Contracture of joint All - MR Egger -12.3936582561227 5.17613731951261 0.0324240244877231
Side salad (ukb-b-1604) Contracture of joint rs7007359 -7.77176664554966 3.17285289042392 0.0143071801353064
Side salad (ukb-b-1604) Contracture of joint All - Inverse variance weighted -1.77810267251682 0.680783304048929 0.0090054220549942
Rose wine (ukb-b-16124) Contracture of joint rs12456862 17.1332832980812 8.07387022675067 0.0338322189291909
Rose wine (ukb-b-16124) Contracture of joint rs13224220 -6.11894588653708 2.31750187293668 0.0082827847973629
Rose wine (ukb-b-16124) Contracture of joint rs591596 20.1343299422351 9.48092444067094 0.0336979671130651
Rose wine (ukb-b-16124) Contracture of joint All - MR Egger -11.0906490680093 3.48577605768216 0.007896425597045
Dark chocolate (ukb-b-16139) Contracture of joint rs6916329 25.2252529223039 11.2170794748088 0.0245236084833097
Dark chocolate (ukb-b-16139) Contracture of joint All - Inverse variance weighted 3.27109099303229 1.58334856668489 0.0388348696780935
Other dessert (ukb-b-17441) Contracture of joint rs4923342 -23.7395471522208 8.30543064880137 0.0042589573157535
Other dessert (ukb-b-17441) Contracture of joint All - MR Egger 10.8293811861953 4.32557459577045 0.0252915734533262
Goat's cheese (ukb-b-20122) Contracture of joint rs402308 44.6899643729234 19.6229134141948 0.022760096160616
Goat's cheese (ukb-b-20122) Contracture of joint rs73127831 16.4172401071492 5.614102625796 0.0034524769486685
Goat's cheese (ukb-b-20122) Contracture of joint rs7734657 -52.0339555613674 22.6297761359385 0.0214846219203627
Goat's cheese (ukb-b-20122) Contracture of joint rs77508780 45.5999492085818 15.9260398810309 0.0041934321202353
Goat's cheese (ukb-b-20122) Contracture of joint All - Inverse variance weighted 5.5648655600532 2.71261080917238 0.0402202706481021
Single crust pastry (ukb-b-2024) Contracture of joint rs144508914 23.3488457785451 11.6923349869327 0.0458321254392676
Single crust pastry (ukb-b-2024) Contracture of joint rs148305053 13.1467925646398 6.18460256558732 0.0335257831438818
Single crust pastry (ukb-b-2024) Contracture of joint All - Inverse variance weighted 4.63163800821898 2.27255336352234 0.0415422651862454
Fresh fruit (ukb-b-3881) Contracture of joint rs2867113 23.7579902745913 10.3025843037098 0.0211093802309965
Fresh fruit (ukb-b-3881) Contracture of joint rs3110611 39.370628094614 18.5475587097854 0.0337802412704752
Fresh fruit (ukb-b-3881) Contracture of joint rs3752712 -33.6219893828631 16.692217055835 0.0439852340497772
Fresh fruit (ukb-b-3881) Contracture of joint All - MR Egger 14.7876469871985 4.5434528896833 0.0014255140764505
Baked bean (ukb-b-4058) Contracture of joint rs112608234 -15.8009740400922 7.49916655795684 0.0351149199480322
Baked bean (ukb-b-4058) Contracture of joint rs4894011 -12.6954623740259 5.98536909776103 0.0339148501739319
Baked bean (ukb-b-4058) Contracture of joint rs78813271 -17.9708099499831 9.09030224718565 0.0480505539445398
Baked bean (ukb-b-4058) Contracture of joint All - Inverse variance weighted -4.06075571718748 2.04758163231423 0.0473455397535632
Apple (ukb-b-4070) Contracture of joint rs7853153 -13.070793211386 4.2315330940394 0.0020089734838054
Green tea (ukb-b-4078) Contracture of joint rs10833476 -0.345365378720949 0.16758920361322 0.0393235209698863
Green tea (ukb-b-4078) Contracture of joint rs138314328 0.826409968181202 0.28596640901618 0.0038538306990949
Green tea (ukb-b-4078) Contracture of joint rs35331067 0.271075590189127 0.112713720460293 0.0161728221020711
Green tea (ukb-b-4078) Contracture of joint All - Inverse variance weighted -0.0276380635367944 0.0120703722110307 0.0220361554329004
Oatcakes (ukb-b-6298) Contracture of joint All - MR Egger -4.10951039328294 1.81703063830584 0.0415034876190577
Crumble (ukb-b-7641) Contracture of joint All - MR Egger -10.7249795229287 4.01525261603201 0.013954523134362
Other egg (ukb-b-8266) Contracture of joint rs148292197 227.765165537512 104.696956857218 0.029594858947272
Other egg (ukb-b-8266) Contracture of joint rs191530496 27.5155567590465 9.87160479263463 0.0053142060805141
Other egg (ukb-b-8266) Contracture of joint rs80253693 31.639704282892 15.0182811815573 0.0351395997887086
Other egg (ukb-b-8266) Contracture of joint All - Inverse variance weighted 8.04743582689457 3.86543950966707 0.0373521410371049